Michael B Brenner MD

E. F. Brigham Professor of Medicine, Brigham and Women's Hospital, Harvard Medical School

Brigham And Women's Hospital Rheumatology Immunology &60 Fenwood Rd. Rm 6002UBoston, MA 02115
Phone+1 617-525-1000

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Education & Training

UCLA David Geffen School of Medicine/UCLA Medical CenterFellowship, Rheumatology, 1979 - 1982
Vanderbilt University Medical CenterResidency, Internal Medicine, 1975 - 1979
Vanderbilt University School of MedicineClass of 1975

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Certifications & Licensure

CA State Medical License 1979 - Present
MA State Medical License 1985 - 2027

Awards, Honors, & Recognition

Fellow (FACR) American College of Rheumatology

Publications & Presentations

PubMed

Functional and dysfunctional T regulatory cell states in human tissues in RA and other autoimmune arthritic diseases.
Byunghee Koh, Shani T Gal Oz, Ryota Sato, Hung N Nguyen, Garrett Dunlap
Nature Immunology. 2026-07-01
16 citations
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis.
Kartik Bhamidipati, Alexa B R McIntyre, Shideh Kazerounian, Gao Ce, Soon W Wong
Nature Immunology. 2026-03-01
Author Correction: Distinct fibroblast subsets drive inflammation and damage in arthritis.
Adam P Croft, Joana Campos, Kathrin Jansen, Jason D Turner, Jennifer Marshall
Nature. 2026-01-01

Journal Articles

Metabolic Reprogramming of Natural Killer Cells in Obesity Limits Antitumor Responses
Ali Tavakkoli, Michael B Brenner, Kevin Wei, Ashley Vernon, Nature
Plateletpheresis-Associated Lymphopenia in Frequent Platelet Donors
Michael B Brenner, A Helena Jonsson, Dan L Longo, Deepak A Rao, Richard M Kaufman, Nancy Berliner, Duane R Wesemann, Blood
High-Throughput Identification of Noncoding Functional SNPs via Type IIS Enzyme Restriction
Soumya Raychaudhuri, Jing Cui, Michael B Brenner, Peter A Nigrovic, Nature

Press Mentions

Newborn Bio Business Mestag Therapeutics Raises $11m Seed CashApril 26th, 2021
Mestag Therapeutics Launches with Seed Financing of $11 Million to Develop Therapeutics Targeting Activated Fibroblast Populations Across Inflammatory Disease and CancerApril 20th, 2021
U.S. Department of Defense Awards $3.3 Million Grant to Alivio TherapeuticsSeptember 12th, 2018

Grant Support

Cellular cross-talk in autoimmune diseaseBRIGHAM AND WOMEN'S HOSPITAL2021–2031
Immunologic Mechanisms and Rheumatic DiseasesBRIGHAM AND WOMEN'S HOSPITAL1985–2030
CD8 T cell derived Granzyme K activates complement that drives synovial fibroblast inflammationBRIGHAM AND WOMEN'S HOSPITAL2023–2028
Single cell and spatial genomic analyses of specimens from patients with autoimmune diseases (Technology Core)BRIGHAM AND WOMEN'S HOSPITAL2022–2026
Expanded fibroblast subset drives pathology in rheumatoid arthritisBRIGHAM AND WOMEN'S HOSPITAL2015–2026