MichaelBBrennerMD

PubMed

• Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles.
  Saori Sakaue, Kathryn Weinand, Shakson Isaac, Kushal K Dey, Karthik Jagadeesh, Masahiro Kanai, Gerald F M Watts, Zhu Zhu, , Andrew McDavid, Laura T Donlin, Alkes L Pri...> ;Nature Genetics. 2024 Apr 9
• 2 citations
  Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution.
  Joyce B Kang, Amber Z Shen, Saisriram Gurajala, Aparna Nathan, Laurie Rumker, Vitor R C Aguiar, Cristian Valencia, Kaitlyn A Lagattuta, Fan Zhang, Anna Helena Jonsson,...> ;Nature Genetics. 2023 Dec 1
• 12 citations
  Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes.
  Fan Zhang, Anna Helena Jonsson, Aparna Nathan, Nghia Millard, Michelle Curtis, Qian Xiao, Maria Gutierrez-Arcelus, William Apruzzese, Gerald F M Watts, Dana Weisenfeld...> ;Nature. 2023 Nov 1
• 1 citations
  Associations Between Rheumatoid Arthritis Clinical Factors and Synovial Cell Types and States.
  Dana Weisenfeld, Fan Zhang, Laura Donlin, Anna Helena Jonsson, William Apruzzese, Debbie Campbell, , Deepak A Rao, Kevin Wei, V Michael Holers, Ellen Gravallese, Larry...> ;Arthritis & Rheumatology. 2024 Mar 1
• 14 citations
  Clonally expanded CD38cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor-associated arthritis.
  Runci Wang, Anvita Singaraju, Kathryne E Marks, Lorien Shakib, Garrett Dunlap, Ifeoluwakiisi Adejoorin, Stinne R Greisen, Lin Chen, Aidan K Tirpack, Carlos Aude, Miria...> ;Science Immunology. 2023 Jul 28
• 3 citations
  The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis.
  Kathryn Weinand, Saori Sakaue, Aparna Nathan, Anna Helena Jonsson, Fan Zhang, Gerald F M Watts, Zhu Zhu, , Deepak A Rao, Jennifer H Anolik, Michael B Brenner, Laura T ...> ;Biorxiv. 2023 Apr 8
• 4 citations
  Clonal associations of lymphocyte subsets and functional states revealed by single cell antigen receptor profiling of T and B cells in rheumatoid arthritis synovium.
  Garrett Dunlap, Aaron Wagner, Nida Meednu, Fan Zhang, A Helena Jonsson, Kevin Wei, Saori Sakaue, Aparna Nathan, , Vivian P Bykerk, Laura T Donlin, Susan M Goodman, Gar...> ;Biorxiv. 2023 Mar 21
• 6 citations
  Mapping the dynamic genetic regulatory architecture ofgenes at single-cell resolution.
  Joyce B Kang, Amber Z Shen, Saori Sakaue, Yang Luo, Saisriram Gurajala, Aparna Nathan, Laurie Rumker, Vitor R C Aguiar, Cristian Valencia, Kaitlyn Lagattuta, Fan Zhang...> ;Medrxiv. 2023 Mar 20
• 2 citations
  Longitudinal analysis of invariant natural killer T cell activation reveals a cMAF-associated transcriptional state of NKT10 cells.
  Harry Kane, Nelson M LaMarche, Áine Ní Scannail, Amanda E Garza, Hui-Fern Koay, Adiba I Azad, Britta Kunkemoeller, Brenneth Stevens, Michael B Brenner, Lydia Lynch> ;Elife. 2022 Dec 2
• 53 citations
  Granzyme KCD8 T cells form a core population in inflamed human tissue.
  A Helena Jonsson, Fan Zhang, Garrett Dunlap, Emma Gomez-Rivas, Gerald F M Watts, Heather J Faust, Karishma Vijay Rupani, Joseph R Mears, Nida Meednu, Runci Wang, Grego...> ;Science Translational Medicine. 2022 Jun 15
• 2 citations
  High incidence of proliferative and membranous nephritis in SLE patients with low proteinuria in the Accelerating Medicines Partnership.
  Philip M Carlucci, Jessica Li, Andrea Fava, Kristina K Deonaraine, David Wofsy, Judith A James, Chaim Putterman, Betty Diamond, Anne Davidson, Derek M Fine, Jose Monro...> ;Rheumatology. 2022 Nov 2
• 49 citations
  Fibroblast pathology in inflammatory diseases.
  Kevin Wei, Hung N. Nguyen, Michael B. Brenner> ;The Journal of Clinical Investigation. 2021 Oct 15
• 179 citations
  Fibroblasts as immune regulators in infection, inflammation and cancer
  Sarah Davidson, Mark Coles, Tom Thomas, George Kollias, Burkhard Ludewig, Shannon J. Turley, Michael B. Brenner, Christopher D. Buckley> ;Nature Reviews. Immunology. 2021 Apr 28
• 77 citations
  Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments
  Noëlla Lopes, Claire McIntyre, Stefania Martin, Mathilde Raverdeau, Nital Sumaria, Ayano C. Kohlgruber, Gina J. Fiala, Leandro Z. Agudelo, Lydia Dyck, Harry Kane, Aaro...> ;Nature Immunology. 2021 Jan 18
• 45 citations
  Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis.
  Nelson M. LaMarche, Harry Kane, Ayano C. Kohlgruber, Han Dong, Lydia Lynch, Michael B. Brenner> ;Cell Metabolism. 2020 Aug 4
• 39 citations
  ImmGen at 15
  Stephanie Vargas Aguilar, Oscar M Aguilar, Rhys S. Allan, El-ad David Amir, Veronique Angeli, Maxim N. Artyomov, Natasha Asinovski, Jilian Astarita, K. Frank Austen, G...> ;Nature Immunology. 2020 Jul 1
• 33 citations
  Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal
  Mattias Svensson, Martina Zoccheddu, Shen Yang, Gyrid Nygaard, Christian Secchi, Karen M. Doody, Kamil Slowikowski, Fumitaka Mizoguchi, Frances Humby, Rebecca Hands, E...> ;Science Advances. 2020 Jun 26
• 41 citations
  Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-γ in NK cells.
  Edy Y. Kim, Hadas Ner-Gaon, Jack Varon, Aidan M. Cullen, Jingyu Guo, Jiyoung Choi, Diana Barragan-Bradford, Angelica Higuera, Mayra Pinilla-Vera, Samuel A.P. Short, An...> ;The Journal of Clinical Investigation. 2020 Jun 1
• 210 citations
  Notch signalling drives synovial fibroblast identity and arthritis pathology
  Kevin Wei, Ilya Korsunsky, Jennifer L. Marshall, Anqi Gao, Gerald F. Watts, Triin Major, Adam P. Croft, Jordan Watts, Philip E. Blazar, Jeffrey K. Lange, Thomas S. Tho...> ;Nature. 2020 Apr 22
• 20 citations
  Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.
  Yeon Jin Kim, Mark S. Sundrud, Changqian Zhou, Maja Edenius, Davide Zocco, Kristen Powers, Miao Zhang, Ralph Mazitschek, Anjana Rao, Chang Yeol Yeo, Erika H. Noss, Mic...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Apr 21
• 18 citations
  A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling
  Carlos Donado, Anh Cao, Daimon P. Simmons, Ben A. Croker, Patrick J. Brennan, Michael B. Brenner> ;Cell Reports. 2020 Apr 7
• 40 citations
  CUX1 and IκBζ (NFKBIZ) mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts.
  Kamil Slowikowski, Hung N. Nguyen, Erika H. Noss, Daimon P. Simmons, Fumitaka Mizoguchi, Gerald F. Watts, Michael F. Gurish, Michael B. Brenner, Soumya Raychaudhuri> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Mar 10
• 1 citations
  Disruptive innovation in rheumatology: new networks of global public–private partnerships are needed to take advantage of scientific progress
  Tom W J Huizinga, V. Michael Holers, Jennifer H. Anolik, Michael B. Brenner, Christopher D. Buckley, Vivian P. Bykerk, Sean E. Connolly, Kevin D. Deane, Jianping Guo, ...> ;Annals of the Rheumatic Diseases. 2020 Mar 5
• 64 citations
  Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci.
  Maria Gutierrez-Arcelus, Yuriy Baglaenko, Jatin Arora, Susan K. Hannes, Yang Luo, Tiffany Amariuta, Nikola Teslovich, Deepak A. Rao, Joerg Ermann, A. Helena Jonsson, C...> ;Nature Genetics. 2020 Feb 17
• 2385 citations
  Fast, sensitive and accurate integration of single-cell data with Harmony.
  Ilya Korsunsky, Nghia Millard, Jean Fan, Kamil Slowikowski, Fan Zhang, Kevin Wei, Yuriy Baglaenko, Michael B. Brenner, Po-Ru Loh, Soumya Raychaudhuri> ;Nature Methods. 2019 Nov 18
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Journal Articles

• Metabolic Reprogramming of Natural Killer Cells in Obesity Limits Antitumor Responses  
  Ali Tavakkoli, Michael B Brenner, Kevin Wei, Ashley Vernon, Nature
• Plateletpheresis-Associated Lymphopenia in Frequent Platelet Donors  
  Michael B Brenner, John M Gansner, A Helena Jonsson, Dan L Longo, Jason M Schenkel, Deepak A Rao, Richard M Kaufman, Nancy Berliner, Duane R Wesemann, Blood
• High-Throughput Identification of Noncoding Functional SNPs via Type IIS Enzyme Restriction  
  Soumya Raychaudhuri, Jing Cui, Michael B Brenner, Peter A Nigrovic, Nature
• Methods for High-Dimensonal Analysis of Cells Dissociated from Cyropreserved Synovial Tissue  
  Paul J Utz, William H Robinson, Ellen M Gravallese, Soumya Raychaudhuri, Alessandra B Pernis, Susan M Goodman, Michael B Brenner, Lionel B Ivashkiv, Brendan F Boyce, P..., BioMed Central
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