MichaelFClarkeMD

Radiation Oncology • Stanford, CA

Professor, Medicine, Stanford University Sch of Med

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Office
300 Pasteur Dr
Stanford, CA 94305
Phone+1 650-498-5710
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Summary

Dr. Michael Clarke, MD is a radiation oncologist in Stanford, California. He is currently licensed to practice medicine in California and Michigan. He is a Professor at Stanford University Sch of Med.

Education & Training

Indiana University School of MedicineResidency, Internal Medicine, 1978 - 1980
University of Missouri-ColumbiaInternship, Internal Medicine, 1977 - 1978
Indiana University School of MedicineClass of 1977

Certifications & Licensure

CA State Medical License 2007 - 2026
MI State Medical License 1986 - 2008
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 1996

Publications & Presentations

PubMed

4 citations
Northstar enables automatic classification of known and novel cell types from tumor samples
Fabio Zanini, Bojk A. Berghuis, Robert C. Jones, Benedetta Nicolis di Robilant, Rachel Yuan Nong, Jeffrey A. Norton, Michael F. Clarke, Stephen R. Quake> ;Scientific Reports. 2020 Sep 17
Usp16 modulates Wnt signaling in primary tissues through Cdkn2a regulation.
Adorno, M.,di Robilant, B. N.,Sikandar, S. S.,Acosta, V. H.,Antony, J.,Heller, C. H.,Clarke, M. F.> ;Sci Rep. 2018 Dec 07
Serially transplantable mammary epithelial cells express the Thy-1 antigen.
Lobo, N. A.,Zabala, M.,Qian, D.,Clarke, M. F.> ;Breast Cancer Res.. 2018 Oct 12
Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis.
Sikandar, S. S.,Kuo, A. H.,Kalisky, T.,Cai, S.,Zabala, M.,Hsieh, R. W.,Lobo, N. A.,Scheeren, F. A.,Sim, S.,Qian, D.,Dirbas, F. M.,Somlo, G.,Quake, S. R.,Clarke, M. F.> ;Nat Commun. 2017 Nov 23
138 citations
A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer.
Paola Betancur, Brian J. Abraham, Ying Y. Yiu, Stephen B. Willingham, Farnaz Khameneh, Mark A. Zarnegar, Angera H. Kuo, Mckenna Kelly Marie, Yoko Kojima, Nicholas J. L...> ;Nature Communications. 2017 Apr 5
176 citations
Colorectal Cancer Liver Metastasis: Evolving Paradigms and Future Directions
Luai Zarour, Sudarshan Anand, Kevin G. Billingsley, William H. Bisson, Andrea Cercek, Michael F. Clarke, Lisa M. Coussens, Charles E. Gast, Cristina B. Geltzeiler, Lis...> ;Cellular and Molecular Gastroenterology and Hepatology. 2017 Mar 1
86 citations
A cell-intrinsic role for TLR2–MYD88 in intestinal and breast epithelia and oncogenesis
Ferenc A. Scheeren, Angera H. Kuo, Linda J. van Weele, Shang Cai, Iris E. Glykofridis, Shaheen S. Sikandar, Maider Zabala, Dalong Qian, Jessica Lam, Darius M. Johnston...> ;Nature Cell Biology. 2014 Dec 1
507 citations
Quantitative assessment of single-cell RNA-sequencing methods
Angela Ruohao Wu, Norma F. Neff, Tomer Kalisky, Piero Dalerba, Barbara Treutlein, Michael E. Rothenberg, Francis M. Mburu, Gary L. Mantalas, Sopheak Sim, Michael F. Cl...> ;Nature Methods. 2014 Jan 1
Usp16 Contributes to Somatic Stem-Cell Defects in down's Syndrome
Samuel Cheshier, Siddhartha S Mitra, Michael F Clarke> ;Nature. 2013 Sep 19
Oncogenic miRNAs and the Perils of Losing Control of a Stem Cell's Epigenetic Identity.
Dalerba, P.,Clarke, M. F.> ;Cell Stem Cell. 2013 Jul 3
194 citations
MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11
Jessica Bockhorn, Rachel Dalton, Chika Nwachukwu, Simo Huang, Aleix Prat, Kathy Yee, Ya Fang Chang, Dezheng Huo, Yujia Wen, Kaitlin E. Swanson, Tyler Qiu, Jun Lu, Seo ...> ;Nature Communications. 2013 Jan 22
84 citations
MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion
Jessica Bockhorn, Kathy Yee, Ya Fang Chang, Aleix Prat, Dezheng Huo, Chika Nwachukwu, Rachel Dalton, Simo Huang, Kaitlin E. Swanson, Charles M. Perou, Olufunmilayo I. ...> ;Breast Cancer Research and Treatment. 2013 Jan 1
Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer.
Kohrt, H.E., Houot, R., Weiskopf, K., Goldstein, M.J., Scheeren, F., Czerwinski, D., Colevas, A.D., Weng, W., Clarke, M.F., Carlson, R.W., Stockdale, F.E., Mollick, J....> ;J Clin Invest. 2012 Mar 1
Identification of a Ckit+ Colonic Crypt Base Secretory Cell that Supports Lgr5+ Stem Cells in Mice.
Rothenberg, M.E., Nusse, Y., Kalisky, T., Lee, J.J., Dalerba, P., Scheeren, F., Lobo, N., Kulkarni, S., Sim, S., Qian, D., Beachy, P.A., Pasricha, P.J., Quake, S.R., C...> ;Gastroenterology. 2012 May
Single-cell dissection of transcriptional heterogeneity in human colon tumors.
Dalerba, P., Kalisky, T., Sahoo, D., Rajendran, P.S., Rothenberg, M.E., Leyrat, A.A., Sim, S., Okamoto, J., Johnston, D.M., Qian, D., Zabala, M., Bueno, J., Neff, N.F....> ;Nat Biotechnol. 2011 Dec
Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models.
Liu, H., Patel, M.R., Prescher, J.A., Patsialou, A., Qian, D., Lin, J., Wen, S., Chang, Y., Bachmann, M.H., Shimono, Y., Dalerba, P., Adorno, M., Lobo, N., Bueno, J., ...> ;Proc Natl Acad Sci U S A. 2010 Oct 19
The Myc connection: ES cells and cancer.
Rothenberg, M.E., Clarke, M.F., Diehn, M.> ;Cell. 2010 Oct 15
DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency.
Hoey, T., Yen, W., Axelrod, F., Basi, J., Donigian, L., Dylla, S., Fitch-Bruhns, M., Lazetic, S., Park, I., Sato, A., Satyal, S., Wang, X., Clarke, M.F., Lewicki, J., ...> ;Cell Stem Cell. 2009-08-07
Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells.
Shimono, Y., Zabala, M., Cho, R.W., Lobo, N., Dalerba, P., Qian, D., Diehn, M., Liu, H., Panula, S.P., Chiao, E., Dirbas, F.M., Somlo, G., Pera, R.R., Lao, K., Clarke,...> ;Cell. 2009-08-07
Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials.
Woodward, W.A., Bristow, R.G., Clarke, M.F., Coppes, R.P., Cristofanilli, M., Duda, D.G., Fike, J.R., Hambardzumyan, D., Hill, R.P., Jordan, C.T., Milas, L., Pajonk, F...> ;Int J Radiat Oncol Biol Phys. 2009-08-01
Therapeutic implications of the cancer stem cell hypothesis.
Diehn, M., Cho, R.W., Clarke, M.F.> ;Semin Radiat Oncol. 2009 Apr
Dysregulated gene expression networks in human acute myelogenous leukemia stem cells.
Majeti, R., Becker, M.W., Tian, Q., Lee, T.M., Yan, X., Liu, R., Chiang, J., Hood, L., Clarke, M.F., Weissman, I.L.> ;Proc Natl Acad Sci U S A. 2009-03-03
Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors.
Cho, R.W., Wang, X., Diehn, M., Shedden, K., Chen, G.Y., Sherlock, G., Gurney, A., Lewicki, J., Clarke, M.F.> ;Stem Cells. 2008 Feb
What can we learn about breast cancer from stem cells?
Clarke, M.F.> ;Adv Exp Med Biol. 2008
Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy.
Dylla, S.J., Beviglia, L., Park, I., Chartier, C., Raval, J., Ngan, L., Pickell, K., Aguilar, J., Lazetic, S., Smith-Berdan, S., Clarke, M.F., Hoey, T., Lewicki, J., G...> ;PLoS One. 2008
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Grant Support

Identification Of Self-Renewal Pathways In Cancer Stem Cells And Development Of TNational Cancer Institute2009–2012
Identification Of Cancer Stem Cell Therapeutic TargetsNational Cancer Institute2009–2012
Animal CoreNational Cancer Institute2009–2012
Adminstrative CoreNational Cancer Institute2009–2012
Self-Renewal Of Normal And Leukemic Stem CellsNational Cancer Institute2006–2012
Cellular Hierachy Of ER- Breast Cancers In Different Ethnic GroupsNational Cancer Institute2010–2011
Cancer Stem CellsNational Cancer Institute2010–2011
BD Facsaria IINational Center For Research Resources2010
Molecular And Functional Characterization Of Colon Tumor Cancer Stem Cells And STNational Cancer Institute2006–2010
Colon Cancer Stem Cells And Their StromaNational Cancer Institute2006–2010
Prog 3- Cancer Stem CellsNational Cancer Institute2007–2009
2007 Gordon Research Conference- Cancer And Stem CellsNational Cancer Institute2007
A Search For Genes That Regulate Stem CellsNational Institute Of Diabetes And Digestive And Kidney Diseases2005–2007
The Role Of Rgs18 In Mouse HematopoiesisNational Heart, Lung, And Blood Institute2006
Analysis Of Leukemia CellsNational Cancer Institute2006
Adminstrative CoreNational Cancer Institute2006
The Role Of Rgs18 In Mouse HematopoiesisNational Heart, Lung, And Blood Institute2004–2005
Self-Renewal Of Normal And Leukemic Stem CellsNational Cancer Institute2004–2005
Analysis Of Leukemia CellsNational Cancer Institute2004–2005
Rgs18 In Mouse HematopoiesisNational Heart, Lung, And Blood Institute2003
Targeting PCD For Cancer TherapyNational Cancer Institute1998–2003
Targeting PCD For Leukemia TreatmentNational Cancer Institute1998–2002
Molecular Analysis Of HematopoiesisNational Institute Of Diabetes And Digestive And Kidney Diseases1997–2001
Technologies Generation Of Full-Length Mammalian CDNANational Cancer Institute1999–2000
Ruthenium Containing MetallopharmaceuticalsNational Institute Of General Medical Sciences1997–2000
P53 Trafficking During Cell CycleNational Cancer Institute1996–2000
P53 Trafficking During Cell CycleNational Cancer Institute1995
Metal Complexes Of Nucleic Acids And Related BasesNational Institute Of General Medical Sciences1990–1993
Hematopoietic Growth Factors, Oncogenes, And LeukemiaNational Cancer Institute1988–1992
Metal Complexes Of Nucleotides And CoenzymesNational Institute Of General Medical Sciences1985–1989