MichaelWilliamLawlorMD

PubMed

• Effects of gene replacement therapy with resamirigene bilparvovec (AT132) on skeletal muscle pathology in X-linked myotubular myopathy: results from a substudy of the ...
  Lawlor, M., Schoser, B., Margeta, M., Sewry, C., Jones, K., Shieh, P., Kuntz, N., Smith, B., Dowling, J., Müller-Felber, W., Bönnemann, C., Seferian, A., Blaschek, A.,...> ;Ebiomedicine. 2024 Jan 1
• 6 citations
  Safety and efficacy of gene replacement therapy for X-linked myotubular myopathy (ASPIRO): a multinational, open-label, dose-escalation trial.
  Perry B Shieh, Nancy L Kuntz, James J Dowling, Wolfgang Müller-Felber, Carsten G Bönnemann, Andreea M Seferian, Laurent Servais, Barbara K Smith, Francesco Muntoni, As...> ;The Lancet. Neurology. 2023 Dec 1
• 4 citations
  Loss of Mtm1 causes cholestatic liver disease in a model of X-linked myotubular myopathy.
  Sophie Karolczak, Ashish R Deshwar, Evangelina Aristegui, Binita M Kamath, Michael W Lawlor, Gaia Andreoletti, Jonathan Volpatti, Jillian L Ellis, Chunyue Yin, James J...> ;The Journal of Clinical Investigation. 2023 Sep 15
• 3 citations
  Aberrations in Energetic Metabolism and Stress-Related Pathways Contribute to Pathophysiology in the Neb Conditional Knockout Mouse Model of Nemaline Myopathy.
  Rebecca A Slick, Jennifer A Tinklenberg, Jessica Sutton, Liwen Zhang, Hui Meng, Margaret J Beatka, Mark Vanden Avond, Mariah J Prom, Emily Ott, Federica Montanaro, Jam...> ;The American Journal of Pathology. 2023 Oct 1
• 3 citations
  Different Mouse Models of Nemaline Myopathy Harboring Acta1 Mutations Display Differing Abnormalities Related to Mitochondrial Biology.
  Jennifer A Tinklenberg, Rebecca A Slick, Jessica Sutton, Liwen Zhang, Hui Meng, Margaret J Beatka, Mark Vanden Avond, Mariah J Prom, Emily Ott, Federica Montanaro, Jam...> ;The American Journal of Pathology. 2023 Oct 1
• 1 citations
  Spinal muscular atrophy-like phenotype in a mouse model of acid ceramidase deficiency.
  Murtaza S Nagree, Jitka Rybova, Annie Kleynerman, Carissa J Ahrenhoerster, Jennifer T Saville, TianMeng Xu, Maxwell Bachochin, William M McKillop, Michael W Lawlor, Al...> ;Communications Biology. 2023 May 25
• Putting It All Together: Postmortem Diagnosis of a Rare Ichthyosis Syndrome.
  Pragya Virendrakumar Jain, Jauntea Maxey, Michael W Lawlor, Lauren N Parsons> ;Cureus. 2023 May 1
• 2 citations
  ACTA1 H40Y mutant iPSC-derived skeletal myocytes display mitochondrial defects in an in vitro model of nemaline myopathy.
  Melanie Gartz, Margaret Haberman, Jessica Sutton, Rebecca A Slick, Shawn M Luttrell, David L Mack, Michael W Lawlor> ;Experimental Cell Research. 2023 Mar 15
• Effects of Regulatory T Cell Depletion in BALB/c Mice Infected with Low Doses of.
  Kaitlyn N Santiago, Tanya Kozlik, Elizabeth S Liedhegner, Rebecca A Slick, Michael W Lawlor, Dean T Nardelli> ;Pathogens. 2023 Jan 25
• 1 citations
  Adherence to and changes in mental and physiological health during an 8-week yoga intervention: A pilot study.
  Bethany Forseth, Michele Polfuss, Michael Brondino, Stacy D Hunter, Michael W Lawlor, Margaret J Beatka, Mariah J Prom, Janis Eells, Jeri-Ann Lyons> ;Journal of Bodywork and Movement Therapies. 2022 Apr 1
• 14 citations
  Muscle-directed gene therapy corrects Pompe disease and uncovers species-specific GAA immunogenicity.
  Michelle Eggers, Charles H Vannoy, Jianyong Huang, Pravinkumar Purushothaman, Jacqueline Brassard, Carlos Fonck, Hui Meng, Mariah J. Prom, Michael W. Lawlor, Justine C...> ;EMBO Molecular Medicine. 2021 Dec 1
• 6 citations
  Cardiomyocyte-produced miR-339-5p mediates pathology in Duchenne muscular dystrophy cardiomyopathy.
  Melanie Gartz, Margaret Beatka, Mariah J. Prom, Jennifer L. Strande, Michael W. Lawlor> ;Human Molecular Genetics. 2021 Nov 16
• 56 citations
  X-Linked Myotubular Myopathy
  Michael W. Lawlor, James J. Dowling> ;Neuromuscular Disorders. 2021 Oct 1
• 16 citations
  Intrahepatic Cholestasis Is a Clinically Significant Feature Associated with Natural History of X-Linked Myotubular Myopathy (XLMTM): A Case Series and Biopsy Report
  Cristina Molera, Tinatin Sarishvili, Andrés Nascimento, Irakli Rtskhiladze, Gema Muñoz Bartolo, Santiago Fernández Cebrián, Justo Valverde Fernández, Beatriz Muñoz Cab...> ;Journal of Neuromuscular Diseases. 2021 Aug 4
• 4 citations
  Cardioprotective effect of nicorandil on isoproterenol induced cardiomyopathy in the Mdx mouse model.
  Rachel T. Sullivan, Ngoc Thien Lam, Margaret Haberman, Margaret Beatka, Muhammad Afzal, Michael W. Lawlor, Jennifer L. Strande> ;BMC Cardiovascular Disorders. 2021 Jun 15
• 9 citations
  Voluntary wheel running complements microdystrophin gene therapy to improve muscle function in mdx mice.
  Shelby E Hamm, Daniel D Fathalikhani, Katherine E Bukovec, Adele K Addington, Haiyan Zhang, Justin B Perry, Ryan P McMillan, Michael W Lawlor, Mariah J Prom, Mark A Va...> ;Molecular Therapy. Methods & Clinical Development. 2021 Jun 11
• 3 citations
  Clonally Focused Public and Private T Cells in Resected Brain Tissue From Surgeries to Treat Children With Intractable Seizures.
  Julia W. Chang, Samuel D. Reyes, Emmanuelle Faure-Kumar, Sandi Lam, Michael W. Lawlor, Richard J. Leventer, Sean M. Lew, Paul J. Lockhart, Kathryn Pope, Howard L. Wein...> ;Frontiers in Immunology. 2021 Apr 6
• 5 citations
  Association between yoga, physiologic and psychologic health: A cross sectional study.
  Bethany Forseth, Michele Polfuss, Michael J. Brondino, Michael W. Lawlor, Margaret Beatka, Mariah J. Prom, Janis T. Eells, Jeri-Ann Lyons> ;Complementary Therapies in Clinical Practice. 2021 Mar 4
• 3 citations
  The Nucleotide Prodrug CERC‐913 Improves mtDNA Content in Primary Hepatocytes from DGUOK‐Deficient Rats
  Mark A. Vanden Avond, Hui Meng, Margaret Beatka, Daniel Helbling, Mariah J. Prom, Jessica L. Sutton, Rebecca A. Slick, David Dimmock, Fabrizio Pertusati, Michaela Serp...> ;Journal of Inherited Metabolic Disease. 2021 Jan 15
• 16 citations
  A Cross-Sectional Study of Nemaline Myopathy.
  Kimberly Amburgey, Meryl Acker, Samia Saeed, Reshma Amin, Alan H. Beggs, Carsten G. Bönnemann, Michael Brudno, Andrei Constantinescu, Jahannaz Dastgir, Mamadou Diallo,...> ;Neurology. 2021 Jan 4
• 8 citations
  The Effect of Immunomodulatory Treatments on Anti-Dystrophin Immune Response After AAV Gene Therapy in Dystrophin Deficient mdx Mice.
  Ning Li, Joanna E. Parkes, Rita Spathis, Melissa Morales, John Mcdonald, Ryan M. Kendra, Emily M. Ott, Kristy J. Brown, Michael W. Lawlor, Kanneboyina Nagaraju> ;Journal of Neuromuscular Diseases. 2021 Jan 1
• 8 citations
  Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function
  Arielle Hall, Tatiana Fontelonga, Alec Wright, Katlynn Bugda Gwilt, Jeffrey J. Widrick, Alessandra Pasut, Francesco Villa, Cindy K. Miranti, Devin E. Gibbs, Evan Jiang...> ;Skeletal Muscle. 2020 Nov 27
• 14 citations
  Duchenne muscular dystrophy (DMD) cardiomyocyte-secreted exosomes promote the pathogenesis of DMD-associated cardiomyopathy.
  Melanie Gartz, Chien-Wei Lin, Mark A. Sussman, Michael W. Lawlor, Jennifer L. Strande> ;Disease Models & Mechanisms. 2020 Nov 1
• 5 citations
  Regulatory T Cells Contribute to Resistance against Lyme Arthritis.
  Emily M. Siebers, Elizabeth S. Liedhegner, Michael W. Lawlor, Ronald F. Schell, Dean T. Nardelli> ;Infection and Immunity. 2020 Oct 19
• 10 citations
  rAAV-related therapy fully rescues myonuclear and myofilament function in X-linked myotubular myopathy
  Jacob A. Ross, Hichem Tasfaout, Yotam Levy, Jennifer E. Morgan, Belinda S. Cowling, Jocelyn Laporte, Edmar Zanoteli, Norma B. Romero, Dawn A. Lowe, Heinz Jungbluth, Mi...> ;Acta Neuropathologica Communications. 2020 Oct 19
• Join now to see all

Journal Articles

• Whole thorax irradiation induces hypoxic respiratory failure, pleural effusions, and congestive heart failure  
  Medhora M, Gao F, Glisch C, Narayanan J, Sharma A, Harmann LM, Lawlor MW, Snyder LA, Fish BL, Down JD, Moulder JE, Strande JL, Jacobs ER, Journal of Radiation Research, 1/3/2014
• Polydopamine coatings enhance biointegration of a model polymeric implant  
  Jeong KJ, Wang LQ, Stefanescu CF, Lawlor MW, Polat J, Dolhman CH, Langer RS, Kohane DS, Soft Matter, 1/1/2011

Books/Book Chapters

• ISN Book on Muscle Disease: Pathology and Genetics 
  Chapter: "Thin filament proteins (nemaline and related myopathies)" 
  Page 145 - 151Lawlor MW, Beggs AHWiley-Blackwell, Hoboken2013
• Rapid Review for the USMLE Step 2 
  Lawlor MWMosby, Philadelphia2007
• Zebra Mussels and Aquatic Nuisance Species 
  Chapter: "The effect of high voltage electrostatic fields on zebra mussels" 
  Page 429 - 438Shana ZA, Maki JS, Zanoni AE, Benes SJ, Mercier CJ, Lawlor MWEditors: FM D'Itri.Ann Arbor Press, Ann Arbor1997

Abstracts/Posters

• Treatment with ActRIIB-mFc Improves Lifespan, Behavior, and Pathology in the Acta1 H40Y Murine Model of Nemaline Myopathy.
  Lawlor MW et al, American Association of Neuropathologists Meeting; New Directions in Biology and Disease of Skeletal Muscle Conference, 1/29/2014
• Gene replacement therapy improves muscle function and pathology in murine and canine models of X-linked myotubular myopathy.
  Lawlor MW et al, American Association of Neuropathologists Meeting, 1/20/2013
• Integration of common data elements into muscle biopsy reporting.
  Dastgir J, Rutkowski A, Alvarez R, Cossette S, Yan K, Hoffmann R, Hayashi Y, Goebel HH, Bonnemann C, Lawlor MW, American Association of Neuropathologists Meeting; Canadian Association of Neuropathologists Meeting, 1/16/2013
• Integration of common data elements into muscle biopsy reporting.
  Dastgir J, Rutkowski A, Alvarez R, Cossette S, Yan K, Hoffmann R, Hayashi Y, Goebel HH, Bonnemann C, Lawlor MW, Muscular Dystrophy Association National Scientific Conference; World Muscle Society Conference, 1/1/2013
• Satellite cell depletion and dysfunction correlates with disease progression in severe murine myotubularin deficiency.
  Lawlor MW, Alexander MS, Viola MG, Meng H, Gupta V, Motohashi N, Manfready RA, Hsu CP, Huang P, Joubert R, Buj Bello A, Kunkel LM, Beggs AH, Gussoni E, American Association of Neuropathologists Meeting; New Directions in Biology and Disease of Skeletal Muscle Meeting, 1/21/2012
• Ultrastructural pathology and functional deficits can be reversed following enzyme replacement in myotubularin deficient mice.
  Lawlor MW, Armstrong D, Viola MG, Meng H, Buj-Bello A, Hsu CP, Pierson CR, Childers MK, Grange RW, Widrick JJ, Beggs AH, American Association of Neuropathologists Meeting; New Directions in Biology and Disease of Skeletal Muscle Meeting, 1/21/2012
• Responses to ActRIIB-mFc treatment are specific to individual muscles in the Mtm1p.R69C model of myotubularin deficiency.
  Lawlor MW, Viola MG, Meng H, Edelstein RV, Pierson CR, Buj-Bello A, Lachey JL, Seehra JS, Beggs AH, New Directions in Biology and Disease of Skeletal Muscle Meeting, 1/17/2012
• Distribution and extent of weakness is dependent on fiber type and mutation in murine models of myotubularin deficiency.
  Lawlor MW, Viola MG, Widrick JJ, Grange RW, Buj-Bello A, Pierson CR, Beggs AH, American Association of Neuropathologists Meeting, Seattle, WA, 1/23/2011
• Responses to treatment are dependent of fiber type, muscle, and mutation in murine models of myotubularin deficiency.
  Lawlor MW, Viola MG, Edelstein RV, Pierson CR, Buj-Bello A, Lachey JL, Seehra JS, Beggs AH, American Association of Neuropathologists Meeting, Seattle, WA, 1/23/2011
• Responses to treatment are dependent on fiber type and mutation in murine models of myotubularin deficiency.
  Lawlor MW, Viola MG, Edelstein RV, Pierson CR, Buj-Bello A, Lachey JL, Seehra JS, Beggs AH, 2011 Muscular Dystrophy Association National Scientific Conference, Las Vegas, NV, 1/13/2011
• Impaired contractile properties in myotubularin deficient mice and dogs.
  Lawlor MW, Grange RW, Edelstein RV, Shelton GD, Pierson CR, Buj Bello A, Tegeler C, Childers MK, Beggs AH, 2010 New Directions in Biology and Disease of Skeletal Muscle Meeting, Ottawa, Canada, 1/5/2010
• Join now to see all

Lectures

• "Treatment with ActRIIB-mFc Improves Lifespan, Behavior, and Pathology in the Acta1 H40Y Murine Model of Nemaline Myopathy" 
  1/2/2014
• "Congenital muscle disease consortium international workshop" (organizer and speaker) 
  Washington, DC - 1/21/2013
• "Diagnostic and genetic considerations in the congenital myopathies." 
  1/19/2013
• "Current advances in nemaline myopathy research" 
  Stanford University - 1/6/2013
• "Emerging treatments for X-linked myotubular myopathy." 
  University of Kentucky, Lexington - 1/1/2013
• "Infrastructure established in the Congenital Muscle Disease Tissue Repository and opportunities for tissue use in biomarker discovery efforts" 
  Pacific Grove, CA - 1/1/2013
• "Pumping up the myotubularin-deficient mouse: A pre-clinical trial for congenital myopathy." 
  University of Pittsburgh Medical Center - 1/1/2009
• "Taking the USMLE Step 2 Exam." 
  Loyola University Chicago - 1/1/2007
• Join now to see all