MichaelJMacDonaldMD

PubMed

• 13 citations
  Metformin's Therapeutic Efficacy in the Treatment of Diabetes Does Not Involve Inhibition of Mitochondrial Glycerol Phosphate Dehydrogenase.
  Michael J. MacDonald, Israrul H. Ansari, Melissa J. Longacre, Scott W. Stoker> ;Diabetes. 2021 Apr 13
• 5 citations
  Differential contribution of pyruvate carboxylation to anaplerosis and cataplerosis during non-gluconeogenic and gluconeogenic conditions in HepG2 cells
  Siriluck Wattanavanitchakorn, Israr H. Ansari, Mahmoud El Azzouny, Melissa J. Longacre, Scott W. Stoker, Michael J. MacDonald, Sarawut Jitrapakdee> ;Archives of Biochemistry and Biophysics. 2019 Nov 15
• 11 citations
  CCAAT-enhancer binding protein-α (C/EBPα) and hepatocyte nuclear factor 4α (HNF4α) regulate expression of the human fructose-1,6-bisphosphatase 1 (FBP1) gene in human ...
  Siriluck Wattanavanitchakorn, Pinnara Rojvirat, Tanit Chavalit, Michael J. MacDonald, Sarawut Jitrapakdee> ;Plos One. 2018 Mar 22
• 29 citations
  Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion
  Israrul H. Ansari, Melissa J. Longacre, Scott W. Stoker, Mindy A. Kendrick, Lucas M. O’Neill, Laura J. Zitur, Luis A. Fernandez, James M. Ntambi, Michael J. MacDonald> ;Archives of Biochemistry and Biophysics. 2017 Mar 15
• 39 citations
  Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells
  Phatchariya Phannasil, Israrul H. Ansari, Mahmoud A. El Azzouny, Melissa J. Longacre, Khanti Rattanapornsompong, Charles F. Burant, Michael J. MacDonald, Sarawut Jitra...> ;Biochimica Et Biophysica Acta. Molecular Basis of Disease. 2017 Feb 1
• 19 citations
  Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion.
  Mahmoud A. El Azzouny, Melissa J. Longacre, Israrul H. Ansari, Robert T. Kennedy, Charles F. Burant, Michael J. MacDonald> ;Molecular Metabolism. 2016 Oct 1
• 6 citations
  Development of filter paper hemoglobin A1c assay applicable to newborn screening.
  Allison J. Pollock, David B. Allen, Donald A. Wiebe, Jens C. Eickhoff, Michael J. MacDonald, Mei W. Baker> ;Clinica Chimica Acta; International Journal of Clinical Chemistry. 2016 Jun 1
• 24 citations
  Discovery of a Genetic Metabolic Cause for Mauriac Syndrome in Type 1 Diabetes
  Michael J. MacDonald, Noaman Hasan, Israrul H. Ansari, Melissa J. Longacre, Mindy A. Kendrick, Scott W. Stoker> ;Diabetes. 2016 Apr 1
• 18 citations
  Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION.
  Israrul H. Ansari, Melissa J. Longacre, Coen C. Paulusma, Scott W. Stoker, Mindy A. Kendrick, Michael J. MacDonald> ;The Journal of Biological Chemistry. 2015 Sep 18
• 22 citations
  Severe Hypertriglyceridemia Causing Acute Pancreatitis in a Child with New Onset Type I Diabetes Mellitus Presenting in Ketoacidosis.
  Peter M. Wolfgram, Michael J. MacDonald> ;Journal of Pediatric Intensive Care. 2015 Jul 28
• 69 citations
  Pyruvate Carboxylase Is Up-Regulated in Breast Cancer and Essential to Support Growth and Invasion of MDA-MB-231 Cells.
  Phatchariya Phannasil, Chanitra Thuwajit, Malee Warnnissorn, John C. Wallace, Michael J. MacDonald, Sarawut Jitrapakdee> ;Plos One. 2015 Jun 12
• 40 citations
  Characterization of Phospholipids in Insulin Secretory Granules and Mitochondria in Pancreatic Beta Cells and Their Changes with Glucose Stimulation
  Michael J. MacDonald, Lacmbouh Ade, James M. Ntambi, Israrul H. Ansari, Scott W. Stoker> ;The Journal of Biological Chemistry. 2015 Apr 24
• 24 citations
  Mitochondrial malic enzyme 3 is important for insulin secretion in pancreatic β-cells.
  Noaman Hasan, Melissa J. Longacre, Scott W. Stoker, Mindy A. Kendrick, Michael J. MacDonald> ;Molecular Endocrinology. 2015 Jan 16
• 15 citations
  Multiple E-Boxes in the Distal Promoter of the Rat Pyruvate Carboxylase Gene Function as a Glucose-Responsive Element
  Apilak Wutthisathapornchai, Tuangtong Vongpipatana, Sureeporn Muangsawat, Thirajit Boonsaen, Michael J. MacDonald, Sarawut Jitrapakdee> ;Plos One. 2014 Jul 23
• 839 citations
  Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
  Anila K. Madiraju, Derek M. Erion, Yasmeen Rahimi, Xian-Man Zhang, Demetrios T. Braddock, Ronald A. Albright, Brett J. Prigaro, John L. Wood, Sanjay Bhanot, Michael J....> ;Nature. 2014 Jun 26
• 25 citations
  Knockdown of both mitochondrial isocitrate dehydrogenase enzymes in pancreatic beta cells inhibits insulin secretion
  Michael J. MacDonald, Laura J. Brown, Melissa J. Longacre, Scott W. Stoker, Mindy A. Kendrick, Noaman Hasan> ;Biochimica Et Biophysica Acta. 2013 Nov 1
• 6 citations
  Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells.
  Michael J. MacDonald, Noaman Hasan, Agnieszka Dobrzyn, Scott W. Stoker, James M. Ntambi, Xueqing Liu, Harini Sampath> ;Archives of Biochemistry and Biophysics. 2013 Apr 1
• 11 citations
  Identification of ATP synthase as a lipid peroxide protein adduct in pancreatic islets from humans with and without type 2 diabetes mellitus
  Michael J. MacDonald, E.-C. Langberg, Annika Tibell, Grzegorz Sabat, M. A. Kendrick, L. I. Szweda, C.-G. Östenson> ;The Journal of Clinical Endocrinology and Metabolism. 2013 Mar 5
• 14 citations
  Characterization of the distal promoter of the human pyruvate carboxylase gene in pancreatic beta cells.
  Ansaya Thonpho, Pinnara Rojvirat, Sarawut Jitrapakdee, Michael J. MacDonald> ;Plos One. 2013 Jan 30
• 9 citations
  High level of ATP citrate lyase expression in human and rat pancreatic islets.
  Michael J. MacDonald, Melissa J. Longacre, Thomas F. Warner, A. Thonpho> ;Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. 2012 Dec 7
• 16 citations
  Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line
  Noaman Hasan, Melissa J. Longacre, Scott W. Stoker, Mindy A. Kendrick, Noah R. Druckenbrod, Suzanne G. Laychock, Lucy D. Mastrandrea, Michael J. MacDonald> ;Archives of Biochemistry and Biophysics. 2012 Feb 1
• 42 citations
  The Complex Mechanism of Glutamate Dehydrogenase in Insulin Secretion
  Leonard A. Fahien, Michael J. MacDonald> ;Diabetes. 2011 Oct 1
• 73 citations
  Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetat...
  Michael J. MacDonald, Melissa J. Longacre, Scott W. Stoker, Mindy A. Kendrick, Ansaya Thonpho, Laura J. Brown, Noaman Hasan, Sarawut Jitrapakdee, Toshiyuki Fukao, Matt...> ;The Journal of Biological Chemistry. 2011 May 27
• 19 citations
  Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin r...
  Noaman Hasan, Melissa J. Longacre, Mohammed Seed Ahmed, Mindy A. Kendrick, Harvest F. Gu, Claes-Göran Östenson, Toshiyuki Fukao, Michael J. MacDonald> ;Archives of Biochemistry and Biophysics. 2010 Jul 1
• 213 citations
  Regulation of insulin secretion: role of mitochondrial signalling
  Sarawut Jitrapakdee, A. Wutthisathapornchai, J C Wallace, Michael J. MacDonald> ;Diabetologia. 2010 Mar 12
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