MichaelJ.MastrangeloMD

Oncology • Philadelphia, PA

Hematologic Oncology, Melanoma

Professor of Medicine, Jefferson Medical College

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Office
925 Chestnut St.,
320A
Philadelphia, PA 19107
Phone+1 215-955-8874

Fax+1 215-503-2715
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Education & Training

Sidney Kimmel Medical College at Thomas Jefferson University/TJUHResidency, Internal Medicine, 1967 - 1971
Sidney Kimmel Medical College at Thomas Jefferson University/TJUHFellowship, Hematology and Medical Oncology, 1969 - 1970
Sidney Kimmel Medical College at Thomas Jefferson University/TJUHInternship, Internal Medicine, 1964 - 1965
Johns Hopkins University School of MedicineClass of 1964

Certifications & Licensure

CA State Medical License 1959 - Present
NJ State Medical License Active through 2025
PA State Medical License 1965 - 2024
IN State Medical License 1960 - 2021
DE State Medical License 2017 - 2019
OR State Medical License 1998 - 2017
MD State Medical License 1970 - 1993
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Patient-Centered Specialty Practice Recognition Program National Committee for Quality Assurance, 2014-2017
CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2012-2013
Super Doctor SuperDoctors.com

Clinical Trials

Vaccine Therapy in Treating Patients With Metastatic Melanoma Start of enrollment: 1996 Apr 01
Unknown status
Phase 1, Phase 2
Phase I Study of Ipilimumab Combined With Whole Brain Radiation Therapy or Radiosurgery for Melanoma Start of enrollment: 2012 Nov 09
Completed
Phase 1
Sunitinib Malate or Valproic Acid in Preventing Metastasis in Patients With High-Risk Uveal Melanoma Start of enrollment: 2014 Nov 19
Active, not recruiting
Phase 2
Vemurafenib Combined With Whole Brain Radiation Therapy or Radiosurgery in Patients With BRAF Mutation-Positive Melanoma and Brain Metastases
Withdrawn
Phase 1
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Publications & Presentations

PubMed

3 citations
Unique geospatial accumulations of uveal melanoma
Marlana Orloff, Michael W. Brennan, Shingo Sato, Carol L. Shields, Jerry A. Shields, Sara E. Lally, Arman Mashayekhi, John O. Mason, Miguel A. Materin, Michael J. Mast...> ;American Journal of Ophthalmology. 2020 Dec 1
51 citations
Insights from immuno-oncology: the Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19.
Paolo A. Ascierto, Bernard A. Fox, Walter J. Urba, Ana C. Anderson, Michael B. Atkins, Ernest C. Borden, Julie R. Brahmer, Lisa H. Butterfield, Alessandra Cesano, Dani...> ;Journal for Immunotherapy of Cancer. 2020 Apr 1
23 citations
An Outcome Assessment of a Single Institution’s Longitudinal Experience with Uveal Melanoma Patients with Liver Metastasis
Rino S. Seedor, David J. Eschelman, Carin F. Gonsalves, Robert D. Adamo, Marlana Orloff, Anjum Amjad, Erin Sharpe-Mills, Inna Chervoneva, Carol L. Shields, Jerry A. Sh...> ;Cancers. 2020 Jan 1
59 citations
PD-L1 expression in tumor metastasis is different between uveal melanoma and cutaneous melanoma
Asad Javed, David Arguello, Curtis Johnston, Zoran Gatalica, Mizue Terai, Ryan M. Weight, Marlana Orloff, Michael J. Mastrangelo, Takami Sato> ;Immunotherapy. 2017 Dec 1
40 citations
Adjuvant Sunitinib in High-Risk Patients with Uveal Melanoma: Comparison with Institutional Controls
Matias E. Valsecchi, Marlana Orloff, Rino Sato, Inna Chervoneva, Carol L. Shields, Jerry A. Shields, Michael J. Mastrangelo, Takami Sato> ;Ophthalmology. 2017 Sep 1
34 citations
Establishment of an orthotopic patient-derived xenograft mouse model using uveal melanoma hepatic metastasis
Ken Kageyama, Masahiro Ohara, Kengo Saito, Shinji Ozaki, Mizue Terai, Michael J. Mastrangelo, Paolo Fortina, Andrew E. Aplin, Takami Sato> ;Journal of Translational Medicine. 2017 Jun 23
26 citations
Phase 1 Study of Ipilimumab Combined With Whole Brain Radiation Therapy or Radiosurgery for Melanoma Patients With Brain Metastases.
Noelle L Williams, Evan J Wuthrick, Hyun Kim, Joshua D Palmer, Shivank Garg, Harriet Eldredge-Hindy, Constantine Daskalakis, Kendra J Feeney, Michael J Mastrangelo, Ly...> ;International Journal of Radiation Oncology, Biology, Physics. 2017 Sep 1
22 citations
Patient Symptoms Are the Most Frequent Indicators of Recurrence in Patients with American Joint Committee on Cancer Stage II Melanoma
Adam C. Berger, David W. Ollila, Adrienne N. Christopher, John C. Kairys, Michael J. Mastrangelo, Kendra J. Feeney, Nooreen Dabbish, Benjamin E. Leiby, Jill A. Frank, ...> ;Journal of the American College of Surgeons. 2017 Apr 1
20 citations
Establishment and Characterization of Orthotopic Mouse Models for Human Uveal Melanoma Hepatic Colonization
Shinji Ozaki, Raja Vuyyuru, Ken Kageyama, Mizue Terai, Masahiro Ohara, Hanyin Cheng, Tim Manser, Michael J. Mastrangelo, Andrew E. Aplin, Takami Sato> ;The American Journal of Pathology. 2016 Jan 1
The Last Chapter.
Michael J. Mastrangelo> ;Seminars in Oncology. 2015 Dec 1
32 citations
Arterial Blood, Rather Than Venous Blood, is a Better Source for Circulating Melanoma Cells.
Mizue Terai, Zhaomei Mu, David J. Eschelman, Carin F. Gonsalves, Ken Kageyama, Inna Chervoneva, Marlana Orloff, Ryan M. Weight, Michael J. Mastrangelo, Massimo Cristof...> ;Ebiomedicine. 2015 Nov 1
49 citations
Double-Blinded, Randomized Phase II Study Using Embolization with or without Granulocyte–Macrophage Colony-Stimulating Factor in Uveal Melanoma with Hepatic Metastases
Matias E. Valsecchi, Mizue Terai, David J. Eschelman, Carin F. Gonsalves, Inna Chervoneva, Jerry A. Shields, Carol L. Shields, Akira Yamamoto, Kevin L. Sullivan, MaryA...> ;Journal of Vascular and Interventional Radiology. 2015 Apr 1
2 citations
Intralesional Therapy for In-transit and Satellite Metastases in Melanoma
Kendra J. Feeney, Michael J. Mastrangelo> ;Surgical Oncology Clinics of North America. 2015 Apr 1
39 citations
Expression of insulin-like growth factor-1 receptor in metastatic uveal melanoma and implications for potential autocrine and paracrine tumor cell growth
Makoto Yoshida, Senthamil R. Selvan, Peter McCue, Tiziana DeAngelis, Renato Baserga, Ami Fujii, Hallgeir Rui, Michael J. Mastrangelo, Takami Sato> ;Pigment Cell & Melanoma Research. 2014 Mar 1
4 citations
Altered drainage patterns in patients with melanoma and previous axillary dissection.
Caitlyn M. Johnson, Charles M. Intenzo, Michael J. Mastrangelo, Kendra J. Feeney, Adam C. Berger> ;The Journal of Dermatology. 2013 Jul 1
63 citations
A pilot study of sunitinib malate in patients with metastatic uveal melanoma.
Amit Mahipal, Lukman Tijani, Kathryn Chan, MaryAnn Laudadio, Michael J. Mastrangelo, Takami Sato> ;Melanoma Research. 2012 Dec 1
30 citations
Interleukin 6 mediates production of interleukin 10 in metastatic melanoma
Mizue Terai, Masumi Eto, Garbo D. Young, David Berd, Michael J. Mastrangelo, Yutaka Tamura, Kenichi Harigaya, Takami Sato> ;Cancer Immunology, Immunotherapy. 2012 Feb 1
13 citations
Lymph node ratio is an important and independent prognostic factor for patients with stage III melanoma
Adam C. Berger, Michael A. Fierro, John C. Kairys, David Berd, Takami Sato, Jocelyn Andrel, Terry Hyslop, Michael J. Mastrangelo> ;Journal of Surgical Oncology. 2012 Jan 1
123 citations
Defining the critical hurdles in cancer immunotherapy
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177 citations
Interleukin 10 in the tumor microenvironment: a target for anticancer immunotherapy.
Takami Sato, Mizue Terai, Yutaka Tamura, Vitali Alexeev, Michael J. Mastrangelo, Senthamil R. Selvan> ;Immunologic Research. 2011 Dec 4
Somatostatin receptor scintigraphy in patients with metastatic uveal melanoma.
Valsecchi ME, Summers D, Intenzo CM, Kim S, Mastrangelo MJ, Sato T> ;J. Clin. Oncol.. 2011-05-20
The results of a randomized phase II study using embolization with or without granulocyte-macrophage colony-stimulating factor (GM-CSF) in uveal melanoma patients with...
Eschelman DJ, Gonsalves CF, Terai M, Laudadio M, Sullivan KL, Mastrangelo MJ, Sato T> ;J. Clin. Oncol.. 2011-05-20
17 citations
Tumor-derived interleukin-10 as a prognostic factor in stage III patients undergoing adjuvant treatment with an autologous melanoma cell vaccine
Amit Mahipal, Mizue Terai, David Berd, Inna Chervoneva, Kashyap Patel, Michael J. Mastrangelo, Takami Sato> ;Cancer Immunology, Immunotherapy. 2011 Apr 26
24 citations
In vitro migration of cytotoxic T lymphocyte derived from a colon carcinoma patient is dependent on CCL2 and CCR2.
Klara Berencsi, Pyapalli Rani, Tianqian Zhang, Laura Gross, Michael J. Mastrangelo, Neal J. Meropol, Dorothee Herlyn, Rajasekharan Somasundaram> ;Journal of Translational Medicine. 2011 Mar 30
12 citations
Conjunctival melanoma: bladder and upper urinary tract metastases.
Binu Chandrasekharapillai Janardanan Nair, Nicole C. Williams, Chunhua Cui, Deborah Summers, Michael J. Mastrangelo, Scott G. Hubosky, Carol L. Shields, Jerry A. Shiel...> ;Journal of Clinical Oncology. 2011 Mar 20
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