MichaelEMcManusMD

Psychiatry • San Diego, CA

Addiction, Child & Adolescent Psychiatry

Associate Professor in Residence, UCSF School of Medicine

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Office
1550 Hotel Circle North
Ste 270
San Diego, CA 92108
Phone+1 619-692-1581

Fax+1 619-528-4625
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Education & Training

University of Michigan Health SystemFellowship, Child and Adolescent Psychiatry, 1977 - 1979
University of Michigan Health SystemResidency, Psychiatry, 1974 - 1977
State University of New York Downstate Medical Center College of MedicineClass of 1974

Certifications & Licensure

CA State Medical License 1985 - 2025
NY State Medical License 1995 - 1997
American Board of Psychiatry and Neurology Psychiatry
American Board of Psychiatry and Neurology Child Psychiatry

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification NextGen Ambulatory EHR, NextGen Healthcare, 2012

Clinical Trials

Efficacy and Safety of Extended-release Guanfacine Hydrochloride in Children and Adolescents Aged 6-17 Years With Attention-Deficit/Hyperactivity Disorder (ADHD) Start of enrollment: 2011 Jan 17
Completed
Phase 3
Dasotraline Pediatric ADHD Study Start of enrollment: 2015 Apr 01
Completed
Phase 2, Phase 3
Safety and Efficacy Study of SHP465 in Children and Adolescents Aged 6-17 Years With Attention-Deficit Hyperactivity Disorder (ADHD) Start of enrollment: 2015 Jun 18
Completed
Phase 3
Dasotraline Binge Eating Disorder Study Start of enrollment: 2015 Oct 01
Completed
Phase 2, Phase 3
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Publications & Presentations

PubMed

40 citations
Human cytosolic sulfotransferase SULT1A1
Nadine Hempel, Niranjali Gamage, Jennifer L. Martin, Michael E. McManus> ;The International Journal of Biochemistry & Cell Biology. 2007 Jan 1
441 citations
Human sulfotransferases and their role in chemical metabolism
Niranjali Gamage, Amanda C. Barnett, Nadine Hempel, Ronald G. Duggleby, Kelly Windmill, Jennifer L. Martin, Michael E. McManus> ;Toxicological Sciences. 2006 Mar 1
85 citations
The Structure of Human SULT1A1 Crystallized with Estradiol AN INSIGHT INTO ACTIVE SITE PLASTICITY AND SUBSTRATE INHIBITION WITH MULTI-RING SUBSTRATES
Niranjali Gamage, Sergey I. Tsvetanov, Ronald G. Duggleby, Michael E. McManus, Jennifer L. Martin> ;The Journal of Biological Chemistry. 2005 Dec 16
10 citations
Human SULT1A genes: cloning and activity assays of the SULT1A promoters.
Nadine Hempel, Masahiko Negishi, Michael E. McManus> ;Methods in Enzymology. 2005 Jan 1
42 citations
The human sulfotransferase SULT1A1 gene is regulated in a synergistic manner by Sp1 and GA binding protein.
Nadine Hempel, Hongbing Wang, Edward L. LeCluyse, Michael E. McManus, Masahiko Negishi> ;Molecular Pharmacology. 2004 Dec 1
44 citations
Active site mutations and substrate inhibition in human sulfotransferase 1A1 and 1A3
Amanda C. Barnett, Sergey I. Tsvetanov, Niranjali Gamage, Jennifer L. Martin, Ronald G. Duggleby, Michael E. McManus> ;The Journal of Biological Chemistry. 2004 Apr 30
36 citations
Localization of a brain sulfotransferase, SULT4A1, in the human and rat brain: an immunohistochemical study.
N. Liyou, Kathryn M. Buller, M. Tresillian, Christopher M. Elvin, H. L. Scott, Peter R. Dodd, Anthony E.G. Tannenberg, Michael E. McManus> ;The Journal of Histochemistry and Cytochemistry. 2003 Dec 1
125 citations
Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition.
Niranjali Gamage, Ronald G. Duggleby, Amanda C. Barnett, M. Tresillian, Catherine F. Latham, N. Liyou, Michael E. McManus, Jennifer L. Martin> ;The Journal of Biological Chemistry. 2003 Feb 28
13 citations
Site-directed mutagenesis of the substrate-binding cleft of human estrogen sulfotransferase.
Nadine Hempel, Amanda C. Barnett, R. Bolton-Grob, N. Liyou, Michael E. McManus> ;Biochemical and Biophysical Research Communications. 2000 Sep 16
106 citations
Localization of N-acetyltransferases NAT1 and NAT2 in human tissues.
Kelly F. Windmill, Andrea Gaedigk, Pauline de la M. Hall, Hema Samaratunga, Denis M. Grant, Michael E. McManus> ;Toxicological Sciences. 2000 Mar 1
53 citations
Analysis of the substrate specificity of human sulfotransferases SULT1A1 and SULT1A3: site-directed mutagenesis and kinetic studies
Lulu A. Brix, Amanda C. Barnett, Ronald G. Duggleby, Barbara A. Leggett, Michael E. McManus> ;Biochemistry. 1999 Aug 10
11 citations
Localisation of aryl sulfotransferase expression in human tissues using hybridisation histochemistry and immunohistochemistry
Kelly F. Windmill, Astrid Christiansen, Jacqueline T Teusner, C Raman Bhasker, Don J Birkett, Xiaoyi Zhu, Michael E. McManus> ;Chemico-Biological Interactions. 1998 Feb 20
104 citations
The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: Functional and localization studies
Kelly F. Windmill, Ross A. McKinnon, Xiaoyi Zhu, Andrea Gaedigk, Denis M. Grant, Michael E. McManus> ;Mutation Research. 1997 May 12
4 citations
Photoaffinity labeling of human recombinant sulfotransferases with 2-azidoadenosine 3′,5′-[5′-32P]bisphosphate
Anna Radominska, Richard R. Drake, Xiaoyi Zhu, Maurice E. Veronese, Joanna M. Little, Susan Nowell, Michael E. McManus, Roger Lester, Charles N. Falany> ;The Journal of Biological Chemistry. 1996 Feb 9
1 citations
Stereoselective and regioselective hydration of 7-methylbenz[c]acridine-5,6-oxide enantiomers by rodent and human microsomal epoxide hydrolases.
Sarah J. Roberts-Thomson, Michael E. McManus, Colin C. Duke, R Agnew, Gerald M. Holder> ;Molecular Pharmacology. 1996 Jan 1
16 citations
Metabolism of Polycyclic Aza-Aromatic Carcinogens Catalyzed by Four Expressed Human Cytochromes P450
Sarah J. Roberts-Thomson, Michael E. McManus, Robert H. Tukey, Frank J. Gonzalez, Gerald M. Holder> ;Cancer Research. 1995 Mar 1
107 citations
Characterisation of CYP3A gene subfamily expression in human gastrointestinal tissues.
Ross A. McKinnon, Wendy Burgess, Pdlm Hall, Sarah J. Roberts-Thomson, Frank J. Gonzalez, Michael E. McManus> ;Gut. 1995 Feb 1
49 citations
The Catalytic Activity of Four Expressed Human Cytochrome P450s Towards Benzo[a]pyrene and the Isomers of Its Proximate Carcinogen
Sarah J. Roberts-Thomson, Michael E. McManus, Robert H. Tukey, F.F. Gonzalez, Gerald M. Holder> ;Biochemical and Biophysical Research Communications. 1993 May 14
7 citations
Measurement of cytochrome P450 activation of xenobiotics using the Ames Salmonella test.
Michael E. McManus, Ross A. McKinnon> ;Methods in Enzymology. 1991 Jan 1
15 citations
Immunohistochemical localization and quantitation of NADPH-cytochrome P-450 reductase in human liver
Michael E. McManus, P D Hall, Ieva Stupans, J Brennan, Wendy Burgess, RA Robson, Donald J. Birkett> ;Molecular Pharmacology. 1987 Aug 1
The effect of misonidazole on the cytotoxicity and DNA cross-linking activity of an activated sulfidocyclophosphamide in hypoxic mouse leukemia cells.
Ramonas LM, Erickson LC, McManus ME> ;Mol. Pharmacol.. 1982-07-01
Structural analysis of the minor human hemoglobin components: Hb AIa1, Hb AIa2 and Hb AIb.
Garrick LM, McDonald MJ, Shapiro R, Bleichman M, McManus M, Bunn HF> ;Eur. J. Biochem.. 1980-05-01
Structural heterogeneity of human hemoglobin A due to nonenzymatic glycosylation.
Bunn HF, Shapiro R, McManus M, Garrick L, McDonald MJ, Gallop PM, Gabbay KH> ;J. Biol. Chem.. 1979-05-25
Nonenzymatic glycosylation of human hemoglobin at multiple sites.
Shapiro R, McManus M, Garrick L, McDonald MJ, Bunn HF> ;Metab. Clin. Exp.. 1979-04-01
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