MichaelDPradosMD

Oncology • San Francisco, CA

Neuro-Oncology

Professor Emeritus of Neurological Surgery, UCSF

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Office
1450 3rd Street
San Francisco, CA 94158
Phone+1 415-476-7217

Fax+1 415-514-9792
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Education & Training

Louisiana State University School of Medicine (Baton Rouge)Residency, Internal Medicine, 1975 - 1977
Louisiana State University School of MedicineInternship, Internal Medicine, 1974 - 1975
Louisiana State University School of Medicine in New OrleansClass of 1974

Certifications & Licensure

CA State Medical License 1985 - 2024
NM State Medical License 1978 - 1989
LA State Medical License 1974 - 1989
American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2006-2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
Super Doctor SuperDoctors.com
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Clinical Trials

O(6)-Benzylguanine in Treating Patients With Malignant Glioma Start of enrollment: 1997 Jun 19
Completed
Phase 1
Temozolomide and Carmustine in Treating Patients With Anaplastic Glioma Start of enrollment: 1998 Mar 25
Completed
Phase 2
Irinotecan in Treating Patients With Progressive or Recurrent Malignant Glioma Start of enrollment: 1998 Oct 22
Completed
Phase 1, Phase 2
Gefitinib Plus Temozolomide in Treating Patients With Malignant Primary Glioma Start of enrollment: 2002 Jan 28
Completed
Phase 1
Biological Therapy and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Start of enrollment: 2002 Oct 23
Terminated
Phase 2
Study of AEE788 in Patients With Recurrent/Relapse Glioblastoma Multiforme (GBM) Start of enrollment: 2004 Jan 01
Completed
Phase 1, Phase 2
Safety and Efficacy Study of Tarceva, Temodar, and Radiation Therapy in Patients With Newly Diagnosed Brain Tumors Start of enrollment: 2004 Aug 01
Completed
Phase 2
Erlotinib in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma Start of enrollment: 2007 Jan 01
Terminated
Phase 2
Study of Bevacizumab Plus Temodar and Tarceva in Patients With Glioblastoma or Gliosarcoma Start of enrollment: 2007 Sep 01
Completed
Phase 2
A Phase I Trial of Nanoliposomal CPT-11 (NL CPT-11) in Patients With Recurrent High-Grade Gliomas Start of enrollment: 2008 Aug 01
Completed
Phase 1
Safety Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Tumors of the Brain Start of enrollment: 2010 Aug 01
Terminated
Phase 2
A Study of PD 0332991 in Patients With Recurrent Rb Positive Glioblastoma Start of enrollment: 2010 Sep 01
Terminated
Phase 2
Ovarian Aging in Low Grade Glioma (LGG) Treated With Temozolomide Start of enrollment: 2011 Oct 01
Terminated
PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children Start of enrollment: 2012 Dec 13
Active, not recruiting
Phase 2
Molecular Profiling in Guiding Individualized Treatment Plan in Adults With Recurrent/Progressive Glioblastoma Start of enrollment: 2014 Aug 01
Completed
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Publications & Presentations

PubMed

2 citations
Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma.
Henry S Friedman, Michael D Prados, Patrick Y Wen, Tom Mikkelsen, David Schiff, Lauren E Abrey, W K Alfred Yung, Nina Paleologos, Martin K Nicholas, Randy Jensen, Jame...> ;Journal of Clinical Oncology. 2023 Nov 10
2 citations
ABTC-0904: targeting glioma stem cells in GBM: a phase 0/II study of hedgehog pathway inhibitor GDC-0449.
Andrew E Sloan, Charles J Nock, Xiaobu Ye, Robert Buerki, Susan Chang, Glenn Lesser, Andrew Norden, Timothy Cloughesy, Jeffrey Olson, Amber Kerstetter-Fogle, Jeremy Ri...> ;Journal of Neuro-Oncology. 2023 Jan 1
16 citations
Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003.
Cassie Kline, Payal Jain, Lindsay Kilburn, Erin R Bonner, Nalin Gupta, John R Crawford, Anu Banerjee, Roger J Packer, Javier Villanueva-Meyer, Tracy Luks, Yalan Zhang,...> ;Clinical Cancer Research. 2022 Sep 15
5 citations
A single institution retrospective analysis on survival based on treatment paradigms for patients with anaplastic oligodendroglioma.
Nancy Ann Oberheim Bush, Jacob S. Young, Yalan Zhang, Cecilia L Dalle Ore, Annette M. Molinaro, Jennie Taylor, Jennifer Clarke, Michael D. Prados, Steve Braunstein, Da...> ;Journal of Neuro-Oncology. 2021 Jun 14
3 citations
BRCA1 Protein Expression Predicts Survival in Glioblastoma Patients from an NRG Oncology RTOG Cohort
Maria Vassilakopoulou, Minhee Won, Walter J. Curran, Luis Souhami, Michael D. Prados, Corey J. Langer, David L. Rimm, Jason A. Hanna, Veronique Neumeister, Edward Meli...> ;Oncology. 2021 May 6
13 citations
Pilot Study of Hyperpolarized 13C Metabolic Imaging in Pediatric Patients with Diffuse Intrinsic Pontine Glioma and Other CNS Cancers
Adam Autry, Ilwoo Park, Cassie Kline, H.-Y. Chen, Jeremy W. Gordon, S. Raber, C. Hoffman, Y. Kim, K. Okamoto, Daniel B. Vigneron, Janine M. Lupo, Michael D. Prados, Yi...> ;AJNR. American Journal of Neuroradiology. 2021 Jan 1
57 citations
Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma
Sabine Mueller, Jared Taitt, Javier Villanueva-Meyer, Erin R Bonner, Takahide Nejo, Rishi Lulla, Stewart Goldman, Anu Banerjee, Susan N. Chi, Nicholas S Whipple, John ...> ;The Journal of Clinical Investigation. 2020 Dec 1
1 citations
Population Pharmacokinetics of Vemurafenib in Children With Recurrent/Refractory BRAF Gene V600E-Mutant Astrocytomas
Hechuan Wang, Janel Long-Boyle, Beth Apsel Winger, Theodore Nicolaides, Sabine Mueller, Michael D. Prados, Vijay Ivaturi> ;Journal of Clinical Pharmacology. 2020 Sep 1
39 citations
Phase I study of vemurafenib in children with recurrent or progressive BRAFV600E mutant brain tumors: Pacific Pediatric Neuro-Oncology Consortium study (PNOC-002).
Theodore Nicolaides, Kellie J. Nazemi, John Robertson Crawford, Lindsay Kilburn, Jane E. Minturn, Amar Gajjar, Karen Gauvain, Sarah Leary, Girish Dhall, Mariam Aboian,...> ;Oncotarget. 2020 May 26
264 citations
Association of Maximal Extent of Resection of Contrast-Enhanced and Non-Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnos...
Annette M. Molinaro, Shawn L. Hervey-Jumper, Ramin A. Morshed, Jacob S. Young, Seunggu J. Han, Pranathi Chunduru, Yalan Zhang, Joanna J. Phillips, Anny Shai, Marisa La...> ;JAMA Oncology. 2020 Apr 1
8 citations
Neuro-Oncology Practice Clinical Debate: targeted therapy vs conventional chemotherapy in pediatric low-grade glioma.
Tabitha Cooney, Kee Kiat Yeo, Cassie Kline, Michael D. Prados, Daphne A. Haas-Kogan, Susan N. Chi, Sabine Mueller> ;Neuro-Oncology Practice. 2020 Jan 31
6 citations
Phase I/II study of sorafenib in combination with erlotinib for recurrent glioblastoma as part of a 3-arm sequential accrual clinical trial: NABTC 05-02
Huanwen Chen, John G. Kuhn, Kathleen R. Lamborn, Lauren E. Abrey, Lisa M. DeAngelis, Frank S. Lieberman, H. Ian Robins, Susan M. Chang, W. K. Alfred Yung, Jan Drappatz...> ;Neuro-Oncology Advances. 2020 Jan 1
9 citations
Temporospatial genomic profiling in glioblastoma identifies commonly altered core pathways underlying tumor progression.
Mylan R. Blomquist, Shannon P. Fortin Ensign, Fulvio D'Angelo, Joanna J. Phillips, Michele Ceccarelli, Sen Peng, Rebecca F. Halperin, Francesca Pia Caruso, Luciano Gar...> ;Neuro-Oncology Advances. 2020 Jan 1
20 citations
Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas
Michael E. Berens, Anup Sood, Jill S. Barnholtz-Sloan, John Frederick Graf, Sanghee Cho, Seungchan Kim, Jeff Kiefer, Sara A. Byron, Rebecca F. Halperin, Sara Nasser, J...> ;Plos One. 2019 Dec 27
75 citations
A pilot precision medicine trial for children with diffuse intrinsic pontine glioma-PNOC003: A report from the Pacific Pediatric Neuro-Oncology Consortium.
Sabine Mueller, Payal Jain, Winnie S. Liang, Lindsay Kilburn, Cassie Kline, Nalin Gupta, Eshini Panditharatna, Suresh N. Magge, Bo Zhang, Yuankun Zhu, John R. Crawford...> ;International Journal of Cancer. 2019 Oct 1
9 citations
Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM
Andrew McKinney, Olle R. Lindberg, Jane R. Engler, Katharine Chen, Anupam Kumar, Henry Gong, Kan V. Lu, Erin F. Simonds, Timothy F. Cloughesy, Linda M. Liau, Michael D...> ;Molecular Cancer Therapeutics. 2019 Sep 1
5 citations
Attitudes toward fertility and fertility preservation in women with glioma
Rachel K Stiner, Jennifer Clarke, Nikita Sinha, Jessica L. Chan, Joseph M. Letourneau, E.E. Niemasik, Jane Rabbitt, Susan M. Chang, Nicholas Butowski, Michael D. Prado...> ;Neuro-Oncology Practice. 2019 May 7
90 citations
Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial.
Patrick Y. Wen, Mehdi Touat, Brian M. Alexander, Ingo K. Mellinghoff, Shakti Ramkissoon, Christine McCluskey, Kristine Pelton, Sam Haidar, Sankha S. Basu, Sarah C. Gaf...> ;Journal of Clinical Oncology. 2019 Feb 4
98 citations
Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy
Eshini Panditharatna, Lindsay Kilburn, Mariam Aboian, Madhuri Kambhampati, Heather Gordish-Dressman, Suresh N. Magge, Nalin Gupta, John S. Myseros, Eugene Hwang, Cassi...> ;Clinical Cancer Research. 2018 Dec 1
112 citations
A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily
Rai, K., Anil Korkut, Sobia Zaidi, Rupa S. Kanchi, Shuyun Rao, Nancy R. Gough, Andre Schultz, Xubin Li, Philip L. Lorenzi, Ashton C. Berger, Gordon Robertson, Lawrence...> ;Cell Systems. 2018 Oct 24
70 citations
Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma
Nalin Gupta, Liliana Goumnerova, Peter E. Manley, Susan N. Chi, Donna Neuberg, Maneka Puligandla, Jason Fangusaro, Stewart Goldman, Tadanori Tomita, Tord D. Alden, Art...> ;Neuro-Oncology. 2018 Oct 9
8 citations
Using genomics to guide treatment for glioblastoma.
Jacob S. Young, Michael D. Prados, Nicholas Butowski> ;Pharmacogenomics. 2018 Sep 11
18 citations
Volumetric response quantified using T1 subtraction predicts long-term survival benefit from cabozantinib monotherapy in recurrent glioblastoma.
Benjamin M. Ellingson, Dana T. Aftab, Gisela Schwab, Colin Hessel, Robert J. Harris, Davis C. Woodworth, Kevin Leu, Ararat Chakhoyan, Catalina Raymond, Jan Drappatz, J...> ;Neuro-Oncology. 2018 Sep 3
68 citations
Phase-2 trial of palbociclib in adult patients with recurrent RB1-positive glioblastoma.
Jennie Taylor, Mili Parikh, Joanna J. Phillips, C. David James, Annette M. Molinaro, Nicholas Butowski, Jennifer Clarke, Nancy Ann Oberheim-Bush, Susan M. Chang, Mitch...> ;Journal of Neuro-Oncology. 2018 Aug 27
249 citations
Erratum: Comprehensive Characterization of Cancer Driver Genes and Mutations (ARTICLE (2018) 173(2) (371–385), (S009286741830237X), (10.1016/j.cell.2018.02.060))
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Journal Articles

Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy
Eugene I Hwang, Cassie Kline, Soonmee Cha, Michael Prados, Lindsay B Kilburn, Nalin Gupta, Roger J Packer, Suresh N Magge, Clinical Cancer Research

Press Mentions

Scientific Symposium Marks the Ten-Year Anniversary of the Pacific Pediatric Neuro-Oncology Consortium (PNOC) and FoundationMay 1st, 2023
5th Annual CBTTC Investigator Meeting – Note from the Executive Board ChairMay 29th, 2019
Researchers to Test Individualized Drug Cocktails for Kids' Brain TumorsAugust 30th, 2018
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