MichaelPulsipherMD

Pediatric Hematology & Oncology • Salt Lake City, UT

Pediatric Hematologic Oncology

Division Chief, Pediatric Hematology and Oncology, Intermountain Primary Children's Hospital. Director, Intermountain and Huntsman Cancer Institute Children's and Adolescent Cancer Initiative IPCH/HCI Presidential Chair in Cancer Research at the Spencer Fox Eccles School of Medicine at the University of Utah

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Office
2000 Circle of Hope Dr.
Rm. 3515
Salt Lake City, UT 84112
Phone+1 801-646-4211
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Summary

I am Division Chief of the Pediatric Hematology and Oncology Program at Intermountain Primary Children's Hospital and Director of the Child and Adolescent Cancer Research Initiative at the Huntsman Cancer Institute at the Spencer Fox Eccles School of Medicine at the University of Utah. I have expertise in cell therapy and BMT and a past group Chair of the Pediatric Transplantation and Cellular Therapy Consortium – an 86-member international clinical trials group.

Education & Training

Children's Hospital/Boston Medical CenterFellowship, Pediatric Hematology/Oncology, 1993 - 1996
Children's Hospital of PhiladelphiaResidency, Pediatrics, 1990 - 1993
Stanford University School of MedicineClass of 1990

Certifications & Licensure

UT State Medical License 1998 - 2026
CA State Medical License 2015 - 2025
ID State Medical License 2013 - 2015
PA State Medical License 1992 - 1994
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

Lifetime Achievement Award Pediatric Transplantation and Cellular Therapy Consortium, 2020

Clinical Trials

Comparison of Fluconazole vs Voriconazole to Treat Fungal Infections for Blood and Marrow Transplants (BMT CTN 0101) Start of enrollment: 2003 Nov 01
Completed
Phase 3
Peripheral Blood Stem Cell Transplant vs Bone Marrow Transplant in Individuals With Hematologic Cancers (BMT CTN 0201) Start of enrollment: 2004 Jan 01
Completed
Phase 3
Tacrolimus and Mycophenolate Mofetil in Preventing Graft-Versus-Host Disease in Patients Who Have Undergone Total-Body Irradiation With or Without Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant for Hematologic Cancer Start of enrollment: 2004 Apr 01
Completed
Phase 2
Pentostatin and Lymphocyte Infusion in Preventing Graft Rejection in Patients Who Have Undergone Donor Stem Cell Transplant Start of enrollment: 2003 May 01
Completed
Phase 2
Rituxan/BEAM vs Bexxar/BEAM in Autologous Hematopoietic Stem Cell Transplant for Non-Hodgkin's Lymphoma (BMTCTN0401) Start of enrollment: 2005 Dec 01
Completed
Phase 3
Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission Start of enrollment: 2007 Mar 01
Completed
Phase 3
Single vs Double Umbilical Cord Blood Transplants in Children With High Risk Leukemia and Myelodysplasia (BMT CTN 0501) Start of enrollment: 2006 Dec 01
Completed
Phase 3
Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases Start of enrollment: 2001 Dec 01
Recruiting
Phase 1, Phase 2
Stem Cell Related Donor Safety Study Start of enrollment: 2010 Jan 01
Completed
Chronic Graft-versus-Host Disease Treatment (BMT CTN 0801) Start of enrollment: 2010 Apr 01
Completed
Phase 2, Phase 3
Natural History Study of SCID Disorders Start of enrollment: 2010 Sep 02
Enrolling by invitation
Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant Start of enrollment: 2010 Nov 01
Completed
Phase 3
Sirolimus, Cyclosporine, and Mycophenolate Mofetil in Preventing Graft-versus-Host Disease in Treating Patients With Blood Cancer Undergoing Donor Peripheral Blood Stem Cell Transplant Start of enrollment: 2010 Dec 01
Completed
Phase 2
Reduced Intensity Regimen vs Myeloablative Regimen for Myeloid Leukemia or Myelodysplastic Syndrome (BMT CTN 0901) Start of enrollment: 2011 Jun 01
Terminated
Phase 3
Patients Treated for SCID (1968-Present) Start of enrollment: 2011 May 15
Enrolling by invitation
MRD Testing Before and After Hematopoietic Cell Transplantation for Pediatric Acute Myeloid Leukemia Start of enrollment: 2011 Oct 01
Completed
Neutrophil Extracellular Trap Formation in Patients Undergoing Bone Marrow Transplant Start of enrollment: 2012 Jun 01
Completed
Abatacept as GVHD Prophylaxis Phase 2 Start of enrollment: 2013 Feb 01
Active, not recruiting
Phase 2
A Study of the Safety and Efficacy of CMX001 for the Prevention of CMV Infection in CMV-seropositive HCT Recipients Start of enrollment: 2013 Aug 01
Completed
Phase 3
Patients Treated for Wiskott-Aldrich Syndrome (WAS) Since 1990 Start of enrollment: 2014 Feb 02
Completed
Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995 Start of enrollment: 2014 Jun 01
Enrolling by invitation
KIR Favorable Mismatched Haplo Transplant and KIR Polymorphism in ALL/AML/MDS Allo-HCT Children Start of enrollment: 2015 Oct 01
Enrolling by invitation
Phase 2
Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant Start of enrollment: 2019 Aug 29
Recruiting
Phase 2
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Publications & Presentations

PubMed

Relevance of lymphocyte proliferation to PHA in severe combined immunodeficiency (SCID) and T cell lymphopenia.
Roshini S Abraham, Amrita Basu, Jennifer R Heimall, Elizabeth Dunn, Alison Yip, Malika Kapadia, Neena Kapoor, Lisa Forbes Satter, Rebecca Buckley, Richard O'Reilly, Ge...> ;Clinical Immunology. 2024 Apr 1
Secondary bone marrow graft loss after third-party virus-specific T cell infusion: Case report of a rare complication.
Michael D Keller, Stefan A Schattgen, Shanmuganathan Chandrakasan, E Kaitlynn Allen, Mariah A Jensen-Wachspress, Christopher A Lazarski, Muna Qayed, Haili Lang, Patric...> ;Nature Communications. 2024 Mar 29
A Validated Risk Stratification That Incorporates MAGIC Biomarkers Predicts Long-Term Outcomes in Pediatric Patients with Acute GVHD.
Kapoor, U., Muna Qayed, Urvi Kapoor, Scott Gillespie, Adrianna Westbrook, Paibel Aguayo-Hiraldo, Francis A Ayuk, Mina Aziz, Janna Baez, Hannah Choe, Zachariah DeFilipp...> ;Transplantation and Cellular Therapy. 2024 Mar 27
Posttransplantation late complications increase over time for patients with SCID: A Primary Immune Deficiency Treatment Consortium (PIDTC) landmark study.
Eissa, H., Thakar, M., Shah, A., Logan, B., Griffith, L., Dong, H., Parrott, R., O'Reilly, R., Dara, J., Kapoor, N., Forbes Satter, L., Chandra, S., Kapadia, M., Chand...> ;The Journal of Allergy and Clinical Immunology. 2024 Jan 1
4 citations
Genotype, oxidase status, and preceding infection or autoinflammation do not affect allogeneic HCT outcomes for CGD.
Jennifer W Leiding, Danielle E Arnold, Suhag Parikh, Brent Logan, Rebecca A Marsh, Linda M Griffith, Ruizhe Wu, Sharon Kidd, Kanwaldeep Mallhi, Deepak Chellapandian, S...> ;Blood. 2023 Dec 14
Pulmonary microbiome and transcriptome signatures reveal distinct pathobiologic states associated with mortality in two cohorts of pediatric stem cell transplant patie...
Gertz, S. J., Gertz, S. J., Hanisch, B. R., Matt S Zinter, Christopher C Dvorak, Madeline Y Mayday, Gustavo Reyes, Miriam R Simon, Emma M Pearce, Hanna Kim, Peter J Sh...> ;Medrxiv. 2023 Nov 29
3 citations
INSPIRED Symposium Part 2: Prevention and Management of Relapse Following Chimeric Antigen Receptor T Cell Therapy for B Cell Acute Lymphoblastic Leukemia.
Adam J Lamble, Amy Moskop, Michael A Pulsipher, Shannon L Maude, Corinne Summers, Colleen Annesley, André Baruchel, Lia Gore, Persis Amrolia, Nirali Shah> ;Transplantation and Cellular Therapy. 2023 Nov 1
2 citations
Intestinal microbiome and metabolome signatures in patients with chronic granulomatous disease.
Prabha Chandrasekaran, Yu Han, Christa S Zerbe, Theo Heller, Suk See DeRavin, Samantha A Kreuzberg, Beatriz E Marciano, Yik Siu, Drew R Jones, Roshini S Abraham, Micha...> ;The Journal of Allergy and Clinical Immunology. 2023 Dec 1
1 citations
Children's Oncology Group's 2023 blueprint for research: Cellular therapy and stem cell transplantation.
Carrie L Kitko, Catherine M Bollard, Mitchell S Cairo, Joseph Chewning, Terry J Fry, Michael A Pulsipher, Shalini Shenoy, Donna A Wall, John E Levine> ;Pediatric Blood & Cancer. 2023 Sep 1
1 citations
Introduction to the Reports from the Insights in Pediatric CAR T-cell Immunotherapy: Recent Advances and Future Directions (INSPIRED) Symposium.
Liora Schultz, Elad Jacoby, Adam J Lamble, Shannon L Maude, Amy Moskop, Regina M Myers, Michael A Pulsipher, Nirali N Shah, McNerney, K.> ;Transplantation and Cellular Therapy. 2023 Oct 1
1 citations
Higher abatacept exposure after transplant decreases acute GVHD risk without increasing adverse events.
Takuto Takahashi, Mahmoud Al-Kofahi, Mutaz Jaber, Brandi Bratrude, Kayla Betz, Yvonne Suessmuth, Alison Yu, Donna S Neuberg, Sung W Choi, Jeffrey Davis, Christine Dunc...> ;Blood. 2023 Aug 24
1 citations
Venetoclax and Azacitidine in the Treatment of-Mutated Donor Cell-Derived Leukemia in a Patient With Fanconi Anemia: Case Report and Literature Review.
Julie Ma, Kenji Morimoto, Michael A Pulsipher, Chintan Parekh> ;JCO Precision Oncology. 2023 Jun 1
5 citations
Prospective PTCTC trial of myeloablative haplo-BMT with posttransplant cyclophosphamide for pediatric acute leukemias.
Juan C Fierro-Pineda, Hua-Ling Tsai, Amanda Blackford, Andrew Cluster, Emi Caywood, Jignesh Dalal, Jeffrey Davis, Maarten Egeler, Jeffrey Huo, Michelle Hudspeth, Amy K...> ;Blood Advances. 2023 Sep 26
1 citations
Alemtuzumab and CXCL9 levels predict likelihood of sustained engraftment after reduced-intensity conditioning HCT.
Ashley V Geerlinks, Brooks Scull, Christa Krupski, Ryan Fleischmann, Michael A Pulsipher, Mary Eapen, James A Connelly, Catherine M Bollard, Sung-Yun Pai, Christine N ...> ;Blood Advances. 2023 Jul 25
Effect of Autograft CD34Dose on Outcome in Pediatric Patients Undergoing Autologous Hematopoietic Stem Cell Transplant for Central Nervous System Tumors.
Tristan E Knight, Kwang Woo Ahn, Kyle M Hebert, Rasha Atshan, Donna A Wall, Kanhatai Chiengthong, Seth J Rotz, Ellen Fraint, Hemalatha G Rangarajan, Jeffery J Auletta,...> ;Transplantation and Cellular Therapy. 2023 Jun 1
4 citations
Secondary Neoplasms After Hematopoietic Cell Transplant for Sickle Cell Disease.
Mary Eapen, Ruta Brazauskas, David A Williams, Mark C Walters, Andrew St Martin, Benjamin L Jacobs, Joseph H Antin, Kira Bona, Sonali Chaudhury, Victoria H Coleman-Cow...> ;Journal of Clinical Oncology. 2023 Apr 20
6 citations
Association of ABO mismatch with the outcomes of allogeneic hematopoietic cell transplantation for acute leukemia.
Guru Subramanian Guru Murthy, Brent R Logan, Stephanie Bo-Subait, Amer Beitinjaneh, Steven Devine, Nosha Farhadfar, Lohith Gowda, Shahrukh Hashmi, Hillard Lazarus, Sun...> ;American Journal of Hematology. 2023 Apr 1
7 citations
KIR-favorable TCR-αβ/CD19-depleted haploidentical HCT in children with ALL/AML/MDS: primary analysis of the PTCTC ONC1401 trial.
Michael A Pulsipher, Kwang W Ahn, Nancy J Bunin, Nahal Lalefar, Eric Anderson, Allyson Flower, Mitchell S Cairo, Julie-An Talano, Sonali Chaudhury, Carrie L Kitko, Jam...> ;Blood. 2022 Dec 15
13 citations
How I use risk factors for success or failure of CD19 CAR T cells to guide management of children and AYA with B-cell ALL.
Regina M Myers, Nirali N Shah, Michael A Pulsipher> ;Blood. 2023 Mar 16
53 citations
Three-Year Update of Tisagenlecleucel in Pediatric and Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia in the ELIANA Trial.
Theodore W Laetsch, Shannon L Maude, Susana Rives, Hidefumi Hiramatsu, Henrique Bittencourt, Peter Bader, André Baruchel, Michael Boyer, Barbara De Moerloose, Muna Qay...> ;Journal of Clinical Oncology. 2023 Mar 20
8 citations
A diagnostic classifier for pediatric chronic graft-versus-host disease: results of the ABLE/PBMTC 1202 study.
Geoffrey D E Cuvelier, Bernard Ng, Sayeh Abdossamadi, Eneida R Nemecek, Alexis Melton, Carrie L Kitko, Victor A Lewis, Tal Schechter, David A Jacobsohn, Andrew C Harri...> ;Blood Advances. 2023 Jul 25
6 citations
Low rate of subsequent malignant neoplasms after CD19 CAR T-cell therapy.
Emily M Hsieh, Regina M Myers, Bonnie Yates, Colleen Annesley, Samuel John, Agne Taraseviciute, Seth M Steinberg, Jennifer Sheppard, Perry Chung, Lee Chen, Daniel W Le...> ;Blood Advances. 2022 Sep 13
15 citations
Haploidentical bone marrow transplantation in patients with relapsed or refractory severe aplastic anaemia in the USA (BMT CTN 1502): a multicentre, single-arm, phase ...
Amy E DeZern, Mary Eapen, Juan Wu, Julie-An Talano, Melhem Solh, Blachy J Dávila Saldaña, Chatchada Karanes, Mitchell E Horwitz, Kanwaldeep Mallhi, Sally Arai, Nosha F...> ;The Lancet. Haematology. 2022 Sep 1
20 citations
Outcomes following treatment for ADA-deficient severe combined immunodeficiency: a report from the PIDTC.
Cuvelier, G., Logan, B., Prockop, S., Buckley, R., Kuo, C., Griffith, L., Liu, X., Yip, A., Hershfield, M., Ayoub, P., Moore, T., Dorsey, M., O'Reilly, R., Kapoor, N.,...> ;Blood. 2022 Aug 18
Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation.
Roxane Labrosse, Ines Boufaied, Benoîte Bourdin, Saideep Gona, Haley E Randolph, Brent R Logan, Sara Bourbonnais, Chloé Berthe, Wendy Chan, Rebecca H Buckley, Roberta ...> ;The Journal of Allergy and Clinical Immunology. 2023 Jan 1
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Abstracts/Posters

Lower Hematopoietic Progenitor Cell Counts and Yields at Subsequent Donations Is Influenced By a Shorter Inter-Donation Interval between the First and Subsequent Mobil...
Michael A. Pulsipher, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
The MAGIC Algorithm Probability (MAP): A Novel Laboratory Biomarker for the Response to Treatment of Acute Graft-Versus-Host Disease
Michael A. Pulsipher, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Next Generation Sequence Minimal Residual Disease (NGS-MRD) Predicts Outstanding Event Free Survival (EFS) Regardless of Hematopoietic Cell Transplantation (HCT) Prepa...
Michael A. Pulsipher, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Tisagenlecleucel Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory Children and Young Adults with Acute Lymphoblastic Leukemia (ALL): Real World E...
Michael A. Pulsipher, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Immunologic and Brain Bases of Neurotoxicity Associated with CAR T-Cell Therapy
Michael A. Pulsipher, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Clinical Experience of CAR T Cell Immunotherapy for Relapsed and Refractory Infant ALL Demonstrates Feasibility and Favorable Responses
Michael A. Pulsipher, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Cell Adhesion of ALL to Stromal Cells May Mediate CAR T-Cell Resistance: A Novel Escape Mechanism for Immunotherapy
Michael A. Pulsipher, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
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Lectures

A Panoply of Immunotherapies for Adult B-Lineage Acute Lymphocytic Leukemia
60th American Society of Hematology Annual Meeting - 12/3/2018
Molecular Detection of Minimal Residual Disease Precedes Morphological Relapse and Could be Used to Identify Relapse in Pediatric and Young Adult B-Cell Acute Lymphobl...
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Weighty Choices: Selecting Optimal G-CSF Doses for Stem Cell Mobilization to Optimize Yield
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
A Panoply of Immunotherapies for Adult B-Lineage Acute Lymphocytic Leukemia
60th American Society of Hematology Annual Meeting - 12/1/2018
ASPHO's 26th Annual Meeting
American Society of Pediatric Hematology/Oncology( ASPHO), Miami, Florida - 4/24/2013
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Press Mentions

Treating ALL with Cellular and Targeted Immunotherapies Reduces the Need for TransplantOctober 2nd, 2019
Immunotherapies in ALL: What’s Best and What’s Next?March 6th, 2019
Bright Future for Gene Therapy in Hematologic MalignanciesFebruary 27th, 2018
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Grant Support

Blood And Marrow Transplant Clinical Trials NetworkNational Heart, Lung, And Blood Institute2011
LATE Effects After Pediatric HSCT: State Of The Science, Future DirectionsNational Cancer Institute2011
Rdsafe: A Multi-Institutional Study Of HSC Donor Safety And Quality LifeNational Heart, Lung, And Blood Institute2009–2011
Blood And Marrow Transplant Clinical Trials NetworkNational Heart, Lung, And Blood Institute2009–2010
Gene Transfer And Functional Studies Of Fanconi AnemiaNational Heart, Lung, And Blood Institute1997