MichaelR.SperlingMD

Neurology • Philadelphia, PA

Epilepsy, Neurophysiology

Professor of Neurology, Thomas Jefferson Univ

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Office
909 Walnut St
2nd Floor
Philadelphia, PA 19107
Phone+1 215-955-1222

Fax+1 215-955-0606
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Summary

Dr. Michael Sperling is a neurologist in Philadelphia, PA and is affiliated with multiple hospitals in the area, including Thomas Jefferson University Hospitals, and Jefferson Health Northeast. He received his medical degree from Lewis Katz School of Medicine at Temple University, completed residency in Neurology at Mount Sinai Hospital, fellowship in Epilepsy and Clinical Neurophysiology at UCLA, and has been in practice 39 years. He specializes in epilepsy and neurophysiology and is experienced in general neurology, temporal lobe epilepsy, electroencephalography, status epilepticus, and epilepsy. He has an active research program in experimental therapeutics, intracranial electrophysiology, genetics, and surgical outcome for epilepsy. He has published over 500 peer reviewed papers, reviews, and books and lectures internationally on epilepsy. He is Editor-in-Chief of Epilepsia and is active in the International League Against Epilepsy and the American Epilepsy Society.

Education & Training

UCLA David Geffen School of Medicine/UCLA Medical CenterFellowship, Epilepsy, 1982 - 1984
Icahn School of Medicine at Mount Sinai/Mount Sinai HospitalResidency, Neurology, 1979 - 1982
Icahn School of Medicine at Mount Sinai/Mount Sinai HospitalInternship, Internal Medicine, 1978 - 1979
Lewis Katz School of Medicine at Temple UniversityClass of 1978

Certifications & Licensure

NY State Medical License 1979 - Present
NJ State Medical License 2019 - 2025
PA State Medical License 1985 - 2024
CA State Medical License 1982 - 2006
American Board of Psychiatry and Neurology Neurology
American Board of Psychiatry and Neurology Epilepsy
American Board of Clinical NeurophysiologyClinical Neurophysiology

Awards, Honors, & Recognition

Herbert H Jasper Award for Lifetime Achievement American Clinical Neurophysiology Society, 2024
Ambassador for Epilepsy International League Against Epilepsy, 2021
Philadelphia Magazine Castle Connolly, 2005-2021
America's Top Doctors Castle Connolly, 2006-2019
J Kiffen Penry Award for Excellence in Epilepsy American Epilepsy Society, 2018
CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2011-2013
Super Doctor SuperDoctors.com
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Clinical Trials

A Study of the Structure and Function of the Retina in Adult Patients With Refractory Complex Partial Seizures Treated With Vigabatrin (Sabril®) Start of enrollment: 2010 Dec 01
Completed
Phase 4
Efficacy and Safety of YKP3089 in Subjects With Treatment Resistant Partial Onset Seizures Start of enrollment: 2011 Jul 06
Completed
Phase 2
Seizure Detection and Warning System for Epilepsy Patients Start of enrollment: 2013 Jul 01
Active, not recruiting
Phase 3 Study of Adjunctive Ganaxolone in Adults With Drug-resistant Partial Onset Seizures and Open-label Extension Start of enrollment: 2013 Oct 01
Completed
Phase 3
Validation Study of the Simplified Seizure Classification Algorithm Start of enrollment: 2019 Jun 02
Completed
A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut Syndrome Start of enrollment: 2022 Mar 04
Recruiting
Phase 3
Roles: Principal Investigator
A Trial of the Efficacy and Safety of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures Start of enrollment: 2020 Jan 27
Recruiting
Phase 2
Roles: Contact
A Study of Soticlestat as an Add-on Therapy in Children, Teenagers, and Adults With Lennox-Gastaut Syndrome Start of enrollment: 2021 Nov 08
Completed
Phase 3
Roles: Principal Investigator
Using Direct Brain Stimulation to Study Cognitive Electrophysiology Start of enrollment: 2019 Sep 23
Enrolling by invitation
Not Applicable
Roles: Principal Investigator, Contact
EpiCare@Home Validation Study for Focal Onset Seizures Start of enrollment: 2023 Jan 23
Recruiting
Not Applicable
Roles: Contact
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Publications & Presentations

PubMed

Simulated resections and RNS placement can optimize post-operative seizure outcomes when guided by fast ripple networks.
Sima Mofakham, Myung Shin Sim, Anatol Bragin, Richard Staba, Jerome Engel Jr, Charles Mikell 3rd, Shennan Aibel Weiss, Michael R Sperling, Anli Liu, Itzhak Fried, Chen...> ;Medrxiv. 2024 Mar 28
Edge-wise analysis reveals white matter connectivity associated with focal to bilateral tonic-clonic seizures.
Sam S Javidi, Xiaosong He, Ankeeta Ankeeta, Qirui Zhang, Salvatore Citro, Joseph I Tracy, Michael R Sperling> ;Epilepsia. 2024 Mar 22
Automated Seizure Detection Based on State-Space Model Identification.
Zhuo Wang, Dale Wyeth, Allon Guez, Michael R Sperling> ;Sensors. 2024 Mar 16
1 citations
Which terms should be used to describe medications used in the treatment of seizure disorders? An ILAE position paper.
Emilio Perucca, Jacqueline A French, Ghaieb Aljandeel, Simona Balestrini, Patricia Braga, Jorge G Burneo, Augustina Charway Felli, J Helen Cross, Aristea S Galanopoulo...> ;Epilepsia. 2024 Mar 1
Stereotactic Electroencephalogram Recordings in Temporal Lobectomy Patients Demonstrates the Predictive Value of Interictal Cross-Frequency Correlations: A Retrospecti...
Anish Vinay Sathe, Mahdi Alizadeh, Emily Johannan, Christian Raimondo, Michael Sperling, Ashwini Sharan, Michael Kogan> ;Brain Sciences. 2024 Feb 26
1 citations
Analyses of patients who self-administered diazepam nasal spray for acute treatment of seizure clusters.
Hogan, R., Davis, C., Rabinowicz, A., Misra, S., Sperling, M., Rao, V., Peters, J., Penovich, P., Wheless, J., Carrazana, E.> ;Epilepsy & Behavior Reports. 2024 Jan 1
Prediction tools and risk stratification in epilepsy surgery.
Hadady, L., Alcala-Zermeno, J., French, J., Dugan, P., Fabó, D., Klivényi, P., Rubboli, G., Beniczky, S., Sperling, M., Jehi, L.> ;Epilepsia. 2024 Feb 1
The Temporal Lobe Club: Newer Approaches to Treat Temporal Lobe Epilepsy.
Kang, J., Makhalova, J., Bartolomei, F., Sperling, M., Wu, C., Southwell, D.> ;Epilepsy Currents. 2023 Dec 6
Pathological neurons generate ripples at the UP-DOWN transition disrupting information transfer.
Shennan A Weiss, Itzhak Fried, Jerome Engel Jr, Anatol Bragin, Shuang Wang, Michael R Sperling, Robert K S Wong, Yuval Nir, Richard J Staba> ;Epilepsia. 2024 Feb 1
Functional and anatomical connectivity predict brain stimulation's mnemonic effects.
Youssef Ezzyat, James E Kragel, Ethan A Solomon, Bradley C Lega, Joshua P Aronson, Barbara C Jobst, Robert E Gross, Michael R Sperling, Gregory A Worrell, Sameer A She...> ;Cerebral Cortex. 2024 Jan 14
Functional and anatomical connectivity predict brain stimulation's mnemonic effects.
Youssef Ezzyat, James E Kragel, Ethan A Solomon, Bradley C Lega, Joshua P Aronson, Barbara C Jobst, Robert E Gross, Michael R Sperling, Gregory A Worrell, Sameer A She...> ;Biorxiv. 2023 Aug 11
Pathological neurons generate ripples at the UP-DOWN transition disrupting information transfer.
Shennan A Weiss, Itzhak Fried, Jerome Engel Jr, Anatol Bragin, Shuang Wang, Michael R Sperling, Robert K S Wong, Yuval Nir, Richard J Staba> ;Medrxiv. 2023 Aug 7
1 citations
Long-term outcomes of mesial temporal laser interstitial thermal therapy for drug-resistant epilepsy and subsequent surgery for seizure recurrence: a multi-centre coho...
Brett E Youngerman, Matei A Banu, Farhan Khan, Guy M McKhann, Catherine A Schevon, Jonathan R Jagid, Iahn Cajigas, Christian B Theodotou, Andrew Ko, Robert Buckley, Je...> ;Journal of Neurology, Neurosurgery, and Psychiatry. 2023 Nov 1
Equity in access to antiseizure medications: Who has the right to decide and what are the consequences of crisis decisions?
Jo M Wilmshurst, Michael R Sperling> ;Epilepsia. 2023 Aug 1
2 citations
Sudden unexpected death in epilepsy during cenobamate clinical development.
William E Rosenfeld, Louis Ferrari, Wesley T Kerr, Michael R Sperling> ;Epilepsia. 2023 Aug 1
An interview with Brad Kamitaki, 2023 Epilepsia Prize Winner for Clinical Research.
Michael R Sperling> ;Epilepsia. 2023 Aug 1
An interview with Riccardo De Feo, 2023 Epilepsia Prize winner for Basic Science Research.
Michael R Sperling> ;Epilepsia. 2023 Aug 1
3 citations
Fast ripples reflect increased excitability that primes epileptiform spikes.
Shennan A Weiss, Itzhak Fried, Jerome Engel Jr, Michael R Sperling, Robert K S Wong, Yuval Nir, Richard J Staba> ;Medrxiv. 2023 Apr 19
A Learned Map for Places and Concepts in the Human Medial Temporal Lobe.
Nora A Herweg, Lukas Kunz, Daniel Schonhaut, Armin Brandt, Paul A Wanda, Ashwini D Sharan, Michael R Sperling, Andreas Schulze-Bonhage, Michael J Kahana> ;The Journal of Neuroscience. 2023 May 10
2 citations
Pre-surgical features of intrinsic brain networks predict single and joint epilepsy surgery outcomes.
Walter Hinds, Shilpi Modi, Ankeeta Ankeeta, Michael R Sperling, Dorian Pustina, Joseph I Tracy> ;Neuroimage. Clinical. 2023 Jan 1
Stimulation better targets fast-ripple generating networks in super responders to the responsive neurostimulator system.
Shennan Aibel Weiss, Dawn Eliashiv, John Stern, Daniel Rubinstein, Itzhak Fried, Chengyuan Wu, Ashwini Sharan, Jerome Engel, Richard Staba, Michael R Sperling> ;Epilepsia. 2023 May 1
7 citations
Failure to use new breakthrough treatments for epilepsy.
Pavel Klein, Gregory L Krauss, Bernhard J Steinhoff, Orrin Devinsky, Michael R Sperling> ;Epilepsia. 2023 Jun 1
Direct brain recordings suggest a causal subsequent-memory effect.
Daniel Y Rubinstein, Christoph T Weidemann, Michael R Sperling, Michael J Kahana> ;Cerebral Cortex. 2023 May 24
6 citations
Graph theoretical measures of fast ripple networks improve the accuracy of post-operative seizure outcome prediction.
Shennan A Weiss, Itzhak Fried, Chengyuan Wu, Ashwini Sharan, Daniel Rubinstein, Jerome Engel Jr, Michael R Sperling, Richard J Staba> ;Scientific Reports. 2023 Jan 7
1 citations
Fast ripples reflect increased excitability that primes epileptiform spikes.
Shennan A Weiss, Itzhak Fried, Jerome Engel Jr, Michael R Sperling, Robert K S Wong, Yuval Nir, Richard J Staba> ;Brain Communications. 2023 Jan 1
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Authored Content

Task Activation and Functional Connectivity Show Concordant Memory Laterality in Temporal Lobe EpilepsyMarch 2018

Press Mentions

‘No Justification’ for Suicide Warning on All Antiseizure MedsAugust 16th, 2021
Proceedings of the 15th Antiepileptic Drug and Device Trials Meeting: State of the ScienceJune 17th, 2020
SK Life Science Receives Schedule V Designation from DEA for XCOPRI® (Cenobamate Tablets)March 10th, 2020
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