MichaelWeiMD

PubMed

• 17 citations
  Phase I Basket Study of Taselisib, an Isoform-Selective PI3K Inhibitor, in Patients with PIK3CA-Mutant Cancers.
  Komal Jhaveri, Matthew T. Chang, Dejan Juric, Cristina Saura, Valentina Gambardella, Anton Melnyk, Manish R. Patel, Vincent Ribrag, Cynthia X. Ma, Raid Aljumaily, Phil...> ;Clinical Cancer Research. 2021 Jan 15
• 21 citations
  High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cells.
  Johan Jeong, Astraea Jager, Pablo Domizi, Mara Pavel-Dinu, Linda Gojenola, Masayuki Iwasaki, Michael C. Wei, Feng Pan, James L. Zehnder, Matthew H. Porteus, Kara L. Da...> ;Blood Advances. 2019 Oct 8
• 2 citations
  A phase Ib, open-label, dose-escalation study of the safety and pharmacology of taselisib (GDC-0032) in combination with either docetaxel or paclitaxel in patients wit...
  , , , , , , , , , , , , , , , > ;Breast Cancer Research and Treatment. 2019 Jul 31
• 8 citations
  CBP Modulates Sensitivity to Dasatinib in Pre-BCR+ Acute Lymphoblastic Leukemia
  Jesus Duque-Afonso, Chiou-Hong Lin, Kyuho Han, David W. Morgens, Edwin E. Jeng, Ziming Weng, Johan Jeong, Stephen H.K. Wong, Li Zhu, Michael C. Wei, Hee-Don Chae, Mart...> ;Cancer Research. 2018 Nov 15
• 41 citations
  Phase II Study of Taselisib (GDC-0032) in Combination with Fulvestrant in Patients with HER2-Negative, Hormone Receptor–Positive Advanced Breast Cancer
  Maura N. Dickler, Cristina Saura, Donald A. Richards, Ian E. Krop, Andrés Cervantes, Philippe L. Bedard, Manish R. Patel, Lajos Pusztai, Mafalda Oliveira, Alison Carde...> ;Clinical Cancer Research. 2018 Sep 15
• 17 citations
  SETDB2 Links E2A-PBX1 to Cell-Cycle Dysregulation in Acute Leukemia through CDKN2C Repression
  Chiou-Hong Lin, Stephen H.K. Wong, Jason H. Kurzer, Corina Schneidawind, Michael C. Wei, Jesus Duque-Afonso, Johan Jeong, Xuhui Feng, Michael L. Cleary> ;Cell Reports. 2018 Apr 24
• 4 citations
  CD47 is not Over-Expressed in Fibrolamellar Hepatocellular Carcinoma
  Tabitha Cooney, Michael C. Wei, Arun Rangaswami, Lei Xu, Julien Sage, Florette K. Hazard> ;Annals of Clinical and Laboratory Science. 2017 Aug 1
• The Association Between Cardiorespiratory Fitness and Impaired Fasting Glucose and Type 2 Diabetes Mellitus in Men
  Michael Wei, MD> ;National Institutes of Health. 1999 Mar 06
• 23 citations
  E2A-PBX1 Remodels Oncogenic Signaling Networks in B-cell Precursor Acute Lymphoid Leukemia
  Jesus Duque-Afonso, Chiou-Hong Lin, Kyuho Han, Michael C. Wei, Jue Feng, Jason H. Kurzer, Corina Schneidawind, Stephen H.K. Wong, Michael C. Bassik, Michael L. Cleary> ;Cancer Research. 2016 Oct 7
• 99 citations
  The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential
  Stephen H.K. Wong, David L Goode, Masayuki Iwasaki, Michael C. Wei, Hsu-Ping Kuo, Li Zhu, Dominik Schneidawind, Jesus Duque-Afonso, Ziming Weng, Michael L. Cleary> ;Cancer Cell. 2015 Aug 10
• 6 citations
  Novel methods and approaches to acute lymphoblastic leukemia drug discovery.
  Michael C. Wei, Michael L. Cleary> ;Expert Opinion on Drug Discovery. 2014 Nov 21
• 61 citations
  Next-Generation NAMPT Inhibitors Identified by Sequential High-Throughput Phenotypic Chemical and Functional Genomic Screens
  Christina J. Matheny, Michael C. Wei, Michael C. Bassik, Alicia J. Donnelly, Martin Kampmann, Masayuki Iwasaki, Obdulio Piloto, David E. Solow-Cordero, Donna M. Bouley...> ;Chemistry & Biology. 2013 Nov 21
• 15 citations
  Nontuberculous mycobacteria infections in immunocompromised patients: single institution experience.
  Michael C. Wei, Niaz Banaei, Mitchell A. Yakrus, Tracey Stoll, Kathleen Gutierrez, Rajni Agarwal> ;Journal of Pediatric Hematology/oncology. 2009 Aug 1
• 7 citations
  Nodular lymphocyte-predominant Hodgkin lymphoma presenting as fulminant hepatic failure in a pediatric patient: a case report with pathologic, immunophenotypic, and mo...
  Kirsten Woolf, Michael C. Wei, Michael P. Link, Daniel A. Arber, Roger A. Warnke> ;Applied Immunohistochemistry & Molecular Morphology. 2008 Mar 1
• 1 citations
  CpG island methylator phenotype and childhood leukemia.
  Norman J. Lacayo, Jorge F. DiMartino, Michael C. Wei, Gary V. Dahl> ;Clinical Cancer Research. 2006 Aug 15
• 22 citations
  Bcl-2-related genes in lymphoid neoplasia.
  Michael C. Wei> ;International Journal of Hematology. 2004 Oct 1
• 82 citations
  BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.
  E H Cheng, M C Wei, S Weiler, R A Flavell, T W Mak, T Lindsten, S J Korsmeyer> ;Molecular Cell. 2001 Sep 1
• 3147 citations
  Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
  Michael C. Wei, Wei-Xing Zong, Emily H. Cheng, Tullia Lindsten, Vily Panoutsakopoulou, Andrea J. Ross, Kevin A. Roth, Grant R. MacGregor, Craig B. Thompson, Stanley J....> ;Science. 2001 Apr 27
• 133 citations
  A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c
  Vamsi K. Mootha, Michael C. Wei, Karolyn F. Buttle, Luca Scorrano, Vily Panoutsakopoulou, Carmen A. Mannella, Stanley J. Korsmeyer> ;The EMBO Journal. 2001 Feb 15
• 1118 citations
  The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.
  Tullia Lindsten, Andrea J. Ross, Ayala King, Wei-Xing Zong, Jeffrey C. Rathmell, Helena Shiels, Eugen Ulrich, Katrina G. Waymire, Patryce L. Mahar, Kenneth A. Frauwirt...> ;Molecular Cell. 2000 Dec 1
• 767 citations
  Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.
  Stanley J. Korsmeyer, Michael C. Wei, Mitsuyoshi Saito, Solly Weiler, Kyoung Joon Oh, Paul H. Schlesinger> ;Cell Death and Differentiation. 2000 Dec 1
• 449 citations
  Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis
  Jiping Zha, Solly Weiler, Kyoung Joon Oh, Michael C. Wei, Stanley J. Korsmeyer> ;Science. 2000 Dec 1
• 955 citations
  tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
  Michael C. Wei, Tullia Lindsten, Vamsi K. Mootha, Solly Weiler, Atan Gross, Mona Ashiya, Craig B. Thompson, Stanley J. Korsmeyer> ;Genes & Development. 2000 Aug 15
• 95 citations
  Transduced p16INK4a Peptides Inhibit Hypophosphorylation of the Retinoblastoma Protein and Cell Cycle Progression Prior to Activation of Cdk2 Complexes in Late G1
  David Gius, Sergei A. Ezhevsky, Michelle Becker-Hapak, Hikaru Nagahara, Michael C. Wei, Steven F. Dowdy> ;Cancer Research. 1999 Jun 1
• 860 citations
  Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death.
  Atan Gross, Xiao Ming Yin, Kun Wang, Michael C. Wei, Jennifer Jockel, Curt L. Milliman, Hediye Erdjument-Bromage, Paul Tempst, Stanley J. Korsmeyer> ;The Journal of Biological Chemistry. 1999 Jan 8
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Abstracts/Posters

• Pharmacodynamic Effects and Immune Correlates of Response to the CD20/CD3 Bispecific Antibody Mosunetuzumab in Relapsed or Refractory Non-Hodgkin Lymphoma
  Michael C Wei, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• An Individualized Risk Mitigation Approach for Safety: Experience from the Mosunetuzumab (CD20/CD3 Bispecific Antibody) Development Program in Relation to Neurotoxicit...
  Michael C Wei, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019