Miguel Pappolla, MD

Miguel Pappolla, MD

Neurology Houston, TX


Office Address

  • 2646 S Loop West Ste 106
    Houston, TX 77054
    Phone: (713) 661-0300
    Fax: (281) 822-0480

Miguel Pappolla, MD

Neurology Houston, TX


Clinical Specialties & Interests

  • Neurology: Interventional, Pain Medicine

Education & Training

  • University of Mississippi Medical CenterUniversity of Mississippi Medical Center
  • University of Mississippi
  • University of Catalunya, Barcelona, Spain
  • University of South AlabamaUniversity of South Alabama
  • Cleveland Clinic Foundation
  • Cleveland Clinic FoundationCleveland Clinic Foundation
  • Case Western Reserve University Affiliated HospitalsCase Western Reserve University Affiliated Hospitals
  • Case Western Reserve UniversityCase Western Reserve University
  • Aultman Hospital
  • University of Buenos AiresUniversity of Buenos Aires

Certifications & Licensure

  • MS State Medical LicenseMS State Medical License2001 - 2015
  • TX State Medical LicenseTX State Medical License1994 - 2016
  • FL State Medical LicenseFL State Medical License1993 - 2017
  • OH State Medical LicenseOH State Medical License1982 - 2016
  • American Board of Psychiatry and NeurologyPain Medicine
  • American Board of PathologyNeuropathology
  • American Board of Psychiatry and NeurologyNeurology
  • American Board of PathologyClinical Pathology
  • American Board of PathologyAnatomic Pathology

    Awards, Honors, & Recognition

    • CMS Meaningful Use Stage 1 CertificationPractice Fusion EHR, Practice Fusion, Inc., 2012, 2013
    • Josephine T. Morse Endowed Professorship in NeuropathologyMedical University of South Carolina, 2006
    • Commendation Award for Academic Excellence and LeadershipLSU Health Sciences Center, New Orleans, 2006

    Publications & Presentations


    Journal Articles

    • Targets for AD treatment: conflicting messages from Gamma-secretase inhibitors.  Sambamurti K, Greig NH, Utsuki T, Barnwell EL, Sharma E, Mazell C, Bhat NR, Kindy MS, Lahiri DK, Pappolla MA, J Neurochem, 5/1/2011
    • Amphiphilic amide nitrones: a new class of protective agents acting as modifiers of mitochondrial metabolism.  J Med Chem, 7/1/2010
    • Differential Accumulation of Secreted AbetaPP Metabolites in Ocular Fluids.  Prakasam A, Muthuswamy A, Ablonczy Z, Greig NH, Fauq A, Rao KJ, Pappolla MA, Sambamurti K, J Alzheimers Dis, 4/22/2010

    Books/Book Chapters

    • Neuropathologia Diagnostico Y Clinica Chapter: Molecular Biology and Neuropathology of Alzheimer's Disease. 
      Pappolla MA
      Editors: F. Cruz-Sanchez.Edimsa
    • Free Radicals in Brain Pathophysiology. Chapter: The role of Transgenic models for the Study of Oxidative Neurotoxicity in Alzheimer’s Disease. 
      M. A. Pappolla, Y-J Chyan, G. Perry, M.A. Smith
      Editors: Poli G and Cadenas E..
    • Alzheimer’s Disease: Biology, Diagnosis and Therapeutics Chapter: Dual Anti-amyloidogenic and Anti-oxidant Properties of Melatonin. A New Therapy for Alzheimer’s Disease? Page 661 - 669
      Pappolla MA, Bozner P, Soto C, Shao H, Brewer G. Robakis NK, Zagorski M, Frangione B, Ghiso J
      Editors: K. Iqbal, B. Winblad, and H.M. Wisniewski.John Wiley & Sons Ltd.


    • Cognitive Impairment in Familial Heterozygous Hypercholesterolemia. Pappolla MA, Sambamurti K, Pacheco J, et al, World Congress of Alzheimer’s Congress, Chicago, IL., 7/1/2008
    • Isoprenoids Phenocopy Familial AD Mutations And Regulate Gamma Secretase. Sambamurti K, Parkasam A, Venugopal, C, Jayachandran AD, Rao KS, Lahiri DK, Greig NH, Pappolla MA, Zhou Y, The Alzheimer's Association International Conference on Alzheimer's Disease (ICAD) McCormick Place, , 1/1/2008
    • Alzheimer's Amyloid Protein Precursor and Neurotrophins in Age Related Retinal Degeneration. Sambamurti K, Pappolla MA, Granholm A-C, A. Prakasam A, Annual ARVO meeting, FT. Lauderdale, FL., 1/1/2008


    • "Interventional Pain Modalities for Spine Care. A Short Review". (Invited Speaker) Charleston Spine Symposium. - 8/24/2007
    • Cholesterol metabolism, hyperhomocysteinemia and oxidative stress: Novel therapeutic targets for Alzheimer’s disease. (Invited Symposium Speaker) 9th International Conference on Alzheimer’s Disease and Related Disorders, Philadelphia, PA. - 7/1/2004
    • Cholesterol metabolism: A risk factor and potential therapeutic target for Alzheimer’s disease. (Invited Symposium Speaker) 8th International Conference on Alzheimer’s Disease and Related Disorders, Stockholm, Sweden. - 7/20/2002


    • Cholesterol, Oxidative Stress and Alzheimer’s disease. Expanding the Horizons of Pathogenesis. (Review) Pappolla MA, Smith MA, Bryant-Thomas T, Bazan N, Petanceska S, Perry G, Thal LJ, Sano M, Refolo LM, Free Radic Biol Med
    • Inhibition of Alzheimer’s Beta Amyloid Fibril Formation. Pappolla M, Bozner P, Zagorski M, Shao H, Frangione B, Ghiso J, Emerging Therapeutic Targets.
    • Oxygen Free Radicals and Amyloidosis in Alzheimer's Disease: Is There a Connection? Editorial. Robakis NK, Pappolla MA, Neurobiol Aging

    Grant Support

    • Cholesterol And AmyloidogenesisNational Institute On Aging
      2004 - 2005
    • Cholesterol And AmyloidogenesisNational Institute On Aging
      2003 - 2003
    • Melatonin- A New Anti-Amyloidogenic &Antioxidant AgentNational Institute On Aging
      2003 - 2003
    • Melatonin- A New Anti-Amyloidogenic &Antioxidant AgentNational Institute On Aging
      2000 - 2003
    • Melatonin And Antioxidants As Therapeutic AgentsNational Institute On Aging
      1998 - 1998
    • Mutations Oxidative Stress And AmyloidogensisNational Institute On Aging
      1996 - 1997
    • Mutations Oxidative Stress And AmyloidogensisNational Institute On Aging
      1995 - 1995

    Hospital Affiliations

    Insurance Accepted

    • Aetna Choice POS II
    • Aetna HMO
    • Anthem Blue Access PPO
    • Anthem Blue Preferred HMO
    • BCBS Blue Card PPO
    • BCBS Illinois PPO
    • BCBS Texas BlueChoice
    • CIGNA Open Access
    • Great West PPO
    • Humana ChoiceCare Network PPO
    • Multiplan PHCS PPO
    • Multiplan PPO
    • United Healthcare - Direct Choice Plus POS
    • United Healthcare - Direct Options PPO
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