Monte Willis, MD

Monte Willis, MD, PhD, MBA, FAHA

Cardiology Chapel Hill, NC

Associate Professor, Pathology & Laboratory Medicine, University of North Carolina at Chapel Hill School of Medicine

Office Address

  • 111 Mason Farm Road
    MBRB 2340
    Chapel Hill, NC 27599
    Phone: (919) 843-1938
    Fax: (919) 843-5515

Monte Willis, MD, PhD, MBA, FAHA

Cardiology Chapel Hill, NC

Associate Professor, Pathology & Laboratory Medicine, University of North Carolina at Chapel Hill School of Medicine

Clinical Specialties & Interests

  • Cardiology: Heart Failure & Transplantation
  • Clinical Interests: Ubiquitin-Protein Ligases; Molecular Models; Transgenic Mice; Molecular Biology; Ubiquitination; Ubiquitin; Signal Transduction; Transcription Factors; Nuclear Proteins; pathology; Proteasome Endopeptidase Complex; Inbred C57BL Mice; Animal Disease Models; Muscle Proteins; Myocardium; Mice; Heart Diseases

Education & Medical Training

  • University of Nebraska College of MedicineUniversity of Nebraska College of Medicine
  • University of Nebraska-Lincoln
  • University of North Carolina
  • University of Texas Southwestern Medical SchoolUniversity of Texas Southwestern Medical School

Certifications & Licensure

  • NC State Medical LicenseNC State Medical License2006 - 2015
  • American Board of PathologyPathology - Clinical, 2008

Awards, Honors, & Recognition

  • Cotran Early Career Investigator AwardAmerican Society of Investigative Pathologists (ASIP), 2011
  • Jefferson-Pilot Fellowship in Academic MedicineUniversity of North Carolina School of Medicine, 2011, 2012, 2013, 2014
  • American Heart Association Basic Cardiovascular Sciences Abstract Travel Grant to AHA Scientific Sessions2007

Publications & Presentations


Journal Articles

  • Myosin light chain phosphorylation is critical for adaptation to cardiac stress.  Warren SA, Briggs LE, Zeng H, Chuang J, Chang EI, Terada R, Li M, Swanson MS, Lecker SH, Willis MS, Spinale FG, Maupine-Furlow J, McMullen JR, Moss RL, Kasahara H, Circulation
  • Bmper inhibits endothelial inflammation and protects against atherosclerosis.  Pi X, Lockyer P, Dyer L, Schisler J, Carey S, Sweet DT, Chen Z, Tzima E, Willis MS, Homeister JW, Moser M, Patterson C, Arterioscler Thromb Vasc Biol
  • A Critical Role for Muscle Ring Finger-1 in Acute Lung Injury-Associated Skeletal Muscle Wasting.  Files DC, Franco RD, Johnston LF, Kesari P, Aggarwal NR, Garibaldi BT, Mock JR, Simmers JL, DeGorordo A, Murdoch J, Willis MS, Patterson C, Tanskersley CG, Messi ML, L..., Am J Respir Crit Care Med

Books/Book Chapters

  • Molecular and Translational Vascular Medicine.  
    Willis MS, Homeister JW
    Editors: .Springer Science, Business Media, New York, NY
  • Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques.  
    Willis MS, Patterson C
    Editors: .Springer Science+Business Media, New York, NY
  • Ubiquitylation dependent signaling in heart disease.  
    Willis MS, Portbury A, Ronnebaum S, Zungu M, Townley-Tilson D, Patterson C
    Editors: Willis MS, Patterson C.Springer Science+Business Media, New York, NY


  • Knockout of the Glucocorticoid Receptor in Cardiomyocytes Leads to Spontaneous Cardiovascular Disease and Death. Cruz-Topete D, Oakley R, Ren R, Willis MS, Cidlowski JA, The Endocrine Society, Glucocorticoids & Glucocorticoid Actions Symposium, San Francisco, CA
  • The molecular pathophysiology, differential diagnosis, and treatment of myeloperoxidase deficiency. Ren R, Fedoriw Y, Willis MS, 2nd International Conference and Exhibition on Pathology, Las Vegas, NV
  • STAT3 activation in cardiac hypertrophy induced by ryanodine receptor 2 mutation. Huang T, Lee J, Zou M, Pasek DA, Willis MS, Meissner G, American Society for Investigative Pathology, Oral presentation: Cardiac Pathobiology Minisymposium, Boston, MA


  • The regulation of cardiac mass and metabolism in cardiac pathology. East Carolina University Department of Pathology, Greenville, NC
  • Regulation of Protein Turnover in the Heart and its Relationship to Cardiac Hypertrophy. Symposium: Mechanisms of Fetal and Neonatal Cardiac Growth. Pediatric Academy of Sciences Annual Meeting. Washington, DC
  • The emerging role of the ubiquitin proteasome system in heart failure and ischemic heart disease. Duke University Department of Pathology, Durham, NC


  • Chest pain, dyspnea, and fatigue in a 57-year-old man. Roth M, Aitsebaomo J, Willis MS, Lab Med
  • Biclonal M-spike in a 7 year-old child. Fritchie K, Willis MS, Lab Med
  • Hepatosplenomegaly in an 8-month-old child. Willis MS, Basinger AA, Fan Z, Pendyal S, Muenzer J, Hammett-Stabler C, Lab Med

Grant Support

  • Myocyte Specific Regulation Of Metabolism And The Response To Biomechanical ForceNational Heart, Lung, And Blood Institute
    2010 - 2011
  • Antigenicity Of Proteins Modified By Alcohol MetabolitesNational Institute On Alcohol Abuse And Alcoholism
    1997 - 2000

Hospital Affiliations

Insurance Accepted

  • CIGNA Open Access
  • United Healthcare - Direct Choice Plus POS
  • United Healthcare - Direct Options PPO
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