NealFlomenbergMDProfessor & Chair

Oncology • Philadelphia, PA

Hematologic Oncology

Chairman, Department of Medical Oncology, Thomas Jefferson University & Hospital

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Office
925 Chestnut St
Ste 220
Philadelphia, PA 19107
Phone+1 215-955-8874

Fax+1 215-955-2340
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Education & Training

Memorial Sloan Kettering Cancer CenterFellowship, Hematology and Medical Oncology, 1980 - 1981
Jacobi Medical Center/Albert Einstein College of MedicineResidency, Internal Medicine, 1976 - 1979
Sidney Kimmel Medical College at Thomas Jefferson UniversityClass of 1976

Certifications & Licensure

NJ State Medical License 2018 - 2025
DE State Medical License 2018 - 2025
PA State Medical License 1994 - 2024
WI State Medical License 1991 - 1995
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Patient-Centered Specialty Practice Recognition Program National Committee for Quality Assurance, 2014-2017
America's Top Doctors Castle Connolly, 2006-2014
Philadelphia Magazine Castle Connolly, 2005-2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013
CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2011-2012
Super Doctor SuperDoctors.com
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Clinical Trials

Biological Therapy in Treating Patients With Multiple Myeloma That Has Recurred Following Bone Marrow Transplantation Start of enrollment: 1998 Jul 22
Completed
Phase 2
Amifostine and Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 1998 Jan 01
Completed
Phase 1
Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma Start of enrollment: 2001 Nov 19
Completed
Phase 2
Study of VELCADE® With Mitoxantrone and Etoposide for Leukemias Start of enrollment: 2006 Jan 01
Completed
Phase 1, Phase 2
A Study to Accelerate Immune System Recovery Following Stem Cell Transplantation Start of enrollment: 2000 Sep 01
Terminated
Phase 2
A Two-Step Approach to Bone Marrow Transplant Using Cells From A Partially-Matched Relative Start of enrollment: 2006 Jan 01
Completed
Phase 1, Phase 2
Safety and Efficacy Study of Immunotherapy With Rituximab and Interleukin-2 in Patients With Non-Hodgkin's Lymphoma Start of enrollment: 2009 Feb 05
Completed
Phase 2
A Study of Bone Marrow Transplantation Using Fully-Matched Relatives as Donors for Patients With Hematological Malignancies Start of enrollment: 2008 Apr 10
Completed
Phase 2
Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies Start of enrollment: 2010 May 01
Completed
Phase 2
A Research Study of Bone Marrow Transplantation From Unrelated or Partially Matched Related Donors Start of enrollment: 2011 Feb 10
Completed
Phase 2
Treatment of Sickle Cell Anemia With Stem Cell Transplant Start of enrollment: 2009 Sep 01
Terminated
Not Applicable
Bone Marrow Transplantation of Patients in Remission Using Partially Matched Relative Donor Start of enrollment: 2010 Jul 01
Completed
Phase 2
Bone Marrow Transplant Using a Reduced Intensity Regimen That is Given in Two Steps Start of enrollment: 2011 Apr 01
Terminated
Phase 1, Phase 2
Combination of Pentostatin, Bendamustine and Ofatumumab for Treatment of Chronic Lymphocytic Leukemia and Lymphoma Start of enrollment: 2011 May 25
Terminated
Phase 1
A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies Start of enrollment: 2011 Aug 04
Completed
Phase 2
Phase I/II Study of Bendamustine in Combination With Ofatumumab, Carboplatin and Etoposide Start of enrollment: 2011 Nov 09
Completed
Phase 1, Phase 2
A Two-Step Approach to Bone Marrow Transplant Using Cells From Two Partially-Matched Relatives Start of enrollment: 2012 Mar 01
Terminated
Phase 2
Donor Stem Cell Boost in Treating Patients With Low Blood Cells After Donor Stem Cell Transplant Start of enrollment: 2012 Aug 01
Withdrawn
Not Applicable
Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies Start of enrollment: 2012 Dec 24
Completed
Phase 2
Sirolimus, Idarubicin, and Cytarabine in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2013 Mar 15
Completed
Early Phase 1
Sirolimus and Azacitidine in Treating Patients With High Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia That is Recurrent or Not Eligible for Intensive Chemotherapy Start of enrollment: 2013 Jul 08
Active, not recruiting
Phase 2
Haploidentical Donor Hematopoietic Stem Cell Transplant in Treating Patients With Hematologic Malignancies Start of enrollment: 2013 May 17
Terminated
Phase 2
Allogeneic Hematopoietic Stem Cell Transplantation for High-Risk Hematologic Malignancies Using One Haploidentical Donor Start of enrollment: 2013 Nov 04
Completed
Phase 2
Bendamustine Hydrochloride, Bortezomib, and Dexamethasone in Treating Patients With Newly Diagnosed Multiple Myeloma Start of enrollment: 2014 Aug 25
Completed
Phase 2
Stem Cell Transplant With or Without Tbo-filgrastim in Treating Patients With Multiple Myeloma or Non-Hodgkin Lymphoma Start of enrollment: 2017 Oct 12
Completed
Phase 2
2-Step Approach to Stem Cell Transplant in Treating Participants With Hematological Malignancies Start of enrollment: 2018 Sep 19
Active, not recruiting
Phase 2
Genetics and Shared Decision Making in Improving Care for Patients With Stage IVA-C Non-small Cell Lung Cancer Start of enrollment: 2019 Feb 08
Completed
Not Applicable
A Two Step Approach to Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Hematologic Malignancies-Increasing GVT Effects Without Increasing Toxicity Start of enrollment: 2017 Jan 31
Recruiting
Phase 2
Roles: Contact
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Publications & Presentations

PubMed

A Prospective, Randomized Trial Examining the Use of G-CSF Versus No G-CSF in Patients Post-Autologous Transplantation.
Dolores Grosso, Benjamin Leiby, Lindsay Wilde, Matthew Carabasi, Joanne Filicko-O'Hara, William O'Hara, John L Wagner, Gina Mateja, Onder Alpdogan, Adam Binder, Margar...> ;Transplantation and Cellular Therapy. 2022 Dec 1
2 citations
Outcomes of two-step haploidentical allogeneic stem cell transplantation in elderly patients with hematologic malignancies.
Xia Bi, Usama Gergis, John L Wagner, Matthew Carabasi, Joanne Filicko-O'Hara, William O'Hara, Thomas Klumpp, Pierluigi Porcu, Neal Flomenberg, Dolores Grosso> ;Bone Marrow Transplantation. 2022 Nov 1
2 citations
The Two-Step Allogeneic Stem Cell Transplantation Approach Results in Rapid Engraftment and Excellent Outcomes in Patients with Lymphoid Malignancies.
Yang Yang, Usama Gergis, Matthew Carabasi, Joanne Filicko-O'Hara, John L Wagner, William O'Hara, Adam Binder, Onder Alpdogan, Ubaldo Martinez-Outschoorn, Pierluigi Por...> ;Transplantation and Cellular Therapy. 2022 Mar 1
1 citations
Design and Implementation of a Multipurpose Information System for Hematopoietic Stem-Cell Transplantation on the Basis of the Biomedical Research Integrated Domain Gr...
Xia Bi, Dania Beadle, Alexander Xu, Joseph Neff, Nicholas DeGregorio, Mouneer Odeh, Christopher McNair, Dolores Grosso, Pierluigi Porcu, Usama Gergis, Neal Flomenberg,...> ;JCO Clinical Cancer Informatics. 2021 Nov 2
3 citations
Engaging Patients with Late-Stage Non-Small Cell Lung Cancer in Shared Decision Making about Treatment
Ronald E. Myers, Shailesh M. Advani, Pamela Myers, Preethi Selvan, Gregory D. Garber, Brooke Worster, Neal Flomenberg, Andrew E. Chapman, Ralph Zinner> ;Journal of Personalized Medicine. 2021 Oct 1
2 citations
An Examination of Cytomegalovirus, Socioeconomic Status, Race, and Ethnicity on Outcomes after Haploidentical Hematopoietic Transplantation.
Chetan Jeurkar, Benjamin E. Leiby, Joshua Banks, Amy Leader, Shannon Rudolph, Gina Mateja, Shaik Rashid, Matthew Carabasi, Joanne Filicko-O'Hara, William O'Hara, John ...> ;Transplantation and Cellular Therapy. 2021 Apr 1
1 citations
Phase I/II study of bendamustine in combination with ofatumumab, carboplatin, etoposide (BOCE) for relapsed or refractory aggressive B-cell non-Hodgkin lymphoma.
Jonathan Pan, Sushil Ghimire, S. Onder Alpdogan, Andrew E. Chapman, Matthew Carabasi, Martina DiMeglio, Jerald Z. Gong, Ubaldo E. Martinez-Outschoorn, Lewis J. Rose, M...> ;Leukemia & Lymphoma. 2021 Feb 23
2 citations
Low Nonrelapse Mortality after HLA-Matched Related 2-Step Hematopoietic Stem Cell Transplantation Using Cyclophosphamide for Graft-versus-Host Disease Prophylaxis and ...
Dolores Grosso, Matthew Carabasi, Joanne Filicko-O'Hara, John L. Wagner, William O'Hara, Michael Sun, Beth W. Colombe, Wenyin Shi, Maria Werner-Wasik, Shannon Rudolph,...> ;Biology of Blood and Marrow Transplantation. 2020 Oct 1
4 citations
Epstein-Barr Virus-Associated Smooth Muscle Tumor of the Spine After Bone Marrow Transplant: Case Report and Review of Literature.
Rebecca Calafiore, Nikolaos Mouchtouris, Neal Flomenberg, James S. Harrop> ;World Neurosurgery. 2020 Mar 1
10 citations
The Presence of a CMV Immunodominant Allele in the Recipient Is Associated With Increased Survival in CMV Positive Patients Undergoing Haploidentical Hematopoietic Ste...
Dolores Grosso, Benjamin E. Leiby, Matthew Carabasi, Joanne Filicko-O'Hara, Sameh Gaballa, William O'Hara, John L. Wagner, Neal Flomenberg> ;Frontiers in Oncology. 2019 Sep 17
3 citations
Cutaneous B-Cell Lymphoblastic Lymphoma.
Dilru C. Amarasekera, Deirdre Connolly, Ashley Gochoco, Sherry Yang, Dolores Grosso, Neal Flomenberg, Wenyin Shi, Seyfettin Onder Alpdogan, Robert Duffy, Joya Sahu> ;The American Journal of Dermatopathology. 2019 Aug 1
8 citations
Final outcomes of escalated melphalan 280 mg/m2 with amifostine cytoprotection followed autologous hematopoietic stem cell transplantation for multiple myeloma: high C...
Parameswaran Hari, Donna E. Reece, Jasleen K Randhawa, Neal Flomenberg, Dianna S. Howard, A. Badros, Aaron P. Rapoport, Joanne Filicko-O'Hara, Gordon L. Phillips, Davi...> ;Bone Marrow Transplantation. 2019 Feb 1
13 citations
Sirolimus enhances remission induction in patients with high risk acute myeloid leukemia and mTORC1 target inhibition
Margaret Kasner, Rosemarie Mick, Grace R. Jeschke, Matthew Carabasi, Joanne Filicko-O'Hara, Neal Flomenberg, Noelle V. Frey, Elizabeth O. Hexner, Selina M. Luger, Alis...> ;Investigational New Drugs. 2018 Apr 2
3 citations
Higher rates of relapse in maternal recipients of haploidentical hematopoietic stem cell transplantation from adult offspring donors for AML and myelodysplastic syndrome.
Praveen Ramakrishnan Geethakumari, Benjamin E. Leiby, Rasmi G. Nair, Seyfettin Onder Alpdogan, Matthew Carabasi, Joanne Filicko-O'Hara, Sameh Gaballa, Margaret Kasner,...> ;Bone Marrow Transplantation. 2017 Oct 1
13 citations
New interleukin-15 superagonist (IL-15SA) significantly enhances graft-versus-tumor activity
Cavan P. Bailey, Tulin Budak-Alpdogan, Christopher Sauter, Michelle M. Panis, Cihangir Buyukgoz, Emily K. Jeng, Hing C. Wong, Neal Flomenberg, Onder Alpdogan> ;Oncotarget. 2017 May 15
2 citations
Relapsed Multiple Myeloma Presenting as Intracranial Plasmacytoma and Malignant Pericardial Effusion following Recent Allogeneic Stem Cell Transplantation.
Jonathan Pan, Jason Chen, Joanne Filicko, Dolores Grosso, Michelle Nagurney, Onder Alpdogan, Neal Flomenberg> ;Case Reports in Oncology. 2017 May 1
28 citations
Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification.
Svetlana Petruk, Samanta A. Mariani, Marco De Dominici, Patrizia Porazzi, Valentina Minieri, Jingli Cai, Lorraine Iacovitti, Neal Flomenberg, Bruno Calabretta, Alexand...> ;Cell Reports. 2017 Apr 11
12 citations
Acquired uniparental disomy in chromosome 6p as a feature of relapse after T-cell replete haploidentical hematopoietic stem cell transplantation using cyclophosphamide...
Dolores Grosso, Erica S. Johnson, Beth W. Colombe, Onder Alpdogan, Matthew Carabasi, Joanne Filicko-O'Hara, Sameh Gaballa, Margaret Kasner, Thomas R. Klumpp, Ubaldo E....> ;Bone Marrow Transplantation. 2017 Jan 9
7 citations
Evaluating frequency and quality of pathogen-specific T cells.
Nadia Anikeeva, Dolores Grosso, Neal Flomenberg, Yuri Sykulev> ;Nature Communications. 2016 Oct 27
19 citations
A Two-Step Haploidentical Versus a Two-Step Matched Related Allogeneic Myeloablative Peripheral Blood Stem Cell Transplantation
Sameh Gaballa, Neil Palmisiano, Onder Alpdogan, Matthew Carabasi, Joanne Filicko-O'Hara, Margaret Kasner, Walter K. Kraft, Benjamin E. Leiby, Ubaldo E. Martinez-Outsch...> ;Biology of Blood and Marrow Transplantation. 2016 Jan 1
35 citations
A two-step approach to myeloablative haploidentical transplantation: low nonrelapse mortality and high survival confirmed in patients with earlier stage disease.
Dolores Grosso, Sameh Gaballa, Onder Alpdogan, Matthew Carabasi, Joanne Filicko-O'Hara, Margaret Kasner, Ubaldo E. Martinez-Outschoorn, John L. Wagner, William O'Hara,...> ;Biology of Blood and Marrow Transplantation. 2015 Apr 1
57 citations
Clostridium difficile colonization and disease in patients undergoing hematopoietic stem cell transplantation
Jackrapong Bruminhent, Zi-Xuan Wang, Carol Hu, John L. Wagner, Richard Sunday, Brent Bobik, Sarah E. Hegarty, Scott W. Keith, Seyfettin Onder Alpdogan, Matthew Carabas...> ;Biology of Blood and Marrow Transplantation. 2014 Sep 1
5 citations
Recent advances in haploidentical stem cell transplantation.
Onder Alpdogan, Dolores Grosso, Neal Flomenberg> ;Discovery Medicine. 2013 Sep 29
36 citations
Reverse Warburg Effect in a Patient With Aggressive B-Cell Lymphoma: Is Lactic Acidosis a Paraneoplastic Syndrome?
Ubaldo E. Martinez-Outschoorn, Diana Whitaker-Menezes, Matias E. Valsecchi, Maria P. Martinez-Cantarin, Alina Dulau-Florea, Jerald Z. Gong, Anthony Howell, Neal Flomen...> ;Seminars in Oncology. 2013 Aug 1
109 citations
Multiple mismatches at the low expression HLA loci DP, DQ, and DRB3/4/5 associate with adverse outcomes in hematopoietic stem cell transplantation.
Marcelo Fernandez-Vina, John P. Klein, Michael Haagenson, Stephen R. Spellman, Claudio Anasetti, Harriet Noreen, Lee Ann Baxter-Lowe, Pedro Cano, Neal Flomenberg, Denn...> ;Blood. 2013 May 30
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Journal Articles

Final Outcomes of Escalated Melphalan 280 mg/m2 with Amifostine Cytoprotection Followed Autologous Hematopoietic Stem Cell Transplantation for Multiple Myeloma: High C...
Neal Flomenberg, Dianna S Howard, Barry R Meisenberg, Parameswaran Hari, Gordon L Phillips, David H Vesole, Jasleen Randhawa, Aaron P Rapoport, Nature

Press Mentions

Tevogen Bio CSO to Discuss Investigational T Cell Therapy at NOLA Conference Focused on Long COVID and COVID-Related Cancer Risk, Alongside Leading Oncology ExpertsApril 26th, 2023
Tevogen Bio Appoints Cell Therapy Expert Dr. Dolores Grosso as Global Clinical Development Lead to Accommodate Its Expanding PortfolioJanuary 4th, 2023
Tevogen Bio Announces Positive Safety Results Upon Completion of Patient Enrollment in Proof-of-Concept Clinical Trial of T Cell Therapy for Elderly or High-Risk COVID-19 PatientsAugust 1st, 2022
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