NeilHowardSegalMDPhD

PubMed

• Final results of urelumab, an anti-CD137 agonist monoclonal antibody, in combination with cetuximab or nivolumab in patients with advanced solid tumors.
  Nikhil I Khushalani, Patrick A Ott, Robert L Ferris, Tina Cascone, Dirk Schadendorf, Dung T Le, Manish R Sharma, Fabrice Barlesi, William Sharfman, Jason J Luke, Ignac...> ;Journal for Immunotherapy of Cancer. 2024 Mar 7
• Immune checkpoint blockade induced sarcoid-like reaction mimicking progression of disease in a patient with microsatellite instable colorectal cancer: case report and ...
  Fergus Keane, Elizabeth Yogiaveetil, Brie Kezlarian, Maria Lagratta, Neil H Segal, Ghassan Abou-Alfa, Eileen M O'Reilly, Leonard Saltz, Imane El Dika> ;Journal of Gastrointestinal Oncology. 2024 Feb 29
• Radiation Therapy for Colorectal Liver Metastasis: The Effect of Radiation Therapy Dose and Chemotherapy on Local Control and Survival.
  Chen, I., Jeong, J., Romesser, P., Hilal, L., Cuaron, J., Zinovoy, M., Hajj, C., Yang, T., Tsai, J., Yamada, Y., Wu, A., White, C., Fiasconaro, M., Segal, N., Kemeny, ...> ;Advances in Radiation Oncology. 2024 Feb 1
• ASO Visual Abstract: Lymph Node Metastases and Associated Recurrence-Free Survival in Microsatellite Stable and Unstable Colon Cancer.
  Lynn Hakki, Asama Khan, Mithat Gonen, Zsofia Stadler, Neil H Segal, Jinru Shia, Maria Widmar, Iris H Wei, J Joshua Smith, Emmanouil P Pappou, Garrett M Nash, Philip B ...> ;Annals of Surgical Oncology. 2023 Dec 1
• 2 citations
  Neoplasia risk in patients with Lynch syndrome treated with immune checkpoint blockade.
  Emily C Harrold, Michael B Foote, Benoit Rousseau, Henry Walch, Yelena Kemel, Allison L Richards, Fergus Keane, Andrea Cercek, Rona Yaeger, Dana Rathkopf, Neil H Segal...> ;Nature Medicine. 2023 Oct 1
• Lymph Node Metastases and Associated Recurrence-Free Survival in Microsatellite Stable and Unstable Colon Cancer.
  Lynn Hakki, Asama Khan, Mithat Gonen, Zsofia Stadler, Neil H Segal, Jinru Shia, Maria Widmar, Iris H Wei, J Joshua Smith, Emmanouil P Pappou, Garrett M Nash, Philip B ...> ;Annals of Surgical Oncology. 2023 Dec 1
• Facts and Hopes in Colorectal Cancer Immunotherapy.
  Michael B Foote, Guillem Argilés, Benoit Rousseau, Neil H Segal> ;Clinical Cancer Research. 2023 Oct 13
• Prevalence and Clinical Implications of Mismatch Repair-Proficient Colorectal Cancer in Patients With Lynch Syndrome.
  Megha Ranganathan, Rosalba E Sacca, Magan Trottier, Anna Maio, Yelena Kemel, Erin Salo-Mullen, Amanda Catchings, Sarah Kane, Chiyun Wang, Vignesh Ravichandran, Ryan Pt...> ;JCO Precision Oncology. 2023 May 1
• 1 citations
  Clinical Importance of Clonal Hematopoiesis in Metastatic Gastrointestinal Tract Cancers.
  Bill H Diplas, Ryan Ptashkin, Joanne F Chou, Shalom Sabwa, Michael B Foote, Benoit Rousseau, Guillem Argilés, James Robert White, Caitlin M Stewart, Kelly Bolton, Sree...> ;JAMA Network Open. 2023 Feb 1
• 201 citations
  Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy.
  Julio Garcia-Aguilar, Sujata Patil, Marc J Gollub, Jin K Kim, Jonathan B Yuval, Hannah M Thompson, Floris S Verheij, Dana M Omer, Meghan Lee, Richard F Dunne, Jorge Ma...> ;Journal of Clinical Oncology. 2022 Aug 10
• 1 citations
  Characteristics of Mismatch Repair-Deficient Colon Cancer in Relation to Mismatch Repair Protein Loss, Hypermethylation Silencing, and Constitutional and Biallelic Som...
  Ajaratu Keshinro, Karuna Ganesh, Chad Vanderbilt, Canan Firat, Jin K Kim, Chin-Tung Chen, Rona Yaeger, Neil H Segal, Mithat Gonen, Jinru Shia, Zsofia K Stadler, Martin...> ;Diseases of the Colon and Rectum. 2023 Apr 1
• 18 citations
  PD-1 Blockade in Solid Tumors with Defects in Polymerase Epsilon.
  Benoit Rousseau, Ivan Bieche, Eric Pasmant, Nadim Hamzaoui, Nicolas Leulliot, Lucas Michon, Aurelien de Reynies, Valerie Attignon, Michael B Foote, Julien Masliah-Plan...> ;Cancer Discovery. 2022 Jun 2
• 1 citations
  Simplified Graded Infusion Strategy for Mitigation of Oxaliplatin Hypersensitivity.
  Salvador Alonso Martinez, Neil H Segal, Andrea Cercek, Rona Yaeger, Zsofia Stadler, Nancy E Kemeny, Maliha Nusrat, Armin Shahrokni, Louise Connell, Leonard B Saltz> ;Clinical Colorectal Cancer. 2022 Jun 1
• 2 citations
  Survival After Induction Chemotherapy and Chemoradiation Versus Chemoradiation and Adjuvant Chemotherapy for Locally Advanced Rectal Cancer.
  Jin K Kim, Michael R Marco, Campbell S D Roxburgh, Chin-Tung Chen, Andrea Cercek, Paul Strombom, Larissa K F Temple, Garrett M Nash, Jose G Guillem, Philip B Paty, Ron...> ;The Oncologist. 2022 May 6
• 5 citations
  Hybrid-control arm construction using historical trial data for an early-phase, randomized controlled trial in metastatic colorectal cancer.
  Chen Li, Ana Ferro, Shivani K Mhatre, Danny Lu, Marcus Lawrance, Xiao Li, Shi Li, Simon Allen, Jayesh Desai, Michael Cecchini, Katrina S Pedersen, Tae You Kim, Irmarie...> ;Communications Medicine. 2022 Jan 1
• 3 citations
  Intratumoral T-cell repertoires in DNA mismatch repair-proficient and -deficient colon tumors containing high or low numbers of tumor-infiltrating lymphocytes.
  Jin K Kim, Chin-Tung Chen, Ajaratu Keshinro, Asama Khan, Canan Firat, Chad Vanderbilt, Neil Segal, Zsofia Stadler, Jinru Shia, Vinod P Balachandran, Martin R Weiser> ;Oncoimmunology. 2022 Jan 1
• 51 citations
  A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers.
  Andrea Cercek, Walid K. Chatila, Rona Yaeger, Henry Walch, Gustavo Dos Santos Fernandes, Asha Krishnan, Lerie Palmaira, Anna Maio, Yelena Kemel, Preethi Srinivasan, Ch...> ;Journal of the National Cancer Institute. 2021 Aug 18
• 17 citations
  Tumor-Infiltrating Lymphocytes, Tumor Mutational Burden, and Genetic Alterations in Microsatellite Unstable, Microsatellite Stable, or Mutant POLE/POLD1 Colon Cancer
  Ajaratu Keshinro, Chad M. Vanderbilt, Jin K Kim, Canan Firat, Chin-Tung Chen, Rona Yaeger, Karuna Ganesh, Neil H. Segal, Mithat Gonen, Jinru Shia, Zsofia K. Stadler, M...> ;JCO Precision Oncology. 2021 May 12
• 42 citations
  Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair-proficient Metastatic Colorectal Cancer.
  Neil H. Segal, Andrea Cercek, Geoffrey Y. Ku, Abraham J. Wu, Andreas Rimner, Danny N. Khalil, Diane Reidy-Lagunes, John J. Cuaron, T. Jonathan Yang, Martin R. Weiser, ...> ;Clinical Cancer Research. 2021 Jan 27
• 30 citations
  Clinical Calculator Based on Molecular and Clinicopathologic Characteristics Predicts Recurrence Following Resection of Stage I-III Colon Cancer.
  Martin R. Weiser, Meier Hsu, Philip S. Bauer, William C. Chapman, Iván González, Deyali Chatterjee, Deepak Lingam, Matthew G. Mutch, Ajaratu Keshinro, Jinru Shia, Efse...> ;Journal of Clinical Oncology. 2021 Jan 13
• 19 citations
  Characterization and Clinical Outcomes of DNA Mismatch Repair-deficient Small Bowel Adenocarcinoma.
  Alicia Latham, Jinru Shia, Zalak Patel, Diane Reidy-Lagunes, Neil H. Segal, Rona Yaeger, Karuna Ganesh, Louise Catherine Connell, Nancy E. Kemeny, David P. Kelsen, Jac...> ;Clinical Cancer Research. 2021 Mar 1
• 4 citations
  Clinical implications of drug-induced liver injury in early-phase oncology clinical trials.
  Sebastian Mondaca, Dazhi Liu, Jessica Flynn, Sandy Badson, Stefan Hamaway, Mrinal M. Gounder, Danny N. Khalil, Alexander Drilon, Bob T. Li, Komal Jhaveri, Alison M. Sc...> ;Cancer. 2020 Nov 15
• 3 citations
  Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer
  Rosa M Jimenez-Rodriguez, Sujata Patil, Ajaratu Keshinro, Jinru Shia, Efsevia Vakiani, Zsofia K. Stadler, Neil H. Segal, Rona Yaeger, Tsuyoshi Konishi, Yoshifumi Shima...> ;Oncoimmunology. 2020 Nov 11
• 142 citations
  Prognostic and Predictive Impact of Circulating Tumor DNA in Patients with Advanced Cancers Treated with Immune Checkpoint Blockade
  Qu Zhang, Jia Luo, Song Wu, Han Si, Chen Gao, Wenjing Xu, Shaad Essa Abdullah, Brandon Higgs, Phillip A. Dennis, Michiel S. van der Heijden, Neil H. Segal, Jamie E. Ch...> ;Cancer Discovery. 2020 Aug 14
• 85 citations
  Mismatch Repair-Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy.
  Andrea Cercek, Gustavo Dos Santos Fernandes, Campbell S.D. Roxburgh, Karuna Ganesh, S.Y. Ng, Francisco Sanchez-Vega, Rona Yaeger, Neil H. Segal, Diane Reidy-Lagunes, A...> ;Clinical Cancer Research. 2020 Mar 6
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Lectures

• First-in-human dose escalation of monalizumab plus durvalumab, with expansion in patients with metastatic microsatellite-stable colorectal cancer. 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/3/2018
• Immune Therapy: Why Don't We Have the KEY for VICTORy? 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/3/2018