NikhilWagleMD

PubMed

• 27 citations
  Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to estrogen receptor-directed therapies.
  Utthara Nayar, Ofir Cohen, Christian Kapstad, Michael S. Cuoco, Adrienne G. Waks, Seth A. Wander, Corrie Painter, Samuel S. Freeman, Nicole S. Persky, Lori Marini, Kar...> ;Nature Genetics. 2019 Feb 1
• KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.
  Hinohara, K.,Wu, H. J.,Vigneau, S.,McDonald, T. O.,Igarashi, K. J.,Yamamoto, K. N.,Madsen, T.,Fassl, A.,Egri, S. B.,Papanastasiou, M.,Ding, L.,Peluffo, G.,Cohen, O.,Ka...> ;Cancer Cell. 2018 Nov 26
• Everolimus and pazopanib (E/P) benefit genomically selected patients with metastatic urothelial carcinoma
  Joaquim Bellmunt, Aly-Khan A. Lalani, Sussana Jacobus, Stephanie A. Wankowicz, Laura Polacek, David Y. Takeda, Lauren C. Harshman, Nikhil Wagle, Irene Moreno, Kevin Lu...> ;British Journal of Cancer. 2018 Sep 1
• Unraveling the clinicopathological features driving the emergence of ESR1 mutations in metastatic breast cancer.
  Yanan Kuang, Bilal Siddiqui, Jiani Hu, Matthew Pun, MacIntosh Cornwell, Gilles Buchwalter, Melissa E. Hughes, Nikhil Wagle, Paul Kirschmeier, Pasi A. Jänne, Cloud P. P...> ;NPJ breast cancer. 2018 Aug 2
• Characterizing reduced coverage regions through comparison of exome and genome sequencing data across 10 centers.
  Rashesh Sanghvi, Christian J. Buhay, Bradford C. Powell, Ellen A. Tsai, Michael O. Dorschner, Celine S. Hong, Matthew S. Lebo, Ariella Sasson, David S. Hanna, Sean McG...> ;Genetics in Medicine. 2018 Aug 1
• 24 citations
  Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects.
  Simona Volpi, Carol J. Bult, Rex L. Chisholm, Patricia A. Deverka, Geoffrey S. Ginsburg, Howard J. Jacob, Melpomeni Kasapi, Howard L. McLeod, Dan M. Roden, Marc S. Wil...> ;Clinical Pharmacology & Therapeutics. 2018 May 1
• 43 citations
  Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations
  Rinath Jeselsohn, Johann Bergholz, Matthew Pun, MacIntosh Cornwell, Weihan Liu, Agostina Nardone, Tengfei Xiao, Wei Li, Xintao Qiu, Gilles Buchwalter, Ariel Feiglin, K...> ;Cancer Cell. 2018 Feb 12
• 35 citations
  Association of Cell-Free DNA Tumor Fraction and Somatic Copy Number Alterations With Survival in Metastatic Triple-Negative Breast Cancer.
  Daniel G. Stover, Heather A. Parsons, Gavin Ha, Samuel S. Freeman, W Barry, Hao Guo, Atish D. Choudhury, Gregory Gydush, Sarah Reed, Justin Rhoades, Denisse Rotem, Mel...> ;Journal of Clinical Oncology. 2018 Jan 3
• 17 citations
  Assigning clinical meaning to somatic and germ-line whole-exome sequencing data in a prospective cancer precision medicine study.
  Arezou A. Ghazani, Nelly Oliver, Joseph P. St. Pierre, Andrea Garofalo, Irene Rainville, Elaine Hiller, Daniel J. Treacy, Vanesa Rojas-Rudilla, Sam Wood, Elizabeth Bai...> ;Genetics in Medicine. 2017 Jan 26
• 56 citations
  The impact of tumor profiling approaches and genomic data strategies for cancer precision medicine
  Andrea Garofalo, Lynette M. Sholl, Brendan Reardon, Amaro Taylor-Weiner, Ali Amin-Mansour, Diana Miao, David Liu, Nelly Oliver, Laura E. MacConaill, Matthew D. Ducar, ...> ;Genome Medicine. 2016 Jul 26
• 56 citations
  Erratum: Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine (American Journal of Human Genetics (2016) 98(6)...
  Robert C. Green, Katrina A.B. Goddard, Gail P. Jarvik, Laura M. Amendola, Paul S. Appelbaum, Jonathan S. Berg, Barbara A. Bernhardt, Leslie G. Biesecker, Sawona Biswas...> ;American Journal of Human Genetics. 2016 Jul 7
• Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine.
  Green RC, Goddard KAB, Jarvik GP, Amendola LM, Appelbaum PS, Berg JS, Bernhardt BA, Biesecker LG, Biswas S, Blout CL, Bowling KM, Brothers KB, Burke W, Caga-Anan CF, C...> ;Am. J. Hum. Genet.. 2016-06-02
• Oncologists' and cancer patients' views on whole-exome sequencing and incidental findings: results from the CanSeq study.
  Stacy W. Gray, Elyse R. Park, Julie Najita, Yolanda Martins, Lara Traeger, Elizabeth Bair, Joshua J. Gagne, Judy Garber, Pasi A. Jänne, Neal I. Lindeman, Carol Lowenst...> ;Genetics in Medicine. 2016 Feb 11
• Phase II study of tivantinib (ARQ 197) in patients with metastatic triple-negative breast cancer
  Sara M. Tolaney, Sally Tan, Hao Guo, William H. Barry, Eliezer M. Van Allen, Nikhil Wagle, Jane E. Brock, Katherine Larrabee, Cloud P. Paweletz, Elena Ivanova, Pasi A....> ;Investigational New Drugs. 2015 Jul 1
• 23 citations
  Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma.
  Eliezer M. Van Allen, Vivian Wai Yan Lui, Ann Marie Egloff, Eva M. Goetz, Hua Li, Jonas T. Johnson, Umamaheswar Duvvuri, Julie E. Bauman, Nicolas Stransky, Yan Zeng, B...> ;JAMA Oncology. 2015 May 1
• 125 citations
  Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations
  Leanne G. Ahronian, Erin M. Sennott, Eliezer M. Van Allen, Nikhil Wagle, Eunice L. Kwak, Jason E. Faris, Jason T. Godfrey, Koki Nishimura, Kerry D. Lynch, Craig H. Mer...> ;Cancer Discovery. 2015 Apr 1
• 116 citations
  Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma
  Jennifer A. Perry, Adam Kiezun, Peter Tonzi, Eliezer M. Van Allen, Scott L. Carter, Sylvan C. Baca, Glenn S. Cowley, Ami S. Bhatt, Esther Rheinbay, Chandra Sekhar Peda...> ;Proceedings of the National Academy of Sciences of the United States of America. 2014 Dec 23
• ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors
  Eva M. Goetz, Mahmoud Ghandi, Daniel J. Treacy, Nikhil Wagle, Levi A. Garraway> ;Cancer Research. 2014 Dec 1
• 133 citations
  Response and Acquired Resistance to Everolimus in Anaplastic Thyroid Cancer
  Nikhil Wagle, Brian C. Grabiner, Eliezer M. Van Allen, Ali Amin-Mansour, Amaro Taylor-Weiner, Mara Rosenberg, Nathanael S. Gray, Justine A. Barletta, Yanan Guo, Scott ...> ;The New England Journal of Medicine. 2014 Oct 8
• 219 citations
  Somatic ERCC2 Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma
  Eliezer M. Van Allen, Kent W. Mouw, Philip H. Kim, Gopa Iyer, Nikhil Wagle, Hikmat Al-Ahmadie, Cong Zhu, Irina Ostrovnaya, Gregory V. Kryukov, Kevin W O'Connor, John P...> ;Cancer Discovery. 2014 Aug 5
• Assessing the clinical utility of cancer genomic and proteomic data across tumor types
  Yuan Yuan, Eliezer M. Van Allen, Larsson Omberg, Nikhil Wagle, Ali Amin-Mansour, Artem Sokolov, Lauren Averett Byers, Yanxun Xu, Kenneth R. Hess, Lixia Diao, Leng Han,...> ;Nature Biotechnology. 2014 Jul 1
• 245 citations
  Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine
  Eliezer M. Van Allen, Nikhil Wagle, Petar Stojanov, Danielle Perrin, Kristian Cibulskis, Sara Marlow, Judit Jané-Valbuena, Dennis C. Friedrich, Gregory V. Kryukov, Sco...> ;Nature Medicine. 2014 Jun 1
• Activating mTOR Mutations in a Patient with an Extraordinary Response on a Phase I Trial of Everolimus and Pazopanib
  Nikhil Wagle, Brian C. Grabiner, Eliezer M. Van Allen, Eran Hodis, Susanna Jacobus, Jeffrey G. Supko, Michelle Stewart, Toni K. Choueiri, Leena Gandhi, James M. Cleary...> ;Cancer Discovery. 2014 May 1
• Successful whole-exome sequencing from a prostate cancer bone metastasis biopsy.
  E.M. Van Allen, Adam Foye, Nikhil Wagle, Won Kim, Scott L. Carter, Aaron McKenna, J. Simko, Levi A. Garraway, Phillip G. Febbo> ;Prostate Cancer and Prostatic Diseases. 2014 Mar 1
• A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma.
  Jonathan E. Rosenberg, Richard Martin Bambury, Eliezer M. Van Allen, Harry A. Drabkin, Primo N. Lara, Andrea L. Harzstark, Nikhil Wagle, Robert A. Figlin, Gregory W. S...> ;Investigational New Drugs. 2014 Feb 1
• Join now to see all