NikhilWagleMD

PubMed

• PACE: A Randomized Phase II Study of Fulvestrant, Palbociclib, and Avelumab After Progression on Cyclin-Dependent Kinase 4/6 Inhibitor and Aromatase Inhibitor for Horm...
  Erica L Mayer, Yue Ren, Nikhil Wagle, Reshma Mahtani, Cynthia Ma, Angela DeMichele, Massimo Cristofanilli, Jane Meisel, Kathy D Miller, Yara Abdou, Elizabeth C Riley, ...> ;Journal of Clinical Oncology. 2024 Mar 21
• Exemestane plus everolimus and palbociclib in metastatic breast cancer: clinical response and genomic/transcriptomic determinants of resistance in a phase I/II trial.
  Jorge Gómez Tejeda Zañudo, Romualdo Barroso-Sousa, Esha Jain, Qingchun Jin, Tianyu Li, Jorge E Buendia-Buendia, Alyssa Pereslete, Daniel L Abravanel, Arlindo R Ferreir...> ;Nature Communications. 2024 Mar 19
• Author Correction: Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments.
  Janiszewska, M., Tabassum, D., Castaño, Z., Cristea, S., Yamamoto, K., Kingston, N., Murphy, K., Shu, S., Harper, N., Del Alcazar, C., Alečković, M., Ekram, M., Cohen,...> ;Nature Cell Biology. 2024 Mar 5
• High FOXA1 levels induce ER transcriptional reprogramming, a pro-metastatic secretome, and metastasis in endocrine-resistant breast cancer.
  Xiaoyong Fu, Resel Pereira, Chia-Chia Liu, Carmine De Angelis, Martin J Shea, Sarmistha Nanda, Lanfang Qin, Tamika Mitchell, Maria L Cataldo, Jamunarani Veeraraghavan,...> ;Cell Reports. 2023 Aug 29
• Genomics of-Positive Breast Cancer in Young Women Before and After Exposure to Chemotherapy Plus Trastuzumab.
  Marla Lipsyc-Sharf, Esha Jain, Laura C Collins, Shoshana M Rosenberg, Kathryn J Ruddy, Rulla M Tamimi, Lidia Schapira, Steven E Come, Jeffrey M Peppercorn, Virginia F ...> ;JCO Precision Oncology. 2023 Jun 1
• 2 citations
  A Gene Panel Associated With Abemaciclib Utility in-Mutated Breast Cancer After Prior Cyclin-Dependent Kinase 4/6-Inhibitor Progression.
  Jamie O Brett, Taronish D Dubash, Gabriela N Johnson, Andrzej Niemierko, Veronica Mariotti, Leslie S L Kim, Jing Xi, Apurva Pandey, Siobhan Dunne, Azadeh Nasrazadani, ...> ;JCO Precision Oncology. 2023 May 1
• 35 citations
  Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer: final 10-year analysis of the open-label, single-arm, phase 2 APT trial.
  Tolaney, S., Tarantino, P., Graham, N., Tayob, N., Parè, L., Villacampa, G., Dang, C., Yardley, D., Moy, B., Marcom, P., Albain, K., Rugo, H., Ellis, M., Shapira, I., ...> ;The Lancet. Oncology. 2023 Mar 1
• 1 citations
  Priorities to Promote Participant Engagement in the Participant Engagement and Cancer Genome Sequencing (PE-CGS) Network.
  Anne Lr Schuster, Norah L Crossnohere, Melinda Bachini, Cindy K Blair, John D Carpten, Elizabeth B Claus, Graham A Colditz, Li Ding, Bettina F Drake, Ryan C Fields, Ka...> ;Cancer Epidemiology, Biomarkers & Prevention. 2023 Apr 3
• 1 citations
  Research Silos in Cancer Disparities: Obstacles to Improving Clinical Outcomes for Underserved Patient Populations.
  Angelique Richardson, Burcu Darst, Genevieve Wojcik, Nikhil Wagle, Svasti Haricharan> ;Clinical Cancer Research. 2023 Apr 3
• 5 citations
  Incidence proportion and prognosis of leptomeningeal disease among patients with breast vs. non-breast primaries.
  Nayan Lamba, Daniel N Cagney, Paul J Catalano, Hesham Elhalawani, Daphne A Haas-Kogan, Patrick Y Wen, Nikhil Wagle, Nancy U Lin, Ayal A Aizer, Shyam Tanguturi> ;Neuro-Oncology. 2023 May 4
• 2 citations
  A patient-driven clinicogenomic partnership for metastatic prostate cancer.
  Jett Crowdis, Sara Balch, Lauren Sterlin, Beena S Thomas, Sabrina Y Camp, Michael Dunphy, Elana Anastasio, Shahrayz Shah, Alyssa L Damon, Rafael Ramos, Delia M Sosa, I...> ;Cell Genomics. 2022 Sep 14
• 6 citations
  Multidimensional Molecular Profiling of Metastatic Triple-Negative Breast Cancer and Immune Checkpoint Inhibitor Benefit.
  Romualdo Barroso-Sousa, Juliet Forman, Katharine Collier, Zachary T Weber, Tejas R Jammihal, Katrina Z Kao, Edward T Richardson 3rd, Tanya Keenan, Ofir Cohen, Michael ...> ;JCO Precision Oncology. 2022 Jul 1
• 11 citations
  Somatic and Germline Genomic Alterations in Very Young Women with Breast Cancer.
  Adrienne G Waks, Dewey Kim, Esha Jain, Craig Snow, Gregory J Kirkner, Shoshana M Rosenberg, Coyin Oh, Philip D Poorvu, Kathryn J Ruddy, Rulla M Tamimi, Jeffrey Pepperc...> ;Clinical Cancer Research. 2022 Jun 1
• ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation.
  Zheqi Li, Olivia McGinn, Yang Wu, Amir Bahreini, Nolan M Priedigkeit, Kai Ding, Sayali Onkar, Caleb Lampenfeld, Carol A Sartorius, Lori Miller, Margaret Rosenzweig, Of...> ;Nature Communications. 2022 Apr 19
• 15 citations
  Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis.
  Zheqi Li, Yang Wu, Megan E Yates, Nilgun Tasdemir, Amir Bahreini, Jian Chen, Kevin M Levine, Nolan M Priedigkeit, Azadeh Nasrazadani, Simak Ali, Laki Buluwela, Spencer...> ;Cancer Research. 2022 Apr 1
• 12 citations
  A Framework for Promoting Diversity, Equity, and Inclusion in Genetics and Genomics Research.
  Timothy R Rebbeck, John F P Bridges, Jennifer W Mack, Stacy W Gray, Jeffrey M Trent, Suzanne George, Norah L Crossnohere, Electra D Paskett, Corrie A Painter, Nikhil W...> ;JAMA Health Forum. 2022 Apr 1
• 1 citations
  cDNA-detector: detection and removal of cDNA contamination in DNA sequencing libraries.
  Meifang Qi, Utthara Nayar, Leif S Ludwig, Nikhil Wagle, Esther Rheinbay> ;BMC Bioinformatics. 2021 Dec 24
• 5 citations
  Cell Line-Specific Network Models of ER+ Breast Cancer Identify Potential PI3Kα Inhibitor Resistance Mechanisms and Drug Combinations.
  Jorge Gómez Tejeda Zañudo, Pingping Mao, Clara Alcon, Kailey J. Kowalski, Gabriela N. Johnson, Guotai Xu, José Baselga, Maurizio Scaltriti, Anthony Letai, Joan Montero...> ;Cancer Research. 2021 Sep 1
• 3 citations
  A phase II study of efficacy, toxicity, and the potential impact of genomic alterations on response to eribulin mesylate in combination with trastuzumab and pertuzumab...
  Sara Balch, Ines Vaz-Luis, Tianyu Li, Nabihah Tayob, Esha Jain, Karla Helvie, Jorge E. Buendia-Buendia, Erin Shannon, Steven J. Isakoff, Nadine Tung, Ian E. Krop, Nan ...> ;Breast Cancer Research and Treatment. 2021 Jul 24
• 14 citations
  ER+ Breast Cancer Strongly Depends on MCL-1 and BCL-xL Anti-Apoptotic Proteins.
  Clara Alcon, Jorge Gómez Tejeda Zañudo, Réka Albert, Nikhil Wagle, Maurizio Scaltriti, Anthony Letai, Josep Samitier, Joan Montero> ;Cells. 2021 Jul 2
• 36 citations
  Clinical Outcomes With Abemaciclib After Prior CDK4/6 Inhibitor Progression in Breast Cancer: A Multicenter Experience.
  Seth A. Wander, Hyo S. Han, Mark L. Zangardi, Andrzej Niemierko, Veronica Mariotti, Leslie S L Kim, Jing Xi, Apurva Pandey, Siobhan Dunne, Azadeh Nasrazadani, Avinash ...> ;Journal of the National Comprehensive Cancer Network. 2021 Mar 24
• 24 citations
  Genomic Characterization of de novo Metastatic Breast Cancer
  Ana C. Garrido-Castro, Liam F. Spurr, Melissa E. Hughes, Yvonne Y. Li, Andrew D. Cherniack, Priti Kumari, Maxwell R. Lloyd, Brittany L. Bychkovsky, Romualdo Barroso-So...> ;Clinical Cancer Research. 2021 Feb 15
• 167 citations
  Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems.
  Shahar Alon, Daniel Goodwin, Anubhav Sinha, Asmamaw T Wassie, Fei Chen, Evan R. Daugharthy, Yosuke Bando, Atsushi Kajita, Andrew G Xue, Karl Marrett, Robert Prior, Yi ...> ;Science. 2021 Jan 29
• 55 citations
  Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma
  Livnat Jerby-Arnon, Cyril Neftel, Marni E. Shore, Hannah R. Weisman, Nathan Mathewson, Matthew J. McBride, Brian J. Haas, Benjamin Izar, Angela Volorio, Gaylor Boulay,...> ;Nature Medicine. 2021 Jan 25
• 65 citations
  Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER+ Metastatic Breast Cancer.
  Pingping Mao, Ofir Cohen, Kailey J. Kowalski, Justin Kusiel, Jorge E. Buendia-Buendia, Michael S. Cuoco, Pedro Exman, Seth A. Wander, Adrienne G. Waks, Utthara Nayar, ...> ;Clinical Cancer Research. 2020 Nov 15
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Journal Articles

• Article KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance  
  Nikhil Wagle, Myles Brown, Rinath Jeselsohn, ScienceDirect