OgoIEgbunaMDMMSc, FASN(He/Him)

Nephrology • Boston, MA

Kidney & Pancreas Transplantation

Vice President, Clinical Development

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Office
50 Fan Pier Blvd
Boston, MA 02210
Phone+1 617-692-0887
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Summary

Therapeutics development

Education & Training

Harvard-MIT School of Health Science and TechnologyMMSC, Clinical Investigation , 2006 - 2008
Brigham and Women’s HospitalPost Doctorate, Endocrinology, 2005 - 2008
Beth Israel Deaconess Medical Center/Harvard Medical SchoolFellowship, Transplant Nephrology, 2005 - 2006
University of RochesterFellowship, Nephrology, 2003 - 2005
Icahn School of Medicine at Mount Sinai (NYC Health and Hospitals/Elmhurst)Residency, Internal Medicine, 2000 - 2003
University of Nigeria Faculty of MedicineClass of 1998

Certifications & Licensure

CA State Medical License 2009 - 2017

Awards, Honors, & Recognition

K08 Investigators Award NIH, 2006-2008
Fellow (ASNF) American Society of Nephrology

Clinical Trials

A Randomized Trial to Reduce the Disparity in Live Donor Kidney Transplantation Start of enrollment: 2007 Aug 01
Completed
Not Applicable

Publications & Presentations

PubMed

23 citations
Inaxaplin for Proteinuric Kidney Disease in Persons with TwoVariants.
Ogo Egbuna, Brandon Zimmerman, George Manos, Anne Fortier, Madalina C Chirieac, Leslie A Dakin, David J Friedman, Kate Bramham, Kirk Campbell, Bertrand Knebelmann, Lau...> ;The New England Journal of Medicine. 2023 Mar 16
Pharmacokinetic/pharmacodynamic and safety study of a single dose of evolocumab 140 mg in healthy Chinese subjects.
Hong Lu, Zhigang Yu, Cheng-Pang Hsu, Brian Tomlinson, Andrea O.Y. Luk, Ogo Egbuna, Jihua Wu, Bassam Abosaleem, Jitesh Rana, Maria Laura Monsalvo> ;International Journal of Clinical Pharmacology and Therapeutics. 2020 Oct 1
26 citations
Romosozumab in Skeletally Mature Adults with a Fresh Unilateral Tibial Diaphyseal Fracture: A Randomized Phase-2 Study.
Mohit Bhandari, Emil H. Schemitsch, Theofilos Karachalios, Parag Sancheti, Rudolf W. Poolman, John Caminis, Nadia Daizadeh, Ricardo E Dent-Acosta, Ogo Egbuna, Arkadi C...> ;The Journal of Bone and Joint Surgery. American Volume. 2020 May 1
41 citations
A Randomized, Placebo-Controlled Study of Romosozumab for the Treatment of Hip Fractures.
Emil H. Schemitsch, Theodore Miclau, Theofilos Karachalios, Lauren L Nowak, Parag Sancheti, Rudolf W. Poolman, John Caminis, Nadia Daizadeh, Ricardo E Dent-Acosta, Ogo...> ;The Journal of Bone and Joint Surgery. American Volume. 2020 Apr 15
3 citations
A Phase 1, Randomized, Double-Blind, Single-Dose, Placebo-Controlled Safety, Tolerability, And Pharmacokinetic/Pharmacodynamic Study Of Evolocumab In Healthy Chinese S...
Chao Liu, Hong Lu, Fei Yuan, Wei-Li Chen, Hong-Rong Xu, Hui Li, Cheng-Pang Hsu, Ogo Egbuna, Jihua Wu, Clapton Dias, Bassam Abosaleem, Jitesh Rana, Maria Laura Monsalvo...> ;Clinical Pharmacology. 2019 Oct 23
7 citations
Influence of Renal Function on Evolocumab Exposure, Pharmacodynamics, and Safety.
Edward Lee, John P. Gibbs, Maurice Emery, Geoffrey A. Block, Scott M. Wasserman, Lisa Hamilton, Sreeneeranj Kasichayanula, Patrick Hanafin, Ransi Somaratne, Ogo Egbuna> ;Clinical Pharmacology in Drug Development. 2019 Apr 1
20 citations
Evaluation of Evolocumab (AMG 145), a Fully Human Anti-PCSK9 IgG2 Monoclonal Antibody, in Subjects With Hepatic Impairment.
John P. Gibbs, J. Greg Slatter, Ogo Egbuna, Michelle Geller, Lisa Hamilton, Clapton Dias, Ren Y. Xu, Jessica Johnson, Scott M. Wasserman, Maurice Emery> ;Journal of Clinical Pharmacology. 2017 Apr 1
18 citations
Pharmacokinetics, Biotransformation, and Excretion of [14C]Etelcalcetide (AMG 416) Following a Single Microtracer Intravenous Dose in Patients with Chronic Kidney Dise...
Raju Subramanian, Xiaochun Zhu, M. Benjamin Hock, Bethlyn Sloey, Benjamin Wu, Sarah F. Wilson, Ogo Egbuna, J. Greg Slatter, Jim J. Xiao, Gary L. Skiles> ;Clinical Pharmacokinetics. 2017 Feb 1
20 citations
Performance of the pegfilgrastim on-body injector as studied with placebo buffer in healthy volunteers.
Rajeshree S Joshi, Ogo Egbuna, Alex S Cairns, Michael Friedman, Bassam Abosaleem, Maureen Reiner, Phuong Khanh Morrow> ;Current Medical Research and Opinion. 2017 Feb 1
6 citations
An open-label study in healthy men to evaluate the risk of seminal fluid transmission of denosumab to pregnant partners.
Winnie Sohn, Edward Lee, Martin Kankam, Ogo Egbuna, Graeme J. Moffat, Jeanine L. Bussiere, Desmond Padhi, Eric W. Ng, Sandeep Kumar, J. Greg Slatter> ;British Journal of Clinical Pharmacology. 2016 Feb 1
19 citations
Readiness of wait-listed black patients to pursue live donor kidney transplant.
James R. Rodrigue, Matthew J. Paek, Ogo I. Egbuna, Amy D. Waterman, Jesse D. Schold, Martha Pavlakis, Didier A. Mandelbrot> ;Progress in Transplantation. 2014 Dec 1
88 citations
Making House Calls Increases Living Donor Inquiries and Evaluations for Blacks on the Kidney Transplant Waiting List
James R. Rodrigue, Matthew J. Paek, Ogo Egbuna, Amy D. Waterman, Jesse D. Schold, Martha Pavlakis, Didier A. Mandelbrot> ;Transplantation. 2014 Nov 15
10 citations
A clinical therapeutic protein drug–drug interaction study: coadministration of denosumab and midazolam in postmenopausal women with osteoporosis
Graham Richard Jang, Allegra Kaufman, Edward Lee, Lisa Hamilton, Shauna Hutton, Ogo Egbuna, Desmond Padhi> ;Pharmacology Research & Perspectives. 2014 Apr 1
73 citations
RANKL inhibition with denosumab does not influence 3-year progression of aortic calcification or incidence of adverse cardiovascular events in postmenopausal women wit...
Elizabeth J. Samelson, Paul D. Miller, Claus Christiansen, Nadia Daizadeh, Luanda Grazette, Mary S. Anthony, Ogo Egbuna, Andrea Wang, S. Siddhanti, Angela M. Cheung, N...> ;Journal of Bone and Mineral Research. 2014 Feb 1
17 citations
CaSR-mediated interactions between calcium and magnesium homeostasis in mice
Stephen J. Quinn, Alex R.B. Thomsen, Ogo Egbuna, Jian Pang, Khanjan Baxi, David Goltzman, Martin R. Pollak, Edward M. Brown> ;American Journal of Physiology. Endocrinology and Metabolism. 2013 Apr 1
6 citations
Willingness to pursue live-donor kidney transplantation among waitlisted patients infected with human immunodeficiency virus (HIV): a preliminary investigation.
James R. Rodrigue, Matthew J. Paek, Ogo Egbuna, Amy D. Waterman, Martha Pavlakis, Didier A. Mandelbrot> ;Transplantation. 2013 Mar 27
42 citations
The "House Calls" Trial: A Randomized Controlled Trial to Reduce Racial Disparities in Live Donor Kidney Transplantation: Rationale and Design☆ , ☆☆
James R. Rodrigue, Martha Pavlakis, Ogo Egbuna, Matthew J. Paek, Amy D. Waterman, Didier A. Mandelbrot> ;Contemporary Clinical Trials. 2012 Jul 1
230 citations
Effects of denosumab on fracture and bone mineral density by level of kidney function
Sophie A. Jamal, Östen Ljunggren, Catherine Stehman-Breen, Steven R. Cummings, Michael R. McClung, Stefan Goemaere, Peter R. Ebeling, Edward Franek, Y.-C. Yang, Ogo Eg...> ;Journal of Bone and Mineral Research. 2011 Aug 1
22 citations
Timing of sirolimus conversion influences recovery of renal function in liver transplant recipients.
Christin C. Rogers, Scott R. Johnson, Didier A. Mandelbrot, Martha Pavlakis, Timothy A. Horwedel, Seth J. Karp, Ogo Egbuna, James R. Rodrigue, Robyn Chudzinski, Alexan...> ;Clinical Transplantation. 2009 Nov 1
96 citations
The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion.
Lakshmi Kantham, Steven Quinn, Ogo Egbuna, Khanjan Baxi, Robert Butters, Jian L. Pang, Martin R. Pollak, David Goltzman, Edward M. Brown> ;American Journal of Physiology. Endocrinology and Metabolism. 2009 Oct 1
9 citations
Outcomes with conversion from calcineurin inhibitors to sirolimus after renal transplantation in the context of steroid withdrawal or steroid continuation.
Ogo Egbuna, Roger B. Davis, Robyn Chudinski, Martha Pavlakis, Christin C. Rogers, Phani Molakatalla, Scott R. Johnson, Seth J. Karp, Anthony P. Monaco, Hongying Tang, ...> ;Transplantation. 2009 Sep 15
26 citations
The full-length calcium-sensing receptor dampens the calcemic response to 1α,25(OH)2 vitamin D3 in vivo independently of parathyroid hormone
Ogo I. Egbuna, Steven Quinn, Lakshmi Kantham, Robert Butters, Jiang Pang, Martin R. Pollak, David Goltzman, Edward M. Brown> ;American Journal of Physiology. Renal Physiology. 2009 Sep 1
The Calcium-Sensing Receptor (CaSR) Defends Against Hypercalcemia Independent of its Regulation of Parathyroid Hormone Secretion.
Kantham, L., Quinn, S.J., Egbuna, O.I., Baxi, K., Butters, R., Pang, J., Pollak, M.R., Goltzman, D., Brown, E.M.> ;Am J Physiol Endocrinol Metab. 2009-07-28
115 citations
Hypercalcaemic and hypocalcaemic conditions due to calcium-sensing receptor mutations.
Ogo I. Egbuna, Edward M. Brown> ;Best Practice & Research. Clinical Rheumatology. 2008 Mar 1
2 citations
Acute Crescentic Glomerulonephritis in a Renal Allograft: An Unusual Complication of Fungal Infection
Ogo Egbuna, Martha Pavlakis, Isaac E. Stillman> ;American Journal of Kidney Diseases. 2007 Sep 1
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Press Mentions

Anatomic Pathology Selected AbstractsJanuary 23rd, 2024
Molecular Pathology Selected AbstractsJanuary 21st, 2024

Grant Support

Human Uremic Persistent Hyperparathyroidism: Functional And Molecular AspectsNational Institute Of Diabetes And Digestive And Kidney Diseases2006–2008