PaulDAllenMDPhD

PubMed

• Is malignant hyperthermia associated with hyperglycaemia?
  Altamirano, F.,Riazi, S.,Ibarra Moreno, C. A.,Kraeva, N.,Uryash, A.,Allen, P. D.,Adams, J. A.,Lopez, J. R.> ;Br J Anaesth. 2018 Dec 24
• 35 citations
  Malignant hyperthermia, environmental heat stress, and intracellular calcium dysregulation in a mouse model expressing the p.G2435R variant of RYR1
  Jose R. Lopez, Vikas Kaura, Christine P. Diggle, Philip M. Hopkins, Paul D. Allen> ;British Journal of Anaesthesia. 2018 Oct 1
• 42 citations
  Altered ROS production, NF-κB activation and interleukin-6 gene expression induced by electrical stimulation in dystrophic mdx skeletal muscle cells
  Carlos Henríquez-Olguín, Francisco Altamirano, Denisse Valladares, Jose R. Lopez, Paul D. Allen, Enrique Jaimovich> ;Biochimica Et Biophysica Acta. 2015 Jul 1
• 19 citations
  Whole Body Periodic Acceleration Is an Effective Therapy to Ameliorate Muscular Dystrophy in mdx Mice
  Francisco Altamirano, Claudio F. Perez, Min Liu, Jeffrey J. Widrick, Elisabeth R. Barton, Paul D. Allen, Jose A. Adams, Jose R. Lopez> ;Plos One. 2014 Sep 2
• Mononuclear cells from dedifferentiation of mouse myotubes display remarkable regenerative capability.
  Yang, Z.,Liu, Q.,Mannix, R. J.,Xu, X.,Li, H.,Ma, Z.,Ingber, D. E.,Allen, P. D.,Wang, Y.> ;Stem Cells. 2014 Jun 12
• Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle.
  Altamirano, F.,Eltit, J. M.,Robin, G.,Linares, N.,Ding, X.,Pessah, I. N.,Allen, P. D.,Lopez, J. R.> ;J. Biol. Chem.. 2014 May 23
• Na+ dysregulation coupled with Ca2+ entry through NCX1 promotes muscular dystrophy in mice.
  Burr, A. R.,Millay, D. P.,Goonasekera, S. A.,Park, K. H.,Sargent, M. A.,Collins, J.,Altamirano, F.,Philipson, K. D.,Allen, P. D.,Ma, J.,López, J. R.,Molkentin, J. D.> ;Mol. Cell. Biol.. 2014 Mar 26
• 41 citations
  Nifedipine Treatment Reduces Resting Calcium Concentration, Oxidative and Apoptotic Gene Expression, and Improves Muscle Function in Dystrophic mdx Mice
  Francisco Altamirano, Denisse Valladares, Carlos Henríquez-Olguín, Mariana Casas, Jose R. Lopez, Paul D. Allen, Enrique Jaimovich> ;Plos One. 2013 Dec 9
• Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia.
  Eltit, J. M.,Ding, X.,Pessah, I. N.,Allen, P. D.,Lopez, J. R.> ;FASEB J.. 2013 Mar
• Dynamic measurement of the calcium buffering properties of the sarcoplasmic reticulum in mouse skeletal muscle.
  Manno C, Sztretye M, Figueroa L, Allen PD, Ríos E> ;J. Physiol. (Lond.). 2013-01-15
• 69 citations
  Th2 cytokine antagonists: potential treatments for severe asthma.
  Philip M. Hansbro, Grace V. Scott, Ama Tawiah Essilfie, Richard Kim, Malcolm R. Starkey, Duc H. Nguyen, Paul D. Allen, Gerard E. Kaiko, Ming Yang, Jay C. Horvat, Paul ...> ;Expert Opinion on Investigational Drugs. 2013 Jan 1
• 24 citations
  Blood-Based Biomarkers of Aggressive Prostate Cancer
  Men Long Liong, Chun Ren Lim, Hengxuan Yang, Samuel Chao, Chin Wei Bong, Wing Seng Leong, Prashanta Kumar Das, Chit Sin Loh, Ban Eng Lau, Choon Geok Yu, Edie Jian Jiek...> ;Plos One. 2012 Sep 28
• Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor.
  Eltit JM, Bannister RA, Moua O, Altamirano F, Hopkins PM, Pessah IN, Molinski TF, López JR, Beam KG, Allen PD> ;Proc. Natl. Acad. Sci. U.S.A.. 2012-05-15
• 69 citations
  Increased resting intracellular calcium modulates NF-κB-dependent inducible nitric-oxide synthase gene expression in dystrophic mdx skeletal myotubes.
  Francisco Altamirano, Jose R. Lopez, Carlos Henríquez, Tadeusz F. Molinski, Paul D. Allen, Enrique Jaimovich> ;The Journal of Biological Chemistry. 2012 Jun 15
• 12 citations
  Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion
  Wenfeng Cai, Tracy J. Pritchard, Stela Florea, Chi Keung Lam, Peidong Han, Xiaoyang Zhou, Qunying Yuan, Stephan E. Lehnart, Paul D. Allen, Evangelia G. Kranias> ;Cardiovascular Research. 2012 May 1
• 210 citations
  Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices.
  Marie-Ève Tremblay, Martha L. Zettel, James R. Ison, Paul D. Allen, Ania K. Majewska> ;Glia. 2012 Apr 1
• Deficits in Responding to Brief Noise Offsets in Kcna1 -/- Mice Reveal a Contribution of This Gene to Precise Temporal Processing Seen Previously Only for Stimulus Ons...
  Ison, J.R., Allen, P.D.> ;J Assoc Res Otolaryngol. 2012 Jun
• Kcna1 gene deletion lowers the behavioral sensitivity of mice to small changes in sound location and increases asynchronous brainstem auditory evoked potentials but do...
  Allen, P. D.,Ison, J. R.> ;J. Neurosci.. 2012 Mar 08
• Gene-dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia susceptible muscle.
  Barrientos, G.C., Feng, W., Truong, K., Matthaei, K.I., Yang, T., Allen, P.D., Lopez, J.R., Pessah, I.N.> ;J Biol Chem. 2012 Jan 20
• Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage.
  Yuen, B., Boncompagni, S., Feng, W., Yang, T., Lopez, J.R., Matthaei, K.I., Goth, S.R., Protasi, F., Franzini-Armstrong, C., Allen, P.D., Pessah, I.N.> ;FASEB J. 2012 Mar
• Measurement of RyR permeability reveals a role of calsequestrin in termination of SR Ca(2+) release in skeletal muscle.
  Sztretye M, Yi J, Figueroa L, Zhou J, Royer L, Allen P, Brum G, Ríos E> ;J. Gen. Physiol.. 2011-08-01
• [Dysfunction of diastolic [Ca²⁺] in cardiomyocytes isolated from chagasic patients].
  López JR, Espinosa R, Landazuru P, Linares N, Allen P, Mijares A> ;Rev Esp Cardiol. 2011-06-01
• Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors.
  Chen, F., Liu, Y., Sugiura, Y., Allen, P.D., Gregg, R.G., Lin, W.> ;Nat Neurosci. 2011 May
• Orthograde dihydropyridine receptor signal regulates ryanodine receptor passive leak.
  Eltit, J.M., Li, H., Ward, C.W., Molinski, T., Pessah, I.N., Allen, P.D., Lopez, J.R.> ;Proc Natl Acad Sci U S A. 2011 Apr 26
• Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible mice.
  Feng, W., Barrientos, G.C., Cherednichenko, G., Yang, T., Padilla, I.T., Truong, K., Allen, P.D., Lopez, J.R., Pessah, I.N.> ;Mol Pharmacol. 2011 Mar
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Journal Articles

• Cellular distribution and pharmacological sensitivity of low KM cyclic nucleotide phosphodiesterase isozymes in cardiac muscle from normal and cardiomyopathic subjects.  
  Silver PJ, Allen PD, Etzler JH, Hamel LT, Bentley RG, Pagani ED, Second Messengers and Phosphoproteins; 13(1):13-25
• Dantrolene reduces myoplasmic free [Ca2+] in patients with malignant hyperthermia.  
  Lopez JR, Lopez M, Allen PD, Act. Cien. Ven; 41:135-137
• Properties of adult rat ventricular cells in long-term culture.  
  Ikeda U, Briggs GM, Allen PD, Sen LY, Medford RM, Smith TW, Cardioscience; (1)3:225-33
• Vascular smooth muscle expresses a truncated NA+, K+-ATPase -1 subunit isoform.  
  Medford RM, Hyman R, Ahmad M, Allen JC, Pressley TA, Allen PD, Nadal-Ginard B, J. Biological Chemistry; 266(27):18308-18312
• Skeletal actin mRNA increases in the human heart during ontogenic development and is the major isoform of control and failing adult hearts.  
  Boheler KR, Carrier L, Bastie D, Allen PD, Komajda M, Mercadier JJ, Schwartz K, J. Clin. Inv; 88:323-30
• Troponin T isoform expression in humans. A comparison among normal and failing adult heart, fetal heart, and adult and fetal skeletal muscle.  
  Anderson PAW, Malouf NN, Oakeley AE, Pagani ED, Allen PD, Circ. Res; 69(5):1226-33
• EU 4093 decreases intracellular [Ca2+] in skeletal muscle fibers from control and malignant hyperthermia - susceptible swine.  
  Allen PD, Lopez JR, Sanchez V, Alamo L, Ryan JF, Sreter FA, Anesthesiology; 76:132-138
• Effects of dantrolene on myoplasmic free [Ca2+] measured in vivo in patients susceptible to malignant hyperthermia.  
  Lopez JR, Gerardi A, Lopez MJ, Allen PD, Anesthesiology; 76:711-719
• Altered Myocardial Force-Frequency Relation in Human Heart Failure.  
  Mulieri LA, Hasenfuss G, Leavitt B, Allen PD, Alpert NR, Circulation; 85(5):1-8
• Na, K-ATPase expression in normal and failing human left ventricle.  
  Allen PD, Schmidt TA, Marsh JD, Kjeldsen K, Basic Res Cardiol; 87(1): 87-94
• Contractile protein function in failing and nonfailing human myocardium.  
  Hasenfuss G, Mulieri LA, Leavitt BJ, Allen PD, Holubarsch C, Just H, Alpert NR, Basic Res Cardiol; 87(1):107-116
• Troponin T isoform expression in the normal and failing human left ventricle: a correlation with myofibrillar ATPase activity.  
  Anderson PAW, Malouf NN, Oakley AE, Pagani ED, Allen PD, Basic Res Cardiol; 87(1):117-127
• Contraction frequency dependence of twitch and diastolic tension in human dilated cardiomyopathy (Tension-frequency relation in cardiomyopathy).  
  Mulieri LA, Leavitt BJ, Hasenfuss G, Allen PD, Alpert NR, Basic Res Cardiol; 87(1):199-212
• Expression of A-, B- and C-type natiuretic peptide genes in the failing and developing human ventricles: comparison with expression of other cardiac genes.  
  Takahashi T, Allen PD, Izumo S, Circ. Res; 71(1):9-17
• Differences in Cardiac Calcium Release Channel (Ryanodine Receptor) Expression in Myocardium from Patients with End-Stage heart Failure Due to Ischemic Versus Dilated ...  
  Brillantes AM, Allen PD, Takahashi T, Izumo S, Marks, AR, Circ Res; 7(1):18-26
• Expression of dihydropyridine receptor (Ca2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure.  
  Takahashi T, Allen PD, Lacro, RV, Marks AR, Dennis AR, Schoen FJ, Grossman W, Marsh JD, Izumo S, J. Clin. Inv; 90:927-35
• Cellular Basis of the Negative Inotropic Effect of 2,3-Butanedione Monoxime in Human Myocardium.  
  Perrault CL, Mulieri LA, Alpert NR, Ransil BJ, Allen PD, Morgan JP, Am J Phys; 263:H503-510
• Negative inotropic and relaxant effects of cocaine on myopathic human ventricular myocardium and epicardial coronary arteries, in vitro.  
  Perreault CL, Hague NL, Morgan KG, Allen PD, Morgan JP, Cardiovascular Research; 27:262-268
• No Adaptation to Digitalization as Evaluated by Digitalis Receptor (Na-K ATPase) quantification in explanted hearts from Donors without heart disease and from Digitali...  
  Schmidt, T.A., Allen, P.D., Colucci, W.S., Marsh, J.D., and Keldsen,K, Am J Car; 71:110-114
• Effect of calcium binding protein modulators on myofibrillar MgATPase activity and cGMP-inhibitable phosphodiesterase activity from human cardiac muscle.  
  Pagani ED, O'Connor B, Allen PD, Hille D, Silver PJ, Drug Dev Res; 29:195-202
• Differences in cardioprotective efficacy of adrenergic receptor antagonists and Ca2+ channel antagonists in an animal model of dilated cardiomyopathy: Effects on gros...  
  Glass MG, Fuleihan F, Liao R, Lincoff AM, Chapados R, Hamlin R, Apstein CS, Allen PD, Ingwall JS, Hajjar RJ, Gwathmey JK, Circ Res; 73(6):1077-1089
• Changes in intracellular Ca2+ concentration induced by inositol 1,4,5 trisphosphate in human malignant hyperthermia skeletal muscle.  
  Lopez JR, Perez C, Alfonzo M, Cordovez G, Linares N, Allen PD, Biophys. (Life Sci. Adv.); 12:131-40
• Effects of inositol 1,4,5 triphosphate on free myoplasmic calcium concentration in malignant hyperthermia patients.  
  Lopez JR, Perez C, Allen P, Alfonzo M, and Linares N, Acta Anaesth Latinoamericana, 56:234-246
• Abnormal Ca2+ release induced by inositol 1,4,5 trisphosphate in malignant hyperthermia skeletal muscle.  
  Lopez JR, Perez C, Allen PD, Minerva Anestesiologicas Italica: 60:141-145
• Myoplasmic Calcium Changes Precede Metabolic and Clinical Signs of Porcine Malignant Hyperthermia.  
  Ryan JF, Lopez JR, Sanchez VB, Sreter FA, Allen PD, Anesth Analg, 79:1007-11
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Books/Book Chapters

• Emergency Medical Procedures. 
  Chapter: Airway Management 
  Page 1 - 43Allen PDEditors: May HL.John Wiley & Sons, New York
• Vivo, En Porcinos Susceptibles Al Sindrome De Hipertermia Maligna Acta Cientifica Venezolana. 
  Chapter: Determinacion De La Concentracion De Calcio Libre Intracelular 
  Page 102 - 104Lopez JR, Alamo LA, Jones D, Papp L, Allen PD, Gergely J, Sreter FA
• Emergency Medical Procedures. 
  Chapter: Airway Management 
  Page 1 - 48Allen PDEditors: May HL.John Wiley & Sons, New York
• Actin-binding proteins and disease. 
  Chapter: Actin and its binding proteins in heart failure 
  Page 318 - 334M Stefani, M Tsubakihara, P D Allen, P S Macdonald, C G dos RemediosEditors: C G dos Remedios and D. Chhabra.Springer
• Heart Failure, Basic Science and Clinical Aspects. 
  Chapter: Alterations in calcium transport in failing human myocardium 
  Gwathmey J and Allen PDEditors: Gwathmey J, Briggs M and Allen PD.Marcell Deckker, New York
• Principles of Endosurgery. 
  Chapter: Anesthesia for Minimally Invasive Surgery 
  Page 54 - 71Allen, PDEditors: Kevin R. Loughlin and David C. Brooks.Blackwell Science
• Calcium Signaling, NATO Sciences series I: Life and Behavioural Sciences. 
  Chapter: The structural basis for RyR-DHPR interactions in muscle cells 
  Page 14 - 21Franzini- Armstrong, C., Feliciano Protasi, F., Allen, P.DEditors: M. Morad and P. Kostyuk.
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Abstracts/Posters

• The mechanical properties of in situ dog skeletal muscle.
  Allen PD, University of Florida, Doctoral Dissertation, Gainesville, Florida
• How do humoral agents impact on anesthesia? Endorphins.
  Allen PD, ASA Refresher Course

Lectures

• Protection of Human Subjects. 
  Biotechnology Symposium, Kuala Lumpur/Penang, Malaysia
• Structure-Function of Ryanodine Receptors. 
  Cardiac Regulatory Mechanisms Gordon Conference, Colby Sawyer College, Plymouth NH
• RyR1-DHPR interactions. 
  International Workshop on Calcium Signaling Proteins, Marbella, Chile
• E-C coupling, Signaling Among Proteins. 
  Satellite Meeting on EC coupling, Heron Island, Australia
• RyR-DHPR interactions A. 
  NATO conference on Ca2+ Signalling, Il Choicco Italy
• Knockout and Expression of RyR-1. 
  The 1st K-JIST International Symposium on Life Science Kwangju, Korea
• 1B5 cells as a model for skeletal EC coupling. 
  Gordon Conference on Excitation Contraction Coupling
• RyR1 deficient mice produce defective skeletal muscle. 
  International Symposia on Malignant Hyperthermia, Minneapolis Minnesota
• Measurements of Intracellular Free Calcium in MH Susceptible Swine. 
  International Symposium on Malignant Hyperthermia, York, England
• Malignant Hyperthermia. 
  Multiple locations, 1987, 1989, 1995, 1996, 1997
• Mechanisms of Anesthetic Induced Cardiac Depression. 
  Latin American Congress of Anesthesia, Caracas Venezuela
• Thin Section SR Calcium Uptake as a Diagnostic Test for MH. 
  International Symposium on Malignant Hyperthermia, Philadelphia, PA
• How do Humoral agents impact on anesthesia? Endorphins. 
  ASA Annual Meeting, Atlanta, GA
• Effects of Fiber Type on Caffeine Contracture. 
  International Symposium on Malignant Hyperthermia, Banff, Alberta, Canada
• Opiates and Opiate Receptors. 
  Connecticut Society of Anesthesia Annual Refresher Course, Waterbury CT
• Pediatric Anesthesia. 
  Pan American Congress of Anesthesia, Puerta La Cruz, Venezuela
• The Promoter Region of the Rat 1 NAKA Gene. 
  International Symposium on Heart Failure, Jouy-en-Jossas, France
• Differences between Fura2 vs Microelectrode Measurements of Intracellular Free Calcium in MH Susceptible Swine. 
  International Symposia on Malignant Hyperthermia, Munich Germany
• Alterations in Na+-K+ ATPase in the Failing Human Heart. 
  Cell and Mol Alterations in the Failing Heart, Gargellen, Austria
• The Difference in InsP3 Effects in Normal and MH Susceptible Individuals. 
  Multiple locations, 1992
• Malignant Hyperthermia: An Anesthetic Nightmare—Causes, Diagnosis and Treatment. 
  Multiple locations, 2012
• Control of Intracellular Ca2+ in Skeletal Muscle: Inside or Outside? 
  Multiple locations, 2012
• Molecular Mechanisms Causing Malignant Hyperthermia. 
  17th International Congress of Biophysics, Bejing, China
• Altered Communication Between Cav1.1 and RyR1 in MH. 
  Malignant Hyperthermia (MH): New Insights and Connections with Other Myopathies, Pittsburgh PA
• Systems Approach to Understanding Cardiac E-C Coupling. 
  UC Davis Cardiovascular Symposium, Davis CA
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