PaulDBrownMD

Radiation Oncology • Rochester, MN

Benign Diseases, Central Nervous System Cancer, Skin Cancer

Professor

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Office
200 1st Street SW
Rochester, MN 55905
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Summary

Dr. Paul Brown is a radiation oncologist in Rochester, MN and is affiliated with Mayo Clinic Hospital - Rochester. He has been in practice 19 years. He specializes in brain metastases and benign diseases and is experienced in primary brain tumors.

Education & Training

Mayo Clinic College of Medicine and Science (Rochester)Residency, Radiation Oncology, 1996 - 2000
Mayo Clinic College of Medicine and Science (Rochester)Internship, Internal Medicine, 1995 - 1996
University of North Dakota School of Medicine and Health SciencesClass of 1995

Certifications & Licensure

MT State Medical License 2020 - 2026
TX State Medical License 2010 - 2025
MN State Medical License 1996 - 2024
WY State Medical License 1999 - 2024
MI State Medical License 2020 - 2023
WI State Medical License 2004 - 2013
FL State Medical License 2001 - 2011
American Board of Radiology Radiation Oncology

Clinical Trials

Temozolomide and Radiation Therapy in Treating Patients With Stage IV Malignant Melanoma With Measurable and Unresectable Cancer of the Central Nervous System Start of enrollment: 2004 Jan 01
Terminated
Phase 2
Temsirolimus, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Start of enrollment: 2006 May 01
Completed
Phase 1
Stereotactic Radiation Therapy With or Without Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases Start of enrollment: 2006 Jul 01
Completed
Phase 3
Evaluation of Single Session Stereotactic Body Radiotherapy Start of enrollment: 2005 Oct 01
Active, not recruiting
Phase 1, Phase 2
Evaluation of a Novel CT-On-Rails or Trilogy Stereotactic Spine Radiotherapy System (SSRS) Start of enrollment: 2002 Oct 25
Active, not recruiting
Phase 1, Phase 2
Everolimus, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Start of enrollment: 2009 Mar 01
Completed
Phase 1, Phase 2
Memantine in Preventing Side Effects in Patients Undergoing Whole-Brain Radiation Therapy for Brain Metastases From Solid Tumors Start of enrollment: 2008 Mar 01
Completed
Phase 3
Improving the Selection of Patients With Glioblastoma Multiforme for Treatment With Epidermal Growth Factor Receptor Inhibitor Therapies Start of enrollment: 2006 Nov 01
Completed
High Dose Intensity Modulated Proton Radiation Treatment +/- Surgical Resection of Sarcomas of the Spine, Sacrum and Base of Skull Start of enrollment: 2012 Dec 01
Active, not recruiting
Not Applicable
Stereotactic Radiosurgery or Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases That Have Been Removed By Surgery Start of enrollment: 2011 Jul 01
Completed
Phase 3
A Prospective Study Using Implanted Fiducial Markers to Assess Treatment Accuracy and Esophageal Toxicity in Spinal Stereotactic Body Radiation Therapy Start of enrollment: 2012 Jun 18
Completed
Not Applicable
Glioblastoma Multiforme (GBM) Proton vs. Intensity Modulated Radiotherapy (IMRT) Start of enrollment: 2013 May 17
Completed
Phase 2
Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease Start of enrollment: 2019 Oct 11
Active, not recruiting
Phase 3
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Publications & Presentations

PubMed

Assessment of minimum target dose as a predictor of local failure after spine SBRT.
Roman O Kowalchuk, Trey C Mullikin, Grant M Spears, Benjamin A Johnson-Tesch, Peter S Rose, Brittany L Siontis, Dong Kun Kim, Brian A Costello, Jonathan M Morris, Robe...> ;Radiotherapy and Oncology. 2024 Mar 27
Hypofractionated Stereotactic Radiosurgery in the Management of Brain Metastases.
Eric J Lehrer, William G Breen, Raj Singh, Joshua D Palmer, Paul D Brown, Daniel M Trifiletti, Jason P Sheehan> ;Neurosurgery. 2024 Mar 21
Pre-operative vs. post-operative stereotactic radiosurgery for operative metastatic brain tumors: study protocol for a phase III clinical trial.
David M Routman, Ignacio Jusue-Torres, Paul D Brown, Daniel M Trifiletti, Sujay A Vora, Desmond A Brown, Ian F Parney, Terry C Burns, Elizabeth Yan> ;BMC Cancer. 2024 Mar 12
Proton versus photon craniospinal irradiation for adult medulloblastoma: A dosimetric, toxicity, and exploratory cost analysis.
Connie S Geno, Jing Qian, William S Harmsen, Michael W Ruff, Jon J Kruse, William G Breen, Mark R Waddle, Terry C Burns, Ugur T Sener, Joon H Uhm, David M Routman, Eli...> ;Neuro-Oncology Advances. 2024 Mar 8
Estimating the risk of brain metastasis for patients newly diagnosed with cancer.
Palmer, J. D., Tian, Z., Lin, C., Wang, M., Miccio, J., Mahase, S., Choi, S., Zacharia, B., Sheehan, J., Brown, P., Trifiletti, D., Palmer, J., Zaorsky, N.> ;Communications Medicine. 2024 Feb 22
Analysis of demographics and the impact of adjuvant radiotherapy on a nationwide cohort of patients with high-grade spinal meningiomas.
El-Hajj, V., Ghaith, A., Nguyen, R., Al-Saidi, N., Hoang, H., Graepel, S., Elmi-Terander, A., Bydon, M., Lehrer, E., Brown, P.> ;Neuro-Oncology Advances. 2024 Feb 5
Proton Craniospinal Irradiation with Immunotherapy in Two Patients with Leptomeningeal Disease from Melanoma.
Sener, U., Webb, M., Breen, W., Neth, B., Laack, N., Routman, D., Brown, P., Mahajan, A., Frechette, K., Dudek, A., Markovic, S., Block, M., McWilliams, R., Dimou, A.,...> ;Journal of Immunotherapy and Precision Oncology. 2024 Feb 1
3 citations
Where Do We (INDI)GO From Here?
Yu, J., Cheng, S., Kinslow, C., Brown, P., Iwamoto, F., Wu, C., Wang, T.> ;International Journal of Radiation Oncology, Biology, Physics. 2024 Feb 1
Evaluating the sensitivity of EQ-5D-5L in patients with brain metastases: a secondary analysis of NRG CC001.
Qu, M., Zafari, Z., Bentzen, S., Armstrong, T., Cherng, H., Gondi, V., Brown, P., Mehta, M., Mishra, M.> ;Journal of the National Cancer Institute. 2024 Jan 27
Chemoimmunotherapy for Untreated Lung Cancer Brain Metastases: A Reason for Optimism While Avoiding Overreaching Interpretations.
Lehrer, E., Trifiletti, D., Fadul, C., Brown, P., Sheehan, J.> ;Journal of Clinical Oncology. 2024 Mar 1
Evaluating the Heterogeneity of Hippocampal Avoidant Whole Brain Radiotherapy Treatment Effect: A Secondary Analysis of NRG CC001.
Sun, K., Bentzen, S., Armstrong, T., Cherng, H., Gondi, V., Brown, P., Mehta, M., Mishra, M.> ;Neuro-Oncology. 2023 Dec 9
A phase II clinical trial of frameless, fractionated stereotactic radiation therapy for brain metastases.
Amit K Garg, Mike Hernandez, Pamela J Schlembach, John R Bowers, Mary F McAleer, Paul D Brown, Ramesh Gopal, Lee Wiederhold, Todd Swanson, Shalin J Shah, Jing Li, Sher...> ;JNCI Cancer Spectrum. 2023 Oct 31
5 citations
Sustained Preservation of Cognition and Prevention of Patient-Reported Symptoms With Hippocampal Avoidance During Whole-Brain Radiation Therapy for Brain Metastases: F...
Baschnagel, A., Vinai Gondi, Snehal Deshmukh, Paul D Brown, Jeffrey S Wefel, Terri S Armstrong, Wolfgang A Tome, Mark R Gilbert, Andre Konski, Clifford G Robinson, Jos...> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Nov 1
Lower Cranial Nerve Schwannomas: Cohort Study and Systematic Review.
Lucas P Carlstrom, Megan M J Bauman, Soliman Oushy, Avital Perry, Paul D Brown, Maria Peris-Celda, Jamie J Van Gompel, Christopher S Graffeo, Michael J Link> ;Neurosurgery. 2024 Apr 1
1 citations
The incorporation of cognitive-sparing techniques into prophylactic cranial irradiation in the management of small cell lung cancer.
Julie R Bloom, Alexandra Hotca, Daniel R Cherry, Daniel R Dickstein, Juliana Runnels, Robert M Samstein, Rajwanth R Veluswamy, Kenneth E Rosenzweig, Paul D Brown, Dani...> ;Chinese Clinical Oncology. 2023 Aug 1
Dosimetric patterns of failure in the era of novel chemoradiotherapy in newly-diagnosed glioblastoma patients.
Maasa H Seaberg, Tomas Kazda, Ryan S Youland, Nadia N Laack, Deanna H Pafundi, S Keith Anderson, Jann N Sarkaria, Evanthia Galanis, Paul D Brown, Debra H Brinkmann> ;Radiotherapy and Oncology. 2023 Nov 1
2 citations
Comparison of first-line radiosurgery for small-cell and non-small cell lung cancer brain metastases (CROSS-FIRE).
Chad G Rusthoven, Alyse W Staley, Dexiang Gao, Shoji Yomo, Denise Bernhardt, Narine Wandrey, Rami El Shafie, Anna Kraemer, Oscar Padilla, Veronica Chiang, Andrew M Far...> ;Journal of the National Cancer Institute. 2023 Aug 8
2 citations
Contemporary radiotherapy and radiosurgery techniques for refractory pituitary adenomas.
Roman O Kowalchuk, Daniel M Trifiletti, Paul D Brown, Jason P Sheehan> ;Pituitary. 2023 Jun 1
18 citations
Alliance A071401: Phase II Trial of Focal Adhesion Kinase Inhibition in Meningiomas With SomaticMutations.
Priscilla K Brastianos, Erin L Twohy, Elizabeth R Gerstner, Timothy J Kaufmann, A John Iafrate, Jochen Lennerz, Suriya Jeyapalan, David E Piccioni, Varun Monga, Camilo...> ;Journal of Clinical Oncology. 2023 Jan 20
4 citations
Genomic markers of recurrence risk in atypical meningioma following gross total resection.
Rachael A Vaubel, Rahul Kumar, Taylor M Weiskittel, Sarah Jenkins, Surendra Dasari, Joon H Uhm, Daniel H Lachance, Paul D Brown, Jamie J Van Gompel, Robert B Jenkins, ...> ;Neuro-Oncology Advances. 2023 Jan 10
1 citations
Development and validation of a unifying pre-treatment decision tool for intracranial and extracranial metastasis-directed radiotherapy.
Roman Kowalchuk, Trey C Mullikin, William Breen, Hunter C Gits, Marcus Florez, Brian De, William S Harmsen, Peter Sean Rose, Brittany L Siontis, Brian A Costello, Jona...> ;Frontiers in Oncology. 2023 Jan 1
1 citations
A Prospective Study of Conventionally Fractionated Dose Constraints for Reirradiation of Primary Brain Tumors in Adults.
Susan L McGovern, Dershan Luo, Jason Johnson, Kham Nguyen, Jing Li, Mary Frances McAleer, Debra Yeboa, David R Grosshans, Amol J Ghia, Caroline Chung, Andrew J Bishop,...> ;Practical Radiation Oncology. 2022 Dec 31
3 citations
Development and validation of a recursive partitioning analysis-based pretreatment decision-making tool identifying ideal candidates for spine stereotactic body radiat...
Roman O Kowalchuk, Trey C Mullikin, Marcus Florez, Brian S De, Grant M Spears, Peter S Rose, Brittany L Siontis, Dong Kun Kim, Brian A Costello, Jonathan M Morris, Jos...> ;Cancer. 2023 Mar 15
1 citations
Association of circulating markers with cognitive decline after radiation therapy for brain metastasis.
Kristin Huntoon, S Keith Anderson, Karla V Ballman, Erin Twohy, Katharine Dooley, Wen Jiang, Yi An, Jing Li, Christina von Roemeling, Yaqing Qie, Owen A Ross, Jane H C...> ;Neuro-Oncology. 2023 Jun 2
23 citations
Association of Long-term Outcomes With Stereotactic Radiosurgery vs Whole-Brain Radiotherapy for Resected Brain Metastasis: A Secondary Analysis of The N107C/CEC.3 (Al...
Joshua D Palmer, Brett G Klamer, Karla V Ballman, Paul D Brown, Jane H Cerhan, S Keith Anderson, Xiomara W Carrero, Anthony C Whitton, Jeffrey Greenspoon, Ian F Parney...> ;JAMA Oncology. 2022 Dec 1
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Journal Articles

Brain Metastases: Fractionated Whole-Brain Radiotherapy
Paul Brown, MD, ScienceDirect
Influence of Residual Disease Following Surgical Resection in Newly Diagnosed Glioblastoma on Clinical, Neurocognitive, and Patient Reported Outcomes
Mark R Gilbert, Kevin S Roof, Paul D Brown, Samuel T Chao, William A Hall, Terri S Armstrong, Minesh P Mehta, Benjamin Movsas, Jeffrey S Wefel, David G Brachman, Merid..., Neurosurgery

Press Mentions

Radiotherapy for Brain Metastases: ASTRO Updates GuidelinesJune 10th, 2022
New Guideline Provides Guidance on the Use of Radiation Therapy to Treat Patients with Brain MetastasesMay 10th, 2022
Avoiding Hippocampus in Brain RT May Help Preserve Cognitive FunctionAugust 13th, 2021
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