PaulaMBokeschMD

Anesthesiology • Lexington, MA

Cardiothoracic Anesthesiology, Pediatric Anesthesiology

Adjunct Assistant Professor, Anesthesiology, Tufts Medical Center

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Office
65 Hayden Ave
Lexington, MA 02421
Phone+1 781-290-9939

Fax+1 781-240-0562
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Education & Training

University of North Carolina HospitalsResidency, Anesthesiology, 1978 - 1981
Wake Forest School of Medicine of Wake Forest Baptist Medical CenterClass of 1978

Certifications & Licensure

MA State Medical License 1982 - 2024
OH State Medical License 1995 - 2023
IL State Medical License 2008 - 2011
GA State Medical License 2003 - 2005
NC State Medical License 1978 - 2002
American Board of Anesthesiology Anesthesiology

Clinical Trials

A Research Study to Evaluate the Effectiveness of Dexmedetomidine in Preventing Delirium After Heart Surgery Start of enrollment: 2007 Apr 01
Withdrawn
Phase 3
Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE) Start of enrollment: 2009 Feb 13
Terminated
Phase 4
Pharmacokinetics (PK) and Safety Evaluation of Daptomycin in Children Ages 3-24 Months With Proven or Suspected Gram-positive Infections or Peri-Operative Subjects Receiving Prophylactic Antibiotics Start of enrollment: 2010 Jan 05
Completed
Phase 1
Study Comparing Cubicin With Vancomycin in Treatment of Participants With Complicated Skin and Skin Structure Infections in a Home Infusion Setting Start of enrollment: 2010 Jul 15
Terminated
Phase 4
Safety & Efficacy of Daptomycin Versus Standard of Care (SOC) in 1 - 17 Year Olds With Staphylococcus Aureus Bacteremia (MK-3009-005) Start of enrollment: 2012 Nov 29
Completed
Phase 4
Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006) Start of enrollment: 2013 Sep 13
Completed
Phase 3
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Publications & Presentations

PubMed

14 citations
Risk factors, resource use, and cost of postoperative low cardiac output syndrome.
Andra E. Duncan, Alex Kartashov, Scott B. Robinson, Doug Randall, Kan Zhang, John Luber, Roberta James, Sven Halvorson, Paula M. Bokesch> ;The Journal of Thoracic and Cardiovascular Surgery. 2020 Jul 16
8 citations
Daptomycin for Pediatric Gram-Positive Acute Hematogenous Osteomyelitis.
John S. Bradley, Antonio Arrieta, Valeri A Digtyar, Myra W. Popejoy, Anjana Grandhi, Paula M. Bokesch, Ellie Hershberger, Mary Beth Dorr, Christopher M. Tan, Yoshihiko...> ;The Pediatric Infectious Disease Journal. 2020 Jun 16
21 citations
Randomized Multicenter Study Comparing Safety and Efficacy of Daptomycin Versus Standard-of-care in Pediatric Patients With Staphylococcal Bacteremia.
Antonio Arrieta, John S. Bradley, Myra W. Popejoy, Mekki Bensaci, Anjana Grandhi, Paula M. Bokesch, Chad Glasser, Lihong Du, Hernando Patino, Nicholas A. Kartsonis> ;The Pediatric Infectious Disease Journal. 2018 Sep 1
25 citations
Daptomycin for Complicated Skin Infections: A Randomized Trial
John S. Bradley, Chad Glasser, Hernando Patino, Sandra R. Arnold, Antonio Arrieta, Blaise L. Congeni, Robert S. Daum, Tsoline Kojaoghlanian, Minjung Yoon, Diane Anasta...> ;Pediatrics. 2017 Mar 1
19 citations
Levosimendan in patients with left ventricular systolic dysfunction undergoing cardiac surgery on cardiopulmonary bypass: Rationale and study design of the Levosimenda...
Rajendra H. Mehta, Sean van Diepen, James M. Meza, Paula M. Bokesch, Jeffrey D. Leimberger, Sandra Tourt-Uhlig, Merri Swartz, Jodi Parrotta, Rachael Jankowich, Douglas...> ;American Heart Journal. 2016 Dec 1
22 citations
Single-dose pharmacokinetics of daptomycin in pediatric patients 3-24 months of age.
John S. Bradley, David Benziger, Paula M. Bokesch, Richard F. Jacobs> ;The Pediatric Infectious Disease Journal. 2014 Sep 1
26 citations
A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardi...
Paula M. Bokesch, Gábor Szabó, Ryszard Wojdyga, Hilary P. Grocott, Peter K. Smith, C. David Mazer, Santosh Vetticaden, Alistair Wheeler, Jerrold H. Levy> ;The Journal of Thoracic and Cardiovascular Surgery. 2012 May 1
304 citations
Delirium Duration and Mortality in Lightly Sedated, Mechanically Ventilated Intensive Care Patients
Yahya Shehabi, Richard R. Riker, Paula M. Bokesch, Wayne Wisemandle, Ayumi Shintani, E. Wesley Ely> ;Critical Care Medicine. 2010 Dec 1
53 citations
A Phase IIIb, randomized, double-blind, placebo-controlled, multicenter study evaluating the safety and efficacy of dexmedetomidine for sedation during awake fiberopti...
Sergio D. Bergese, Keith A. Candiotti, Paula M. Bokesch, Andrew Zura, Wayne Wisemandle, Alex Bekker> ;American Journal of Therapeutics. 2010 Nov 1
90 citations
A cost-minimization analysis of dexmedetomidine compared with midazolam for long-term sedation in the intensive care unit*
Joseph F. Dasta, Sandra L. Kane-Gill, Michael J. Pencina, Yahya Shehabi, Paula M. Bokesch, Wayne Wisemandle, Richard R. Riker> ;Critical Care Medicine. 2010 Feb 1
156 citations
Monitored anesthesia care with dexmedetomidine: a prospective, randomized, double-blind, multicenter trial.
Keith A. Candiotti, Sergio D. Bergese, Paula M. Bokesch, Marc A. Feldman, Wayne Wisemandle, Alex Bekker> ;Anesthesia and Analgesia. 2010 Jan 1
1006 citations
Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial.
Richard R. Riker, Yahya Shehabi, Paula M. Bokesch, Daniel Ceraso, Wayne Wisemandle, Firas Koura, Patrick Whitten, Benjamin D. Margolis, Daniel W. Byrne, E. Wesley Ely,...> ;JAMA. 2009 Feb 4
15 citations
Perioperative course in 118 infants and children undergoing coarctation repair via a thoracotomy: a prospective, multicenter experience.
Sarah Tabbutt, Susan C. Nicolson, Troy E. Dominguez, Winfield J. Wells, Carl L. Backer, James S. Tweddell, Paula M. Bokesch, Mark S. Schreiner> ;The Journal of Thoracic and Cardiovascular Surgery. 2008 Nov 1
38 citations
The safety, efficacy, and pharmacokinetics of esmolol for blood pressure control immediately after repair of coarctation of the aorta in infants and children: a multic...
Sarah Tabbutt, Susan C. Nicolson, Peter C. Adamson, Xuemei Zhang, Marc L. Hoffman, Winfield J. Wells, Carl L. Backer, Francis X. McGowan, James S. Tweddell, Paula M. B...> ;The Journal of Thoracic and Cardiovascular Surgery. 2008 Aug 1
93 citations
Dosing of Clopidogrel for Platelet Inhibition in Infants and Young Children : Primary Results of the Platelet Inhibition in Children On cLOpidogrel (PICOLO) Trial
Jennifer S. Li, Eric Yow, Katherine Y. Berezny, Paula M. Bokesch, Matsato Takahashi, Thomas P. Graham, Stephen P. Sanders, Daniel Sidi, Damien Bonnet, Peter Ewert, Lis...> ;Circulation. 2008 Jan 29
101 citations
Clinical outcomes of palliative surgery including a systemic-to-pulmonary artery shunt in infants with cyanotic congenital heart disease: does aspirin make a difference?
Jennifer S. Li, Eric Yow, Katherine Y. Berezny, John F. Rhodes, Paula M. Bokesch, John R. Charpie, Geoffrey A. Forbus, Lynn Mahony, Lynn K. Boshkov, Virginie Lambert, ...> ;Circulation. 2007 Jul 17
30 citations
Perioperative Serum Interleukins in Neonates With Hypoplastic Left-Heart Syndrome and Transposition of the Great Arteries
Elumalai Appachi, Emad Mossad, Roger B.B. Mee, Paula M. Bokesch> ;Journal of Cardiothoracic and Vascular Anesthesia. 2007 Apr 1
5 citations
Untying the Gordian knot.
Paula M. Bokesch> ;Anesthesia and Analgesia. 2006 Jul 1
37 citations
NMDA Receptor Antibodies Predict Adverse Neurological Outcome After Cardiac Surgery in High-Risk Patients
Paula M. Bokesch, Galina A. Izykenova, Joseph B. Justice, Kirk A. Easley, Svetlana A. Dambinova> ;Stroke. 2006 Jun 1
29 citations
Increased Transcription Factor Expression and Permeability of the Blood Brain Barrier Associated With Cardiopulmonary Bypass in Lambs
Marco Cavaglia, Shivaprakash G. Seshadri, James E. Marchand, Carrie L. Ochocki, Roger B.B. Mee, Paula M. Bokesch> ;The Annals of Thoracic Surgery. 2004 Oct 1
58 citations
Soluble Human Complement Receptor 1 Limits Ischemic Damage in Cardiac Surgery Patients at High Risk Requiring Cardiopulmonary Bypass
Harold L. Lazar, Paula M. Bokesch, Frederick van Lenta, Carmel Fitzgerald, Constance D. Emmett, Henry C. Marsh, Una S. Ryan, Obe> ;Circulation. 2004 Sep 14
21 citations
Pharmacokinetics and safety of TP10, soluble complement receptor 1, in infants undergoing cardiopulmonary bypass.
Jennifer S. Li, Stephen P. Sanders, April Perry, Sandra S. Stinnett, James Jaggers, Paula M. Bokesch, Laurie Reynolds, Rashid Nassar, Page A.W. Anderson> ;American Heart Journal. 2004 Jan 1
10 citations
Serum creatinine and estimated creatinine clearance do not predict perioperatively measured creatinine clearance in neonates undergoing congenital heart surgery.
A. Marc Harrison, Steve Davis, Suzanne Eggleston, Robert J. Cunningham, Roger B.B. Mee, Paula M. Bokesch> ;Pediatric Critical Care Medicine. 2003 Jan 1
26 citations
A glial-derived protein, S100B, in neonates and infants with congenital heart disease: evidence for preexisting neurologic injury.
Paula M. Bokesch, Elumalai Appachi, Marco Cavaglia, Emad B. Mossad, Roger B.B. Mee> ;Anesthesia and Analgesia. 2002 Oct 1
208 citations
Regional variation in brain capillary density and vascular response to ischemia.
Marco Cavaglia, Stephen M. Dombrowski, Judith A. Drazba, Amit Vasanji, Paula M. Bokesch, Damir Janigro> ;Brain Research. 2001 Aug 10
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Press Mentions

Tenax Therapeutics Issues Employment Inducement Award with Appointment of Paula Bokesch, M.D., as Chief Medical OfficerFebruary 20th, 2015
Tenax Therapeutics Announces Appointment of Paula Bokesch, M.D., as Chief Medical OfficerFebruary 3rd, 2015

Hospital Affiliations

St. Elizabeth's Medical CenterBrighton, Massachusetts