PhilipCrawfordAmreinMD

Oncology • Boston, MA

Hematologic Oncology

Assistant Professor of Medicine, Massachusetts General Hospital

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Office
55 Fruit St Yaw 7
Hematology Oncology
Boston, MA 02114
Phone+1 617-726-8748

Fax+1 617-643-1915
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Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Dana-Farber Cancer InstituteFellowship, Hematology and Medical Oncology, 1977 - 1980
Yale-New Haven Medical Center (Waterbury)Residency, Internal Medicine, 1974 - 1977
Johns Hopkins University School of MedicineClass of 1974

Certifications & Licensure

MA State Medical License 1979 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Teaching Award APP Group at MGH, 2021
The One Hundred MGH Cancer Center, 2016
Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2012

Clinical Trials

Paclitaxel and Radiation Therapy Plus Chemoprotection With Amifostine in Treating Patients With Stage III or Stage IV Head and Neck Cancer Start of enrollment: 1998 Jan 01
Completed
Phase 1, Phase 2
Dasatinib in Relapsed Chronic Lymphocytic Leukemia Start of enrollment: 2006 Dec 01
Completed
Phase 2
VELCADE in Combination With Idarubicin and Cytosine Arabinoside in Patients With Acute Myelogenous Leukemia Start of enrollment: 2003 Jul 01
Completed
Phase 1
Study of Cordycepin Plus Pentostatin in Patients With Refractory TdT-Positive Leukemia Start of enrollment: 2008 Jun 01
Unknown status
Phase 1, Phase 2
Dasatinib With Fludarabine and Rituximab in Relapsed and Refractory CLL and SLL Start of enrollment: 2010 Jul 01
Terminated
Phase 2
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Publications & Presentations

PubMed

4 citations
Multicenter Phase I Trial of Ivosidenib as Maintenance Treatment Following Allogeneic Hematopoietic Cell Transplantation for IDH1-Mutated Acute Myeloid Leukemia.
Amir T Fathi, Haesook T Kim, Robert J Soiffer, Mark J Levis, Shuli Li, Annette S Kim, Zachariah DeFilipp, Areej El-Jawahri, Steve L McAfee, Andrew M Brunner, Philip C ...> ;Clinical Cancer Research. 2023 Jun 1
4 citations
Ixazomib in addition to chemotherapy for the treatment of acute lymphoblastic leukemia in older adults.
Philip Amrein, Karen Ballen, Kristen Stevenson, Andrew Brunner, Gabriela Hobbs, Hanno Hock, Steven McAfee, Jenna Moran, Meghan Bergeron, Julia Foster, Christina Bertol...> ;Leukemia & Lymphoma. 2022 Jun 1
A nonrandomized phase I and biomarker trial of regorafenib in advanced myeloid malignancies.
How, J., Ren, S., Lombardi-Story, J., Bergeron, M., Foster, J., Amrein, P., Brunner, A., Fathi, A., Hock, H., Khachatryan, A., Kikuchi, H., Ng, M., Moran, J., Narayan,...> ;Ejhaem. 2022 May 1
1 citations
Chemotherapy Resistance in B-ALL with Cryptic NUP214-ABL1 Is Amenable to Kinase Inhibition and Immunotherapy.
Valentina Nardi, Steven L McAfee, Paola Dal Cin, Harrison K Tsai, Philip C Amrein, Gabriela S Hobbs, Andrew M Brunner, Julia Foster, Amir T Fathi, Hanno Hock, Narayan, R.> ;The Oncologist. 2022 Mar 4
1 citations
Low-dose dasatinib: when less can be more.
Philip C. Amrein> ;The Lancet. Haematology. 2021 Dec 1
1 citations
Case 33-2021: A 68-Year-Old Man with Painful Mouth Ulcers.
Sook-Bin Woo, Markus Wu, Nathaniel S. Treister, Philip C Amrein, Daniela Kroshinsky, Robert P. Hasserjian> ;The New England Journal of Medicine. 2021 Oct 28
Arsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia
Ashley Ott, Vinayak Venkataraman, Yousef R. Badran, Rose H. Goldman, Smiljana Spasic, Darshali A. Vyas, Philip C. Amrein, Steven L. McAfee, Andrew M. Brunner, Amir T. ...> ;Clinical Case Reports. 2021 May 1
2 citations
Incidence of Invasive Fungal Infections in Acute Myeloid Leukemia Without Antifungal Prophylaxis
Jessie Signorelli, Matthew Lei, Jenna Lam, Marla M. Jalbut, Philip C. Amrein, Amir T. Fathi, Gabriela S. Hobbs, Hanno Hock, Steven L. McAfee, Alyssa R. Letourneau, Rup...> ;Clinical Lymphoma, Myeloma & Leukemia. 2020 Nov 1
3 citations
Long: molecular tracking of CML with bilineal inv(16) myeloid and del(9) lymphoid blast crisis and durable response to CD19-directed CAR-T therapy.
Vinayak Venkataraman, Keagan S Casey, Maristela L. Onozato, Paola Dal Cin, Valentina Nardi, Philip C. Amrein, Meghan Bergeron, Andrew M. Brunner, Amir T. Fathi, Julia ...> ;Leukemia. 2020 Jul 16
20 citations
Alisertib Plus Induction Chemotherapy in Previously Untreated Patients With High-Risk, Acute Myeloid Leukaemia: A Single-Arm, Phase 2 Trial
Andrew M. Brunner, Traci M. Blonquist, Daniel J. DeAngelo, Malgorzata McMasters, Geoffrey Fell, Nicole M. Hermance, Eric S. Winer, R. Coleman Lindsley, Gabriela S. Hob...> ;The Lancet. Haematology. 2020 Feb 1
17 citations
Clinical response to larotrectinib in adult Philadelphia chromosome–like ALL with cryptic ETV6-NTRK3 rearrangement
Valentina Nardi, Nora Ku, Matthew J. Frigault, Adrian M. Dubuc, Harrison Tsai, Philip C. Amrein, Gabriela S. Hobbs, Andrew M. Brunner, Meghan Burke, Julia Foster, Paol...> ;Blood Advances. 2020 Jan 14
14 citations
A phase 1 study of the antibody-drug conjugate brentuximab vedotin with re-induction chemotherapy in patients with CD30-expressing relapsed/refractory acute myeloid le...
Rupa Narayan, Traci M. Blonquist, Ashkan Emadi, Robert P. Hasserjian, Meghan Burke, Christopher Lescinskas, Donna Neuberg, Andrew M. Brunner, Gabriela S. Hobbs, Hanno ...> ;Cancer. 2020 Mar 15
9 citations
Outcomes for older adults with acute myeloid leukemia after an intensive care unit admission
Samuel D. Slavin, Alyssa L. Fenech, Amanda L. Jankowski, Gregory A. Abel, Andrew M. Brunner, David P. Steensma, Amir T. Fathi, Daniel J. DeAngelo, Martha Wadleigh, Gab...> ;Cancer. 2019 Nov 1
5 citations
Cardiac and genetic predictors of cardiovascular risk in patients with myelodysplastic syndromes
Evan C. Chen, Lillian Werner, Gabriela S. Hobbs, Rupa Narayan, Philip C. Amrein, Amir T. Fathi, Andrew M. Brunner> ;Leukemia & Lymphoma. 2019 May 23
4 citations
Phase 1 study of lenalidomide, bendamustine, and rituximab in previously untreated patients with chronic lymphocytic leukemia.
Jacob D. Soumerai, Matthew S. Davids, Lillian Werner, David C. Fisher, Philippe Armand, Philip C. Amrein, Donna Neuberg, Ephraim P. Hochberg, Jennifer R. Brown, Jeremy...> ;Leukemia & Lymphoma. 2019 May 10
81 citations
An oral fixed-dose combination of decitabine and cedazuridine in myelodysplastic syndromes: a multicentre, open-label, dose-escalation, phase 1 study
Michael R. Savona, Olatoyosi Odenike, Philip C. Amrein, David P. Steensma, Amy E. DeZern, Laura C. Michaelis, Stefan Faderl, Wael Harb, Hagop M. Kantarjian, James N. L...> ;The Lancet. Haematology. 2019 Apr 1
39 citations
Quality of life and mood of older patients with acute myeloid leukemia (AML) receiving intensive and non-intensive chemotherapy.
Areej El-Jawahri, Gregory A. Abel, Lara Traeger, Lauren Waldman, Netana Markovitz, Harry VanDusen, Amir T. Fathi, David P. Steensma, Thomas W. LeBlanc, Nora Horick, Da...> ;Leukemia. 2019 Mar 28
20 citations
Isocitrate dehydrogenase 1 and 2 mutations, 2-hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia
Andrew M. Brunner, Donna Neuberg, Seth A. Wander, Hossein Sadrzadeh, Karen K. Ballen, Philip C. Amrein, Eyal C. Attar, Gabriela S. Hobbs, Yi-Bin Chen, Ashley M. Perry,...> ;Cancer. 2019 Feb 15
47 citations
Patient-Clinician Discordance in Perceptions of Treatment Risks and Benefits in Older Patients with Acute Myeloid Leukemia.
Areej El-Jawahri, Margaret Nelson-Lowe, Harry VanDusen, Lara Traeger, Gregory A. Abel, Joseph A. Greer, Amir T. Fathi, David P. Steensma, Thomas W. LeBlanc, Zhigang Li...> ;The Oncologist. 2019 Feb 1
2 citations
Early infectious complications among patients treated with induction compared to hypomethylating therapy for acute myeloid leukemia.
Marla M. Jalbut, Andrew M. Brunner, Philip C. Amrein, Karen K. Ballen, Gabriela S. Hobbs, Ashley M. Perry, Christelle Joseph, Amir T. Fathi> ;Leukemia & Lymphoma. 2018 Apr 1
12 citations
A phase I study of lenalidomide plus chemotherapy with mitoxantrone, etoposide, and cytarabine for the reinduction of patients with acute myeloid leukemia.
Daniel J. DeAngelo, Andrew M. Brunner, Lillian Werner, David Avigan, Amir T. Fathi, Adam S. Sperling, Abigail Washington, Dina Stroopinsky, Jacalyn Rosenblatt, Malgorz...> ;American Journal of Hematology. 2018 Feb 1
30 citations
Asparaginase Erwinia chrysanthemi effectively depletes plasma glutamine in adult patients with relapsed/refractory acute myeloid leukemia.
Ashkan Emadi, Jennie Y. Law, Erin T. Strovel, Rena G. Lapidus, Linda J. B. Jeng, Myounghee Lee, Miriam G. Blitzer, Brandon Carter-Cooper, Danielle Sewell, Isabella Van...> ;Cancer Chemotherapy and Pharmacology. 2018 Jan 1
43 citations
Risk and timing of cardiovascular death among patients with myelodysplastic syndromes.
Andrew M. Brunner, Traci M. Blonquist, Gabriela S. Hobbs, Philip C. Amrein, Donna Neuberg, David P. Steensma, Gregory A. Abel, Amir T. Fathi> ;Blood Advances. 2017 Oct 24
22 citations
Cabozantinib is well tolerated in acute myeloid leukemia and effectively inhibits the resistance-conferring FLT3/tyrosine kinase domain/F691 mutation.
Amir T. Fathi, Traci M. Blonquist, Daniela Hernandez, Philip C. Amrein, Karen K. Ballen, Malgorzata McMasters, David Avigan, Robin Joyce, Emma Logan, Gabriela S. Hobbs...> ;Cancer. 2018 Jan 15
30 citations
Association between insurance status at diagnosis and overall survival in chronic myeloid leukemia: A population‐based study
Ashley M. Perry, Andrew M. Brunner, Tao Zou, Kristin McGregor, Philip C. Amrein, Gabriela S. Hobbs, Karen K. Ballen, Donna Neuberg, Amir T. Fathi> ;Cancer. 2017 Jul 1
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