PhilipLCohenMD

Rheumatology • Philadelphia, PA

Physician

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Office
3401 N Broad St
Philadelphia, PA 19140
Phone+1 215-707-0791

Fax+1 215-707-3508
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Education & Training

University of Texas Southwestern Medical CenterFellowship, Rheumatology, 1976 - 1978
New York Presbyterian Hospital (Columbia Campus)Residency, Internal Medicine, 1975 - 1976
National Institutes of Health Clinical CenterFellowship, Allergy and Immunology, 1973 - 1975
New York Presbyterian Hospital (Columbia Campus)Internship, Internal Medicine, 1972 - 1973
Yale School of MedicineClass of 1972

Certifications & Licensure

PA State Medical License 1999 - 2024
NC State Medical License 1979 - 2000
TX State Medical License 1976 - 1979
NY State Medical License 1975 - 1978
DC State Medical License 1973 - 1976
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Rheumatology

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 1986
Super Doctor SuperDoctors.com
Fellow (FACR) American College of Rheumatology

Clinical Trials

Anti-CD20 Antibody Therapy for Sjogren's Syndrome Start of enrollment: 2004 Apr 01
Completed
Phase 1

Publications & Presentations

PubMed

6 citations
Fingolimod reduces salivary infiltrates and increases salivary secretion in a murine Sjögren's model.
Philip L. Cohen, Amanda McCulloch> ;Journal of Autoimmunity. 2020 Dec 1
21 citations
Gas6/TAM Receptors in Systemic Lupus Erythematosus.
Philip L. Cohen, Wen-Hai Shao> ;Disease Markers. 2019 Jul 9
14 citations
Antibody Cross-Linking of CD14 Activates MerTK and Promotes Human Macrophage Clearance of Apoptotic Neutrophils: the Dual Role of CD14 at the Crossroads Between M1 and...
Gaetano Zizzo, Philip L. Cohen> ;Inflammation. 2018 Dec 1
46 citations
Prion-like Aggregation of Mitochondrial Antiviral Signaling Protein in Lupus Patients Is Associated With Increased Levels of Type I Interferon.
Wen-Hai Shao, Daniel H. Shu, Yuxuan Zhen, Brendan Hilliard, Stephen O. Priest, Matteo Cesaroni, Jenny P.-Y. Ting, Philip L. Cohen> ;Arthritis & Rheumatology. 2016 Nov 1
15 citations
Stat1 Regulates Lupus-like Chronic Graft-versus-Host Disease Severity via Interactions with Stat3.
Wen-Hai Shao, Ana M. Gamero, Yuxuan Zhen, Monica J. Lobue, Stephen O. Priest, Hazem J. Albandar, Philip L. Cohen> ;Journal of Immunology. 2015 Sep 21
Comment on “Aminoacyl tRNA Synthetase–Interacting Multifunctional Protein 1 Acts as a Novel B Cell–Activating Factor In Vitro and In Vivo”
Philip L. Cohen> ;Journal of Immunology. 2015 Aug 15
65 citations
The PPAR-γ antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-γ in human macrophage polarization.
Gaetano Zizzo, Philip L. Cohen> ;Journal of Inflammation. 2015 May 3
21 citations
Monocyte and plasma expression of TAM ligand and receptor in renal failure: Links to unregulated immunity and chronic inflammation.
Iris J. Lee, Brendan Hilliard, Mehriban Ulas, Daohai Yu, Chandan Vangala, Swati Rao, Jean Lee, Crystal A. Gadegbeku, Philip L. Cohen> ;Clinical Immunology. 2015 Jun 1
7 citations
The Mertk receptor tyrosine kinase promotes T–B interaction stimulated by IgD B-cell receptor cross-linking
Wen-Hai Shao, Yuxuan Zhen, Fred D. Finkelman, Philip L. Cohen> ;Journal of Autoimmunity. 2014 Sep 1
23 citations
Genomic alterations in abnormal neutrophils isolated from adult patients with systemic lupus erythematosus
Namrata Singh, Pamela Traisak, Kayla A. Martin, Mariana J. Kaplan, Philip L. Cohen, Michael F. Denny> ;Arthritis Research & Therapy. 2014 Aug 8
95 citations
Hypoxia and hypoxia-inducible factor-1α provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis
Fanlei Hu, Rong Mu, Jiaxin Zhu, Lianjie Shi, Yingni Li, Xu Liu, Wenwei Shao, Gui-ye Li, Minghui Li, Yin Su, Philip L. Cohen, Xiaoyan Qiu, Zhanguo Li> ;Annals of the Rheumatic Diseases. 2014 May 1
21 citations
The role of tyrosine kinases in systemic lupus erythematosus and their potential as therapeutic targets.
Wen-Hai Shao, Philip L. Cohen> ;Expert Review of Clinical Immunology. 2014 Apr 16
30 citations
Increased expression of Mer tyrosine kinase in circulating dendritic cells and monocytes of lupus patients: correlations with plasma interferon activity and steroid th...
Brendan Hilliard, Gaetano Zizzo, Mehriban Ulas, Margaret K Linan, Jessica Schreiter, Philip L. Cohen> ;Arthritis Research & Therapy. 2014 Mar 21
10 citations
Persistence and selection of an expanded B-cell clone in the setting of rituximab therapy for Sjögren’s syndrome
Uri Hershberg, Wenzhao Meng, Bochao Zhang, Nancy Haff, E. William St. Clair, Philip L. Cohen, Patrice D. McNair, Ling-Ling Li, Marc C. Levesque, Eline T. Luning Prak> ;Arthritis Research & Therapy. 2014 Feb 11
64 citations
Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity
Gaetano Zizzo, Justus Guerrieri, Lindsay M Dittman, Joan T. Merrill, Philip L. Cohen> ;Arthritis Research & Therapy. 2013 Dec 10
96 citations
IL-17 Stimulates Differentiation of Human Anti-Inflammatory Macrophages and Phagocytosis of Apoptotic Neutrophils in Response to IL-10 and Glucocorticoids
Gaetano Zizzo, Philip L. Cohen> ;Journal of Immunology. 2013 May 15
75 citations
Rituximab Therapy for Primary Sjögren’s Syndrome: An Open-Label Clinical Trial and Mechanistic Analysis
E. William St. Clair, Marc C. Levesque, Eline T. Luning Prak, Frederick B. Vivino, Chacko J. Alappatt, Meagan E. Spychala, Josiah Wedgwood, James McNamara, Kathy L. Si...> ;Arthritis and Rheumatism. 2013 Apr 1
27 citations
Tuberous sclerosis and fulminant lupus in a young woman.
Namrata Singh, Mark Birkenbach, Tiffany Caza, Andras Perl, Philip L. Cohen> ;Journal of Clinical Rheumatology. 2013 Apr 1
4 citations
Intrinsic unresponsiveness of Mertk−/− B cells to chronic graft-versus-host disease is associated with unmodulated CD1d expression
Wen-Hai Shao, Yuxuan Zhen, Fred D. Finkelman, Robert A. Eisenberg, Philip L. Cohen> ;Journal of Autoimmunity. 2012 Dec 1
39 citations
Growth arrest-specific gene 6 (Gas6) levels are elevated in patients with chronic renal failure
Iris J. Lee, Brendan Hilliard, Abhishek Swami, John C. Madara, Swati Rao, Tapan P. Patel, John P. Gaughan, Jean Lee, Crystal A. Gadegbeku, Philip L. Cohen> ;Nephrology, Dialysis, Transplantation. 2012 Nov 1
400 citations
Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction
Gaetano Zizzo, Brendan Hilliard, Marc Monestier, Philip L. Cohen> ;Journal of Immunology. 2012 Oct 1
114 citations
The T cell in Sjogren's syndrome: force majeure, not spectateur.
Namrata Singh, Philip L. Cohen> ;Journal of Autoimmunity. 2012 Sep 1
25 citations
Living life without B cells: is repeated B-cell depletion a safe and effective long-term treatment plan for rheumatoid arthritis?
David R Chen, Philip L Cohen> ;International Journal of Clinical Rheumatology. 2012 Apr 1
11 citations
B-Cell Tolerance Defects in the B6.Aec1/2 Mouse Model of Sjögren’s Syndrome
Wenzhao Meng, Yongmei Li, Emily Xue, Minoru Satoh, Ammon B. Peck, Philip L. Cohen, Robert A. Eisenberg, Eline T. Luning Prak> ;Journal of Clinical Immunology. 2012 Feb 17
183 citations
Coordinate regulation of neutrophil homeostasis by liver X receptors in mice.
Cynthia Hong, Yoko Kidani, Noelia A-Gonzalez, Tram Phung, Ayaka Ito, Xin Rong, Katrin Ericson, Hanna K. A. Mikkola, Simon W. Beaven, Lloyd S. Miller, Wen-Hai Shao, Phi...> ;The Journal of Clinical Investigation. 2012 Jan 3
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Professional Memberships

American College of Rheumatology - ACR
Fellow

Hospital Affiliations

Temple University HospitalPhiladelphia, Pennsylvania