PhilipLouisMcCarthyMD

Hematology • Buffalo, NY

Hematologic Oncology

Professor of Oncology and Internal Medicine, Roswell Park Cancer Institute and SUNY at Buffalo School of Medicine

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Office
Elm And Carlton St
Buffalo, NY 14263
Phone+1 716-845-4074

Fax+1 716-845-3272
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Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Dana-Farber Cancer InstituteFellowship, Hematology and Medical Oncology, 1985 - 1989
Yale-New Haven Medical CenterResidency, Internal Medicine, 1982 - 1985
Tufts University School of MedicineClass of 1982

Certifications & Licensure

NY State Medical License 1996 - 2025
MA State Medical License 1987 - 2016
TX State Medical License 1992 - 2000
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Clinical Trials

Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer Start of enrollment: 1998 Oct 19
Completed
Phase 2, Phase 3
Peripheral Stem Cell Transplantation With or Without Stromagen Following Chemotherapy in Treating Women With Metastatic Breast Cancer Start of enrollment: 1998 Sep 01
Completed
Phase 1, Phase 2
Sargramostim in Reducing Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplantation for Hematologic Cancer or Aplastic Anemia Start of enrollment: 2002 Jun 01
Completed
Not Applicable
NMA Allogeneic Hematopoietic Cell Transplant in Hematologic Cancer/Disorders Start of enrollment: 2002 Jan 29
Completed
Phase 2
Donor Umbilical Cord Blood Transplantation in Treating Patients With Leukemia, Lymphoma, or Nonmalignant Hematologic Disorders Start of enrollment: 2003 Jan 01
Completed
Phase 2
Compassionate Use of Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Gastrointestinal Tract Start of enrollment: 2001 Mar 01
Completed
Not Applicable
High-Dose Chemotherapy, Total-Body Irradiation, and Autologous Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Hematologic Cancer or Solid Tumors Start of enrollment: 1991 Dec 01
Completed
Phase 2
Peripheral Blood Stem Cell Transplant vs Bone Marrow Transplant in Individuals With Hematologic Cancers (BMT CTN 0201) Start of enrollment: 2004 Jan 01
Completed
Phase 3
Lenalidomide in Treating Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplant Start of enrollment: 2004 Dec 15
Active, not recruiting
Phase 3
Safety and Efficacy Study of Adult Human Mesenchymal Stem Cells to Treat Acute Graft Versus Host Disease (GVHD) Start of enrollment: 2005 Apr 27
Completed
Phase 2
Fludarabine-based Conditioning for Severe Aplastic Anemia (BMT CTN 0301) Start of enrollment: 2006 Jan 01
Completed
Phase 1, Phase 2
Rituxan/BEAM vs Bexxar/BEAM in Autologous Hematopoietic Stem Cell Transplant for Non-Hodgkin's Lymphoma (BMTCTN0401) Start of enrollment: 2005 Dec 01
Completed
Phase 3
Study of Parathyroid Hormone Following Sequential Cord Blood Transplantation From an Unrelated Donor Start of enrollment: 2006 Sep 01
Terminated
Phase 2
Sirolimus/Tacrolimus Versus Tacrolimus/Methotrexate for Preventing Graft-Versus-Host Disease (GVHD) (BMT CTN 0402) Start of enrollment: 2006 Nov 01
Completed
Phase 3
Donor Lymphocyte Infusion in Treating Patients With Recurrent or Persistent Hematologic Cancer After Donor Stem Cell Transplant Start of enrollment: 2003 Oct 01
Completed
Not Applicable
High-Dose Chemotherapy With or Without Total-Body Irradiation Followed by Autologous Stem Cell Transplant in Treating Patients With Hematologic Cancer or Solid Tumors Start of enrollment: 2006 Jun 29
Completed
Not Applicable
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) Start of enrollment: 2011 Oct 01
Recruiting
Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant Start of enrollment: 2012 May 01
Withdrawn
Not Applicable
Double Cord Versus Haploidentical (BMT CTN 1101) Start of enrollment: 2012 Jun 01
Completed
Phase 3
Denosumab in Treating Patients With Bone Loss Due to Donor Stem Cell Transplant Start of enrollment: 2019 Dec 19
Completed
Phase 2
MM CAR-T to Upgrade Response BMTCTN1902 Start of enrollment: 2022 Jan 05
Active, not recruiting
Phase 2
Roles: Contact
A Study of TAK-007 in Adults With Relapsed or Refractory (r/r) B-cell Non-Hodgkin Lymphoma (NHL) Start of enrollment: 2021 Nov 12
Recruiting
Phase 2
Roles: Principal Investigator
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Publications & Presentations

PubMed

Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies.
Saeed Daneshmandi, Jee Eun Choi, Qi Yan, Cameron R MacDonald, Mounika Goruganthu, Nathan Roberts, Prashant K Singh, Richard M Higashi, Andrew N Lane, Teresa W-M Fan, J...> ;Nature Communications. 2024 Mar 30
A robust quality infrastructure is key to safe and effective delivery of immune effector cells: how FACT-finding can help.
Kevin J Curran, Sarah Nikiforow, Carlos Bachier, Yen-Michael Hsu, Marcela V Maus, Basem William, Kara Wacker, Phyllis Warkentin, Helen E Heslop, David Maloney, Philip ...> ;Blood Advances. 2024 Feb 27
Galectin-3 predicts acute GvHD and overall mortality post reduced intensity allo-HCT: a BMT-CTN biorepository study.
Philip L McCarthy, Kristopher M Attwood, Xiaojun Liu, George L Chen, Hans Minderman, Amin Alousi, Asad Bashey, Robert Lowsky, David B Miklos, John Hansen, Peter Wester...> ;Bone Marrow Transplantation. 2024 Mar 1
1 citations
Randomized Phase II Trial of Dendritic Cell/Myeloma Fusion Vaccine with Lenalidomide Maintenance after Upfront Autologous Hematopoietic Cell Transplantation for Multip...
David J Chung, Nina Shah, Juan Wu, Brent Logan, Lina Bisharat, Natalie Callander, Giulia Cheloni, Kenneth Anderson, Thinle Chodon, Binod Dhakal, Steve Devine, Poorvi S...> ;Clinical Cancer Research. 2023 Dec 1
Associations of minor histocompatibility antigens with outcomes following allogeneic hematopoietic cell transplantation.
Othmane Jadi, Hancong Tang, Kelly Olsen, Steven Vensko, Qianqian Zhu, Yiwen Wang, Christopher A Haiman, Loreall Pooler, Xin Sheng, Guy Brock, Amy Webb, Marcelo C Pasqu...> ;American Journal of Hematology. 2023 Jun 1
2 citations
Galectin-3 expression in donor T cells reduces GvHD severity and lethality after allogeneic hematopoietic cell transplantation.
Hemn Mohammadpour, Takemasa Tsuji, Cameron R MacDonald, Joseph L Sarow, Hanna Rosenheck, Saeed Daneshmandi, Jee Eun Choi, Jingxin Qiu, Junko Matsuzaki, Agnieszka K Wit...> ;Cell Reports. 2023 Mar 28
5 citations
Cytomegalovirus reactivation after CD19 CAR T-cell therapy is clinically significant.
George Chen, Megan Herr, Jan Nowak, Christine Ho, Nikolaos Almyroudis, Kristopher Attwood, John Bonnewell, Marissa Walsh, Brahm Segal, Maureen Ross, Philip McCarthy, T...> ;Haematologica. 2023 Feb 1
Short-Term Storage of Mobilized Peripheral Blood Stem Cells in a Closed System Changes the Microenvironment and May Affect the Quantity of CD34Cells.and CD34CD38CD45RA...
Amro Elshoury, Orla Maguire, Alexis Conway, Joseph Tario, Kah Teong Soh, Maureen Ross, Theresa Hahn, Joanne Becker, Paul Wallace, Philip L McCarthy, Hans Minderman, Ge...> ;Transplantation and Cellular Therapy. 2023 Feb 1
24 citations
Autologous T cell therapy for MAGE-A4solid cancers in HLA-A*02patients: a phase 1 trial.
David S Hong, Brian A Van Tine, Swethajit Biswas, Cheryl McAlpine, Melissa L Johnson, Anthony J Olszanski, Jeffrey M Clarke, Dejka Araujo, George R Blumenschein Jr, Pa...> ;Nature Medicine. 2023 Jan 1
2 citations
Shared graft-versus-leukemia minor histocompatibility antigens in DISCOVeRY-BMT.
Kelly S Olsen, Othmane Jadi, Sarah Dexheimer, Dante S Bortone, Steven P Vensko, Sarah Bennett, Hancong Tang, Marisa Diiorio, Tanvi Saran, David Dingfelder, Qianqian Zh...> ;Blood Advances. 2023 May 9
1 citations
Spatiotemporal assessment of immunogenomic heterogeneity in multiple myeloma.
Maximilian Merz, Qiang Hu, Almuth Maria Anni Merz, Jie Wang, Nicholas Hutson, Cherie Rondeau, Kimberly Celotto, Ahmed Belal, Ronald Alberico, AnneMarie W Block, Hemn M...> ;Blood Advances. 2023 Mar 14
126 citations
Triplet Therapy, Transplantation, and Maintenance until Progression in Myeloma.
Paul G Richardson, Susanna J Jacobus, Edie A Weller, Hani Hassoun, Sagar Lonial, Noopur S Raje, Eva Medvedova, Philip L McCarthy, Edward N Libby, Peter M Voorhees, Rob...> ;The New England Journal of Medicine. 2022 Jul 14
2 citations
A Multicenter Phase II, Double-Blind, Placebo-Controlled Trial of Maintenance Ixazomib After Allogeneic Transplantation for High-Risk Multiple Myeloma: Results of the ...
Qaiser Bashir, Taiga Nishihori, Marcelo C Pasquini, Michael J Martens, Juan Wu, Melissa Alsina, Claudio Anasetti, Claudio Brunstein, Peter Dawson, Yvonne Efebera, Cris...> ;Transplantation and Cellular Therapy. 2023 Jun 1
16 citations
Gaps and opportunities in the treatment of relapsed-refractory multiple myeloma: Consensus recommendations of the NCI Multiple Myeloma Steering Committee.
Shaji Kumar, Lawrence Baizer, Natalie S Callander, Sergio A Giralt, Jens Hillengass, Boris Freidlin, Antje Hoering, Paul G Richardson, Elena I Schwartz, Anthony Reiman...> ;Blood Cancer Journal. 2022 Jun 29
9 citations
Whole-body magnetic resonance imaging plus serological follow-up for early identification of progression in smouldering myeloma patients to prevent development of end-...
Markus Wennmann, Hartmut Goldschmidt, Jennifer Mosebach, Thomas Hielscher, Tobias Bäuerle, Dorde Komljenovic, Philip L McCarthy, Maximilian Merz, Heinz-Peter Schlemmer...> ;British Journal of Haematology. 2022 Oct 1
Proceedings from the Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Immune and Cellular Therapy in Multiple Myeloma.
Sarah A Holstein, Fotis Asimakopoulos, Abdel Kareem Azab, Giada Bianchi, Manisha Bhutani, Leslie A Crews, Tom Cupedo, Hannah Giles, Sarah Gooding, Jens Hillengass, Luk...> ;Transplantation and Cellular Therapy. 2022 Aug 1
11 citations
Trajectories of quality of life recovery and symptom burden after autologous hematopoietic cell transplantation in multiple myeloma.
Anita D'Souza, Ruta Brazauskas, Edward A Stadtmauer, Marcelo C Pasquini, Parameswaran Hari, Asad Bashey, Natalie Callander, Steven Devine, Yvonne Efebera, Siddhartha G...> ;American Journal of Hematology. 2023 Jan 1
2 citations
A review of the current status of lenalidomide maintenance therapy in multiple myeloma in 2022.
Ravi Kumar Gupta, Ashish Gupta, Jens Hillengass, Sarah A Holstein, Vera J Suman, Alankrita Taneja, Philip L McCarthy> ;Expert Review of Anticancer Therapy. 2022 May 1
15 citations
Deciphering spatial genomic heterogeneity at a single cell resolution in multiple myeloma.
Maximilian Merz, Almuth Maria Anni Merz, Jie Wang, Lei Wei, Qiang Hu, Nicholas Hutson, Cherie Rondeau, Kimberly Celotto, Ahmed Belal, Ronald Alberico, AnneMarie W Bloc...> ;Nature Communications. 2022 Feb 10
16 citations
Mass-Fix better predicts for PFS and OS than standard methods among multiple myeloma patients participating on the STAMINA trial (BMT CTN 0702 /07LT).
Angela Dispenzieri, Amrita Krishnan, Bonnie Arendt, Beth Blackwell, Paul K Wallace, Surendra Dasari, Dan T Vogl, Yvonne Efebera, Mingwei Fei, Nancy Geller, Sergio Gira...> ;Blood Cancer Journal. 2022 Feb 10
41 citations
Consensus guidelines and recommendations for infection prevention in multiple myeloma: a report from the International Myeloma Working Group.
Noopur S Raje, Elias Anaissie, Shaji K Kumar, Sagar Lonial, Thomas Martin, Morie A Gertz, Amrita Krishnan, Parameswaran Hari, Heinz Ludwig, Elizabeth O'Donnell, Andrew...> ;The Lancet. Haematology. 2022 Feb 1
38 citations
β2-adrenergic receptor signaling regulates metabolic pathways critical to myeloid-derived suppressor cell function within the TME.
Hemn Mohammadpour, Cameron R. MacDonald, Philip L. McCarthy, Scott I. Abrams, Elizabeth A. Repasky> ;Cell Reports. 2021 Oct 26
3 citations
The 2020 BMT CTN Myeloma Intergroup Workshop on Immune Profiling and Minimal Residual Disease Testing in Multiple Myeloma.
Sarah A. Holstein, Nizar J. Bahlis, P. Leif Bergsagel, Manisha Bhutani, Niccolo Bolli, Carrie Brownstein, Pierre Demolis, David M. Foureau, Irene M. Ghobrial, Nicole J...> ;Transplantation and Cellular Therapy. 2021 Oct 1
14 citations
A phase I/II study of ixazomib, pomalidomide and dexamethasone for lenalidomide and proteasome inhibitor refractory multiple myeloma. (Alliance A061202)
Peter M. Voorhees, Vera J. Suman, Sascha A. Tuchman, Jacob P. Laubach, Hani Hassoun, Yvonne A. Efebera, Flora Mulkey, Misty Bova-Solem, Katelyn Santo, Destin Carlisle,...> ;American Journal of Hematology. 2021 Sep 24
5 citations
Novel genetic variants associated with mortality after unrelated donor allogeneic hematopoietic cell transplantation.
Theresa Hahn, Junke Wang, Leah Preus, Ezgi Karaesmen, Abbas Rizvi, Alyssa I. Clay-Gilmour, Qianqian Zhu, Yiwen Wang, Li Yan, Song Liu, Daniel O. Stram, Loreall Pooler,...> ;Eclinicalmedicine. 2021 Aug 25
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Abstracts/Posters

Genome Wide Interaction Analysis Identifies Expression Quantitative Trait Loci Associated with Reduced Survival after Reduced Intensity Conditioning HLA-Matched Unrela...
Philip L. McCarthy, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Results of a Phase I Study of Pnk-007, Allogeneic, Off the Shelf NK Cell, Post Autologous Transplant in Multiple Myeloma (NCT02955550)
Philip L. McCarthy, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
_2- Adrenergic Signaling Regulates Graft Versus Host Disease after Allogenic Transplantation While Preserving Graft Versus Leukemia Effect
Philip L. McCarthy, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
De Novo and Therapy-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome: Similarities and Differences in SNP-Array Detected Chromosomal Aberrations in Pre-Tran...
Philip L. McCarthy, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
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Lectures

Genome Wide Association Analyses Identify Pleiotropic Variants Associated with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Susceptibility
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Press Mentions

Castle Connolly Names 38 Roswell Park Physicians to ‘Top Doctors’ ListFebruary 2nd, 2023
Roswell Park Oncology Experts Named to Castle Connolly ‘Top Doctors’ ListAugust 4th, 2022
Roswell Park Researchers Identify Key Link Between Stress and CancerNovember 5th, 2021
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