RakeshSindhiMDFACS

Transplantation

Raizman Haney Chair, and Professor Department of Surgery School of Medicine University of Pittsburgh Co-Director, Pediatric Transplant Surgery Director, Pediatric Transplant Research UPMC-Children’s Hospital of Pittsburgh

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Office
4401 Penn Avenue
Children's Hospital
Pittsburgh, PA 15224
Phone+1 412-692-7849
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Education & Training

University of Nebraska Medical Center College of MedicineResidency, Surgery, 1993 - 1995
Tufts Medical CenterResidency, Surgery, 1988 - 1993
Lincoln Medical and Mental Health CenterInternship, Transitional Year, 1987 - 1988
ArMed Forces Medical College PuneClass of 1981

Certifications & Licensure

CA State Medical License 1995 - Present
VA State Medical License 2014 - 2026
FL State Medical License 2018 - 2026
PA State Medical License 1998 - 2024
SC State Medical License 1996 - 1998
American Board of Surgery Surgery

Awards, Honors, & Recognition

Fellow (FACS) American College of Surgeons

Clinical Trials

Biomarkers in Transplant Recipients to Improve Outcomes Start of enrollment: 2005 Mar 01
Recruiting
rATG Induction and Tacrolimus Monotherapy in Pediatric Liver Transplantation Start of enrollment: 2006 Aug 01
Completed
Safety and Efficacy of Alemtuzumab in Pediatric Intestinal Transplantation Start of enrollment: 2007 Apr 01
Completed
Phase 2
Hepatocyte Transplantation for Acute Decompensated Liver Failure Start of enrollment: 2011 Mar 01
Withdrawn
Phase 1
Hepatocyte Transplantation for Liver Based Metabolic Disorders Start of enrollment: 2011 Mar 01
Terminated
Phase 1
Liver Cell Transplant for Phenylketonuria Start of enrollment: 2011 Oct 12
Terminated
Phase 1, Phase 2
Personalizing Immune Checkpoint Inhibitor Therapy Start of enrollment: 2019 Feb 01
Withdrawn
Cell-based Assays for Antibody-mediated Transplant Rejection Start of enrollment: 2019 Apr 15
Recruiting
Collection of Tissue Samples for Cancer Research Start of enrollment: 2006 Jul 06
Recruiting
Roles: Contact
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Publications & Presentations

PubMed

Kidney transplant in pediatric gut transplant recipients - Technical challenges and outcomes.
Arpit Amin, Bishoy Emmanuel, Vikram Raghu, Ajai Khanna, Kyle Soltys, Rakesh Sindhi, Amit Tevar, Michael L Moritz, Abhinav Humar, George Mazariegos, Armando Ganoza> ;Pediatric Transplantation. 2024 May 1
Enhanced Donor Antigen Presentation by B Cells Predicts Acute Cellular Rejection and Late Outcomes After Transplantation.
Ashokkumar, C., Ningappa, M., Raghu, V., Mazariegos, G., Higgs, B., Morgan, P., Remaley, L., Fazzolare Martin, T., Holzer, P., Trostle, K., Xu, Q., Zeevi, A., Squires,...> ;Transplantation Direct. 2024 Mar 1
3 citations
Biliary atresia is associated with polygenic susceptibility in ciliogenesis and planar polarity effector genes.
Joseph T Glessner, Mylarappa B Ningappa, Kim A Ngo, Maliha Zahid, Juhoon So, Brandon W Higgs, Patrick M A Sleiman, Tejaswini Narayanan, Sarangarajan Ranganathan, Micha...> ;Journal of Hepatology. 2023 Dec 1
Impaired Cellular and Antibody immunity after COVID-19 in Chronically Immunosuppressed Transplant Recipients.
Chethan Ashokkumar, Vinayak Rohan, Alexander H Kroemer, Sohail Rao, George Mazariegos, Brandon W Higgs, Satish Nadig, Jose Almeda, Harmeet Dhani, Khalid Khan, Nada Yaz...> ;Journal of Surgery and Research. 2023 Jan 1
Operational tolerance after intestine re-transplantation in childhood and immunological correlates. Case report and review.
Lisa Remaley, Chethan Ashokkumar, Kyle A Soltys, George Vincent Mazariegos, Geoffrey James Bond, Ajai Khanna, Armando Ganoza, Miguel Reyes-Mugica, Adriana Zeevi, Rakes...> ;Pediatric Transplantation. 2023 May 1
The Role of Dynamic DNA Methylation in Liver Transplant Rejection in Children.
Mylarappa Ningappa, Xiaojian Shao, Chethan Ashokkumar, Qingyong Xu, Adriana Zeevi, Elin Grundberg, Tomi Pastinen, Rakesh Sindhi> ;Transplantation Direct. 2022 Nov 1
Technical variant liver grafts in pediatric transplantation: Call to action.
George V Mazariegos, Rakesh Sindhi, Armando Ganoza, Kyle Soltys> ;Pediatric Transplantation. 2023 Feb 1
1 citations
Long-term outcomes of intestinal transplantation from donors aged under 1 year.
Yu-Tang Chang, Kyle Soltys, Ajai Khanna, Geoffrey J Bond, Armando Ganoza, Jeffrey A Rudolph, Rakesh Sindhi, George V Mazariegos> ;Pediatric Transplantation. 2022 Jun 1
2 citations
Domino liver transplant from a donor with maple syrup urine disease into a recipient with phenylketonuria.
Vikram K Raghu, Steven F Dobrowolski, Rakesh Sindhi, Kevin A Strauss, George V Mazariegos, Jerry Vockley, Kyle Soltys> ;Molecular Genetics and Metabolism Reports. 2022 Jun 1
4 citations
A network-based approach to identify expression modules underlying rejection in pediatric liver transplantation.
Mylarappa Ningappa, Syed A Rahman, Brandon W Higgs, Chethan S Ashokkumar, Nidhi Sahni, Rakesh Sindhi, Jishnu Das> ;Cell Reports. Medicine. 2022 Apr 19
20 citations
Immune Response in Severe and Non-Severe Coronavirus Disease 2019 (COVID-19) Infection: A Mechanistic Landscape.
Kavitha Mukund, Priya Nayak, Chethan Ashokkumar, Sohail Rao, Jose Luis Almeda, Monica M. Betancourt-Garcia, Rakesh Sindhi, Shankar Subramaniam> ;Frontiers in Immunology. 2021 Oct 13
2 citations
Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 (Man1a2) Mutants.
Mylarappa Ningappa, Morayooluwa Adenuga, Kim A. Ngo, Nada Mohamed, Tejaswini Narayanan, Krishna Prasadan, Chethan Ashokkumar, Jishnu Das, Lori Schmitt, Hannah Hartman,...> ;Frontiers in Physiology. 2021 Jul 14
4 citations
Metabolic Control and "Ideal" Outcomes in Liver Transplantation for Maple Syrup Urine Disease.
Caroline B Ewing, Kyle Soltys, Kevin A. Strauss, Rakesh Sindhi, Jerry Vockley, Patrick J. McKiernan, Robert H. Squires, Geoffrey Bond, Armando Ganoza, Ajai Khanna, Geo...> ;The Journal of Pediatrics. 2021 Jun 18
5 citations
Longitudinal Outcomes in Young Patients with Alpha-1-Antitrypsin Deficiency with Native Liver Reveal that Neonatal Cholestasis is a Poor Predictor of Future Portal Hyp...
Jeffrey Teckman, Philip J. Rosenthal, Kieran Hawthorne, Cathie Spino, Lee M. Bass, Karen F. Murray, Nanda Kerkar, John C. Magee, Saul J. Karpen, James E. Heubi, Jean P...> ;The Journal of Pediatrics. 2020 Dec 1
13 citations
Biliary-Atresia-Associated Mannosidase-1-Alpha-2 Gene Regulates Biliary and Ciliary Morphogenesis and Laterality.
Juhoon So, Mylarappa Ningappa, Joseph T. Glessner, Jun Min, Chethan Ashokkumar, Sarangarajan Ranganathan, Brandon W. Higgs, Dong Li, Qing Sun, Lori Schmitt, A. Biery, ...> ;Frontiers in Physiology. 2020 Oct 30
2 citations
Liver transplant for inherited metabolic disease among siblings
Patrick J. McKiernan, James E. Squires, Robert H. Squires, Jerry Vockley, George V. Mazariegos, Kyle Soltys, Armando Ganoza, Kevin A. Strauss, Ajai Khanna, Rakesh Sindhi> ;Clinical Transplantation. 2020 Sep 21
2 citations
Systems Analysis of Biliary Atresia Through Integration of High-Throughput Biological Data
Jun Min, Mylarappa Ningappa, Juhoon So, Donghun Shin, Rakesh Sindhi, Shankar Subramaniam> ;Frontiers in Physiology. 2020 Aug 7
6 citations
Operational tolerance in intestinal transplantation.
Alexander Kroemer, Khalid Khan, Stuart S. Kaufman, Jiman Kang, Joshua Weiner, Anju Duttargi, Leonid Belyayev, Chethan Ashokkumar, Rakesh Sindhi, Olga A. Timofeeva, Mic...> ;American Journal of Transplantation. 2021 Feb 1
7 citations
Induction regimens and post-transplantation lymphoproliferative disorder after pediatric intestinal transplantation: Single-center experience.
Kaitlin Devine, Sarangarajan Ranganathan, George V. Mazariegos, Geoffrey J. Bond, Kyle Soltys, Armando Ganoza, Qing Sun, Rakesh Sindhi> ;Pediatric Transplantation. 2020 Aug 1
5 citations
Factors Associated With Neurobehavioral Complications in Pediatric Abdominal Organ Transplant Recipients Identified Using Computable Composite Definitions.
Alicia M. Alcamo, Robert S. B. Clark, Alicia K. Au, Sajel Kantawala, Eric Yablonsky, Rakesh Sindhi, George V. Mazariegos, Rajesh K. Aneja, Christopher M. Horvat> ;Pediatric Critical Care Medicine. 2020 Apr 23
12 citations
Use of C-Reactive Protein and Ferritin Biomarkers in Daily Pediatric Practice.
Matthew D. Taylor, Vivek Allada, Michael L. Moritz, Andrew J. Nowalk, Rakesh Sindhi, Rajesh Aneja, Kathryn Torok, Michael J. Morowitz, Marian G. Michaels, Joseph A. Ca...> ;Pediatrics in Review. 2020 Apr 1
19 citations
Liver Transplantation for Pediatric Liver Cancer.
Rakesh Sindhi, Vinayak Rohan, Andrew Bukowinski, Sameh S. Tadros, Jean de Ville de Goyet, Louis Rapkin, Sarangarajan Ranganathan> ;Cancers. 2020 Mar 19
9 citations
CD154-expressing CMV-specific T cells associate with freedom from DNAemia and may be protective in seronegative recipients after liver or intestine transplantation
Chethan Ashokkumar, Michael Green, Kyle Soltys, Marian G. Michaels, George V. Mazariegos, Miguel Reyes-Múgica, Brandon W. Higgs, Brianna Spishock, Madison Zaccagnini, ...> ;Pediatric Transplantation. 2020 Feb 1
18 citations
Technique and outcome of domino liver transplantation from patients with maple syrup urine disease: Expanding the donor pool for live donor liver transplantation.
Neslihan Celik, Beau Kelly, Kyle Soltys, James E. Squires, Jerry Vockley, Diana A. Shellmer, Kevin A. Strauss, Patrick J. McKiernan, Armando Ganoza, Rakesh Sindhi, Geo...> ;Clinical Transplantation. 2019 Nov 1
22 citations
Domino liver transplantation for select metabolic disorders: Expanding the living donor pool.
Neslihan Celik, James E. Squires, Kyle Soltys, Jerry Vockley, Diana A. Shellmer, Wonbae Chang, Kevin A. Strauss, Patrick J. McKiernan, Armando Ganoza, Rakesh Sindhi, G...> ;JIMD Reports. 2019 Jun 19
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