RebeccaAnnSagerMD

PubMed

• Second international symposium on the chaperone code, 2023.
  Johannes Buchner, Milad J Alasady, Sarah J Backe, Brian S J Blagg, Richard L Carpenter, Giorgio Colombo, Ioannis Gelis, Daniel T Gewirth, Lila M Gierasch, Walid A Hour...> ;Cell Stress & Chaperones. 2024 Feb 1
• 1 citations
  Catalytic inhibitor of Protein Phosphatase 5 activates the extrinsic apoptotic pathway by disrupting complex II in kidney cancer.
  Elham F Ahanin, Rebecca A Sager, Sarah J Backe, Diana M Dunn, Natela Dushukyan, Adam R Blanden, Nilamber A Mate, Tamie Suzuki, Tyler Anderson, Merin Roy, Jasmeen Obero...> ;Cell Chemical Biology. 2023 Oct 19
• 4 citations
  Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery.
  Sarah J Backe, Rebecca A Sager, Jennifer A Heritz, Laura A Wengert, Katherine A Meluni, Xavier Aran-Guiu, Barry Panaretou, Mark R Woodford, Chrisostomos Prodromou, Dim...> ;Cell Reports. 2023 Jul 25
• Detecting Posttranslational Modifications of Hsp90 Isoforms.
  Rebecca A Sager, Sarah J Backe, Len Neckers, Mark R Woodford, Mehdi Mollapour> ;Methods in Molecular Biology. 2023 Jan 1
• 2 citations
  Impact of Co-chaperones and Posttranslational Modifications Toward Hsp90 Drug Sensitivity.
  Sarah J Backe, Mark R Woodford, Elham Ahanin, Rebecca A Sager, Dimitra Bourboulia, Mehdi Mollapour> ;Sub-Cellular Biochemistry. 2023 Jan 1
• 14 citations
  A specialized Hsp90 co-chaperone network regulates steroid hormone receptor response to ligand.
  Sarah J Backe, Rebecca A Sager, Bethany R Regan, Julian Sit, Lauren A Major, Gennady Bratslavsky, Mark R Woodford, Dimitra Bourboulia, Mehdi Mollapour> ;Cell Reports. 2022 Jul 12
• 1 citations
  Emerging Link between Tsc1 and FNIP Co-Chaperones of Hsp90 and Cancer.
  Sarah J Backe, Rebecca A Sager, Katherine A Meluni, Mark R Woodford, Dimitra Bourboulia, Mehdi Mollapour> ;Biomolecules. 2022 Jul 1
• 10 citations
  Therapeutic potential of CDK4/6 inhibitors in renal cell carcinoma.
  Rebecca A Sager, Sarah J Backe, Elham Ahanin, Garrett Smith, Imad Nsouli, Mark R Woodford, Gennady Bratslavsky, Dimitra Bourboulia, Mehdi Mollapour> ;Nature Reviews. Urology. 2022 May 1
• 8 citations
  Targeting extracellular Hsp90: A unique frontier against cancer.
  Rebecca A Sager, Farzana Khan, Lorenzo Toneatto, SarahBeth D Votra, Sarah J Backe, Mark R Woodford, Mehdi Mollapour, Dimitra Bourboulia> ;Frontiers in Molecular Biosciences. 2022 Jan 1
• 15 citations
  The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect
  Mark R. Woodford, Alexander J. Baker-Williams, Rebecca A. Sager, Sarah J. Backe, Adam R. Blanden, Fiza Hashmi, Priyanka Kancherla, Alessandro Gori, David R. Loiselle, ...> ;Nature Structural & Molecular Biology. 2021 Aug 1
• 4 citations
  The Role of Heat Shock Protein-90 in the Pathogenesis of Birt-Hogg-Dubé and Tuberous Sclerosis Complex Syndromes
  Mark R. Woodford, Sarah J. Backe, Rebecca A. Sager, Dimitra Bourboulia, Gennady Bratslavsky, Mehdi Mollapour> ;Urologic Oncology. 2021 Jun 1
• 10 citations
  Fumarate hydratase as a therapeutic target in renal cancer.
  Priyanka Kancherla, Michael Daneshvar, Rebecca A. Sager, Mehdi Mollapour, Gennady Bratslavsky> ;Expert Opinion on Therapeutic Targets. 2020 Oct 6
• 85 citations
  Post-translational modifications of Hsp90 and translating the chaperone code.
  Sarah J. Backe, Rebecca A. Sager, Mark R. Woodford, Alan M. Makedon, Mehdi Mollapour> ;The Journal of Biological Chemistry. 2020 Aug 7
• 37 citations
  Chemical Perturbation of Oncogenic Protein Folding: from the Prediction of Locally Unstable Structures to the Design of Disruptors of Hsp90–Client Interactions
  Antonella Paladino, Mark R. Woodford, Sarah J. Backe, Rebecca A. Sager, Priyanka Kancherla, Michael Daneshvar, Victor Z. Chen, Dimitra Bourboulia, Elham F. Ahanin, Chr...> ;Chemistry. 2020 Aug 3
• 20 citations
  Structure and function of the co-chaperone protein phosphatase 5 in cancer.
  Rebecca A. Sager, Natela Dushukyan, Mark R. Woodford, Mehdi Mollapour> ;Cell Stress & Chaperones. 2020 Apr 2
• 13 citations
  Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity.
  Michael Hughes, Rebecca A. Sager, Sarah J. Backe, Alexander J. Baker-Williams, Michael S. Bratslavsky, Joseph M. Jacob, Oleg Shapiro, Michael Wong, Gennady Bratslavsky...> ;Oncotarget. 2019 Oct 8
• 32 citations
  Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90
  Rebecca A. Sager, Mark R. Woodford, Sarah J. Backe, Alan M. Makedon, Alexander J. Baker-Williams, Bryanna T. DiGregorio, David R. Loiselle, Timothy A.J. Haystead, Nata...> ;Cell Reports. 2019 Jan 29
• 13 citations
  The mTOR Independent Function of Tsc1 and FNIPs
  Rebecca A. Sager, Mark R. Woodford, Mehdi Mollapour> ;Trends in Biochemical Sciences. 2018 Oct 22
• 10 citations
  Sporadic renal angiomyolipoma in a patient with Birt-Hogg-Dubé: chaperones in pathogenesis.
  Rebecca A. Sager, Mark R. Woodford, Oleg Shapiro, Mehdi Mollapour, Gennady Bratslavsky> ;Oncotarget. 2018 Apr 24
• 9 citations
  Detecting Posttranslational Modifications of Hsp90.
  Rebecca A. Sager, Mark R. Woodford, Len Neckers, Mehdi Mollapour> ;Methods in Molecular Biology. 2018 Jan 1
• 55 citations
  Tumor suppressor Tsc1 is a new Hsp90 co‐chaperone that facilitates folding of kinase and non‐kinase clients
  Mark R. Woodford, Rebecca A. Sager, Elijah Marris, Diana M. Dunn, Adam R. Blanden, Ryan L Murphy, Oleg Shapiro, Barry Panaretou, Chrisostomos Prodromou, Stewart N. Loh...> ;The EMBO Journal. 2017 Nov 10
• Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer.
  Dushukyan, N.,Dunn, D. M.,Sager, R. A.,Woodford, M. R.,Loiselle, D. R.,Daneshvar, M.,Baker-Williams, A. J.,Chisholm, J. D.,Truman, A. W.,Vaughan, C. K.,Haystead, T. A....> ;Cell Rep. 2017 Nov 16
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