RichardBHorensteinMD

PubMed

• Effects of APOC3 Heterozygous Deficiency on Plasma Lipid and Lipoprotein Metabolism.
  Reyes-Soffer, G., Sztalryd, C., Horenstein, R. B., Holleran, S., Matveyenko, A., Thomas, T., Nandakumar, R., Ngai, C., Karmally, W., Ginsberg, H. N., Ramakrishnan, R.,...> ;Arteriosclerosis, thrombosis, and vascular biology. 2018 Dec 26
• Genome-wide association analysis of common genetic variants of resistant hypertension.
  Rouby, N. E., McDonough, C. W., Gong, Y., McClure, L. A., Mitchell, B. D., Horenstein, R. B., Talbert, R. L., Crawford, D. C., , Gitzendanner, M. A., Takahashi, A., Ta...> ;The pharmacogenomics journal. 2018 Sep 22
• 10 citations
  Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.
  Larisa H. Cavallari, Craig R. Lee, Amber L. Beitelshees, Rhonda M. Cooper-DeHoff, Julio D. Duarte, Deepak Voora, Stephen E. Kimmel, Caitrin W. McDonough, Yan Gong, Chi...> ;Jacc-cardiovascular Interventions. 2018 Jan 22
• Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel P...
  Thomas O. Bergmeijer, Jean-Luc Reny, Ruth E. Pakyz, Li Gong, Joshua P. Lewis, Eun-Young Kim, Daniel Aradi, Israel Fernandez-Cadenas, Richard B. Horenstein, Ming Ta Mic...> ;American Heart Journal. 2017 Dec 1
• Identifying clinically relevant sources of variability: The clopidogrel challenge.
  Samant S, Jiang XL, Peletier LA, Shuldiner AR, Horenstein RB, Lewis JP, Lesko LJ, Schmidt S> ;Clin. Pharmacol. Ther.. 2016-08-24
• 2 citations
  A systematic analysis and comparison of warfarin initiation strategies.
  French, B., Wang, L., Gage, B. F., Horenstein, R. B., Limdi, N. A., Kimmel, S. E.> ;Pharmacogenetics and genomics. 2016 Jul 8
• 2 citations
  Development of a physiology-directed population pharmacokinetic and pharmacodynamic model for characterizing the impact of genetic and demographic factors on clopidogr...
  Jiang, X., Samant, S., Lewis, J. P., Horenstein, R. B., Shuldiner, A. R., Yerges-Armstrong, L. M., Peletier, L. A., Lesko, L. J., Schmidt, S.> ;European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2015 Nov 3
• Oxylipid Profile of Low-Dose Aspirin Exposure: A Pharmacometabolomics Study.
  Ellero-Simatos, S., Beitelshees, A. L., Lewis, J. P., Yerges-Armstrong, L. M., Georgiades, A., Dane, A., Harms, A. C., Strassburg, K., Guled, F., Hendriks, M. M., Hore...> ;Journal of the American Heart Association. 2015 Oct 28
• 4 citations
  The Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study: Variation in Platelet Response to Clopidogrel and Aspirin.
  Bozzi, L. M., Mitchell, B. D., Lewis, J. P., Ryan, K. A., Herzog, W. R., O'Connell, J. R., Horenstein, R. B., Shuldiner, A. R., Yerges-Armstrong, L. M.> ;Current vascular pharmacology. 2015 Sep 17
• 11 citations
  CYP2C19 Metabolizer Status and Clopidogrel Efficacy in the Secondary Prevention of Small Subcortical Strokes (SPS3) Study
  Caitrin W. McDonough, Leslie A. McClure, Braxton D. Mitchell, Yan Gong, Richard B. Horenstein, Joshua P. Lewis, Thalia S. Field, Robert L. Talbert, Oscar R. Benavente,...> ;Journal of the American Heart Association. 2015 May 27
• 15 citations
  Effectiveness of clopidogrel dose escalation to normalize active metabolite exposure and antiplatelet effects in CYP2C19 poor metabolizers.
  Horenstein, R. B., Madabushi, R., Zineh, I., Yerges-Armstrong, L. M., Peer, C. J., Schuck, R. N., Figg, W. D., Shuldiner, A. R., Pacanowski, M. A.> ;Journal of clinical pharmacology. 2014 Apr 9
• 25 citations
  Implementation of pharmacogenetics: the University of Maryland Personalized Anti-platelet Pharmacogenetics Program.
  Shuldiner, A. R., Palmer, K., Pakyz, R. E., Alestock, T. D., Maloney, K. A., O'Neill, C., Bhatty, S., Schub, J., Overby, C. L., Horenstein, R. B., Pollin, T. I., Kelem...> ;American journal of medical genetics. Part C, Seminars in medical genetics. 2014 Mar 13
• 19 citations
  A pharmacogenetic versus a clinical algorithm for warfarin dosing.
  Kimmel, S. E., French, B., Kasner, S. E., Johnson, J. A., Anderson, J. L., Gage, B. F., Rosenberg, Y. D., Eby, C. S., Madigan, R. A., McBane, R. B., Abdel-Rahman, S. Z...> ;The New England journal of medicine. 2013 Nov 21
• The CYP2C19*17 variant is not independently associated with clopidogrel response.
  Lewis, J. P.,Stephens, S. H.,Horenstein, R. B.,O'Connell, J. R.,Ryan, K.,Peer, C. J.,Figg, W. D.,Spencer, S. D.,Pacanowski, M. A.,Mitchell, B. D.,Shuldiner, A. R.> ;J. Thromb. Haemost.. 2013 Sep
• 4 citations
  Pharmacogenomics of anti-platelet and anti-coagulation therapy.
  Fisch, A. S., Perry, C. G., Stephens, S. H., Horenstein, R. B., Shuldiner, A. R.> ;Current cardiology reports. 2013 Jun 26
• Purine Pathway Implicated in Mechanism of Resistance to Aspirin Therapy: Pharmacometabolomics-Informed Pharmacogenomics.
  Yerges-Armstrong, L. M.,Ellero-Simatos, S.,Georgiades, A.,Zhu, H.,Lewis, J. P.,Horenstein, R. B.,Beitelshees, A. L.,Dane, A.,Reijmers, T.,Hankemeier, T.,Fiehn, O.,Shul...> ;Clin. Pharmacol. Ther.. 2013 Oct
• 36 citations
  Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes.
  Joshua P. Lewis, Kathleen A. Ryan, Jeffrey R. O'Connell, Richard B. Horenstein, Coleen M. Damcott, Quince Gibson, Toni I. Pollin, Braxton D. Mitchell, Amber L. Beitels...> ;Circulation-cardiovascular Genetics. 2013 Apr 1
• The ABCG8 G574R variant, serum plant sterol levels, and cardiovascular disease risk in the Old Order Amish.
  Horenstein, R. B., Mitchell, B. D., Post, W. S., Lütjohann, D., von Bergmann, K., Ryan, K. A., Terrin, M. L., Shuldiner, A. R., Steinle, N. I.> ;Arteriosclerosis, thrombosis, and vascular biology. 2012 Dec 18
• 64 citations
  The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response.
  Lewis, J. P., Horenstein, R. B., Ryan, K. A., O'Connell, J. R., Gibson, Q., Mitchell, B. D., Tanner, K., Chai, S., Bliden, K. P., Tantry, U. S., Peer, C. J., Figg, W. ...> ;Pharmacogenetics and genomics. 2012 Nov 1
• 59 citations
  Analysis of the gut microbiota in the old order Amish and its relation to the metabolic syndrome.
  Margaret L. Zupancic, Brandi L. Cantarel, Zhenqiu Liu, Elliott F. Drabek, Kathleen A. Ryan, Shana Cirimotich, Cheron Jones, Rob Knight, William A. Walters, Dan Knights...> ;PLOS ONE. 2012 Aug 15
• 18 citations
  A sensitive and rapid ultra HPLC-MS/MS method for the simultaneous detection of clopidogrel and its derivatized active thiol metabolite in human plasma.
  Peer, C. J., Spencer, S. D., VanDenBerg, D. A., Pacanowski, M. A., Horenstein, R. B., Figg, W. D.> ;Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Dec 16
• 15 citations
  Pharmacogenetics and clopidogrel response in patients undergoing percutaneous coronary interventions.
  Beitelshees, A. L., Horenstein, R. B., Vesely, M. R., Mehra, M. R., Shuldiner, A. R.> ;Clinical pharmacology and therapeutics. 2011 Jan 29
• 19 citations
  Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish.
  Shen, H., Damcott, C. M., Rampersaud, E., Pollin, T. I., Horenstein, R. B., McArdle, P. F., Peyser, P. A., Bielak, L. F., Post, W. S., Chang, Y. C., Ryan, K. A., Mille...> ;Archives of internal medicine. 2010 Nov 10
• 705 citations
  Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.
  Shuldiner, A. R., O'Connell, J. R., Bliden, K. P., Gandhi, A., Ryan, K. A., Horenstein, R. B., Damcott, C. M., Pakyz, R., Tantry, U. S., Gibson, Q., Pollin, T. I., Pos...> ;JAMA. 2009 Aug 27
• 14 citations
  Circulating CD34+ Cell Count is Associated with Extent of Subclinical Atherosclerosis in Asymptomatic Amish Men, Independent of 10-Year Framingham Risk
  Lawrence F. Bielak, Richard B. Horenstein, Kathleen A. Ryan, Patrick F. Sheedy, John A. Rumberger, Keith Tanner, Wendy Post, B.D. Mitchell, Alan R. Shuldiner, Patricia...> ;Clinical medicine. Cardiology. 2009 May 27
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Lectures

• Vitamin D Inhibits Human Platelet Aggregation: Implications for Hypercoagulable State in Diabetes 
  Baltimore, MD - 6/15/2014