RichardLeeMD

PubMed

• Aminomethyl spectinomycins: a novel antibacterial chemotype for biothreat pathogens.
  Scarff, J. M.,Waidyarachchi, S. L.,Meyer, C. J.,Lane, D. J.,Chai, W.,Lemmon, M. M.,Liu, J.,Butler, M. M.,Bowlin, T. L.,Lee, R. E.,Panchal, R. G.> ;J. Antibiot.. 2019 Jun 06
• The Efficacy of Aminomethyl Spectinomycins against Complex Upper Respiratory Tract Bacterial Infections.
  Iverson, A.,Meyer, C. J.,Vogel, P.,Waidyarachchi, S.,Das, N.,Bruhn, D. F.,Poole, A.,Butler, M. M.,Bowlin, T. L.,Lee, R. E.,Rosch, J. W.> ;Antimicrob. Agents Chemother.. 2019 Mar 13
• The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis.
  Brewer, C. T.,Yang, L.,Edwards, A.,Lu, Y.,Low, J.,Wu, J.,Lee, R. E.,Chen, T.> ;Toxicol. Sci.. 2018 Dec 06
• Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice.
  Rathi, C.,Lukka, P. B.,Wagh, S.,Lee, R. E.,Lenaerts, A. J.,Braunstein, M.,Hickey, A.,Gonzalez-Juarrero, M.,Meibohm, B.> ;Tuberculosis (Edinb). 2019 Feb 04
• Dynamic time-kill curve characterization of spectinamide antibiotics 1445 and 1599 for the treatment of tuberculosis.
  Vaddady, P. K.,Trivedi, A.,Rathi, C.,Madhura, D. B.,Liu, J.,Lee, R. E.,Meibohm, B.> ;Eur J Pharm Sci. 2018 Nov 13
• New β-lactam - Tetramic acid hybrids show promising antibacterial activities.
  Cherian, P. T.,Cheramie, M. N.,Marreddy, RKR.,Fernando, D. M.,Hurdle, J. G.,Lee, R. E.> ;Bioorg. Med. Chem. Lett.. 2018 Aug 12
• HASH(0x2afaf38)
  Griffith, E. C.,Wallace, M. J.,Wu, Y.,Kumar, G.,Gajewski, S.,Jackson, P.,Phelps, G. A.,Zheng, Z.,Rock, C. O.,Lee, R. E.,White, S. W.> ;Front Microbiol. 2018 Aug 02
• CINPA1 binds directly to constitutive androstane receptor and inhibits its activity.
  Cherian, M. T.,Chai, S. C.,Wright, W. C.,Singh, A.,Alexandra Casal, M.,Zheng, J.,Wu, J.,Lee, R. E.,Griffin, P. R.,Chen, T.> ;Biochem. Pharmacol.. 2018 Apr 03
• In Vivo and in Vitro Effects of a ClpP Activating Antibiotic Against Vancomycin Resistant Enterococci
  Richard Lee, MD> ;10.1128/AAC.00424-18. 2018 May 23
• Aminomethyl Spectinomycins as Therapeutics for Drug-Resistant Gonorrhea and Chlamydial Co-Infections
  Michelle M Butler, Richard E Lee, Stephan A Kohlhoff> ;mBio. 2018 Feb 28
• Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.
  Shadrick, W. R.,Slavish, P. J.,Chai, S. C.,Waddell, B.,Connelly, M.,Low, J. A.,Tallant, C.,Young, B. M.,Bharatham, N.,Knapp, S.,Boyd, V. A.,Morfouace, M.,Roussel, M. F...> ;Bioorg. Med. Chem.. 2017 Nov 25
• Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models.
  Robertson GT, Scherman MS, Bruhn DF, Liu J, Hastings C, McNeil MR, Butler MM, Bowlin TL, Lee RB, Lee RE, Lenaerts AJ> ;J. Antimicrob. Chemother.. 2016-12-20
• Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes.
  Bruhn, D. F.,Wyllie, S.,Rodríguez-Cortés, A.,Carrillo, A. K.,Guy, R. K.,Fairlamb, A. H.,Lee, R. E.> ;J. Antimicrob. Chemother.. 2015 Dec 20
• Synthesis and evaluation of colletoic acid core derivatives.
  Ling, T.,Gautam, L. N.,Griffith, E.,Das, S.,Lang, W.,Shadrick, W. R.,Shelat, A.,Lee, R.,Rivas, F.> ;Eur J Med Chem. 2016 Jan 29
• In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics.
  Bruhn DF, Scherman MS, Liu J, Scherbakov D, Meibohm B, Böttger EC, Lenaerts AJ, Lee RE> ;Sci Rep. 2015-09-14
• Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening.
  Zheng, Z.,Parsons, J. B.,Tangallapally, R.,Zhang, W.,Rock, C. O.,Lee, R. E.> ;Bioorg. Med. Chem. Lett.. 2014 Apr 24
• New Approaches to Target the Mycolic Acid Biosynthesis Pathway for the Development of Tuberculosis Therapeutics.
  North, E. J.,Jackson, M.,Lee, R. E.> ;Curr. Pharm. Des.. 2013 Nov 20
• The membrane as a target for controlling hypervirulent Clostridium difficile infections.
  Wu X, Cherian PT, Lee RE, Hurdle JG> ;J. Antimicrob. Chemother.. 2013-04-01
• Reutericyclin and related analogues kill stationary phase Clostridium difficile at achievable colonic concentrations.
  Hurdle JG, Heathcott AE, Yang L, Yan B, Lee RE> ;J. Antimicrob. Chemother.. 2011-08-01
• Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections.
  Hurdle JG, Yendapally R, Sun D, Lee RE> ;Antimicrob. Agents Chemother.. 2009-09-01
• Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity.
  Sun D, Scherman MS, Jones V, Hurdle JG, Woolhiser LK, Knudson SE, Lenaerts AJ, Slayden RA, McNeil MR, Lee RE> ;Bioorg. Med. Chem.. 2009-05-15
• Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria.
  Grimes KD, Lu Y, Zhang Y, Luna VA, Hurdle JG, Carson EI, Qi J, Kudrimoti S, Rock CO, Lee RE> ;ChemMedChem. 2008-12-01
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