RichardAllenMorrisonMD

PubMed

• 12 citations
  The impact of protein on Caco-2 permeability of low mass balance compounds for absorption projection and efflux substrate identification.
  Tongtong Liu, Lee-Jah Chang, Annette S. Uss, Inhou Chu, Richard A. Morrison, Lydia Wang, Dan Prelusky, Kuo-Chi Cheng, Cheng Li> ;Journal of Pharmaceutical and Biomedical Analysis. 2010 Apr 6
• Quantitative PCR assay for cytochromes P450 2B and 3A induction in rat precision-cut liver slices: correlation study with induction in vivo.
  Cui, X., Thomas, A., Han, Y., Palamanda, J., Montgomery, D., White, R.E., Morrison, R.A., Cheng, K.> ;J Pharmacol Toxicol Methods. 2005-09-01
• 4 citations
  Rat PXR reporter-gene activity correlates with the induction of CYP3A in rat precision-cut liver slices.
  Xiaoming Cui, Ann Thomas, Diana Montgomery, Chunyan Gu, Richard A. Morrison, Ronald E. White, K.-C. Cheng> ;Combinatorial Chemistry & High Throughput Screening. 2005 May 31
• 4 citations
  Multiple pathways are involved in the oral absorption of BMS-262084, a tryptase inhibitor, in rats: role of paracellular transport, binding to trypsin, and P-glycoprot...
  Amrita Kamath, Richard A. Morrison, Timothy W. Harper, Shih-Jung Lan, Anthony M. Marino, Saeho Chong> ;Journal of Pharmaceutical Sciences. 2005 May 1
• 1 citations
  Application of structure–metabolism relationships in the identification of a selective endothelin A antagonist, BMS-193884, with favourable pharmacokinetic properties
  William G. Humphreys, Mary T. Obermeier, Joel C. Barrish, S. Chong, A. M. Marino, N. Murugesan, D. Wang-Iverson, Richard A. Morrison> ;Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 2003 Nov 1
• 38 citations
  A rapid and sensitive LC/MS/MS assay for quantitative determination of digoxin in rat plasma.
  Ming Yao, Hongjian Zhang, Saeho Chong, Mingshe Zhu, Richard A. Morrison> ;Journal of Pharmaceutical and Biomedical Analysis. 2003 Aug 21
• 33 citations
  Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,...
  Natesan Murugesan, Zhengxiang Gu, Steven H. Spergel, Marian Young, Ping Chen, Arvind Mathur, Leslie Leith, Mark A. Hermsmeier, Eddie C.-K. Liu, Rongan Zhang, Eileen Bi...> ;Journal of Medicinal Chemistry. 2003 Jan 2
• 9 citations
  Oxidative activation of acylguanidine prodrugs: intestinal presystemic activation in rats limits absorption and can be inhibited by co-administration of ketoconazole.
  William G. Humphreys, Mary T. Obermeier, S. Chong, Kimball Sd, Jagabandhu Das, Ping Chen, Robert V. Moquin, Wen-Ching Han, R. Gedamke, Ronald E. White, Richard A. Morr...> ;Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 2003 Jan 1
• 27 citations
  Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists.
  Natesan Murugesan, John E. Tellew, Zhengxiang Gu, Bridgette L. Kunst, Leena Fadnis, Cornelius Lyndon A M, Rose Ann F Baska, Yifan Yang, Sophie Beyer, Hossain Monshizad...> ;Journal of Medicinal Chemistry. 2002 Aug 8
• 22 citations
  A rapid screening system to determine drug affinities for the intestinal dipeptide transporter 2: affinities of ACE inhibitors.
  Vanessa A. Moore, William J. Irwin, Peter Timmins, Peter A. Lambert, Saeho Chong, Sandra A. Dando, Richard A. Morrison> ;International Journal of Pharmaceutics. 2000 Dec 4
• 16 citations
  A rapid screening system to determine drug affinities for the intestinal dipeptide transporter 1: system characterisation
  Vanessa A. Moore, William J. Irwin, Peter Timmins, Saeho Chong, Sandra A. Dando, Richard A. Morrison> ;International Journal of Pharmaceutics. 2000 Dec 4
• 9 citations
  Disposition of radiolabeled ifetroban in rats, dogs, monkeys, and humans.
  Randy C. Dockens, Kenneth S. Santone, James Mitroka, Richard A. Morrison, Mohammed Jemal, Douglas S. Greene, Rashmi H. Barbhaiya> ;Drug Metabolism and Disposition. 2000 Aug 1
• 18 citations
  Biphenylsulfonamide Endothelin Receptor Antagonists. 2. Discovery of 4‘-Oxazolyl Biphenylsulfonamides as a New Class of Potent, Highly Selective ETA Antagonists
  Natesan Murugesan, Zhengxiang Gu, Philip D. Stein, Steven H. Spergel, Arvind Mathur, Leslie Leith, Eddie C.-K. Liu, Rongan Zhang, Eileen Bird, T.L. Waldron, Anthony M....> ;Journal of Medicinal Chemistry. 2000 Jul 19
• 166 citations
  CURRENT METHODOLOGIES USED FOR EVALUATION OF INTESTINAL PERMEABILITY AND ABSORPTION
  Praveen Balimane, Saeho Chong, Richard A. Morrison> ;Journal of Pharmacological and Toxicological Methods. 2000 Jul 1
• 4 citations
  Continuous Blood Withdrawal as a Rapid Screening Method for Determining Clearance and Oral Bioavailability in Rats
  William G. Humphreys, Mary T. Obermeier, Richard A. Morrison> ;Pharmaceutical Research. 1998 Aug 1
• 74 citations
  Evaluation of Biocoat® Intestinal Epithelium Differentiation Environment (3-Day Cultured Caco-2 Cells) as an Absorption Screening Model with Improved Productivity
  Saeho Chong, Sandra A. Dando, Richard A. Morrison> ;Pharmaceutical Research. 1997 Dec 1
• 1 citations
  Intestinal absorption of captopril and two thioester analogs in rats and dogs.
  Richard A. Morrison, Kishin J. Kripalani, Anthony M. Marino, A. V. Dean, B. H. Migdalof, S. H. Weinstein, N. B. Jain, M. S. Bathala, S M Singhvi> ;Biopharmaceutics & Drug Disposition. 1997 Jan 1
• 11 citations
  Prodrugs of BMS‐183920: Metabolism and permeability considerations
  Mary T. Obermeier, Saeho Chong, Sandra A. Dando, Anthony M. Marino, Denis E. Ryono, Anne Starrett-Arroyo, Gerald C. DiDonato, Bethanne M. Warrack, Ronald E. White, Ric...> ;Journal of Pharmaceutical Sciences. 1996 Aug 1
• 20 citations
  Suitability of enalapril as a probe of the dipeptide transporter system: in vitro and in vivo studies.
  Richard A. Morrison, Saeho Chong, Anthony M. Marino, Martin A. Wasserman, Peter Timmins, Vanessa A. Moore, William J. Irwin> ;Pharmaceutical Research. 1996 Jul 1
• 6 citations
  Distribution of the Dipeptide Transporter System along the Gastrointestinal Tract of Rats Based on Absorption of a Stable and Specific Probe, SQ-29852
  Anthony M. Marino, Saeho Chong, Sandra A. Dando, K.J. Kripalani, M. S. Bathala, Richard A. Morrison> ;Journal of Pharmaceutical Sciences. 1996 Mar 1
• 82 citations
  In vitro permeability through caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system.
  Saeho Chong, Sandra A. Dando, Kathleen M. Soucek, Richard A. Morrison> ;Pharmaceutical Research. 1996 Jan 1
• 4 citations
  SITES OF FIRST-PASS BIOACTIVATION (HYDROLYSIS) OF ORALLY ADMINISTERED ZOFENOPRIL CALCIUM IN DOGS
  Richard A. Morrison, Dennis E. Burkett, Mark E. Arnold, Celia D’Arienzo, Stephen H. Weinstein> ;Pharmaceutical Research. 1991 Mar 1
• 8 citations
  Disposition of Zofenopril Calcium in Healthy Subjects
  S. M. Singhvi, James E. Foley, D. A. Willard, Richard A. Morrison> ;Journal of Pharmaceutical Sciences. 1990 Nov 1
• Relationship between metabolism and pharmacologic activity of SQ 27,786, an angiotensin converting enzyme inhibitor with potent diuretic activity.
  D.W. Everett, S M Singhvi, DeForrest Jm, Richard A. Morrison, Weinstein Sh, B. H. Migdalof> ;Drug Design and Delivery. 1987 Sep 1
• Determination of the partitioning, stability, and metabolite formation of isosorbide dinitrate in human and rat blood using an improved gas-liquid chromatographic assay.
  Morrison, R. A., Fung, H. L.> ;J Chromatogr. 1984 Jun 8
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