RichardHuntSmithMD

PubMed

• 29 citations
  Intraprocedural predictors of post-stent retriever thrombectomy subarachnoid hemorrhage in middle cerebral artery stroke.
  Perry P. Ng, Theodore C Larson, Christopher W Nichols, Mark M Murray, Karen L. Salzman, Richard H Smith> ;Journal of Neurointerventional Surgery. 2019 Feb 1
• Energetic effects for observed and unobserved HIV-1 reverse transcriptase mutations of residues L100, V106, and Y181 in the presence of nevirapine and efavirenz.
  Smith, M. B., Rader, L. H., Franklin, A. M., Taylor, E. V., Smith, K. D., Smith, R. H., Tirado-Rives, J., Jorgensen, W. L.> ;Bioorg Med Chem Lett. 2008 Feb 1
• Assault on resistance: the use of computational chemistry in the development of anti-HIV drugs.
  Smith, M. B., Smith, R. H., Jorgensen, W. L.> ;Curr Pharm Des. 2006
• Molecular modeling calculations of HIV-1 reverse transcriptase nonnucleoside inhibitors: correlation of binding energy with biological activity for novel 2-aryl-substi...
  Kroeger Smith, M. B., Hose, B. M., Hawkins, A., Lipchock, J., Farnsworth, D. W., Rizzo, R. C., Tirado-Rives, J., Arnold, E., Zhang, W., Hughes, S. H., Jorgensen, W. L....> ;J Med Chem. 2003 May 8
• HIV-1 reverse transcriptase variants: molecular modeling of Y181C, V106A, L100I, and K103N mutations with nonnucleoside inhibitors using Monte Carlo simulations in com...
  Smith, M. B., Ruby, S., Horouzhenko, S., Buckingham, B., Richardson, J., Puleri, I., Potts, E., Jorgensen, W. L., Arnold, E., Zhang, W., Hughes, S. H., Michejda, C. J....> ;Drug Des Discov. 2003
• Prediction of activity for nonnucleoside inhibitors with HIV-1 reverse transcriptase based on Monte Carlo simulations.
  Rizzo, R. C., Udier-Blagovi?, M., Wang, D. P., Watkins, E. K., Kroeger Smith, M. B., Smith, R. H., Tirado-Rives, J., Jorgensen, W. L.> ;J Med Chem. 2002 Jul 4
• Monte Carlo calculations on HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor 8-Cl TIBO: contribution of the L100I and Y181C variants to protein ...
  Smith, M. B., Lamb, M. L., Tirado-Rives, J., Jorgensen, W. L., Michejda, C. J., Ruby, S. K., Smith, R. H.> ;Protein Eng. 2000 Jun
• Prediction of binding affinities for TIBO inhibitors of HIV-1 reverse transcriptase using Monte Carlo simulations in a linear response method.
  Smith, R. H., Jorgensen, W. L., Tirado-Rives, J., Lamb, M. L., Janssen, P. A., Michejda, C. J., Kroeger Smith, M. B.> ;J Med Chem. 1998 Dec 17
• Molecular modeling of HIV-1 reverse transcriptase drug-resistant mutant strains: implications for the mechanism of polymerase action.
  Kroeger Smith, M. B., Michejda, C. J., Hughes, S. H., Boyer, P. L., Janssen, P. A., Andries, K., Buckheit, R. W., Smith, R. H.> ;Protein Eng. 1997 Dec
• Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant.
  Das, K., Ding, J., Hsiou, Y., Clark, A. D., Moereels, H., Koymans, L., Andries, K., Pauwels, R., Janssen, P. A., Boyer, P. L., Clark, P., Smith, R. H., Kroeger Smith, ...> ;J Mol Biol. 1996 Dec 20
• Specificity of DNA alkylation by 1-(2-chloroethyl)-3-alkyl-3-acyltriazenes depends on the structure of the acyl group: kinetic and product studies.
  Smith, M. B., Schmidt, B. F., Czerwinski, G., Taneyhill, L. A., Snyder, E. J., Kline, A. M., Michejda, C. J., Smith, R. H.> ;Chem Res Toxicol. 1996 Mar
• Base sequence selectivity in the alkylation of DNA by 1,3-dialkyl-3-acyltriazenes.
  Kroeger Smith, M. B., Taneyhill, L. A., Michejda, C. J., Smith, R. H.> ;Chem Res Toxicol.
• Oxidative metabolism of 1-(2-chloroethyl)-3-alkyl-3- (methylcarbamoyl)triazenes: formation of chloroacetaldehyde and relevance to biological activity.
  Rouzer, C. A., Sabourin, M., Skinner, T. L., Thompson, E. J., Wood, T. O., Chmurny, G. N., Klose, J. R., Roman, J. M., Smith, R. H., Michejda, C. J.> ;Chem Res Toxicol.
• DNA alkylation by triazenes and related compounds.
  Michejda, C. J., Smith, R. H., Kroeger Koepke, M. B.> ;IARC Sci Publ. 1994
• An unexpected pathway for the metabolic degradation of 1,3-dialkyl-3-acyltriazenes.
  Rouzer, C. A., Thompson, E. J., Skinner, T. L., Heavner, P. A., Bartolini, W. P., Mitchell, K., Kurz, E., Smith, R. H., Michejda, C. J.> ;Biochem Pharmacol. 1993 Jul 6
• Alkylation of DNA by 1,3-dialkyl-3-acyltriazenes: correlation of biological activity with chemical behavior.
  Kroeger-Koepke, M. B., Michejda, C. J., Smith, R. H.> ;Chem Res Toxicol.
• 1,3-Dialkyltriazenes: reactive intermediates and DNA alkylation.
  Kroeger-Koepke, M. B., Smith, R. H., Goodnow, E. A., Brashears, J., Kratz, L., Andrews, A. W., Alvord, W. G., Michejda, C. J.> ;Chem Res Toxicol.
• 1,3-Dialkyl-3-acyltriazenes, a novel class of antineoplastic alkylating agents.
  Smith, R. H., Scudiero, D. A., Michejda, C. J.> ;J Med Chem. 1990 Sep
• Tumors in F344 rats by oral administration of 1,3-diethyltriazene.
  Smith, R. H., Kovatch, R. M., Lijinsky, W., Thomas, B. J., Michejda, C. J.> ;Cancer Lett. 1987 May
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