R. JamesWhiteMDPhD

PubMed

• Cardiac effort and 6-min walk distance correlate with stroke volume measured by cardiac magnetic resonance imaging.
  Michael D Lachant, Deborah Haight, Daniel J Lachant, R James White> ;Pulmonary Circulation. 2024 Apr 1
• Risk scores as a surrogate in pulmonary arterial hypertension: a different lens.
  R James White, Daniel J Lachant, Raymond L Benza> ;The Lancet. Respiratory Medicine. 2024 Mar 1
• Oral Treprostinil is Associated with Improved Survival in FREEDOM-EV and its Open-Label Extension.
  Grünig, E., Rahaghi, F., Elwing, J., Vizza, C., Pepke-Zaba, J., Shen, J., Yao, H., Hage, A., Rosenkranz, S., Vonk, M., Balasubramanian, V., Yuanhua, Y., Yu, Z., Lordan...> ;Advances in Therapy. 2024 Feb 1
• Risk Stratification in Pulmonary Arterial Hypertension: Perhaps Simple Is Not Best?
  Charles Fauvel, R James White, Rebecca R Vanderpool, Roberto Badagliacca, Tobore Tobore, Mohammad Rahman, Carmine Dario Vizza, Shili Lin, Allen D Everett, Scott H Viso...> ;Chest. 2024 Feb 1
• Regional Variation in Pulmonary Arterial Hypertension in the United States: The Pulmonary Hypertension Association Registry.
  Connor Fling, Teresa De Marco, Noah A Kime, Matthew R Lammi, Laura J Oppegard, John J Ryan, Corey E Ventetuolo, R James White, Roham T Zamanian, Peter J Leary> ;Annals of the American Thoracic Society. 2023 Dec 1
• 7 citations
  Contemporary risk scores predict clinical worsening in pulmonary arterial hypertension - An analysis of FREEDOM-EV.
  Raymond L Benza, Mardi Gomberg-Maitland, Harrison W Farber, Carmine Dario Vizza, Meredith Broderick, Louis Holdstock, Andrew C Nelsen, Chunqin Deng, Youlan Rao, R Jame...> ;The Journal of Heart and Lung Transplantation. 2022 Nov 1
• 3 citations
  Cardiac Effort to Compare Clinic and Remote 6-Minute Walk Testing in Pulmonary Arterial Hypertension.
  Daniel Lachant, Ethan Kennedy, Blaise Derenze, Allison Light, Michael Lachant, R James White> ;Chest. 2022 Dec 1
• 4 citations
  Delphi consensus recommendation for optimization of pulmonary hypertension therapy focusing on switching from a phosphodiesterase 5 inhibitor to riociguat.
  Franck F Rahaghi, Vijay P Balasubramanian, Robert C Bourge, Charles D Burger, Murali M Chakinala, Michael S Eggert, Jean M Elwing, Jeremy Feldman, Christopher King, Ja...> ;Pulmonary Circulation. 2022 Apr 1
• 20 citations
  Aggressive Afterload Lowering to Improve the Right Ventricle: A New Target for Medical Therapy in Pulmonary Arterial Hypertension?
  Carmine Dario Vizza, Irene M Lang, Roberto Badagliacca, Raymond L Benza, Stephan Rosenkranz, R James White, Yochai Adir, Arne K Andreassen, Vijay Balasubramanian, Sonj...> ;American Journal of Respiratory and Critical Care Medicine. 2022 Apr 1
• 3 citations
  Comparison of chest- and wrist-based actigraphy in pulmonary arterial hypertension.
  Daniel Lachant, Allison Light, Kevin Hannon, Farrukh Abbas, Michael Lachant, R James White> ;European Heart Journal. Digital Health. 2022 Mar 1
• 6 citations
  Oral treprostinil improves pulmonary vascular compliance in pulmonary arterial hypertension.
  Akram Khan, R James White, Gisela Meyer, Tomas R Pulido Zamudio, Carlos Jerjes-Sanchez, Dana Johnson, Rob Grover, Meredith Broderick, Aliou Ousmanou, Louis Holdstock, ...> ;Respiratory Medicine. 2022 Mar 1
• 2 citations
  Transitioning selexipag to oral treprostinil in patients with pulmonary artery hypertension.
  Carlo Arevalo, R James White, Daniel Lachant> ;Respiratory Medicine Case Reports. 2022 Jan 1
• 9 citations
  Reduced Notch1 Cleavage Promotes the Development of Pulmonary Hypertension.
  Shumin Wang, Guofu Zhu, Dongyang Jiang, Jordan Rhen, Xiankai Li, Hao Liu, Yuyan Lyu, Patrick Tsai, Yara Rose, Tiffany Nguyen, R. James White, Gloria S. Pryhuber, Thoma...> ;Hypertension. 2021 Nov 5
• 3 citations
  Vasodilator use in precapillary pulmonary hypertension with end stage kidney disease: A single center experience.
  Carlo Arevalo, R. James White, Thu H Le, Daniel J. Lachant> ;Respiratory Medicine. 2021 Nov 1
• 1 citations
  An untapped resource: characteristics of thrombus recovered from intermediate or high risk pulmonary embolus patients.
  Geoffrey Newcomb, Bennett L. Wilson, R. James White, Bruce I. Goldman, Neil A Lachant, Daniel J. Lachant> ;Cardiovascular Pathology. 2022 Mar 1
• Resting heart rate as a surrogate for improvement in intermediate risk pulmonary embolus patients
  Dominick Roto, Neil A. Lachant, R. James White, Daniel J. Lachant> ;Respiratory Medicine. 2021 Oct 1
• 12 citations
  Selonsertib in adults with pulmonary arterial hypertension (ARROW): a randomised, double-blind, placebo-controlled, phase 2 trial.
  Stephan Rosenkranz, Jeremy Feldman, Vallerie V. McLaughlin, Franz Rischard, Tobias J. Lange, R. James White, Andrew J. Peacock, Felix Gerhardt, Ramin Ebrahimi, Gabriel...> ;The Lancet. Respiratory Medicine. 2021 Aug 20
• 4 citations
  Venous thromboembolism associates with SARS-CoV-2 more than seasonal influenza.
  Daniel J. Lachant, Dominick Roto, Stephen Rappaport, Paritosh Prasad, Neil A. Lachant, R. James White> ;Thrombosis Research. 2021 Jul 3
• 3 citations
  Evaluation of Clinical Recovery After Surgical Treatment for Hand Ischemia From Vasospastic and Occlusive Disease Using PROMIS.
  David N. Bernstein, John A Cliburn, Daniel J. Lachant, R. James White, Warren C. Hammert> ;Hand. 2021 Mar 31
• 44 citations
  Safety and Efficacy of B-Cell Depletion with Rituximab for the Treatment of Systemic Sclerosis-associated Pulmonary Arterial Hypertension: A Multicenter, Double-Blind,...
  Roham T. Zamanian, David B. Badesch, Lorinda Chung, Robyn T. Domsic, Thomas A. Medsger, Ashley Pinckney, Lynette Keyes-Elstein, Carla D’Aveta, Meagan Spychala, R. Jame...> ;American Journal of Respiratory and Critical Care Medicine. 2021 Mar 2
• 12 citations
  Direct oral anticoagulant therapy in patients with morbid obesity after intermediate- or high-risk pulmonary emboli.
  Daniel J. Lachant, Christina Bach, Alexander Fe, R. James White, Neil A. Lachant> ;ERJ Open Research. 2021 Jan 1
• 20 citations
  United States Pulmonary Hypertension Scientific Registry: Baseline Characteristics.
  J. Badlam, David B. Badesch, Eric D. Austin, Raymond L. Benza, Wendy K. Chung, Harrison W. Farber, K. Feldkircher, Adaani E. Frost, Abby Poms, Katie A. Lutz, Michael W...> ;Chest. 2021 Jan 1
• 7 citations
  Heart rate monitoring improves clinical assessment during 6-min walk.
  Daniel J. Lachant, Allison Light, Melissa Offen, Jamie L Adams, R. James White> ;Pulmonary Circulation. 2020 Dec 9
• 1 citations
  Long-term study of oral treprostinil to treat pulmonary arterial hypertension: dosing, tolerability, and pharmacokinetics:
  R. James White, Keyur Parikh, Roblee P Allen, Jeremy Feldman, Carlos Jerjez-Sanchez, Lei Pan, Anne Keogh, C. Dario Vizza, Shelley Shapiro, Kathryn Gordon, Meredith Bro...> ;Pulmonary Circulation. 2020 Dec 8
• 5 citations
  Clinical and imaging outcomes after intermediate- or high-risk pulmonary embolus.
  Daniel J. Lachant, Christina Bach, Bennett L. Wilson, Vaseem U. Chengazi, Bruce I. Goldman, Neil A. Lachant, Anthony P. Pietropaoli, Scott J. Cameron, R. James White> ;Pulmonary Circulation. 2020 Sep 21
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Journal Articles

• Drug discovery in pulmonary arterial hypertension: attacking the enigmatic root of a deadly weed  
  White R. J., Lannan K. L., Phipps R. P., Drug Discov Today, 1/1/2014
• Thrombosis, platelets, microparticles and PAH: more than a clot  
  Lannan K. L., Phipps R. P., White R. J, Drug Discov Today, 1/1/2014
• Pharmacokinetics of oral treprostinil diolamine sustained release tablets during chronic administration to patients with pulmonary arterial hypertension  
  White, R. J., Torres, F, Allen, R., Jerjes, C, Pulido, T., Yehle, D., Howell, M, Laliberte, K, Marier, JF, Tapson, VF, J Cardiovasc Pharmacol, 1/1/2013
• Efficacy and safety of oral treprostinil monotherapy for the treatment of pulmonary arterial hypertension: a randomized controlled trial  
  Jing, Z. C., Parikh, K., Pulido, T., Jerjes-Sanchez, C., White, R. J., Allen, R., Torbicki, A., Xu, KF, Yehle, D., Laliberte, K, Arneson, C., Rubin L., Circulation, 1/1/2013
• Rapid transition from inhaled iloprost to inhaled treprostinil in patients with pulmonary arterial hypertension  
  Bourge, R. C., Tapson, V. F., Safdar, Z., Benza, R. L., Channick, R. N., Rosenzweig, E. B., Shapiro, S., White, R. J., McSwain, C.S., Gotzkowsky, S.K., Nelsen, A. C., ..., Cardiovascular Therapeutics, 1/1/2013
• miR-26a Linked to Pulmonary Hypertension by Global Assessment of Circulating Extracellular MicroRNAs  
  Schlosser, K., White, R. J., Stewart, D. J., Am J Resp Crit Care Med, 1/1/2013
• Subcutaneous treprostinil is welltolerated with infrequent site changes and analgesics  
  White, R. J., Levin, Y. D., Wessman, K., Heininger, A., Frutiger, K, Pulm. Circ, 1/1/2013
• Thrombin and Platelets in Pulmonary Hypertension: A Lot More than Clot  
  White, R. J., Adv. Pulmon. Hypertens, 1/1/2012
• Understanding the Low Penetrance of Bone Morphogenetic Protein Receptor 2 Gene Mutations: Another Needle in the Haystack  
  White, R. J., Morrell, N. W., Circulation, 1/1/2012
• AHA Scientific Statement: Management of Massive and Submassive Pulmonary Embolism, Iliofemoral Deep Vein Thrombosis, and Chronic Thromboembolic Pulmonary Hypertension  
  McMurtry, M. S,, Archer, S.L., Cushman, M., Goldenberg, N., Goldhaber, S. Z., Jenkins, J. S., Kline, J. A., Michaels, A. D., Thistlethwaite, P. A., Vedantham, S., Whit..., Circulation, 1/1/2011
• Neonatal hyperoxia causes pulmonary vascular disease and shortens life-span in aging mice  
  Yee, M., White, R. J., Awad, H., Bates, W.A., O’Reilly, M.A., Amer J. Pathology, 1/1/2011
• Novel Therapeutic Approaches in Pulmonary Arterial Hypertension: Focus on Tadalafil  
  Levin, Y.D., White, R. J., Drugs of Today, 1/1/2011
• Inhaled Treprostinil for Pulmonary Arterial Hypertension  
  Ferrantino, M, White, R. J., Expert Opin. Pharmacotherapy, 1/1/2011
• Exercise improvement and plasma biomarker changes during intravenous treprostinil therapy for pulmonary arterial hypertension: a placebocontrolled trial  
  Hiremath, J., Thanikachalam, S., Parikh, K., Shanmugasundaram, S., Bangera, S., Shapiro, L., Pott, G.B., Vnencak-Jones, C., Arneson, C., Wade, M., White, R. J., J Heart Lung Transplant, 1/1/2010
• Endothelin-1 induces pulmonary but not aortic smooth muscle cell migration by activating ERK1/2 MAP kinase  
  Meoli, D.F., White, R. J., Canadian J Pharmacol Physiol, 1/1/2010
• Rationale for the judicious use of placebos in PAH trials  
  White, R. J., Hiremath, J., J Heart Lung Transplant, 1/1/2010
• Sildenafil improves hemodynamics in liver transplantation candidates with pulmonary hypertension  
  Gough, M.S. and White, R.J., Liver Transplant, 1/1/2009
• Tadalafil therapy for pulmonary arterial hypertension  
  Galie, N., Brundage, B.H., Ghofrani, A., Oudiz, R. J., Simonneau, G., Safdar, Z., Shapiro, S., White, R. J., Chan, M., Beardsworth, A., Frumkin, L., Barst, R. J., Circulation, 1/1/2009
• Thrombin induces fibronectin-specific migration of pulmonary microvascular endothelial cells: requirement of calcium-calmodulin dependent protein kinase II  
  Meoli, D.F., White, R. J., Am J Physiol: Lung Cell Molec Physiol, 1/1/2009
• Update on the development of oral prostacyclin analogs for the treatment of pulmonary arterial hypertension  
  White, R. J., Adv. Pulmon. Hypertens, 1/1/2009
• Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary hypertension  
  White, R.J., Meoli, D.F., Swarthout, R.F., Kallop, D.Y., Galaria, I.I., Harvey, J.L., Miller, C.M., Blaxall, B.C., Hall, C.M., Pierce, R.A., Cool, C.D., Taubman, M.B., Am J Physiol: Lung Cell Mol Physiol, 1/1/2007
• Tissue factor is induced in a rodent model of severe pulmonary hypertension characterized by neointimal lesions typical of human disease  
  White, R.J., Galaria, I.I., Harvey, J., Blaxall, B.C., Cool, C.D., Taubman, M.B., Chest, 1/1/2005
• A “Radical” Idea Comes of Age: Mitochondrial Oxidant Signaling in Health and Disease  
  White, R.J., Journal of Molecular and Cellular Cardiology, 1/1/2004
• Pulmonary Arterial Hypertension: Building a Better Mouse Trap for 2010  
  White, R.J., Drug Discovery Today: Therapeutic Strategies, 1/1/2004
• Mitochondria Accumulate Ca2+ Following Intense Glutamate Stimulation Of Cultured Forebrain Neurones  
  White, R.J. and Reynolds, I.J., J Physiol (Lond), 1/1/1997
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Books/Book Chapters

• Lung injury: Mechanisms, pathophysiology and treatment 
  Chapter: Gene therapy for lung injury 
  Sime P.J., White R.J., Kolb M, Hitt M, and Gauldie J.Editors: Notter, R, Finkelstein, J, and Holm.Marcel-Dekker, New York, NY2004

Abstracts/Posters

• Sex-specific response to therapy in rats with severe PAH
  White, RJ., Mini-Symposium, 1/1/2013
• Ixolaris, a Tissue Factor Inhibitor, Preserves Vascular Perfusion as Assessed by Quantitative Micro CT Scan in Rats with Established Pulmonary Arterial Hypertension (PAH)
  Meoli, DF, Haight, D, Franciscetti, I, Awad, H, White, RJ., Amer J Resp Crit Care Med, 1/1/2009
• Thrombin Induces Fibronectin-Dependent Migration of Pulmonary Microvascular Endothelial Cells: Involvement of v 3 Integrin, Talin Phosphorylation, and Calcium Signaling
  Meoli, DF, White, RJ, Amer J Resp Crit Care Med, 1/1/2009
• Sustained Plasma Concentrations of Treprostinil Following Chronic Dosing in Patients with Pulmonary Arterial Hypertension (PAH)
  White, RJ, Allen, R, Torres, F, Jerjes, C, Pulido, T, Carroll, J, Yehle, D, Laliberte, K, Mottola, D, Galie, N, Simmoneau, G, Tapson, VF, Amer J Resp Crit Care Med, 1/1/2009
• Oral Treprostinil Diethanolamine Provides Sustained Therapeutic Plasma Levels over a Wide Range of Doses in Patients with Pulmonary Arterial Hypertension
  White, RJ, R. Allen, D. Yehle, K. Laliberte, D. Mottola, N. Galie, G. Simonneau, V.F. Tapson, Amer J Resp Crit Care Med, 1/1/2008
• Intravenous Treprostinil Reduced Angiopoietin-2 Levels during 12 Weeks of Blinded Therapy: A Study of 11 Biomarkers in Pulmonary Arterial Hypertension
  White, RJ, M. Wade, C. Arneson, Amer J Resp Crit Care Med, 1/1/2008
• Calcium Calmodulin-Dependent Protein Kinase II (CaMKII) Specifically Mediates Thrombin/Fibronectin-Induced Migration of Pulmonary Microvascular Endothelial Cells
  Meoli, DF, White, RJ, Amer J Resp Crit Care Med, 1/1/2008
• Ixolaris, a Tissue Factor Inhibitor, Reduces Vascular Pruning and Delays Death in Rats with Established Pulmonary Arterial Hypertension
  D.F. Meoli, R.F. Swarthout, M.B. Taubman, R.J. White, Amer J Resp Crit Care Med, 1/1/2008
• Proliferating Vascular Lesions with a Plexiform Appearance in a Rodent Model of Severe Pulmonary Hypertension: Tissue Factor is Abnormally Expressed
  White, RJ, Harvey, J, Galaria, II, Moore, CH, Pierce, RA, Miller, CE, Georger, MA, Taubman, MB, Cool, CD, Am J Resp Crit Care Med, 1/1/2004
• Mitochondrial Calcium Uptake is Altered in Liver Mitochondria Isolated from Endotoxin Treated Rats
  White, RJ, Rice, EJ, Gunter, KK, Callahan, LA, Supinski, GS, Am J Resp Crit Care Med, 1/1/2002
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Lectures

• Pulmonary Arterial Hypertension: Breathing Easier 
  Multiple locations, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012 - 1/1/2014
• Clinical update on Prostacyclins as Early Therapy for Advanced PAH 
  Multiple locations, 2008, 2009, 2013, 2012 - 1/1/2014
• Tissue Factor in Severe Pulmonary Arterial Hypertension 
  Multiple locations, 2005, 2007, 2008, 2009, 2010, 2011, 2012 - 1/1/2012