RizwanSAkhtarMDPhD

Neurology • Chicago, IL

Movement Disorder, Neurodegenerative

Assistant Professor of Neurology

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Office
259 E Erie St, Lavin Pavilion
19th Floor, Suite 1900
Chicago, IL 60611
Phone+1 312-695-7950
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Education & Training

University of Pennsylvania Health SystemFellowship, Neuromuscular Medicine (Neurology), 2011 - 2013
University of Pennsylvania Health SystemResidency, Neurology, 2008 - 2011
University of Alabama Medical CenterInternship, Internal Medicine, 2007 - 2008
University of Alabama School of MedicineClass of 2007

Certifications & Licensure

IL State Medical License 2020 - 2026
PA State Medical License 2008 - 2021
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013

Clinical Trials

Study to Identify Clinical, Imaging and Biologic Markers of Parkinson Disease Progression Start of enrollment: 2010 Jun 01
Completed
Phase 2

Publications & Presentations

PubMed

Novel THAP1 missense variant with incomplete penetrance in a case of generalized young onset dystonia showing good response to deep brain stimulation.
Ignacio J Keller Sarmiento, Avram Fraint, Lisa Kinsley, Rizwan S Akhtar, Vincenzo Silani, Steven J Lubbe, Dimitri Krainc, Niccolò E Mencacci> ;Parkinsonism & Related Disorders. 2022 Dec 1
2 citations
Novel bi-allelic FBXO7 variants in a family with early-onset typical Parkinson's disease.
Ignacio J Keller Sarmiento, Mitra Afshari, Lisa Kinsley, Vincenzo Silani, Rizwan S Akhtar, Tanya Simuni, Steven J Lubbe, Dimitri Krainc, Niccolò E Mencacci> ;Parkinsonism & Related Disorders. 2022 Nov 1
2 citations
Whole Clinic Research Enrollment in Parkinson's Disease: The Molecular Integration in Neurological Diagnosis (MIND) Study.
Thomas F. Tropea, Noor Amari, Noah Han, Jacqueline Rick, EunRan Suh, Rizwan S. Akhtar, Nabila Dahodwala, Andres Deik, Pedro Gonzalez-Alegre, Howard I. Hurtig, Andrew S...> ;Journal of Parkinson's Disease. 2021 Jan 1
30 citations
Subjective Cognitive Complaint in Parkinson's Disease Patients With Normal Cognition: Canary in the Coal Mine?
Rachael Purri, Laura Brennan, Jacqueline Rick, Sharon X. Xie, Benjamin L. Deck, Lana M. Chahine, Nabila Dahodwala, Alice Chen-Plotkin, John E. Duda, James F. Morley, R...> ;Movement Disorders. 2020 Jun 10
2 citations
High serum neurofilament light chain predicts a worse fate in early parkinsonism
Rizwan S. Akhtar, Tomoo Mano> ;Neurology. 2019 Mar 26
77 citations
Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders
David G. Coughlin, Sharon X. Xie, Mendy Liang, Andrew Williams, Claire Peterson, Daniel Weintraub, Corey T. McMillan, David A. Wolk, Rizwan S. Akhtar, Howard I. Hurtig...> ;Annals of Neurology. 2018 Dec 14
59 citations
CSF tau and β-amyloid predict cerebral synucleinopathy in autopsied Lewy body disorders.
David J. Irwin, Sharon X. Xie, David G. Coughlin, Naomi Nevler, Rizwan S. Akhtar, Corey T. McMillan, Edward B. Lee, David A. Wolk, Daniel Weintraub, Alice Chen-Plotkin...> ;Neurology. 2018 Mar 20
40 citations
Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease
Rizwan S. Akhtar, Joseph P. Licata, Kelvin C. Luk, Leslie M. Shaw, John Q. Trojanowski, Virginia M.-Y. Lee> ;Journal of Neurochemistry. 2018 Jun 1
26 citations
Regional brain amyloid-β accumulation associates with domain-specific cognitive performance in Parkinson disease without dementia
Rizwan S. Akhtar, Sharon X. Xie, Yin J. Chen, Jacqueline Rick, Rachel G. Gross, Ilya M. Nasrallah, Vivianna M. Van Deerlin, John Q. Trojanowski, Alice Chen-Plotkin, Ho...> ;Plos One. 2017 May 25
45 citations
Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease.
Dustin J. Covell, John L. Robinson, Rizwan S. Akhtar, Murray Grossman, Dan Weintraub, H. M. Bucklin, Rose M. Pitkin, Dawn M. Riddle, Ahmed Yousef, John Q. Trojanowski,...> ;Neuropathology and Applied Neurobiology. 2017 May 15
24 citations
Amyloid-Beta Positron Emission Tomography Imaging of Alzheimer's Pathology in Parkinson's Disease Dementia.
Rizwan S. Akhtar, Sharon X. Xie, Laura Brennan, Michael J. Pontecorvo, Howard I. Hurtig, John Q. Trojanowski, Daniel Weintraub, Andrew Siderowf> ;Movement Disorders Clinical Practice. 2016 Jan 5
156 citations
Longitudinal study of normal cognition in Parkinson disease.
Kara Pigott, Jacqueline Rick, Sharon X. Xie, Howard I. Hurtig, Alice Chen-Plotkin, John E. Duda, James F. Morley, Lama M. Chahine, Nabila Dahodwala, Rizwan S. Akhtar, ...> ;Neurology. 2015 Oct 13
15 citations
New concepts in the early and preclinical detection of Parkinson's disease: therapeutic implications.
Rizwan S. Akhtar, Matthew B. Stern> ;Expert Review of Neurotherapeutics. 2012 Dec 1
42 citations
Cytoplasmic p53 and activated Bax regulate p53-dependent, transcription-independent neural precursor cell apoptosis.
Ying Geng, Ken C. Walls, Arindam P. Ghosh, Rizwan S. Akhtar, Barbara J. Klocke, Kevin A. Roth> ;The Journal of Histochemistry and Cytochemistry. 2010 Mar 1
23 citations
Loss of BH3-only Protein Bim Inhibits Apoptosis of Hemopoietic Cells in the Fetal Liver and Male Germ Cells but Not Neuronal Cells in Bcl-x–deficient Mice
Rizwan S. Akhtar, Barbara J. Klocke, Andreas Strasser, Kevin A. Roth> ;The Journal of Histochemistry and Cytochemistry. 2008 Oct 1
11 citations
Immunohistochemical detection with quantum dots.
Rizwan S. Akhtar, Cecelia B. Latham, Dario Siniscalco, Carlo Fuccio, Kevin A. Roth> ;Methods in Molecular Biology. 2007 Jan 1
22 citations
p53 transcription-dependent and -independent regulation of cerebellar neural precursor cell apoptosis.
Ying Geng, Rizwan S. Akhtar, John J. Shacka, Barbara J. Klocke, Jin Zhang, Xinbin Chen, Kevin A. Roth> ;Journal of Neuropathology and Experimental Neurology. 2007 Jan 1
50 citations
BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death.
Rizwan S. Akhtar, Ying Geng, Barbara J. Klocke, Cecelia B. Latham, Andreas Villunger, Ewa M. Michalak, Andreas Strasser, Steven L. Carroll, Kevin A. Roth> ;The Journal of Neuroscience. 2006 Jul 5
38 citations
Neural precursor cells possess multiple p53-dependent apoptotic pathways
Rizwan S. Akhtar, Ying Geng, Barbara J. Klocke, Kevin A. Roth> ;Cell Death and Differentiation. 2006 Mar 3
154 citations
Bcl-2 family regulation of neuronal development and neurodegeneration.
Rizwan S. Akhtar, Jayne Ness, Kevin A. Roth> ;Biochimica Et Biophysica Acta. 2004 Mar 1
55 citations
Combined Tyramide Signal Amplification and Quantum Dots for Sensitive and Photostable Immunofluorescence Detection
Jayne Ness, Rizwan S. Akhtar, Cecelia B. Latham, Kevin A. Roth> ;The Journal of Histochemistry and Cytochemistry. 2003 Aug 1
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