RobertJrAbelJr.MD

Ophthalmology • Wilmington, DE

Physician

Join to view full profile

Dr. Abel is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Abel's full profile

Already have an account?

Office
3509 Silverside Rd
Wilmington, DE 19810
Phone+1 302-479-3937

Fax+1 302-477-2650
Is this information wrong?

Education & Training

University of FloridaResidency, Ophthalmology, 1973 - 1974
Icahn School of Medicine at Mount Sinai/Mount Sinai HospitalResidency, Ophthalmology, 1970 - 1973
Temple University HospitalInternship, Internal Medicine, 1969 - 1970
Sidney Kimmel Medical College at Thomas Jefferson UniversityClass of 1969

Certifications & Licensure

CA State Medical License 1975 - Present
DE State Medical License 1974 - 2025
NJ State Medical License 1989 - 2011
PA State Medical License 1971 - 2008
NY State Medical License 1970 - 2005
FL State Medical License 1974 - 1987
American Board of Ophthalmology Ophthalmology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification SRS EHR, SRSsoft, 2012-2013
Fellow (FAAO) American Academy of Ophthalmology

Publications & Presentations

PubMed

56 citations
Efficient Exploration of Chemical Space with Docking and Deep Learning.
Ying Yang, Kun Yao, Matthew P. Repasky, Karl Leswing, Robert Abel, Brian K. Shoichet, Steven V. Jerome> ;Journal of Chemical Theory and Computation. 2021 Sep 30
20 citations
From computer-aided drug discovery to computer-driven drug discovery
Leah L. Frye, Sathesh Bhat, Karen Akinsanya, Robert Abel> ;Drug Discovery Today. Technologies. 2021 Aug 30
434 citations
OPLS4: Improving Force Field Accuracy on Challenging Regimes of Chemical Space.
Chao Lu, Chuanjie Wu, Delaram Ghoreishi, Wei Chen, Lingle Wang, Wolfgang Damm, Gregory A. Ross, Markus K. Dahlgren, Ellery Russell, Christopher D Von Bargen, Robert Ab...> ;Journal of Chemical Theory and Computation. 2021 Jun 7
48 citations
Reliable and Accurate Solution to the Induced Fit Docking Problem for Protein–Ligand Binding
Edward B. Miller, Robert B. Murphy, Daniel J. Sindhikara, Kenneth W. Borrelli, Matthew J Grisewood, Fabio Ranalli, Steven L. Dixon, Steven V. Jerome, Nicholas A. Boyle...> ;Journal of Chemical Theory and Computation. 2021 Mar 29
13 citations
General Theory of Fragment Linking in Molecular Design: Why Fragment Linking Rarely Succeeds and How to Improve Outcomes.
Haoyu S. Yu, Kalyan Modugula, Osamu Ichihara, Kimberly Kramschuster, Simon Keng, Robert Abel, Lingle Wang> ;Journal of Chemical Theory and Computation. 2021 Jan 12
16 citations
Is Structure-Based Drug Design Ready for Selectivity Optimization?
Steven K. Albanese, John D. Chodera, Andrea Volkamer, Simon Keng, Robert Abel, Lingle Wang> ;Journal of Chemical Information and Modeling. 2020 Oct 29
43 citations
Enhancing Water Sampling in Free Energy Calculations with Grand Canonical Monte Carlo.
Gregory A. Ross, Ellery Russell, Yuqing Deng, Chao Lu, Edward Harder, Robert Abel, Lingle Wang> ;Journal of Chemical Theory and Computation. 2020 Oct 2
6 citations
Advancing Free-Energy Calculations of Metalloenzymes in Drug Discovery via Implementation of LFMM Potentials.
Steven Dajnowicz, Delaram Ghoreishi, Kalyan Modugula, Wolfgang Damm, Edward Harder, Robert Abel, Lingle Wang, Haoyu S. Yu> ;Journal of Chemical Theory and Computation. 2020 Sep 10
22 citations
Combining Cloud-Based Free-Energy Calculations, Synthetically Aware Enumerations, and Goal-Directed Generative Machine Learning for Rapid Large-Scale Chemical Explorat...
Phani Ghanakota, Pieter H. Bos, Kyle D. Konze, Joshua Staker, Gabriel Marques, Kyle Marshall, Karl Leswing, Robert Abel, Sathesh Bhat> ;Journal of Chemical Information and Modeling. 2020 Jun 19
18 citations
Toward Atomistic Modeling of Irreversible Covalent Inhibitor Binding Kinetics
Haoyu S. Yu, Cen Gao, Dmitry Lupyan, Yujie Wu, Takayuki Kimura, Chuanjie Wu, Leif D. Jacobson, Edward Harder, Robert Abel, Lingle Wang> ;Journal of Chemical Information and Modeling. 2019 Aug 19
52 citations
Reaction-Based Enumeration, Active Learning, and Free Energy Calculations To Rapidly Explore Synthetically Tractable Chemical Space and Optimize Potency of Cyclin-Depe...
Kyle D. Konze, Pieter H. Bos, Markus K. Dahlgren, Karl Leswing, Ivan Tubert-Brohman, Bortolato Andrea, Braxton Robbason, Robert Abel, Sathesh Bhat> ;Journal of Chemical Information and Modeling. 2019 Aug 12
14 citations
Noncovalent inhibitors reveal BTK gatekeeper and auto-inhibitory residues that control its transforming activity
Shenqiu Wang, Sayan Mondal, Chunying Zhao, Marjan Berishaj, Phani Ghanakota, Connie Lee Batlevi, Ahmet Dogan, Venkatraman E. Seshan, Robert Abel, Michael R. Green, Ana...> ;JCI Insight. 2019 Jun 20
13 citations
Application of Free Energy Perturbation (FEP+) to Understanding Ligand Selectivity: A Case Study to Assess Selectivity Between Pairs of Phosphodiesterases (PDE’s)
Francesca Moraca, Andrea Negri, Cesar de Oliveira, Robert Abel> ;Journal of Chemical Information and Modeling. 2019 Jun 12
48 citations
Relative Binding Affinity Prediction of Charge-Changing Sequence Mutations with FEP in Protein-Protein Interfaces
Anthony J. Clark, Christopher Negron, Kevin Hauser, Mengzhen Sun, Lingle Wang, Robert Abel, Richard A. Friesner> ;Journal of Molecular Biology. 2019 Mar 29
542 citations
OPLS3e: Extending Force Field Coverage for Drug-Like Small Molecules.
Katarina Roos, Chuanjie Wu, Wolfgang Damm, Mark Reboul, James Stevenson, Chao Lu, Markus K. Dahlgren, Sayan Mondal, Wei Chen, Lingle Wang, Robert Abel, Richard A. Frie...> ;Journal of Chemical Theory and Computation. 2019 Mar 4
30 citations
Molecular Structure Extraction from Documents Using Deep Learning.
Joshua Staker, Kyle Marshall, Robert Abel, Carolyn M. McQuaw> ;Journal of Chemical Information and Modeling. 2019 Feb 13
28 citations
Protein-Ligand Binding Free Energy Calculations with FEP.
Lingle Wang, Jennifer M. Chambers, Robert Abel> ;Methods in Molecular Biology. 2019 Jan 1
62 citations
Accurate Calculation of Relative Binding Free Energies between Ligands with Different Net Charges.
Wei Chen, Yuqing Deng, Ellery Russell, Yujie Wu, Robert Abel, Lingle Wang> ;Journal of Chemical Theory and Computation. 2018 Oct 30
11 citations
Modeling the value of predictive affinity scoring in preclinical drug discovery.
Robert Abel, Eric S. Manas, Richard A. Friesner, Ramy Farid, Lingle Wang> ;Current Opinion in Structural Biology. 2018 Oct 1
9 citations
Conformational Free Energy Changes via an Alchemical Path without Reaction Coordinates.
Peng He, Bin W. Zhang, Shima Arasteh, Lingle Wang, Robert Abel, Ronald M. Levy> ;The Journal of Physical Chemistry Letters. 2018 Jul 19
57 citations
Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations.
Kevin Hauser, Christopher Negron, Steven K. Albanese, Soumya S. Ray, Thomas Steinbrecher, Robert Abel, John D. Chodera, Lingle Wang> ;Communications Biology. 2018 Jun 13
34 citations
Accurate and Reliable Prediction of the Binding Affinities of Macrocycles to Their Protein Targets.
Haoyu S. Yu, Yuqing Deng, Yujie Wu, Daniel J. Sindhikara, Amy R. Rask, Takayuki Kimura, Robert Abel, Lingle Wang> ;Journal of Chemical Theory and Computation. 2017 Nov 30
65 citations
A Critical Review of Validation, Blind Testing, and Real- World Use of Alchemical Protein-Ligand Binding Free Energy Calculations.
Robert Abel, Lingle Wang, David L. Mobley, Richard A. Friesner> ;Current Topics in Medicinal Chemistry. 2017 Aug 31
168 citations
Advancing Drug Discovery through Enhanced Free Energy Calculations.
Robert Abel, Lingle Wang, Edward Harder, Bruce J. Berne, Richard A. Friesner> ;Accounts of Chemical Research. 2017 Jul 5
71 citations
Predicting the Effect of Amino Acid Single-Point Mutations on Protein Stability-Large-Scale Validation of MD-Based Relative Free Energy Calculations.
Thomas Steinbrecher, Chongkai Zhu, Lingle Wang, Robert Abel, Christopher Negron, David A. Pearlman, Eric Feyfant, Jianxin Duan, Woody Sherman> ;Journal of Molecular Biology. 2017 Apr 7
Join now to see all