RobertMarkHershbergMD

Medical Genetics • Seattle, WA

Clinical Genetics

Physician

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Office
1959 Ne Pacific St
Seattle, WA 98195
Phone+1 206-616-2135
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Summary

Dr. Robert Hershberg, MD is a medical geneticist in Seattle, Washington. He is currently licensed to practice medicine in Washington. He is affiliated with UW Medicine/University of Washington Medical Center.

Education & Training

University of WashingtonResidency, Medical Genetics and Genomics, 1997 - 1999
Virginia Mason Franciscan HealthResidency, Surgery, 1994 - 1996
University of WashingtonResidency, Ophthalmology, 1993 - 1994
University of Washington School of MedicineInternship, Transitional Year, 1992 - 1993
David Geffen School of Medicine at UCLAClass of 1992

Certifications & Licensure

WA State Medical License 1994 - 2025

Publications & Presentations

PubMed

4 citations
Genetic program activity delineates risk, relapse, and therapy responsiveness in multiple myeloma.
Matthew A. Wall, Serdar Turkarslan, Wei-Ju Wu, Samuel A. Danziger, David J. Reiss, Michael Mason, Andrew Dervan, Matthew William Burnell Trotter, Douglas Bassett, Robe...> ;NPJ Precision Oncology. 2021 Jun 28
26 citations
Bone marrow microenvironments that contribute to patient outcomes in newly diagnosed multiple myeloma: A cohort study of patients in the Total Therapy clinical trials.
, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Plos Medicine. 2020 Nov 4
13 citations
A generalizable data-driven multicellular model of pancreatic ductal adenocarcinoma.
Boris Aguilar, David L Gibbs, David J. Reiss, Mark McConnell, Samuel A. Danziger, Andrew Dervan, Matthew Trotter, Douglas Bassett, Robert M. Hershberg, Alexander V. Ra...> ;Gigascience. 2020 Jul 1
67 citations
Effect of Adding Motolimod to Standard Combination Chemotherapy and Cetuximab Treatment of Patients With Squamous Cell Carcinoma of the Head and Neck: The Active8 Rand...
Robert L. Ferris, Nabil F. Saba, Barbara J. Gitlitz, Robert I. Haddad, Ammar Sukari, Prakash Neupane, John C. Morris, Krzysztof Misiukiewicz, Julie E. Bauman, Moon Fen...> ;JAMA Oncology. 2018 Nov 1
Mycobacterium Tuberculosis Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors Within a Cell Network
Robert L Modlin, Sarah Fortune, Philip O Scumpia, Robert M Hershberg, Peter C Dedon> ;The Journal of Immunology. 2018 Apr 04
18 citations
TLR8 ligation induces apoptosis of monocytic myeloid-derived suppressor cells.
Yushe Dang, Zina Jeyapalan Rutnam, Gregory N. Dietsch, Hailing Lu, Yi Yang, Robert M. Hershberg, Mary L. Disis> ;Journal of Leukocyte Biology. 2018 Jan 1
53 citations
Phase Ib Study of Immune Biomarker Modulation with Neoadjuvant Cetuximab and TLR8 Stimulation in Head and Neck Cancer to Overcome Suppressive Myeloid Signals.
Gulidanna Shayan, Benjamin A. Kansy, Sandra P. Gibson, Raghvendra M. Srivastava, James Kyle Bryan, Julie E. Bauman, James Ohr, Seungwon Kim, Umamaheswar Duvvuri, David...> ;Clinical Cancer Research. 2018 Jan 1
81 citations
Phase Ib Trial of the Toll-like Receptor 8 Agonist, Motolimod (VTX-2337), Combined with Cetuximab in Patients with Recurrent or Metastatic SCCHN.
Laura Q.M. Chow, Chihiro Morishima, Keith D. Eaton, Christina S. Baik, Bernardo H. L. Goulart, Leslie N. Anderson, Kristi Manjarrez, Gregory N. Dietsch, James Kyle Bry...> ;Clinical Cancer Research. 2017 May 15
58 citations
A phase 2, randomized, double-blind, placebo- controlled study of chemo-immunotherapy combination using motolimod with pegylated liposomal doxorubicin in recurrent or ...
Bradley J. Monk, Mark F. Brady, Carol Aghajanian, Heather A. Lankes, Tina Rizack, J. Leach, Jeffrey M. Fowler, Robert V. Higgins, Parviz Hanjani, Mark A. Morgan, Rober...> ;Annals of Oncology. 2017 May 1
27 citations
Integrative Development of a TLR8 Agonist for Ovarian Cancer Chemoimmunotherapy.
Bradley J. Monk, Andrea Facciabene, William E. Brady, Carol Aghajanian, Paula M. Fracasso, Joan L. Walker, Heather A. Lankes, Kristi Manjarrez, Gwenn Danet-Desnoyers, ...> ;Clinical Cancer Research. 2017 Apr 15
67 citations
Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization.
Simon D. van Haren, David J. Dowling, Willemina Foppen, Dennis Christensen, Peter Andersen, Steven G. Reed, Robert M. Hershberg, Lindsey R. Baden, Ofer Levy> ;Journal of Immunology. 2016 Oct 28
136 citations
The Human Vaccines Project: A roadmap for cancer vaccine development
Pedro Romero, Jacques Banchereau, Nina Bhardwaj, Mark I. Cockett, Mary L. Disis, Glenn Dranoff, Eli Gilboa, Scott A. Hammond, Robert M. Hershberg, Alan J. Korman, Pia ...> ;Science Translational Medicine. 2016 Apr 13
7 citations
VTX‐1463, a novel TLR‐8 agonist, attenuates nasal congestion after ragweed challenge in sensitized beagle dogs
Christopher Royer, Karin Rudolph, Gregory N. Dietsch, Robert M. Hershberg, Edward G. Barrett> ;Immunity, Inflammation and Disease. 2016 Mar 1
71 citations
Somatic Mosaic Mutations in PPM1D and TP53 in the Blood of Women With Ovarian Carcinoma
Elizabeth M. Swisher, Maria I. Harrell, Barbara M. Norquist, Tom Walsh, Mark F. Brady, Ming Lee, Robert M. Hershberg, Kimberly R. Kalli, Heather A. Lankes, Eric Q. Kon...> ;JAMA Oncology. 2016 Mar 1
44 citations
Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity
Gregory N. Dietsch, Hailing Lu, Yi Yang, Chihiro Morishima, Laura Qm Chow, Mary L. Disis, Robert M. Hershberg> ;Plos One. 2016 Feb 29
14 citations
Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination.
Kavin Fatehchand, Li Ren, Saranya Elavazhagan, Huiqing Fang, Xiaokui Mo, John P. Vasilakos, Gregory N. Dietsch, Robert M. Hershberg, Susheela Tridandapani, Jonathan P....> ;The Journal of Biological Chemistry. 2016 Feb 19
30 citations
Late Stage Cancer Patients Remain Highly Responsive to Immune Activation by the Selective TLR8 Agonist Motolimod (VTX-2337)
Gregory N. Dietsch, Tressa D. Randall, Raphael Gottardo, Donald W. Northfelt, Ramesh K. Ramanathan, Peter A. Cohen, Kristi Manjarrez, Mona Newkirk, James Kyle Bryan, R...> ;Clinical Cancer Research. 2015 Dec 15
31 citations
Granzyme B Expression Is Enhanced in Human Monocytes by TLR8 Agonists and Contributes to Antibody-Dependent Cellular Cytotoxicity
Saranya Elavazhagan, Kavin Fatehchand, Vikram Santhanam, Huiqing Fang, Li Ren, Shalini Gautam, Brenda F. Reader, Xiaokui Mo, Carolyn Cheney, Edward L. Briercheck, John...> ;Journal of Immunology. 2015 Mar 15
39 citations
A Phase I Dose-Finding Study of the Novel Toll-like Receptor 8 Agonist VTX-2337 in Adult Subjects with Advanced Solid Tumors or Lymphoma
Donald W. Northfelt, Ramesh K. Ramanathan, Peter A. Cohen, Daniel D. Von Hoff, Glen J. Weiss, Gregory N. Dietsch, Kristi Manjarrez, Tressa D. Randall, Robert M. Hershberg> ;Clinical Cancer Research. 2014 Jul 15
59 citations
TLR8 stimulation enhances cetuximab-mediated natural killer cell lysis of head and neck cancer cells and dendritic cell cross-priming of EGFR-specific CD8+ T cells.
Ryan M. Stephenson, Chwee Ming Lim, Maura Matthews, Gregory N. Dietsch, Robert M. Hershberg, Robert L. Ferris> ;Cancer Immunology, Immunotherapy. 2013 May 18
57 citations
The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes
David J. Dowling, Zhen Tan, Zofia M. Prokopowicz, Christine D. Palmer, Maura Matthews, Gregory N. Dietsch, Robert M. Hershberg, Ofer Levy> ;Plos One. 2013 Mar 4
15 citations
Lineage targeted MHC-II transgenic mice demonstrate the role of dendritic cells in bacterial-driven colitis.
Lillian Maggio-Price, Audrey Seamons, Helle Bielefeldt-Ohmann, Weiping Zeng, Thea Brabb, Carol B. Ware, Mingzu Lei, Robert M. Hershberg> ;Inflammatory Bowel Diseases. 2013 Jan 1
130 citations
VTX-2337 Is a Novel TLR8 Agonist That Activates NK Cells and Augments ADCC
Hailing Lu, Gregory N. Dietsch, Maura Matthews, Yi Yang, Smita Ghanekar, Margaret Inokuma, Maria A. Suni, Vernon C. Maino, Katherine E. Henderson, J. Jeffry Howbert, M...> ;Clinical Cancer Research. 2012 Jan 15
36 citations
Ca2+-dependent Calmodulin Binding to FcRn Affects Immunoglobulin G Transport in the Transcytotic Pathway
Bonny L. Dickinson, Steven M. Claypool, June A. D’Angelo, Martha L. Aiken, Nanda Venu, Elizabeth H. Yen, Jessica Wagner, Jason A. Borawski, Amy T. Pierce, Robert M. He...> ;Molecular Biology of the Cell. 2008 Jan 1
84 citations
Anti-flagellin (CBir1) phenotypic and genetic Crohn's disease associations.
Konstantinos A. Papadakis, Huiying Yang, Andrew Ippoliti, Ling Mei, Charles O. Elson, Robert M. Hershberg, Eric A. Vasiliauskas, Phillip Fleshner, Maria T. Abreu, Kent...> ;Inflammatory Bowel Diseases. 2007 May 1
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Grant Support

Class II Function In Intestinal Epithelial CellsNational Institute Of Diabetes And Digestive And Kidney Diseases2000–2003
Class II Function In Intestinal Epithelial CellsNational Institute Of Diabetes And Digestive And Kidney Diseases1999–2000
Class II Function In Intestinal Epithelial CellsNational Institute Of Diabetes And Digestive And Kidney Diseases1999

Hospital Affiliations

UW Medicine/University of Washington Medical CenterSeattle, Washington