RonaldBNataleMD

Oncology • West Hollywood, CA

Professor of Medicine, University Mich Medical School

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Office
8700 Beverly Blvd
#Ac1042b
West Hollywood, CA 90048
Phone+1 310-423-1101

Fax+1 310-659-3928
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Education & Training

Memorial Sloan Kettering Cancer CenterFellowship, Hematology and Medical Oncology, 1977 - 1980
Wayne State University School of MedicineResidency, Internal Medicine, 1974 - 1976
Wayne State University School of MedicineClass of 1974

Certifications & Licensure

NY State Medical License 1978 - Present
CA State Medical License 1993 - 2024
MI State Medical License Active through 1994
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2014
Top Doctors:LA Area Castle Connolly, 2013
America's Top Doctors for Cancer Castle Connolly, 2005-2013
Top Doctors:Southern California Castle Connolly, 2012
Whos Who in Medicine and Healthcare Marquis Whos Who
Super Doctor SuperDoctors.com
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Clinical Trials

S0124: Cisplatin Combined With Irinotecan or Etoposide For Extensive-Stage Small Cell Lung Cancer Start of enrollment: 2002 Nov 01
Completed
Phase 3
Bortezomib (Velcade) + Pemetrexed (Alimta) in Advanced NSCLC Start of enrollment: 2006 Jan 01
Unknown status
Phase 1, Phase 2
Gemcitabine Hydrochloride or Pemetrexed Disodium and Carboplatin With or Without Celecoxib in Treating Patients With Advanced Non-Small Cell Lung Cancer Start of enrollment: 2010 Feb 01
Terminated
Phase 3
Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer Start of enrollment: 2011 Jan 11
Terminated
Phase 3
Compound 31543 (Calcitriol, USP) in Patients Receiving Taxane-based Chemotherapy Regimens for Advanced or Recurrent Disease Start of enrollment: 2012 Jul 01
Completed
Phase 1
A Study of Emibetuzumab in Non Small Cell Lung Cancer (NSCLC) Participants Start of enrollment: 2013 Aug 01
Completed
Phase 2
A Study of Abemaciclib (LY2835219) in Participants With Previously Treated KRAS Mutated Lung Cancer Start of enrollment: 2014 Oct 03
Active, not recruiting
Phase 3
Study to Evaluate Monotherapy and Combination Immunotherapies in Participants With PD-L1 Positive Non-small Cell Lung Cancer Start of enrollment: 2020 May 28
Active, not recruiting
Phase 2
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Publications & Presentations

PubMed

Tumor hyaluronan as a novel biomarker in non-small cell lung cancer: A retrospective study.
Jun Gong, Michelle Guan, Haesoo Kim, Natalie Moshayedi, Sejal Mehta, Galen Cook-Wiens, Brent K Larson, Jenny Zhou, Rishi Patel, Isaac Lapite, Veronica R Placencio-Hick...> ;Oncotarget. 2022 Nov 2
10 citations
Patient-Reported Outcomes with Durvalumab With or Without Tremelimumab Versus Standard Chemotherapy as First-Line Treatment of Metastatic Non–Small-Cell Lung Cancer (M...
Edward B. Garon, Byoung Chul Cho, Niels Reinmuth, Ki Hyeong Lee, Alexander Luft, Myung-Ju Ahn, Gilles Robinet, Sylvestre Le Moulec, Ronald B. Natale, Jeffrey Gary Schn...> ;Clinical Lung Cancer. 2021 Feb 19
Three Primary Tumors Including EGFR-mutated Non-Small Cell Lung Cancer as First Presentation in Patient With Li-Fraumeni Syndrome.
Arjan Gower, Jong Kim, Kellie Spector, Daniella Menashe, Eric Vail, Ronald B. Natale> ;Clinical Lung Cancer. 2021 Jan 1
383 citations
Durvalumab With or Without Tremelimumab vs Standard Chemotherapy in First-line Treatment of Metastatic Non–Small Cell Lung Cancer: The MYSTIC Phase 3 Randomized Clinic...
Naiyer A. Rizvi, Byoung Chul Cho, Niels Reinmuth, Ki Hyeong Lee, Alexander Luft, Myung-Ju Ahn, Michel M. van den Heuvel, M. Cobo, David Vicente, Alexey Smolin, Vladimi...> ;JAMA Oncology. 2020 May 1
180 citations
Osimertinib in patients with epidermal growth factor receptor mutation-positive non-small-cell lung cancer and leptomeningeal metastases: The BLOOM study
James Chih-Hsin Yang, Sang We Kim, Dong Wan Kim, Jong Seok Lee, Byoung Chul Cho, Jin Seok Ahn, Dae H. Lee, Tae Min Kim, Jonathan W. Goldman, Ronald B. Natale, Andrew P...> ;Journal of Clinical Oncology. 2020 Feb 20
20 citations
Predictive biomarkers for response to EGFR-directed monoclonal antibodies for advanced squamous cell lung cancer
Philip Bonomi, David R. Gandara, Fred R. Hirsch, Keith M. Kerr, Coleman K. Obasaju, Luis Paz-Ares, C. Bellomo, Jeffrey D. Bradley, Paul A. Bunn, Melissa Culligan, Jame...> ;Annals of Oncology. 2018 Aug 1
11 citations
Molecular and Immune Biomarker Testing in Squamous-Cell Lung Cancer: Effect of Current and Future Therapies and Technologies.
Fred R. Hirsch, Keith M. Kerr, Paul A. Bunn, Edward S. Kim, Coleman K. Obasaju, Maurice Pérol, Philip Bonomi, Jeffrey D. Bradley, David R. Gandara, James R. Jett, Core...> ;Clinical Lung Cancer. 2018 Jul 1
30 citations
Phase I Study of MEDI3617, a Selective Angiopoietin-2 Inhibitor Alone and Combined with Carboplatin/Paclitaxel, Paclitaxel, or Bevacizumab for Advanced Solid Tumors
David M. Hyman, Naiyer A. Rizvi, Ronald B. Natale, Deborah K. Armstrong, Michael J. Birrer, Lawrence Recht, Efrat Dotan, Vicky Makker, Thomas Kaley, Denison Kuruvilla,...> ;Clinical Cancer Research. 2018 Jun 15
27 citations
Randomized phase III study of docetaxel plus bavituximab in previously treated advanced non-squamous non-small-cell lung cancer.
David E. Gerber, Leora Horn, M. Boyer, Rachel E. Sanborn, Ronald B. Natale, Ramon Palmero, P. Bidoli, Igor Bondarenko, Paul Germonpré, D. Ghizdavescu, Athanasios Kotsa...> ;Annals of Oncology. 2018 Jul 1
110 citations
Current and Emergent Therapy Options for Advanced Squamous Cell Lung Cancer
Mark A. Socinski, Coleman K. Obasaju, David R. Gandara, Fred R. Hirsch, Philip Bonomi, Paul A. Bunn, Edward S. Kim, Corey J. Langer, Ronald B. Natale, Silvia Novello, ...> ;Journal of Thoracic Oncology. 2017 Nov 23
76 citations
Activity and safety of AZD3759 in EGFR-mutant non-small-cell lung cancer with CNS metastases (BLOOM): a phase 1, open-label, dose-escalation and dose-expansion study.
Myung-Ju Ahn, Dong Wan Kim, Byoung Chul Cho, Sang We Kim, Jong Seok Lee, Jin Seok Ahn, Tae Min Kim, Chia-Chi Lin, Hye Ryun Kim, Thomas John, Steven Kao, Jonathan W. Go...> ;The Lancet. Respiratory Medicine. 2017 Nov 1
9 citations
Phase 2 study of intermittent pulse dacomitinib in patients with advanced non-small cell lung cancers
Helena A. Yu, Myung-Ju Ahn, Byoung Chul Cho, David E. Gerber, Ronald B. Natale, Mark A. Socinski, Nagdeep Giri, Susan Quinn, Eric Sbar, Hui Zhang, Giuseppe Giaccone> ;Lung Cancer. 2017 Oct 1
15 citations
An Open-Label, Randomized, Controlled Phase II Study of Paclitaxel-Carboplatin Chemotherapy With Necitumumab Versus Paclitaxel-Carboplatin Alone in First-Line Treatmen...
David R. Spigel, Alexander Luft, H. Depenbrock, Rodryg Ramlau, Mazen Khalil, Joo Hang Kim, Carlos Mayo, Grace Chao, Coleman K. Obasaju, Ronald B. Natale> ;Clinical Lung Cancer. 2017 Sep 1
23 citations
Phase I trial of MEK 1/2 inhibitor pimasertib combined with mTOR inhibitor temsirolimus in patients with advanced solid tumors.
Monica M. Mita, Siqing Fu, Sarina Anne Piha-Paul, Filip Janku, Alain C. Mita, Ronald B. Natale, Wei Guo, C. Zhao, Razelle Kurzrock, Aung Naing> ;Investigational New Drugs. 2017 Feb 13
45 citations
Incremental innovation and progress in advanced squamous cell lung cancer: current status and future impact of treatment.
Corey J. Langer, Coleman K. Obasaju, Paul A. Bunn, Philip Bonomi, David R. Gandara, Fred R. Hirsch, Edward S. Kim, Ronald B. Natale, Silvia Novello, Luis Paz-Ares, Mau...> ;Journal of Thoracic Oncology. 2016 Dec 1
11 citations
A Phase I, First-in-Human Study of AMG 780, an Angiopoietin-1 and -2 Inhibitor, in Patients with Advanced Solid Tumors
Afshin Dowlati, Gordana Vlahovic, Ronald B. Natale, Erik Rasmussen, Indrajeet Singh, Yuying C. Hwang, John M. Rossi, Michael Bass, Gregory Friberg, Cheryl A. Pickett> ;Clinical Cancer Research. 2016 Sep 15
91 citations
Clinicopathologic Features of Advanced Squamous NSCLC
Mark A. Socinski, Coleman K. Obasaju, David R. Gandara, Fred R. Hirsch, Philip Bonomi, Paul A. Bunn, Edward S. Kim, Corey J. Langer, Ronald B. Natale, Silvia Novello, ...> ;Journal of Thoracic Oncology. 2016 Sep 1
45 citations
Pharmacokinetic study of aldoxorubicin in patients with solid tumors.
Monica M. Mita, Ronald B. Natale, Edward M. Wolin, Brenda Laabs, Hillary Dinh, Scott Wieland, Daniel J. Levitt, Alain C. Mita> ;Investigational New Drugs. 2015 Apr 1
22 citations
Evaluation of Antitumor Activity Using Change in Tumor Size of the Survivin Antisense Oligonucleotide LY2181308 in Combination with Docetaxel for Second-Line Treatment...
Ronald B. Natale, Fiona H Blackhall, Dariusz M. Kowalski, Rodryg Ramlau, Gerold Bepler, Francesco Grossi, Christian A. Lerchenmuller, Mary Pinder-Schenck, J. Mezger, S...> ;Journal of Thoracic Oncology. 2014 Nov 1
Pulmonary squamous cell carcinoma and sorafenib
Russell P. Gollard, Diana Garcia, Ronald B. Natale> ;Clinical Case Reports. 2014 Oct 1
11 citations
A phase II study of enzastaurin in combination with erlotinib in patients with previously treated advanced non-small cell lung cancer.
Christelle Clément-Duchêne, Ronald B. Natale, Thierry Jahan, Yelena Krupitskaya, Raymond U. Osarogiagbon, Rachel E. Sanborn, Eric D. Bernstein, Arkadiusz Z. Dudek, Jan...> ;Lung Cancer. 2012 Oct 1
122 citations
Healthcare Costs and Workloss Burden of Patients with Chemotherapy-Associated Peripheral Neuropathy in Breast, Ovarian, Head and Neck, and Nonsmall Cell Lung Cancer
Crystal Pike, Howard G. Birnbaum, Catherine Muehlenbein, Gerhardt Pohl, Ronald B. Natale> ;Chemotherapy Research and Practice. 2012 Mar 14
14 citations
Phase II study of sunitinib as maintenance therapy in patients with locally advanced or metastatic non-small cell lung cancer.
Radj Gervais, John D. Hainsworth, Normand Blais, Benjamin Besse, Janessa Laskin, John T. Hamm, Allan Lipton, Kathy S. Albain, Gregory A. Masters, Ronald B. Natale, Pau...> ;Lung Cancer. 2011 Dec 1
233 citations
Phase III Trial of Vandetanib Compared With Erlotinib in Patients With Previously Treated Advanced Non–Small-Cell Lung Cancer
Ronald B. Natale, Sumitra Thongprasert, F. Anthony Greco, Michael Thomas, Chun-Ming Tsai, Patrapim Sunpaweravong, D. R. Ferry, Clive Mulatero, Robert C. Whorf, Joyce T...> ;Journal of Clinical Oncology. 2011 Mar 10
34 citations
Common Arm Comparative Outcomes Analysis of Phase 3 Trials of Cisplatin + Irinotecan Versus Cisplatin + Etoposide in Extensive Stage Small Cell Lung Cancer: Final Pati...
Primo N. Lara, Kari Chansky, Taro Shibata, Haruhiko Fukuda, Tomohide Tamura, John Crowley, Mary W. Redman, Ronald B. Natale, Nagahiro Saijo, David R. Gandara> ;Cancer. 2010 Dec 15
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Journal Articles

Predictive Biomarkers for Response to EGFR-Directed Monoclonal Antibodies for Advanced Squamous Cell Lung Cancer
D R Spigel, E S Kim, S S Ramalingam, M A Socinski, C Obasaju, C J Langer, R B Natale, P D Bonomi, H Wakelee, Annals of Oncology

Press Mentions

Cancer Nearly Gone for Redondo Beach Mayor Bill BrandMay 28th, 2021

Grant Support

Core--Clinical Investigations Support FacilityNational Cancer Institute1996–2000
Southwest Oncology GroupNational Cancer Institute1995–1996
Southwest Oncology GroupNational Cancer Institute1985–1993
Testing The Predictions Of A Human Tumor Cloning AssayNational Cancer Institute1985–1987