RupalSatishBhattMD

Assistant Professor, Medicine, Harvard Medical School Clinical Fellow, Hematology-Oncology, Beth Israel Deaconess Medical Cente

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Office
330 Brookline Ave
Rw-563
Boston, MA 02215
Phone+1 617-667-5288
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Education & Training

Beth Israel Deaconess Medical CenterFellowship, Hematology and Medical Oncology, 2002 - 2006
Beth Israel Deaconess Medical CenterResidency, Internal Medicine, 2000 - 2002
Weill Cornell MedicineClass of 2000

Certifications & Licensure

MA State Medical License 2002 - 2025

Awards, Honors, & Recognition

Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2011

Clinical Trials

RF Ablation of Treatment of Metastatic Lesions in Patients Undergoing Antiangiogenic Therapy for Stage IV Renal Cell Carcinoma Start of enrollment: 2007 Jun 01
Withdrawn
Not Applicable
A Phase 2 Study of ASONEP™ to Treat Unresectable and Refractory Renal Cell Carcinoma Start of enrollment: 2013 Feb 01
Terminated
Phase 2
Study of Proscavax Vaccine in Patients With Localized Prostate Cancer vs Active Surveillance Start of enrollment: 2019 Feb 28
Not yet recruiting
Phase 2

Publications & Presentations

PubMed

1 citations
Circulating Cell-Free DNA as Biomarker of Taxane Resistance in Metastatic Castration-Resistant Prostate Cancer.
Edoardo Francini, Fang-Shu Ou, Justin Rhoades, Eric G. Wolfe, Edward P. O’Connor, Gavin Ha, Gregory Gydush, Kaitlin M. Kelleher, Rupal S. Bhatt, Steven P. Balk, Christ...> ;Cancers. 2021 Aug 12
1 citations
Combining VEGF receptor inhibitors and angiotensin-(1-7) to target renal cell carcinoma.
Thomas Walther, Prateek Khanna, Rupal S. Bhatt> ;Molecular & Cellular Oncology. 2021 Jun 12
10 citations
Phase II Multicenter Study of Enzalutamide in Metastatic Castration-Resistant Prostate Cancer to Identify Mechanisms Driving Resistance.
Rana R. McKay, Lucia Kwak, Jett Crowdis, Jamie M. Sperger, Shuang G. Zhao, Wanling Xie, Lillian Werner, Rosina T. Lis, Zhenwei Zhang, Xiao X. Wei, Joshua M. Lang, Elie...> ;Clinical Cancer Research. 2021 Apr 13
6 citations
Enzalutamide With Radiation Therapy for Intermediate-Risk Prostate Cancer: A Phase 2 Study.
Irving D. Kaplan, Glenn J. Bubley, Rupal S. Bhatt, Mary-Ellen Taplin, Shanna Dowling, Kathleen M. Mahoney, E. Werner, Paul L. Nguyen> ;International Journal of Radiation Oncology, Biology, Physics. 2021 Feb 23
10 citations
Arterial Spin Labeled Perfusion MRI for the Evaluation of Response to Tyrosine Kinase Inhibition Therapy in Metastatic Renal Cell Carcinoma.
Leo L. Tsai, Rupal S. Bhatt, Meaghan F Strob, Opeyemi Jegede, Maryellen R. M. Sun, David C. Alsop, Paul J. Catalano, David F. McDermott, Philip M. Robson, Michael B. A...> ;Radiology. 2021 Feb 1
25 citations
ACE2 abrogates tumor resistance to VEGFR inhibitors suggesting angiotensin-(1-7) as a therapy for clear cell renal cell carcinoma.
Prateek Khanna, Hong Jie Soh, Chun-Hau Chen, Ruchi Saxena, Seema Amin, Maura Naughton, Patrick Neset Joslin, Andrew M. Moore, Ziad Bakouny, Carol O'Callaghan, Paul J. ...> ;Science Translational Medicine. 2021 Jan 20
6 citations
Plasma KIM-1 Is Associated with Recurrence Risk after Nephrectomy for Localized Renal Cell Carcinoma: A Trial of the ECOG-ACRIN Research Group (E2805).
Wenxin Xu, Maneka Puligandla, Brian Halbert, Naomi B. Haas, Keith T. Flaherty, Robert G. Uzzo, Janice P. Dutcher, Robert S. DiPaola, Venkata S. Sabbisetti, Rupal S. Bhatt> ;Clinical Cancer Research. 2021 Apr 8
48 citations
KIR3DL3 is an inhibitory receptor for HHLA2 that mediates an alternative immunoinhibitory pathway to PD1
Rupal S. Bhatt, Abdulla Berjis, Julie C. Konge, Kathleen M. Mahoney, Alyssa N. Klee, Samuel S. Freeman, Chun-Hau Chen, Opeyemi Jegede, Paul J. Catalano, Jean-Christoph...> ;Cancer Immunology Research. 2021 Feb 1
24 citations
Taxane resistance in prostate cancer is mediated by decreased drug-target engagement
Ada Gjyrezi, Fang Xie, Olga Voznesensky, Prateek Khanna, Carla Calagua, Yang Bai, Justin W. Kung, Jim S. Wu, Eva Corey, Bruce Montgomery, Sandrine Mace, Diego A. Giano...> ;The Journal of Clinical Investigation. 2020 Jun 1
11 citations
Angiogenic Factor and Cytokine Analysis among Patients Treated with Adjuvant VEGFR TKIs in Resected Renal Cell Carcinoma
Wenxin Xu, Maneka Puligandla, Judith Manola, Andrea J. Bullock, Daniel Tamasauskas, David F. McDermott, Michael B. Atkins, Naomi B. Haas, Keith T. Flaherty, Robert G. ...> ;Clinical Cancer Research. 2019 Oct 15
11 citations
Inhibition of Sphingosine Phosphate Receptor 1 Signaling Enhances the Efficacy of VEGF Receptor Inhibition.
Anthony S. Fischl, Xiaoen Wang, Beverly L. Falcon, Rowena Almonte-Baldonado, Diane M. Bodenmiller, Glenn F. Evans, Julie Stewart, Takako Wilson, Philip Arthur Hipskind...> ;Molecular Cancer Therapeutics. 2019 Apr 1
A phase 2, randomized trial evaluating the combination of dalantercept plus axitinib in patients with advanced clear cell renal cell carcinoma.
Voss, M. H.,Bhatt, R. S.,Vogelzang, N. J.,Fishman, M.,Alter, R. S.,Rini, B. I.,Beck, J. T.,Joshi, M.,Hauke, R.,Atkins, M. B.,Burgess, E.,Logan, T. F.,Shaffer, D.,Parik...> ;Cancer. 2019 Apr 06
20 citations
Study of Cathepsin B inhibition in VEGFR TKI treated human renal cell carcinoma xenografts.
Chun-Hau Chen, Swati S. Bhasin, Prateek Khanna, Joshi M, Joslin Pm, Ruchi Saxena, Amin S, Liu S, Sindhu S, Walker, Paul J. Catalano, David A. Frank, Seth L. Alper, Man...> ;Oncogenesis. 2019 Feb 22
2 citations
Case of Basal Cell Carcinoma of the Prostate Successfully Treated Before and After a BRCA2 Reversion Mutation.
Joseph Elan Grossman, Yubo Wu, Huihui Ye, Rupal S. Bhatt> ;JCO Precision Oncology. 2018 Nov 16
5 citations
Comprehensive Genomic Profiling of Metastatic Tumors in a Phase 2 Biomarker Study of Everolimus in Advanced Renal Cell Carcinoma
Xin Gao, Opeyemi Jegede, Connor Gray, Paul J. Catalano, Jesse Novak, David J. Kwiatkowski, Rana R. McKay, Daniel J. George, Toni K. Choueiri, David F. McDermott, Sabin...> ;Clinical Genitourinary Cancer. 2018 Oct 1
A Non-integrating Lentiviral Approach Overcomes Cas9-Induced Immune Rejection to Establish an Immunocompetent Metastatic Renal Cancer Model.
Hu, J.,Schokrpur, S.,Archang, M.,Hermann, K.,Sharrow, A. C.,Khanna, P.,Novak, J.,Signoretti, S.,Bhatt, R. S.,Knudsen, B. S.,Xu, H.,Wu, L.> ;Mol Ther Methods Clin Dev. 2018 May 17
Differential expression of c-Met between primary and metastatic sites in clear-cell renal cell carcinoma and its association with PD-L1 expression.
Lalani, A. A.,Gray, K. P.,Albiges, L.,Callea, M.,Pignon, J. C.,Pal, S.,Gupta, M.,Bhatt, R. S.,McDermott, D. F.,Atkins, M. B.,Woude, GFV.,Harshman, L. C.,Choueiri, T. K...> ;Oncotarget. 2017 Dec 22
8 citations
Transforming the Perioperative Treatment Paradigm in Non-Metastatic RCC—A Possible Path Forward
Lauren C. Harshman, Charles G. Drake, Naomi B. Haas, Judith Manola, Maneka Puligandla, Sabina Signoretti, David Cella, Rajan T. Gupta, Rupal S. Bhatt, E.M. Van Allen, ...> ;Kidney Cancer. 2017 Jul 26
18 citations
The DART Study: Results from the Dose-Escalation and Expansion Cohorts Evaluating the Combination of Dalantercept plus Axitinib in Advanced Renal Cell Carcinoma.
Martin H. Voss, Rupal S. Bhatt, Elizabeth R. Plimack, Brian I. Rini, Robert S. Alter, J. Thaddeus Beck, Dawn Wilson, Xiaosha Zhang, Musa Mutyaba, Chad E. Glasser, Kenn...> ;Clinical Cancer Research. 2017 Jul 15
Phase 2 Study of Bevacizumab and Temsirolimus After VEGFR TKI in Metastatic Renal Cell Carcinoma.
Mahoney KM, Jacobus S, Bhatt RS, Song J, Carvo I, Cheng S, Simpson M, Fay AP, Puzanov I, Michaelson MD, Atkins MB, McDermott DF, Signoretti S, Choueiri TK> ;Clin Genitourin Cancer. 2016-08-01
Inhibition of ALK1 signaling with dalantercept combined with VEGFR TKI leads to tumor stasis in renal cell carcinoma.
Wang X, Solban N, Khanna P, Callea M, Song J, Alsop DC, Pearsall RS, Atkins MB, Mier JW, Signoretti S, Alimzhanov M, Kumar R, Bhasin MK, Bhatt RS> ;Oncotarget. 2016-07-05
15 citations
International cancer seminars : a focus on kidney cancer.
Ghislaine Scelo, Jonathan N. Hofmann, Rosamonde E. Banks, Pierre Bigot, Rupal S. Bhatt, G. Cancel-Tassin, S. K. Chew, Chad J. Creighton, Olivier Cussenot, Ian J. Davis...> ;Annals of Oncology. 2016 Apr 29
Statins and survival outcomes in patients with metastatic renal cell carcinoma.
McKay RR, Lin X, Albiges L, Fay AP, Kaymakcalan MD, Mickey SS, Ghoroghchian PP, Bhatt RS, Kaffenberger SD, Simantov R, Choueiri TK, Heng DYC> ;Eur. J. Cancer. 2016-01-01
Selective spectroscopic imaging of hyperpolarized pyruvate and its metabolites using a single-echo variable phase advance method in balanced SSFP.
Varma, G.,Wang, X.,Vinogradov, E.,Bhatt, R. S.,Sukhatme, V. P.,Seth, P.,Lenkinski, R. E.,Alsop, D. C.,Grant, A. K.> ;Magn Reson Med. 2015 Oct 29
Differential Expression of PD-L1 between Primary and Metastatic Sites in Clear-Cell Renal Cell Carcinoma.
Callea M, Albiges L, Gupta M, Cheng S, Genega EM, Fay AP, Song J, Carvo I, Bhatt RS, Atkins MB, Hodi FS, Choueiri TK, McDermott DF, Freeman GJ, Signoretti S> ;Cancer Immunol Res. 2015-10-01
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Journal Articles

Study of Cathepsin B Inhibition in VEGFR TKI Treated Human Renal Cell Carcinoma Xenografts
David A Frank, Rupal S Bhatt, Seth L Alper, Prateek Khanna, Nature

Press Mentions

Promising Triple Therapy Approach Identified for Renal Cell CarcinomaJanuary 21st, 2021
Beth Israel Deaconess Medical Center Expert Sources Available for Prostate Health MonthAugust 23rd, 2019
Blood Test Could Detect Kidney Cancer up to Five Years Prior to Clinical DiagnosisAugust 16th, 2018
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