SamuelJacobKlempnerMD

PubMed

• Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer.
  Rona Yaeger, Nataliya V Uboha, Meredith S Pelster, Tanios S Bekaii-Saab, Minal Barve, Joel Saltzman, Joshua K Sabari, Julio A Peguero, Andrew Scott Paulson, Pasi A Jän...> ;Cancer Discovery. 2024 Apr 8
• Gastroesophageal Adenocarcinomas With Defective Mismatch Repair: Current Knowledge and Clinical Management.
  Matthew R Strickland, Eric M Lander, Michael K Gibson, David H Ilson, Jaffer A Ajani, Samuel J Klempner> ;Journal of the National Comprehensive Cancer Network. 2024 Mar 19
• Pathologic complete response in patients with esophageal cancer receiving neoadjuvant chemotherapy or chemoradiation: A systematic review and meta-analysis.
  Charles E Gaber, Jyotirmoy Sarker, Abdullah I Abdelaziz, Ebere Okpara, Todd A Lee, Samuel J Klempner, Ryan D Nipp> ;Cancer Medicine. 2024 Feb 1
• DNA Damage by Radiopharmaceuticals and Mechanisms of Cellular Repair.
  Yousef Khazaei Monfared, Pedram Heidari, Samuel J Klempner, Umar Mahmood, Aparna R Parikh, Theodore S Hong, Matthew R Strickland, Shadi A Esfahani> ;Pharmaceutics. 2023 Dec 12
• 3 citations
  Patient-derived exosomes facilitate therapeutic targeting of oncogenic MET in advanced gastric cancer.
  Sujin Hyung, Jihoon Ko, You Jeong Heo, Steven M Blum, Seung Tae Kim, Se Hoon Park, Joon Oh Park, Won Ki Kang, Ho Yeong Lim, Samuel J Klempner, Jeeyun Lee> ;Science Advances. 2023 Nov 24
• Recent Advances in the Management of Anal Cancer.
  Hartzell, M., Upadhyay, L., Parikh, A., Strickland, M., Klempner, S., Malla, M.> ;Healthcare. 2023 Nov 21
• Patient-Reported Outcomes, Tumor Markers, and Survival Outcomes in Advanced GI Cancer.
  Joy X Jarnagin, Anurag Saraf, Islam Baiev, Gary Chi, Emily E van Seventer, Amirkasra Mojtahed, Jill N Allen, Jeffrey W Clark, Lawrence Blaszkowsky, Bruce J Giantonio, ...> ;JAMA Network Open. 2023 Nov 1
• 3 citations
  ILUSTRO: Phase II Multicohort Trial of Zolbetuximab in Patients with Advanced or Metastatic Claudin 18.2-Positive Gastric or Gastroesophageal Junction Adenocarcinoma.
  Samuel J Klempner, Keun-Wook Lee, Kohei Shitara, Jean-Phillippe Metges, Sara Lonardi, David H Ilson, Nicola Fazio, Tae Yong Kim, Li-Yuan Bai, Diarmuid Moran, Jianning ...> ;Clinical Cancer Research. 2023 Oct 2
• 2 citations
  Outcomes and a prognostic classifier in patients with microsatellite instability-high metastatic gastric cancer receiving PD-1 blockade.
  Giovanni Randon, Yu Aoki, Romain Cohen, Leonardo Provenzano, Vincenzo Nasca, Samuel J Klempner, Steven B Maron, Riccardo Cerantola, Joseph Chao, Lorenzo Fornaro, Walte...> ;Journal for Immunotherapy of Cancer. 2023 Jun 1
• Reply to S. Chakrabarti and A. Mahipal.
  Brandon M Huffman, Adham Jurdi, Alexey Aleshin, Minetta C Liu, Samuel J Klempner> ;JCO Precision Oncology. 2023 Mar 1
• 2 citations
  Claudin18.who? Examining biomarker overlap and outcomes in claudin18.2-positive gastroesophageal adenocarcinomas.
  S J Klempner, Y Y Janjigian, Z A Wainberg> ;ESMO Open. 2023 Apr 1
• 24 citations
  Combined PD-1, BRAF and MEK inhibition in BRAFcolorectal cancer: a phase 2 trial.
  Jun Tian, Jonathan H Chen, Sherry X Chao, Karin Pelka, Marios Giannakis, Julian Hess, Kelly Burke, Vjola Jorgji, Princy Sindurakar, Jonathan Braverman, Arnav Mehta, To...> ;Nature Medicine. 2023 Feb 1
• 82 citations
  Adagrasib with or without Cetuximab in Colorectal Cancer with MutatedG12C.
  Rona Yaeger, Jared Weiss, Meredith S Pelster, Alexander I Spira, Minal Barve, Sai-Hong I Ou, Ticiana A Leal, Tanios S Bekaii-Saab, Cloud P Paweletz, Grace A Heavey, Ja...> ;The New England Journal of Medicine. 2023 Jan 5
• 11 citations
  Comparative Effectiveness of Immune Checkpoint Inhibitors vs Chemotherapy in Patients With Metastatic Colorectal Cancer With Measures of Microsatellite Instability, Mi...
  Julia C F Quintanilha, Ryon P Graf, Virginia A Fisher, Geoffrey R Oxnard, Haley Ellis, Nicole Panarelli, Douglas I Lin, Gerald Li, Richard S P Huang, Jeffrey S Ross, P...> ;JAMA Network Open. 2023 Jan 3
• 3 citations
  A human vascularized microtumor model of patient-derived colorectal cancer recapitulates clinical disease.
  Stephanie J Hachey, Agua Sobrino, John G Lee, Mehraneh D Jafari, Samuel J Klempner, Eric J Puttock, Robert A Edwards, John S Lowengrub, Marian L Waterman, Jason A Zell...> ;Translational Research. 2023 May 1
• 7 citations
  Epacadostat Plus Pembrolizumab and Chemotherapy for Advanced Solid Tumors: Results from the Phase I/II ECHO-207/KEYNOTE-723 Study.
  John D Powderly, Samuel J Klempner, Aung Naing, Johanna Bendell, Ignacio Garrido-Laguna, Daniel V T Catenacci, Matthew H Taylor, James J Lee, Fred Zheng, Feng Zhou, Xi...> ;The Oncologist. 2022 Nov 3
• 2 citations
  Real-world Validation of TMB and Microsatellite Instability as Predictive Biomarkers of Immune Checkpoint Inhibitor Effectiveness in Advanced Gastroesophageal Cancer.
  Ryon P Graf, Virginia Fisher, James Creeden, Alexa B Schrock, Jeffrey S Ross, Halla Nimeiri, Geoffrey R Oxnard, Samuel J Klempner> ;Cancer Research Communications. 2022 Sep 1
• 18 citations
  Margetuximab with retifanlimab as first-line therapy in HER2+/PD-L1+ unresectable or metastatic gastroesophageal adenocarcinoma: MAHOGANY cohort A.
  D V T Catenacci, Y-K Kang, H H Yoon, B Y Shim, S T Kim, D-Y Oh, A I Spira, S V Ulahannan, E J Avery, P M Boland, J Chao, H C Chung, F Gardner, S J Klempner, K-W Lee, S...> ;ESMO Open. 2022 Oct 1
• 7 citations
  Epidermal Growth Factor Receptor Inhibition in Epidermal Growth Factor Receptor-Amplified Gastroesophageal Cancer: Retrospective Global Experience.
  Steven B Maron, Stephanie Moya, Federica Morano, Matthew J Emmett, Joanne F Chou, Shalom Sabwa, Henry Walch, Bryan Peterson, Alexa B Schrock, Liangliang Zhang, Yelena ...> ;Journal of Clinical Oncology. 2022 Aug 1
• 16 citations
  The Genomics of Colorectal Cancer in Populations with African and European Ancestry.
  Myer, P., Lee, J., Madison, R., Pradhan, K., Newberg, J., Isasi, C., Klempner, S., Frampton, G., Ross, J., Venstrom, J., Schrock, A., Das, S., Augenlicht, L., Verma, A...> ;Cancer Discovery. 2022 May 2
• 1 citations
  Therapeutic Advances and Challenges in the Management of HER2-Positive Gastroesophageal Cancers.
  Jeremy Chuang, Samuel Klempner, Kevin Waters, Katelyn Atkins, Joseph Chao, May Cho, Andrew Hendifar, Alexandra Gangi, Miguel Burch, Pareen Mehta, Jun Gong> ;Diseases. 2022 Apr 19
• 8 citations
  ALK Inhibitors in Patients With ALK Fusion-Positive GI Cancers: An International Data Set and a Molecular Case Series.
  Margherita Ambrosini, Marzia Del Re, Paolo Manca, Andrew Hendifar, Alexander Drilon, Guilherme Harada, Anne Hansen Ree, Samuel Klempner, Gunhild Mari Mælandsmo, Kjerst...> ;JCO Precision Oncology. 2022 Apr 1
• 5 citations
  Association Between Aspirin Use and Gastric Adenocarcinoma: A Prospective Cohort Study.
  Sohee Kwon, Wenjie Ma, David A Drew, Samuel J Klempner, Brianna M Leonardo, Jacqueline J Flynn, Yin Cao, Edward L Giovannucci, Ying Bao, Charles S Fuchs, Mingyang Song...> ;Cancer Prevention Research. 2022 Apr 1
• 45 citations
  Early Tumor-Immune Microenvironmental Remodeling and Response to First-Line Fluoropyrimidine and Platinum Chemotherapy in Advanced Gastric Cancer.
  Ryul Kim, Minae An, Hyuk Lee, Arnav Mehta, You Jeong Heo, Kyoung-Mee Kim, Song-Yi Lee, Jeonghyeon Moon, Seung Tae Kim, Byung-Hoon Min, Tae Jun Kim, Sun Young Rha, Won ...> ;Cancer Discovery. 2022 Apr 1
• Are You a TMBeliever? Mutations and Atezolizumab Response in Solid Tumors.
  Steven B Maron, Samuel J Klempner> ;Cancer Discovery. 2022 Mar 1
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Journal Articles

• PD-1 as an emerging target in gastric cancer: current evidence  
  Tran PN, Sarkissian S, Chao J, Klempner SJ, Gastrointestinal Cancer: Targets and Therapy, 1/1/2017
• Moving Molecular Subtypes to the Clinic in Gastric Cancer  
  Chao J, Lee J, Klempner SJ, Transl Cancer Res, 1/1/2016
• ROS1 (c-ros oncogene 1)  
  Klempner SJ, Ou, SH, Atlas Genet Cytogenet Oncol Haematol, 1/1/2014

Books/Book Chapters

• Targeted Therapy in Cancer 
  Chapter: The Phosphatidylinositol 3-kinase Pathway in Human Malignancy. 
  Klempner SJ, Vo T, Myers AP, Cantley LCEditors: Kurzrock R, Anderson KC and Tsimberidou AM.Wiley, New York, NY2015
• The PI3K Pathway in Colorectal Cancer. 
  Chapter: Molecular Pathogenesis of Colorectal Cancer. 
  Yun J, Poulogiannis G, Brown E, Klempner S, Cantley LCEditors: K.M. Haigis.Springer, New York, NY2013

Abstracts/Posters

• Neoadjuvant Chemotherapy Improves Survival In Patients With Clinical T4b Colon Cancer.
  Dehal A, Graff-Baker AN, Voung B, Fischer T, Klempner SJ, et al, Digestive Disease Week, Chicago, IL, 1/6/2017
• A Phase 1 Study of LY3022855 (A Colony-Stimulating Factor-1 receptor [CSF-1R] inhibitor) in Patients (pts) With Advanced Solid Tumors
  Dowlati A, Rugo HS, et al, ASCO, 1/1/2017
• Comprehensive genomic profiling (CGP) of esophageal and tubular GI tumors identifies differing frequencies of ErbB family member amplifications with therapeutic implic...
  Bailey M, Ali SM, Schrock AB, Klempner SJ, George B, Lipson D, et al, GI ASCO, 1/1/2017
• Genomic profiling of circulating tumor DNA (ctDNA) from patients with advanced cancers of the GI tract and anus.
  Schrock AB, Young L, Klempner SJ, Bordoni R, Ross JS, et al, GI ASCO, 1/1/2017
• Mutational load as a potential biomarker for PD1/PD-L1 therapy in colorectal cancer.
  George TA, Frampton GM, Sun J, Gowen K, Kennedy M, Greenbowe JR, Schrock AB, Ali SM, Klempner SJ, Hezel AF, Ross JS, Stephens P, Miller VA, Fabrizio D, ASCO Annual Meeting, 1/1/2016
• The impact of sex, race, and socioeconomic status (SES) on outcomes in 6,870 patients with esophageal cancer.
  Tran P, Taylor TH, Klempner SJ, Zell J, ASCO Annual Meeting, 1/1/2016
• Advanced Acinic Cell Carcinomas Harbor Recurrent BRAF Kinase Domain Duplications, NTRK3 fusions and Genomic Alterations Hyperactivating the mTOR Pathway.
  Ali SM, Fedorchak K, Schrock AB, Johnson J, Gowen K, Elvin JA, Vergilio J, Klempner SJ, Mehra R, Ho A, Pavlick D, Suh JH, Bordoni R, Jung DH, Stephens PJ, Chung C, Ros..., ESMO, 1/1/2016
• HER2 V659 and G660 transmembrane mutations that stabilize homo- and hetero-dimerization are rare oncogenic drivers in lung adenocarcinoma that are clinically responsiv...
  Ali SM, Khollar B, Bailey M, Schrock AB, Frampton G, Fabrizio D, Ou SH, Klempner SJ, He J, Suh JH, Ross JS, Stephens PJ, Miller VA, Patel M, ESMO, 1/1/2016
• Broad detection of alterations predicted to confer lack of benefit from EGFR antibodies or sensitivity to targeted therapy in advanced colorectal cancer.
  Klempner SJ, Rankin A, Erlich RA, Sun J, Grothey A, Fakih M, George TJ, Lee J, Ross JS, Stephens PJ, Miller VA, Ali SM, Schrock AB, ESMO, 1/1/2016
• Small cell lung carcinoma harbors targetable alterations including MYCL1 fusions responding to Aurora kinase inhibitor.
  Ali SM, Khollar B, Bailey M, Schrock AB, Frampton G, Fabrizio D, Ou SH, Klempner SJ, He J, Suh JH, Ross JS, Stephens PJ, Miller VA, Patel M, ESMO Congress, 1/1/2016
• Comprehensive Genomic Profiling Assesses Mutational Load in Gastric and Esophageal Adenocarcinomas: Implications for Immunotherapies.
  Frampton GM, Schrock A, Chalmers Z, Sun J, Gowen K, Beg M, Rubinson D, Stephens PJ, Miller VA, Ross JS, Ali SM, Klempner SJ, J Clin Oncol, 1/1/2016
• Comprehensive genomic profiling of advanced colorectal carcinoma in the course of clinical care identifies KRAS insertions not detected by focused molecular testing.
  Rankin A, Schrock AB, Elvin JA, Chmielecki J, Erlich R, Morosini D, Frampton GM, Grothey A, Rosenblum A, Bufill JA, Helton DA, Sequeria J, George TJ, Klempner SJ, Ross..., J Clin Oncol, 1/1/2016
• Bone Mineral Density Loss in Thoracic and Lumber Vertebrae Following Radiation for Abdominal Cancers.
  Jung BC, Wei RL, Manzano W, Seghal V, Lee S, Klempner SJ, Ramsinghani N, Lall C, ASTRO, Boston, MA, 1/1/2016
• PTEN loss is a context dependent determinant of patient outcomes in obese and non-obese endometrioid endometrial cancer patients.
  Ju Z, Westin S, Broaddus R, Li J, Pal N, Lu K, Coleman RL, Klempner SJ, Cantley LC, Mills GB, Myers AP, J Clin Oncol; ASCO Annual Meeting, Chicago, IL, 1/1/2013
• Derivation and characterization of endometrial cancer cells resistant to phosphatidylinositol-3-kinase (PI3K) pathway inhibitors.
  Klempner SJ, Myers AP, Li J, Mills G, Cantley L, Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; ; AACR Annual Meeting, Washington, DC, 1/1/2013
• Apoptosis precedes removal of avian thyroglossal duct and suggests cell culling in early bilobed thyroid.
  Miller SA, Campbell C, Ransom E, Klempner SJ, Experimental Biology, FASEB late-breaking abstracts program, Washington, DC, 1/21/2004
• Apoptosis plays a role in removal of the first and second aortic arch arteries, in remodeling of the thyroid rudiment and in rupture of closing plates in chick embryos.
  Klempner SJ, Miller SA, 62nd Annual Society of Developmental Biology Meeting, Developmental Biology, Boston, MA, 1/1/2003
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Lectures

• DKN-01 in combination with pembrolizumab in patients with advanced gastroesophageal adenocarcinoma (GEA): Tumoral DKK1 expression as a predictor of response and survival. 
  ASCO Gastrointestinal Cancers Symposium - San Francisco, CA - 1/23/2020
• Early Is Better: The Roles of Prevention, Screening, and Early Detection 
  ASCO Gastrointestinal Cancers Symposium - San Francisco, CA - 1/23/2020
• Help From Within: DNA to Personalized Therapy for Gastric Cancer 
  1/18/2017
• Considerations for Implementation of Cancer Molecular Diagnostics into Clinical Care 
  1/1/2017
• Genomics in Cancer 
  Long Beach, CA - 1/29/2016
• ASCO Highlights, Gastrointestinal 
  Long Beach, CA - 1/16/2016
• Cancer Epidemiology – Lecture on Lung Cancer Epidemiology 
  UCI - 1/27/2015
• Molecular Testing in NSCLC 
  Fountain Valley Hospital - 1/25/2015
• Gastric and Esophageal Cancer 
  UCI - 1/19/2015
• Esophageal Cancer 
  Huntington Beach Hospital, 2014; Fountain Valley Hospital, 2015 - 1/17/2015
• ASCO Highlights 
  Long Beach, CA - 1/16/2015
• Gastric Cancer 
  Anaheim Regional Medical Center - 1/13/2015
• Clinical Cancer for Basic Scientists 
  UCI - 1/1/2015
• Lung Cancer Update 
  Los Alamitos Medical Center - 1/23/2014
• New Paradigms in the Treatment of Esophageal and Gastric Cancer 
  Disney Grand Hotel, Anaheim, CA - 1/21/2014
• Lung Cancer 
  Fountain Valley Hospital - 1/21/2014
• New Concept in Molecular Medicine 
  Temple Community Hospital - 1/21/2014
• Updates in Lung Cancer 
  La Palma Hospital - 1/10/2014
• Lung Cancer: A Review and What's New 
  Desert Valley Hospital, Victorville, CA - 1/27/2013
• Updates in Lung Cancer. 
  UCI - 1/26/2013
• Gastric and Esophageal Cancer: ABIM 101. 
  Long Beach VA Medical Center - 1/21/2013
• Cool Toys, Few Joys: Capitalizing on Personalized Medicine 
  UCI - 1/20/2013
• Mechanisms of Resistance to compounds targeting the PI3-kinase pathway in Endometrial Cancer 
  Beth Israel Deaconess Medical Center - 1/19/2013
• Gastric and Esophageal Cancer: ABIM 101 
  UCI - 1/9/2013
• Signaling Changes During Chronic PI3K Pathway Inhibition in Endometrial Cancer 
  Boston, MA - 1/8/2013
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Other

• Navigating the complexity of cancer with tumor mutational burden (TMB). 
  Klempner SJ, Oncology Times
  1/1/2017
• Advancing precision medicine in colorectal cancer. 
  Klempner SJ, Pharma Letter
  1/1/2017