SandaAlexandrescuMD

PubMed

• MRC1 and LYVE1 expressing macrophages in vascular beds of GNAQ p.R183Q driven capillary malformations in Sturge Weber syndrome.
  Sana Nasim, Colette Bichsel, Stephen Dayneka, Robert Mannix, Annegret Holm, Mathew Vivero, Donald E Ingber, Joyce Bischoff, Sanda Alexandrescu, Anna Pinto, Arin K Greene> ;Acta Neuropathologica Communications. 2024 Mar 26
• CKLF instigates a "cold" microenvironment to promote MYCN-mediated tumor aggressiveness.
  Xiaodan Qin, Andrew Lam, Xu Zhang, Satyaki Sengupta, J Bryan Iorgulescu, Hongru Ni, Sanjukta Das, Madison Rager, Zhenwei Zhou, Tao Zuo, Grace K Meara, Alexander E Flor...> ;Science Advances. 2024 Mar 15
• 1 citations
  Multiomic Analysis of Neuroinflammation and Occult Infection in Sudden Infant Death Syndrome.
  Ramachandran, P., Okaty, B., Riehs, M., Wapniarski, A., Hershey, D., Harb, H., Zia, M., Haas, E., Alexandrescu, S., Sleeper, L., Vargas, S., Gorman, M., Campman, S., M...> ;JAMA Neurology. 2024 Mar 1
• Discovery and Characterization of Ephrin B2 and EphB4 Dysregulation and Novel Mutations in Cerebral Cavernous Malformations: In Vitro and Patient-Derived Evidence of E...
  Sesen, J., Ghalali, A., Driscoll, J., Martinez, T., Lupieri, A., Zurakowski, D., Smith, E., Alexandrescu, S., Fehnel, K.> ;Cellular and Molecular Neurobiology. 2023 Dec 27
• H3K27-altered diffuse midline gliomas with MAPK pathway alterations: Prognostic and therapeutic implications.
  Catherine Gestrich, Kristina Grieco, Hart G Lidov, Lissa C Baird, Kee Kiat Yeo, David M Meredith, Sanda Alexandrescu, Katie P Fehnel> ;Journal of Neuropathology and Experimental Neurology. 2023 Dec 22
• 1 citations
  Systematic characterization of antibody-drug conjugate targets in central nervous system tumors.
  Shannon Coy, Jong Suk Lee, Sabrina J Chan, Terri Woo, Jacquelyn Jones, Sanda Alexandrescu, Patrick Y Wen, Peter K Sorger, Keith L Ligon, Sandro Santagata> ;Neuro-Oncology. 2024 Mar 4
• 1 citations
  ROS1 Alterations as a Potential Driver of Gliomas in Infant, Pediatric, and Adult Patients.
  David M Meredith, Linda D Cooley, Adrian Dubuc, Jennifer Morrissette, Robyn T Sussman, MacLean P Nasrallah, Pamela Rathbun, Kai Lee Yap, Nitin Wadhwani, Liming Bao, Da...> ;Modern Pathology. 2023 Nov 1
• 1 citations
  Eastern Equine Encephalitis Virus Diversity in Massachusetts Patients, 1938-2020.
  Rose M Langsjoen, Autum Key, Nima Shariatzadeh, Christopher R Jackson, Faisal Mahmood, Knarik Arkun, Sanda Alexandrescu, Isaac H Solomon, Anne Piantadosi> ;The American Journal of Tropical Medicine and Hygiene. 2023 Aug 2
• Double-stranded RNA immunohistochemistry as a screening tool for viral encephalitis.
  Anne Piantadosi, Nima Shariatzadeh, Andrei Bombin, Knarik Arkun, Sanda Alexandrescu, B K Kleinschmidt-DeMasters, Isaac H Solomon> ;American Journal of Clinical Pathology. 2023 Aug 1
• 12 citations
  Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy.
  Sattar Khoshkhoo, Yilan Wang, Yasmine Chahine, E Zeynep Erson-Omay, Stephanie M Robert, Emre Kiziltug, Eyiyemisi C Damisah, Carol Nelson-Williams, Guangya Zhu, Wenna K...> ;JAMA Neurology. 2023 Jun 1
• 5 citations
  Clear cell tumor with melanocytic differentiation and MITF::CREM translocation.
  Sanda Alexandrescu, Alma Imamovic-Tuco, Katherine Janeway, John Hanna> ;Journal of Cutaneous Pathology. 2023 Jul 1
• 5 citations
  Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions.
  Henri Bogumil, Martin Sill, Daniel Schrimpf, Britta Ismer, Christina Blume, Ramin Rahmanzade, Felix Hinz, Asan Cherkezov, Rouzbeh Banan, Dennis Friedel, David E Reuss,...> ;Acta Neuropathologica. 2023 May 1
• Molecular profiling identifies at least 3 distinct types of posttransplant lymphoproliferative disorder involving the CNS.
  Ekin Guney, Calixto-Hope G Lucas, Kunwar Singh, Melike Pekmezci, Sebastian Fernandez-Pol, Kanish Mirchia, Angus Toland, Hannes Vogel, Serguei Bannykh, Kristian T Schaf...> ;Blood Advances. 2023 Jul 11
• 2 citations
  Copy Number Variation and Structural Genomic Findings in 116 Cases of Sudden Unexplained Death between 1 and 28 Months of Age.
  Catherine A Brownstein, Elise Douard, Robin L Haynes, Hyun Yong Koh, Alireza Haghighi, Christine Keywan, Bree Martin, Sanda Alexandrescu, Elisabeth A Haas, Sara O Varg...> ;Advanced Genetics. 2023 Mar 1
• 2 citations
  ALK Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma.
  Anne-Florence Blandin, Ross Giglio, Maya Srikanth Graham, Guadalupe Garcia, Seth Malinowski, Jared K Woods, Shakti Ramkissoon, Lori Ramkissoon, Frank Dubois, Kathleen ...> ;Clinical Cancer Research. 2023 Jul 14
• 35 citations
  The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location.
  Ilon Liu, Li Jiang, Erik R Samuelsson, Sergio Marco Salas, Alexander Beck, Olivia A Hack, Daeun Jeong, McKenzie L Shaw, Bernhard Englinger, Jenna LaBelle, Hafsa M Mire...> ;Nature Genetics. 2022 Dec 1
• 8 citations
  Expanded analysis of high-grade astrocytoma with piloid features identifies an epigenetically and clinically distinct subtype associated with neurofibromatosis type 1.
  Patrick J Cimino, Courtney Ketchum, Rust Turakulov, Omkar Singh, Zied Abdullaev, Caterina Giannini, Peter Pytel, Giselle Yvette Lopez, Howard Colman, MacLean P Nasrall...> ;Acta Neuropathologica. 2023 Jan 1
• 3 citations
  Mimics of Pediatric Small Vessel Primary Angiitis of the Central Nervous System.
  Coral M Stredny, Melissa M Blessing, Vivian Yi, Morgan E Ryan, Bo Zhang, Isaac H Solomon, Sanjay P Prabhu, Sanda Alexandrescu, Mark P Gorman> ;Annals of Neurology. 2023 Jan 1
• 21 citations
  A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma.
  Sharmistha Pal, Jakub P Kaplan, Huy Nguyen, Sylwia A Stopka, Milan R Savani, Michael S Regan, Quang-De Nguyen, Kristen L Jones, Lisa A Moreau, Jingyu Peng, Marina G Di...> ;Cancer Cell. 2022 Sep 12
• 1 citations
  PD-L1 and PD-1 expression in pediatric central nervous system germ cell tumors.
  Jared K Woods, Hart G Lidov, Keith L Ligon, Sandro Santagata, Susan N Chi, Kee Kiat Yeo, Sanda Alexandrescu> ;Modern Pathology. 2022 Dec 1
• 11 citations
  Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas.
  Nofar Harpaz, Tamir Mittelman, Olga Beresh, Ofir Griess, Noa Furth, Tomer-Meir Salame, Roni Oren, Liat Fellus-Alyagor, Alon Harmelin, Sanda Alexandrescu, Joana Graca M...> ;Molecular Cell. 2022 Jul 21
• 6 citations
  Embryonal and non-meningothelial mesenchymal tumors of the central nervous system - Advances in diagnosis and prognostication.
  David M Meredith, Sanda Alexandrescu> ;Brain Pathology. 2022 Jul 1
• 5 citations
  Multi-institutional study of the frequency, genomic landscape, and outcome of IDH-mutant glioma in pediatrics.
  Kee Kiat Yeo, Sanda Alexandrescu, Jennifer A Cotter, Jayne Vogelzang, Varun Bhave, Marilyn M Li, Jianling Ji, Jamal K Benhamida, Marc K Rosenblum, Tejus A Bale, Nancy ...> ;Neuro-Oncology. 2023 Jan 5
• 2 citations
  DICER1 mutations in primary central nervous system tumors: new insights into histologies, mutations, and prognosis.
  Kevin X Liu, Helen H Shang, Ayal A Aizer, Rifaquat Rahman, Seth Malinowski, David M Meredith, Junne Kamihara, Patrick Y Wen, Keith L Ligon, Susan N Chi, Karen J Marcus...> ;Journal of Neuro-Oncology. 2022 May 1
• 14 citations
  Upfront molecular targeted therapy for the treatment of BRAF-mutant pediatric high-grade glioma.
  Tom Rosenberg, Kee Kiat Yeo, Audrey Mauguen, Sanda Alexandrescu, Sanjay P Prabhu, Jessica W Tsai, Seth Malinowski, Mrinal Joshirao, Karishma Parikh, Sameer Farouk Sait...> ;Neuro-Oncology. 2022 Nov 2
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Journal Articles

• Association of Somatic GNAQ Mutation with Capillary Malformations in a Case of Choroidal Hemangioma  
  Lois E Smith, Marcelo Hochman, Sanda Alexandrescu, JAMA