Scott Diede, MD

Scott Diede, MD, PhD

Pediatric Hematology & Oncology Seattle, WA

Attending, Seattle Children's Hospital

Office Address

Office Map
  • 4800 Sand Point Way Ne
    Mailstop B-6553
    Seattle, WA 98105
    Phone: (206) 987-2106
    Fax: (206) 987-3946


  • The goal of my research is to determine the role DNA methylation plays in the formation of pediatric cancers. Pediatric cancers are fundamentally different from adult malignancies, being less genetically complex and also embryonal in nature, a characteristic that suggests a block in the normal process of differentiation may exist. As opposed to the acquisition of genetic mutations, aberrant epigenetic regulation, such as DNA methylation, may play a crucial role in this block, and provides an attractive target for novel therapies. Attempting to correct genetic mutations that drive cancer growth is a daunting task, however reversing epigenetic changes such as abnormal DNA methylation may be much more amenable to drug development. Cancer-specific DNA methylation may also provide valuable biomarkers for cancer detection, diagnosis, and risk assessment. I have a broad background in chromatin and chromosome maintenance, with specific training and expertise in molecular biology and assay development. These skills were first honed during my Ph.D. thesis work using yeast as a model organism to study telomere biology and have subsequently been developed during my work as a clinical fellow and junior faculty member studying genomic and epigenomic changes that occur in pediatric cancer. As a practicing pediatric hematologist and oncologist, I am also able to identify challenges in the clinical setting and bring these problems back into the laboratory and attempt to solve them. In summary, I have a demonstrated record of innovative research projects in the subject of cancer biology, and my expertise and experience have prepared me to translate new discoveries made in the laboratory into new treatments for children with cancer.

Dr. Diede's Clinical Specialties & Interests

  • Pediatric Hematology & Oncology: General Pediatric Hematology & Oncology
  • Clinical Interests: Transcription Factors; Caenorhabditis elegans Proteins; DNA-Binding Proteins; Tumor Cell Line; Caenorhabditis elegans; DNA Methylation; Gene Amplification; Saccharomyces cerevisiae Proteins

Dr. Diede's Faculty Appointments & Work History

  • Attending PhysicianSeattle Children's Hospital
    Seattle, WA
  • Acting Assistant ProfessorUniversity of Washington School of Medicine
    Seattle, WA
  • Associate in Clinical ResearchFred Hutchinson Cancer Research Center
    Seattle, WA

Dr. Diede's Education & Medical Training

  • University of WashingtonUniversity of WashingtonFellowship, Pediatric Hematology/Oncology
  • University of WashingtonUniversity of WashingtonResidency, Pediatrics
  • University of WashingtonUniversity of WashingtonInternship, Pediatrics
  • U of Chicago, Pritzker Sch of MedUniversity of Chicago Pritzker School of MedicineMedical School
  • University of ChicagoUniversity of ChicagoOther Training, PhD, Pathology
  • University of ChicagoUniversity of ChicagoOther Training, BA, Chemistry

Dr. Diede's Certifications & Licensure

  • WA State Medical LicenseWA State Medical License2005 - 2015
  • American Board of PediatricsAmerican Board of PediatricsPediatrics, 2007
  • American Board of PediatricsAmerican Board of PediatricsPediatric Hematology-Oncology, 2011

Dr. Diede's Awards, Honors, & Recognition

  • Go4theGoal Pediatric Cancer FoundationEstablished Investigator AwardGo4theGoal Pediatric Cancer Foundation, 2013
  • Alex's Lemonade Stand for Childhood Cancer ResearchYoung Investigator AwardAlex's Lemonade Stand for Childhood Cancer Research, 2010
  • St. Baldrick's FoundationScholarSt. Baldrick's Foundation, 2010
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Dr. Diede's Publications & Presentations

PubMed | Citations by Web of Science®

Hospital Affiliations

Insurance Accepted

  • Aetna Choice POS II
  • BCBS Alabama PPO
  • BCBS Blue Card PPO
  • BCBS Illinois PPO
  • CIGNA Open Access
  • First Choice
  • First Health PPO
  • Great West PPO
  • Humana ChoiceCare Network PPO
  • Multiplan PHCS PPO
  • Multiplan PPO
  • Premera BCBS Heritage & Heritage Plus 1
  • Providence Health System Personal Option
  • Regence Washington - Preferred Provider Network
  • United Healthcare - Direct Choice Plus POS
  • United Healthcare - Direct Options PPO

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