SeethaShankaranMD

Neonat/Perinatology • Detroit, MI

Professor, Pediatrics, Wayne State University School of Medicine

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Office
Childrens Hospital Mi Neonatology
3901 Beaubien 2nd Floor - Main Building
Detroit, MI 48201
Phone+1 313-745-1436
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Summary

Dr. Seetha Shankaran, MD is a neonatologist in Detroit, Michigan. She is currently licensed to practice medicine in Michigan. She is affiliated with DMC Children's Hospital of Michigan and DMC Harper University Hospital.

Education & Training

Children's Hospital of MichiganFellowship, Neonatal-Perinatal Medicine, 1973 - 1975
Maimonides Medical Center/Infants and Children's Hospital of BrooklynResidency, Pediatrics, 1971 - 1973
Madras Medical CollegeClass of 1970

Certifications & Licensure

MI State Medical License 1974 - 2024
American Board of Pediatrics Pediatrics
American Board of Pediatrics Neonatal-Perinatal Medicine

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014
Super Doctor SuperDoctors.com
Fellow (FAAP) American Academy of Pediatrics

Clinical Trials

Whole-Body Cooling for Birth Asphyxia in Term Infants Start of enrollment: 1999 Oct 01
Completed
Phase 3
Early Inhaled Nitric Oxide for Respiratory Failure in Newborns Start of enrollment: 1998 Aug 01
Terminated
Phase 3
Early Surfactant to Reduce Use of Mechanical Breathing in Low Birth Weight Infants Start of enrollment: 2000 May 01
Terminated
Phase 3
Glutamine Supplementation to Prevent Death or Infection in Extremely Premature Infants Start of enrollment: 1999 Jul 01
Completed
Phase 3
Inhaled Nitric Oxide Study for Respiratory Failure in Newborns Start of enrollment: 1995 Oct 01
Terminated
Phase 3
Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE) Start of enrollment: 1998 Feb 01
Terminated
Phase 3
Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage Start of enrollment: 1993 Feb 01
Completed
Phase 3
Follow-up Visit of High Risk Infants Start of enrollment: 1993 Jan 01
Recruiting
Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP) Start of enrollment: 1993 Nov 01
Completed
Phase 3
Dexamethasone Therapy in VLBW Infants at Risk of CLD Start of enrollment: 1992 Sep 01
Completed
Phase 3
Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure Start of enrollment: 2001 Jan 01
Terminated
Phase 3
The Maternal Lifestyle Study (MLS) Start of enrollment: 1993 May 01
Completed
Generic Database of Very Low Birth Weight Infants Start of enrollment: 1987 Jan 01
Recruiting
Benchmarking Initiative to Reduce Bronchopulmonary Dysplasia Start of enrollment: 2001 Mar 01
Completed
Not Applicable
Early Diagnosis of Candidiasis in Premature Infants Start of enrollment: 2004 Mar 01
Completed
Trial of Aggressive Versus Conservative Phototherapy in Infants <1,000 Grams Birth Weight Start of enrollment: 2002 Sep 01
Completed
Phase 3
Surfactant Positive Airway Pressure and Pulse Oximetry Trial Start of enrollment: 2005 Feb 01
Completed
Phase 3
Immunogenicity of PCV-7 Vaccine in VLBW Infants Start of enrollment: 2004 Jul 01
Completed
Single-Dose Intravenous Inositol Pharmacokinetics in Preterm Infants Start of enrollment: 2006 Jun 01
Completed
Phase 2
Inhaled PGE1 in Neonatal Hypoxemic Respiratory Failure Start of enrollment: 2008 May 01
Withdrawn
Phase 2
Late Hypothermia for Hypoxic-Ischemic Encephalopathy Start of enrollment: 2008 Apr 01
Completed
Not Applicable
Cerebral Function Monitoring in Premature Infants Start of enrollment: 2009 Jul 01
Completed
Early-Onset Sepsis Surveillance Study Start of enrollment: 2006 Feb 01
Completed
Early Blood Pressure Management in Extremely Premature Infants Start of enrollment: 2009 Jul 01
Completed
Phase 1
Hypotension in Neonates Start of enrollment: 2009 Apr 01
Completed
Laparotomy vs. Drainage for Infants With Necrotizing Enterocolitis Start of enrollment: 2010 Jan 01
Completed
Not Applicable
Multi-dose Pharmacokinetics and Dose Ranging of Inositol in Premature Infants (INS-2) Start of enrollment: 2010 Jan 01
Completed
Phase 2
Inflammatory Cytokines Associated With Perinatal Brain Injury Start of enrollment: 1999 Jul 01
Completed
Optimizing (Longer, Deeper) Cooling for Neonatal Hypoxic-Ischemic Encephalopathy(HIE) Start of enrollment: 2010 Sep 01
Terminated
Not Applicable
Vitamin E for Extremely Preterm Infants Start of enrollment: 2010 Oct 01
Completed
Phase 1
Exosurf Neonatal and Survanta for Treatment of Respiratory Distress Syndrome Start of enrollment: 1991 Jan 01
Completed
Phase 2, Phase 3
Prediction of Jaundice in Term Infants Start of enrollment: 1991 Nov 01
Completed
Persistent Pulmonary Hypertension of the Newborn (PPHN) Observational Study Start of enrollment: 1993 Oct 01
Completed
Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity Start of enrollment: 1994 Feb 01
Completed
Phase 2, Phase 3
Development of Standards for the New Ballard Maturation Score Start of enrollment: 1994 Jun 01
Completed
Growth Observational Study Start of enrollment: 1994 Aug 01
Completed
In Utero Magnesium Sulfate Exposure: Effects on Extremely-Low-Birth-Weight Infants Start of enrollment: 1996 Jul 01
Completed
The Effects of Erythropoietin (EPO) on the Transfusion Requirements of Very Low Birth Weight Infants Start of enrollment: 1997 Aug 01
Completed
Phase 2, Phase 3
Observational Study of Surgical Treatment of Necrotizing Enterocolotis Start of enrollment: 2001 Mar 01
Completed
Physiologic Definition of Bronchopulmonary Dysplasia Start of enrollment: 2005 May 01
Completed
Hydrocortisone for BPD Start of enrollment: 2011 Aug 11
Active, not recruiting
Phase 3
Donor Milk vs. Formula in Extremely Low Birth Weight (ELBW) Infants Start of enrollment: 2012 Aug 01
Completed
Phase 3
Transfusion of Prematures Trial Start of enrollment: 2012 Dec 01
Active, not recruiting
Phase 3
Prospective Research in Infants With Mild Encephalopathy Start of enrollment: 2012 Dec 01
Completed
Hypothermia for Encephalopathy in Low Income Countries-Feasibilty Start of enrollment: 2013 Apr 01
Completed
Not Applicable
Generic Database of Moderate Preterm Infants Start of enrollment: 2012 Mar 01
Completed
Preemie Hypothermia for Neonatal Encephalopathy Start of enrollment: 2015 May 01
Completed
Not Applicable
Cycled Phototherapy: A Safer Effective Treatment for Small Premature Infants? Start of enrollment: 2014 Mar 01
Unknown status
Not Applicable
Hydrocortisone for Term Hypotension Start of enrollment: 2014 Jun 19
Completed
Phase 3
Inositol to Reduce Retinopathy of Prematurity Start of enrollment: 2014 Apr 17
Terminated
Phase 3
Incubator Weaning of Moderately Preterm Infants Start of enrollment: 2015 Feb 01
Completed
Not Applicable
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Publications & Presentations

PubMed

Whole-Blood Gene Expression Profile After Hypoxic-Ischemic Encephalopathy.
Montaldo, P., Burgod, C., Herberg, J., Kaforou, M., Cunnington, A., Mejias, A., Cirillo, G., Miraglia Del Giudice, E., Capristo, C., Bandiya, P., Kamalaratnam, C., Cha...> ;JAMA Network Open. 2024 Feb 5
1 citations
Duration of birth depression and neurodevelopmental outcomes after whole-body hypothermia for hypoxic ischemic encephalopathy in India, Sri Lanka and Bangladesh - an e...
Burgod, C., Mazlan, M., Pant, S., Krishnan, V., Garegrat, R., Montaldo, P., Muraleedharan, P., Bandiya, P., Kamalaratnam, C., Chandramohan, R., Manerkar, S., Jahan, I....> ;The Lancet Regional Health. Southeast Asia. 2024 Jan 1
4 citations
Do Bayley-III Composite Scores at 18-22 Months Corrected Age Predict Full-Scale IQ at 6-7 Years in Children Born Extremely Preterm?
Jean Lowe, Carla M Bann, Allison G Dempsey, Janell Fuller, H Gerry Taylor, Kathryn E Gustafson, Victoria E Watson, Betty R Vohr, Abhik Das, Seetha Shankaran, Kimberly ...> ;The Journal of Pediatrics. 2023 Dec 1
1 citations
Serum ferritin values in neonates <29 weeks' gestation are highly variable and do not correlate with reticulocyte hemoglobin content.
Timothy M Bahr, Sylvia Tan, Emily Smith, Sandra S Beauman, Kurt R Schibler, Cathy A Grisby, Jean R Lowe, Edward F Bell, Abbot R Laptook, Seetha Shankaran, David P Carl...> ;Journal of Perinatology. 2023 Nov 1
4 citations
Whole-Body Hypothermia, Cerebral Magnetic Resonance Biomarkers, and Outcomes in Neonates With Moderate or Severe Hypoxic-Ischemic Encephalopathy Born at Tertiary Care ...
Sudhin Thayyil, Paolo Montaldo, Vaisakh Krishnan, Phoebe Ivain, Stuti Pant, Peter J Lally, Prathik Bandiya, Naveen Benkappa, Chinnathambi N Kamalaratnam, Rema Chandram...> ;JAMA Network Open. 2023 May 1
4 citations
Evaluation of heterogeneity in effect of therapeutic hypothermia by sex among infants with neonatal encephalopathy.
Elizabeth K Sewell, Seetha Shankaran, Girija Natarajan, Abbot Laptook, Abhik Das, Scott A McDonald, Shannon Hamrick, Michelle Baack, Matthew Rysavy, Rosemary D Higgins...> ;Pediatric Research. 2023 Oct 1
2 citations
Antiseizure medication at discharge in infants with hypoxic-ischaemic encephalopathy: an observational study.
Elizabeth K Sewell, Seetha Shankaran, Scott A McDonald, Shannon Hamrick, Courtney J Wusthoff, Ira Adams-Chapman, Lina F Chalak, Alexis S Davis, Krisa Van Meurs, Abhik ...> ;Archives of Disease in Childhood. Fetal and Neonatal Edition. 2023 Jul 1
5 citations
Association of Antenatal Steroid Exposure at 21 to 22 Weeks of Gestation With Neonatal Survival and Survival Without Morbidities.
Brion, L. P., Sanjay Chawla, Myra H Wyckoff, Matthew A Rysavy, Ravi Mangal Patel, Dhuly Chowdhury, Girija Natarajan, Abbot R Laptook, Satyan Lakshminrusimha, Edward F ...> ;JAMA Network Open. 2022 Sep 1
2 citations
Neuroprotection for hypoxic-ischemic encephalopathy: Contributions from the neonatal research network.
Sonia Lomeli Bonifacio, Lina F Chalak, Krisa P Van Meurs, Abbot R Laptook, Seetha Shankaran> ;Seminars in Perinatology. 2022 Nov 1
7 citations
Predictive Ability of 10-Minute Apgar Scores for Mortality and Neurodevelopmental Disability.
Vivek V Shukla, Carla M Bann, Maran Ramani, Namasivayam Ambalavanan, Myriam Peralta-Carcelen, Susan R Hintz, Rosemary D Higgins, Girija Natarajan, Abbot R Laptook, See...> ;Pediatrics. 2022 Apr 1
4 citations
Model for severe intracranial hemorrhage and role of early indomethacin in extreme preterm infants.
Sanjay Chawla, Girija Natarajan, Abbot R Laptook, Dhuly Chowdhury, Edward F Bell, Namasivayam Ambalavanan, Waldemar A Carlo, Marie Gantz, Abhik Das, Jose L Tapia, Heid...> ;Pediatric Research. 2022 Dec 1
3 citations
Blanket temperature during therapeutic hypothermia and outcomes in hypoxic ischemic encephalopathy.
John Flibotte, Abbot R Laptook, Seetha Shankaran, Scott A McDonald, Mariana C Baserga, Edward F Bell, C Michael Cotten, Abhik Das, Sara B DeMauro, Tara L DuPont, Eric ...> ;Journal of Perinatology. 2022 Mar 1
From Therapeutic Hypothermia to Targeted Temperature Management in Low-Resource Settings.
Sudhin Thayyil, Seetha Shankaran> ;Indian Pediatrics. 2022 Jan 15
2 citations
Questions about the HELIX trial - Authors' reply.
Sudhin Thayyil, Paul Bassett, Seetha Shankaran> ;The Lancet. Global Health. 2021 Dec 1
Rise and Fall of Therapeutic Hypothermia in Low-Resource Settings: Lessons from the HELIX Trial: Authors' Reply.
Sudhin Thayyil, Seetha Shankaran> ;Indian Journal of Pediatrics. 2021 Nov 12
11 citations
Association of Increased Seizures During Rewarming With Abnormal Neurodevelopmental Outcomes at 2-Year Follow-up: A Nested Multisite Cohort Study.
Brion, L. P., , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;JAMA Neurology. 2021 Oct 18
Association of Increased Seizures During Rewarming With Abnormal Neurodevelopmental Outcomes at 2-Year Follow-up: A Nested Multisite Cohort Study.
Lina F. Chalak, Athina Pappas, Sylvia Tan, Abhik Das, Pablo J. Sánchez, Abbot R. Laptook, Krisa P. Van Meurs, Seetha Shankaran, Edward F. Bell, Alexis S. Davis, Roy J....> ;JAMA Neurology. 2021 Oct 18
1 citations
Hypothermia for neonatal encephalopathy: how do we move forward?
Seetha Shankaran, Abbot R. Laptook, Sudhin Thayyil> ;Archives of Disease in Childhood. Fetal and Neonatal Edition. 2021 Oct 16
121 citations
Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Ba...
Sudhin Thayyil, Stuti Pant, Paolo Montaldo, Deepika Shukla, Vania Oliveira, Phoebe Ivain, Paul Bassett, Ravi Swamy, Josephine Mendoza, Maria Moreno-Morales, Peter J La...> ;The Lancet. Global Health. 2021 Aug 3
15 citations
Neurological and developmental outcomes following neonatal encephalopathy treated with therapeutic hypothermia
Neil Marlow, Seetha Shankaran, Elizabeth E. Rogers, Nathalie L. Maitre, Christopher D. Smyser> ;Seminars in Fetal & Neonatal Medicine. 2021 Jul 26
12 citations
Need for more evidence in the prevention and management of perinatal asphyxia and neonatal encephalopathy in low and middle-income countries: A call for action.
Vaisakh Krishnan, Vijay Kumar, Gabriel Fernando Todeschi Variane, Waldemar A. Carlo, Zulfiqar A Bhutta, Stéphane Sizonenko, Anne Hansen, Seetha Shankaran, Sudhin Thayyil> ;Seminars in Fetal & Neonatal Medicine. 2021 Jul 24
22 citations
Rise and Fall of Therapeutic Hypothermia in Low-Resource Settings: Lessons from the HELIX Trial
Vaisakh Krishnan, Vijay Kumar, Seetha Shankaran, Sudhin Thayyil> ;Indian Journal of Pediatrics. 2021 Jul 23
44 citations
Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multic...
Martin L. Blakely, Jon E. Tyson, Kevin P. Lally, Susan R. Hintz, Barry Eggleston, David K. Stevenson, Gail E. Besner, Abhik Das, Robin K. Ohls, William E Truog, Leif D...> ;Annals of Surgery. 2021 Oct 1
2 citations
Growth Rates of Infants Randomized to Continuous Positive Airway Pressure or Intubation After Extremely Preterm Birth.
Ariel A. Salas, Waldemar A. Carlo, Barbara Do, Edward F. Bell, Abhik Das, Krisa P. Van Meurs, Brenda B. Poindexter, Seetha Shankaran, Noelle Younge, Kristi L. Watterbe...> ;The Journal of Pediatrics. 2021 Jun 19
10 citations
Early Determination of Prognosis in Neonatal Moderate or Severe Hypoxic-Ischemic Encephalopathy
Namasivayam Ambalavanan, Seetha Shankaran, Abbot R. Laptook, Benjamin Carper, Abhik Das, Waldemar A. Carlo, C. Michael Cotten, Andrea F Duncan, Rosemary D. Higgins> ;Pediatrics. 2021 May 13
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Authored Content

Racial/Ethnic Disparities Among Extremely Preterm Infants in the United States from 2002 to 2016June 2020

Press Mentions

Neurodevelopmental and Growth Impairment Among Extremely Low-Birth-Weight Infants with Neonatal InfectionNovember 17th, 2019
Greater Cooling of Oxygen-Deprived Infants Fails to Improve Survival - US NewsDecember 23rd, 2014

Professional Memberships

American Academy of Pediatrics - AAP
Fellow

Hospital Affiliations

DMC Children's Hospital of MichiganDetroit, Michigan
DMC Harper University HospitalDetroit, Michigan