SerdarBulunMD

Obstetrics & Gynecology • Chicago, IL

Reproductive Endocrinology & Infertility

Chair, Department of Obstetrics and Gynecology

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Office
Prentice Women's Hospital
250 E Superior Street, Room 3-2306
Chicago, IL 60611
Phone+1 312-472-3636

Fax+1 312-472-3740
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Summary

Our Women's Health Services - Prentice Women's Hospital

From gynecologic and pregnancy care to menopause and beyond, Prentice Women's Hospital is dedicated to the health and happiness of women in all the stages of th

Education & Training

University of Texas Southwestern Medical CenterFellowship, Reproductive Endocrinology and Infertility, 1991 - 1993
University at BuffaloResidency, Obstetrics and Gynecology, 1988 - 1991
Harlem Hospital CenterResidency, Obstetrics and Gynecology, 1987 - 1988
University of Arizona College of Medicine-TucsonInternship, Transitional Year, 1986 - 1987
Istanbul University FomClass of 1983

Certifications & Licensure

IL State Medical License 1999 - 2026
TX State Medical License 1991 - 1999
NY State Medical License 1989 - 1997
American Board of Obstetrics and Gynecology Obstetrics & Gynecology
American Board of Obstetrics and Gynecology Reproductive Endocrinology/Infertility

Awards, Honors, & Recognition

President Society for Reproductive (formerly Gynecologic) Investigation, 2015
Member Association of American Physicians, 2012
Member American Gynecological and Obstetrical Society, 2007
Member American Society of Clinical Investigation, 2003
Fellow (FACOG) American Congress of Obstetricians and Gynecologists
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Clinical Trials

Ulipristal for Endometriosis-related Pelvic Pain Start of enrollment: 2015 Feb 01
Unknown status
Phase 4

Publications & Presentations

PubMed

MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas.
Azna Zuberi, Yongchao Huang, Ariel J Dotts, Helen Wei, John S Coon 5th, Shimeng Liu, Takashi Iizuka, Olivia Wu, Olivia Sotos, Priyanka Saini, Debabrata Chakravarti, Th...> ;JCI Insight. 2023 Sep 22
5 citations
Engineered MED12 mutations drive leiomyoma-like transcriptional and metabolic programs by altering the 3D genome compartmentalization.
Kadir Buyukcelebi, Xintong Chen, Fatih Abdula, Hoda Elkafas, Alexander James Duval, Harun Ozturk, Fidan Seker-Polat, Qiushi Jin, Ping Yin, Yue Feng, Serdar E Bulun, Ji...> ;Nature Communications. 2023 Jul 10
10 citations
Endometriosis and adenomyosis: shared pathophysiology.
Serdar E Bulun, Sule Yildiz, Mazhar Adli, Debabrata Chakravarti, James Brandon Parker, Magdy Milad, Linda Yang, Angela Chaudhari, Susan Tsai, Jian Jun Wei, Ping Yin> ;Fertility and Sterility. 2023 May 1
Engineered MED12 mutations drive uterine fibroid-like transcriptional and metabolic programs by altering the 3D genome compartmentalization.
Kadir Buyukcelebi, Xintong Chen, Fatih Abdula, Alexander Duval, Harun Ozturk, Fidan Seker-Polat, Qiushi Jin, Ping Yin, Yue Feng, Jian-Jun Wei, Serdar Bulun, Feng Yue, ...> ;Research Square. 2023 Feb 9
Adenomyosis: single-cell transcriptomic analysis reveals a paracrine mesenchymal-epithelial interaction involving the WNT/SFRP pathway.
Sule Yildiz, Meric Kinali, Jian Jun Wei, Magdy Milad, Ping Yin, Mazhar Adli, Serdar E Bulun> ;Fertility and Sterility. 2023 May 1
Loss of dystrophin is common in uterine leiomyosarcoma: a potential biomarker for clinical application.
Brian Vadasz, Christopher Felicelli, Yue Feng, Ping Yin, Qing Zhang, Serdar Bulun, Jian-Jun Wei> ;Human Pathology. 2023 Apr 1
11 citations
Mono-(2-ethyl-5-hydroxyhexyl) phthalate promotes uterine leiomyoma cell survival through tryptophan-kynurenine-AHR pathway activation.
Takashi Iizuka, Ping Yin, Azna Zuberi, Stacy Kujawa, John S Coon 5th, Richelle D Björvang, Pauliina Damdimopoulou, Diana C Pacyga, Rita S Strakovsky, Jodi A Flaws, Ser...> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Nov 22
4 citations
Uterine Leiomyosarcoma Associated With Leiomyoma With Bizarre Nuclei: Histology and Genomic Analysis of 2 Cases.
Jean V Fischer, Melissa Mejia-Bautista, Brian Vadasz, Ping Yin, Serdar Bulun, Edward J Tanner, Xinyan Lu, Jian-Jun Wei> ;International Journal of Gynecological Pathology. 2022 Nov 1
6 citations
Endometriosis caused by retrograde menstruation: now demonstrated by DNA evidence.
Serdar E Bulun> ;Fertility and Sterility. 2022 Sep 1
11 citations
Single-cell sequencing reveals novel cellular heterogeneity in uterine leiomyomas.
Jyoti Goad, Joshua Rudolph, Mehrdad Zandigohar, Matthew Tae, Yang Dai, Jian-Jun Wei, Serdar E Bulun, Debabrata Chakravarti, Aleksandar Rajkovic> ;Human Reproduction. 2022 Sep 30
Histological and molecular analysis of cellular leiomyoma with sclerosis: linked to HMGA2 overexpression.
Brannan B Griffin, Yue Feng, Priyanka Saini, Xinyan Lu, Serdar Bulun, Debabrata Chakravarti, Jian-Jun Wei> ;Histopathology. 2022 Nov 1
2 citations
Epigenomic and enhancer dysregulation in uterine leiomyomas.
Oliwia W Mlodawska, Priyanka Saini, J Brandon Parker, Jian-Jun Wei, Serdar E Bulun, Melissa A Simon, Debabrata Chakravarti> ;Human Reproduction Update. 2022 Jun 30
2 citations
In Vivo Genome-Wide PGR Binding in Pregnant Human Myometrium Identifies Potential Regulators of Labor.
Ariel J Dotts, Derek Reiman, Ping Yin, Stacy Kujawa, William A Grobman, Yang Dai, Serdar E Bulun> ;Reproductive Sciences. 2023 Feb 1
2 citations
An estrogen-sensitive fibroblast population drives abdominal muscle fibrosis in an inguinal hernia mouse model.
Tanvi Potluri, Matthew J Taylor, Jonah J Stulberg, Richard L Lieber, Hong Zhao, Serdar E Bulun> ;JCI Insight. 2022 Apr 19
7 citations
Tryptophan 2,3-Dioxygenase-2 in Uterine Leiomyoma: Dysregulation by MED12 Mutation Status.
Anne P Hutchinson, Ping Yin, Ilona Neale, John S Coon 5th, Stacy A Kujawa, Shimeng Liu, Serdar E Bulun> ;Reproductive Sciences. 2022 Mar 1
4 citations
Midlife Urinary Phthalate Metabolite Concentrations and Prior Uterine Fibroid Diagnosis.
Diana C Pacyga, Brad A Ryva, Romana A Nowak, Serdar E Bulun, Ping Yin, Zhong Li, Jodi A Flaws, Rita S Strakovsky> ;International Journal of Environmental Research and Public Health. 2022 Feb 26
24 citations
Gut microbiota-derived short-chain fatty acids protect against the progression of endometriosis.
Sangappa B Chadchan, Pooja Popli, Chandrasekhar R Ambati, Eric Tycksen, Sang Jun Han, Serdar E. Bulun, Nagireddy Putluri, S.W. Biest, Ramakrishna Kommagani> ;Life Science Alliance. 2021 Dec 1
10 citations
Progesterone receptor-DNA methylation crosstalk regulates depletion of uterine leiomyoma stem cells: A potential therapeutic target
Shimeng Liu, Ping Yin, Jingting Xu, Ariel J. Dotts, Stacy A. Kujawa, John S. Coon, Hong Zhao, Yang Dai, Serdar E. Bulun> ;Stem Cell Reports. 2021 Sep 14
1 citations
Molecular Effects of Topical Estrogen on Vaginal Granulation Tissue in Postpartum Women.
Katarzyna Bochenska, Stacy A. Kujawa, Hong Zhao, Kimberly Kenton, Serdar E. Bulun, Christina Lewicky-Gaupp> ;Female Pelvic Medicine & Reconstructive Surgery. 2021 Aug 1
37 citations
Adenomyosis pathogenesis: insights from next-generation sequencing
Serdar E. Bulun, Sule Yildiz, Mazhar Adli, Jian-Jun Wei> ;Human Reproduction Update. 2021 Jun 15
10 citations
ARID1 proteins: from transcriptional and post-translational regulation to carcinogenesis and potential therapeutics.
Olena Odnokoz, Cindy Wavelet-Vermuse, Shelby L Hophan, Serdar E. Bulun, Yong Wan> ;Epigenomics. 2021 Apr 23
10 citations
Epigenomic tensor predicts disease subtypes and reveals constrained tumor evolution.
Jacob R. Leistico, Priyanka Saini, Christopher R. Futtner, Miroslav Hejna, Yasuhiro Omura, Pritin N. Soni, Poorva Sandlesh, Magdy P. Milad, Jian-Jun Wei, Serdar E. Bul...> ;Cell Reports. 2021 Mar 30
5 citations
Integrated histologic and molecular analysis of uterine leiomyosarcoma and two benign variants with nuclear atypia
Tingting Gao, Brian S. Finkelman, Yanli Ban, Yinuo Li, Ping Yin, Serdar E. Bulun, Xinyan Lu, Chunfang Ha, Jian-Jun Wei> ;Cancer Science. 2021 Mar 22
5 citations
Summary of the Proceedings of the Basic Science of Uterine Fibroids Meeting: New Developments February 28, 2020.
Phyllis C. Leppert, Ayman Al-Hendy, Donna D. Baird, Serdar E. Bulun, William H. Catherino, Darlene Dixon, Merrick T. Ducharme, Quaker E. Harmon, Friederike L. Jayes, E...> ;F&S Science. 2021 Feb 1
13 citations
Activation of protein kinase B by WNT4 as a regulator of uterine leiomyoma stem cell function.
Shimeng Liu, Ping Yin, Ariel J. Dotts, Stacy A. Kujawa, John S. Coon, Jian Jun Wei, Debabrata Chakravarti, Serdar E. Bulun> ;Fertility and Sterility. 2020 Dec 1
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Journal Articles

"Menstruation: Science and Society" - American Journal of Obstetrics & Gynecology
Serdar E Bulun, Kristen A Matteson, Hugh S Taylor, American Journal of Obstetrics and Gynecology

Authored Content

"Menstruation: Science and Society" - American Journal of Obstetrics & GynecologyJuly 2020
"Menstruation: Science and Society" - American Journal of Obstetrics & GynecologyJuly 2020

Press Mentions

People with Endometriosis Might One Day Benefit from an Antibody InjectionMarch 11th, 2023
An Antibody Injection Could One Day Help People with EndometriosisMarch 7th, 2023
Endometriosis: New Research, New DirectionsMarch 1st, 2023
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