SimonAClarkDO

PubMed

• 6 citations
  Comparison of pellicle and shake flask-grown BCG strains by quality control assays and protection studies
  Megan Fitzpatrick, Mei Mei Ho, Simon Clark, Belinda Dagg, Bhagwati Khatri, Faye Lanni, Ann Williams, Michael J. Brennan, Dominick Laddy, Barry Walker> ;Tuberculosis. 2019 Jan 1
• 13 citations
  Label-free optical vibrational spectroscopy to detect the metabolic state of M. tuberculosis cells at the site of disease.
  Vincent O Baron, Mingzhou Chen, Simon O Clark, Ann Williams, Robert J H Hammond, Kishan Dholakia, Stephen H Gillespie> ;Scientific reports. 2017 Aug 29
• 84 citations
  Alternative BCG delivery strategies improve protection against Mycobacterium tuberculosis in non-human primates: Protection associated with mycobacterial antigen-speci...
  Sally Sharpe, Andrew White, Charlotte Sarfas, Laura Sibley, Fergus V. Gleeson, Anthony McIntyre, Randall J. Basaraba, Simon Clark, Graham Hall, Emma Rayner, Ann Willia...> ;Tuberculosis. 2016 Dec 1
• 42 citations
  Ultra low dose aerosol challenge with Mycobacterium tuberculosis leads to divergent outcomes in rhesus and cynomolgus macaques.
  Sally Sharpe, Andrew White, Fergus V. Gleeson, Anthony McIntyre, Donna Smyth, Simon Clark, Charlotte Sarfas, Dominick Laddy, Emma Rayner, Graham Hall, Ann Williams, Mi...> ;Tuberculosis. 2016 Jan 1
• 14 citations
  Route of delivery to the airway influences the distribution of pulmonary disease but not the outcome of Mycobacterium tuberculosis infection in rhesus macaques.
  Laura Sibley, Mike Dennis, Charlotte Sarfas, Andrew White, Simon Clark, Fergus V. Gleeson, Anthony McIntyre, Emma Rayner, Geoffrey Pearson, Ann Williams, Philip Marsh,...> ;Tuberculosis. 2016 Jan 1
• 36 citations
  Deletion of zmp1 improves Mycobacterium bovis BCG-mediated protection in a guinea pig model of tuberculosis
  Peter Sander, Simon Clark, Agnese Petrera, Cristina Vilaplana, Michael Meuli, Petra Selchow, Andrea Zelmer, Deepa Mohanan, Nuria Andreu, Emma Rayner, Michael Dal Molin...> ;Vaccine. 2015 Mar 10
• 18 citations
  Early lesions following aerosol infection of rhesus macaques (Macaca mulatta) with Mycobacterium tuberculosis strain H37RV.
  Emma Rayner, Geoff Pearson, Graham Hall, Randall J. Basaraba, Fergus V. Gleeson, A. McIntyre, Simon Clark, Ann Williams, Mike Dennis, Sally Sharpe> ;Journal of Comparative Pathology. 2013 Nov 1
• 25 citations
  Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in experimental animal models of infection and have minima...
  A. Afonso-Barroso, Simon O. Clark, Ann Williams, G.T. Rosa, Claudia Nobrega, Sandro Silva-Gomes, Sílvia Vale-Costa, Roy Ummels, Neil G. Stoker, Farahnaz Movahedzadeh, ...> ;Cellular Microbiology. 2013 Apr 1
• 13 citations
  Oral delivery of BCG Moreau Rio de Janeiro gives equivalent protection against tuberculosis but with reduced pathology compared to parenteral BCG Danish vaccination
  Simon O. Clark, Dominic L.F. Kelly, Edgar Badell, Luiz Roberto Ribeiro Castello-Branco, Frank E. Aldwell, Nathalie Winter, David J. M. Lewis, Philip Marsh> ;Vaccine. 2010 Oct 8
• 99 citations
  Establishment of an Aerosol Challenge Model of Tuberculosis in Rhesus Macaques and an Evaluation of Endpoints for Vaccine Testing
  Sally Sharpe, Helen McShane, Mike Dennis, Randall J. Basaraba, Fergus V. Gleeson, Graham Hall, A. McIntyre, Karen E. Gooch, Simon O. Clark, Natalie E. R. Beveridge, E....> ;Clinical and Vaccine Immunology. 2010 Aug 1
• 47 citations
  Determination of lesion volume by MRI and stereology in a macaque model of tuberculosis
  Sally Sharpe, E. Eschelbach, Randall J. Basaraba, Fergus V. Gleeson, Graham Hall, A. McIntyre, Ann Williams, Susan L. Kraft, Simon O. Clark, Karen E. Gooch, George F. ...> ;Tuberculosis. 2009 Nov 1
• 2 citations
  Construction of a severely attenuated mutant of Mycobacterium tuberculosis for reducing risk to laboratory workers.
  Farahnaz Movahedzadeh, Ann Williams, Simon O. Clark, Graham J. Hatch, Debbie A. Smith, Annemieke Ten Bokum, Tanya Parish, Joanna Bacon, Neil G. Stoker> ;Tuberculosis. 2008 Sep 1
• 9 citations
  Re-formulation of selected DNA vaccine candidates and their evaluation as protein vaccines using a guinea pig aerosol infection model of tuberculosis
  Julia Vipond, Simon O. Clark, Graham J. Hatch, Richard Vipond, Else Marie Agger, Julia A. Tree, Ann Williams, Philip Marsh> ;Tuberculosis. 2006 May 1
• 36 citations
  Intranasal IFNγ extends passive IgA antibody protection of mice against Mycobacterium tuberculosis lung infection
  Rajko Reljic, Simon O. Clark, Ann Williams, Gustavo Falero-Diaz, Mahavir Singh, Stephen Challacombe, Philip Marsh, Juraj Ivanyi> ;Clinical and Experimental Immunology. 2006 Mar 1
• 3 citations
  Induction of high levels of protective immunity in mice after vaccination using dendritic cells infected with auxotrophic mutants of Mycobacterium tuberculosis.
  Eleanor Roy, A. Dharshan De Silva, Vasan K. Sambandamurthy, Simon O. Clark, Evangelos Stavropoulos, William R. Jacobs, John Brennan, John Chan, Ann Williams, M. Joseph...> ;Immunology Letters. 2006 Mar 15
• 131 citations
  Evaluation of vaccines in the EU TB vaccine cluster using a guinea pig aerosol infection model of tuberculosis
  Ann Williams, Graham J. Hatch, Simon O. Clark, Karen E. Gooch, Kim A. Hatch, Graham Hall, Kris Huygen, Tom H. M. Ottenhoff, Kees L. M. C. Franken, Peter Andersen, T. M...> ;Tuberculosis. 2005 Jan 1
• 23 citations
  Intranasal bacille Calmette–Guérin (BCG) vaccine dosage needs balancing between protection and lung pathology
  Julia A. Tree, Alison Williams, Simon O. Clark, Graham Hall, Philip Marsh, Juraj Ivanyi> ;Clinical and Experimental Immunology. 2004 Dec 1
• 118 citations
  Passive protection with immunoglobulin A antibodies against tuberculous early infection of the lungs.
  Ann Williams, Rajko Reljic, Irene Naylor, Simon O. Clark, Gustavo Falero-Diaz, Mahavir Singh, Stephen Challacombe, Philip Marsh, Juraj Ivanyi> ;Immunology. 2004 Mar 1
• 4 citations
  Bordetella pertussis fimbriae are effective carrier proteins in Neisseria meningitidis serogroup C conjugate vaccines
  Karen M. Reddin, Annette Crowley-Luke, Simon O. Clark, Philip J Vincent, Andrew Gorringe, Michael J. Hudson, Andrew Robinson> ;Fems Immunology and Medical Microbiology. 2001 Aug 1
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