SouhelNajjarMDProfessor and Chairman, Neurology

PubMed

• Neuromyelitis Optica Spectrum Disorder Mimicking Pontine Stroke: A Case Report and Systematic Literature Review.
  Rohan Arora, Spencer McFarlane, Joseph A Diamond, Souhel Najjar, Huang, B.> ;Cureus. 2023 Jun 1
• 6 citations
  Autoimmune Encephalitis: A Physician's Guide to the Clinical Spectrum Diagnosis and Management.
  Arpan Patel, Yue Meng, Amanda Najjar, Fred Lado, Souhel Najjar> ;Brain Sciences. 2022 Aug 25
• 9 citations
  Immune cell profiles of patients with interstitial cystitis/bladder pain syndrome.
  Robert M Moldwin, Vishaan Nursey, Oksana Yaskiv, Siddhartha Dalvi, Eric J Macdonald, Michael Funaro, Chengliang Zhang, William DeGouveia, Marina Ruzimovsky, Horacio R ...> ;Journal of Translational Medicine. 2022 Feb 21
• 5 citations
  EEG Abnormalities and Their Radiographic Correlates in a COVID-19 Inpatient Cohort.
  Sean T Hwang, Ahmad A Ballout, Anup N Sonti, Claudia Kirsch, Neeraj Singh, Noah Markowitz, Tung Ming Leung, Derek J Chong, Richard Temes, Steven V Pacia, Ruben I Kuzni...> ;Neurology. Clinical Practice. 2022 Feb 1
• Case report: Bilateral globus pallidus lesions and delayed progressive leukoencephalopathy in COVID-19: Effects of hypoxia alone or combination of hypoxia and inflamma...
  Ahmad A Ballout, Michael Kolesnik, Yuna Choi, Marc S Ayoub, Asaff Harel, Souhel Najjar> ;Frontiers in Neurology. 2022 Jan 1
• 2 citations
  Rare variants and HLA haplotypes associated in patients with neuromyelitis optica spectrum disorders.
  Inna Tabansky, Akemi J Tanaka, Jiayao Wang, Guanglan Zhang, Irena Dujmovic, Simone Mader, Venkatesh Jeganathan, Tracey DeAngelis, Michael Funaro, Asaff Harel, Mark Mes...> ;Frontiers in Immunology. 2022 Jan 1
• 8 citations
  A Single-Health System Case Series of New-Onset CNS Inflammatory Disorders Temporally Associated With mRNA-Based SARS-CoV-2 Vaccines.
  Ahmad A Ballout, Anna Babaie, Michael Kolesnik, Jian Yi Li, Natasha Hameed, Glenn Waldman, Frasat Chaudhry, Sami Saba, Asaff Harel, Souhel Najjar> ;Frontiers in Neurology. 2022 Jan 1
• Reader Response: Clinical, Neuroimmunologic, and CSF Investigations in First Episode Psychosis.
  Thomas A Pollak, Harald Prüss, Karl Bechter, Souhel Najjar, Angela Vincent> ;Neurology. 2021 Nov 23
• 6 citations
  Dietary factors in experimental autoimmune encephalomyelitis and multiple sclerosis: A comprehensive review:
  Claire Valburg, Anup N. Sonti, Joel N. H. Stern, Souhel Najjar, Asaff Harel> ;Multiple Sclerosis. 2021 Apr 1
• 18 citations
  COVID-19 Severity and Stroke: Correlation of Imaging and Laboratory Markers.
  Jeffrey M. Katz, Richard B. Libman, Jason J. Wang, Christopher G. Filippi, Pina C. Sanelli, A. Zlochower, Michele Gribko, Steven V. Pacia, Ruben Kuzniecky, Souhel Najj...> ;AJNR. American Journal of Neuroradiology. 2021 Feb 1
• 3 citations
  Case Report: HSV-2 Encephalitis Presenting With Chorea; Effects of Infection Alone or Combination of Infection and Autoimmunity?
  Michael Kolesnik, Ahmad A Ballout, Natasha Hameed, Souhel Najjar> ;Frontiers in Neurology. 2021 Jan 1
• 9 citations
  Acute Seizures Occurring in Association With SARS-CoV-2.
  Sean T. Hwang, Ahmad A. Ballout, Usman Mirza, Anup N. Sonti, Arif Husain, Claudia Kirsch, Ruben Kuzniecky, Souhel Najjar> ;Frontiers in Neurology. 2020 Nov 5
• 150 citations
  Central nervous system complications associated with SARS-CoV-2 infection: integrative concepts of pathophysiology and case reports.
  Souhel Najjar, Amanda Najjar, Derek J Chong, Bidyut Pramanik, Claudia Kirsch, Ruben I. Kuzniecky, Steven V. Pacia, Salman Azhar> ;Journal of Neuroinflammation. 2020 Aug 6
• 90 citations
  Cerebrovascular Complications of COVID-19.
  Jeffrey M. Katz, Richard B. Libman, Jason J. Wang, Pina C. Sanelli, Christopher G. Filippi, Michele Gribko, Steven V. Pacia, Ruben Kuzniecky, Souhel Najjar, Salman Azhar> ;Stroke. 2020 Aug 6
• 4 citations
  Defining the role of T lymphocytes in the immunopathogenesis of neuromyelitis optica spectrum disorder.
  Dennis P. Fitzgerald, Micheline Laurent, Michael Funaro, Asaff Harel, Tracey DeAngelis, Catherine Bangeranye, Souhel Najjar, Inna Tabansky, Joel N. H. Stern> ;Discovery Medicine. 2020 Mar 1
• 2 citations
  Autoimmune psychosis - Authors' reply.
  Thomas A Pollak, Harald Prüss, Ludger Tebartz van Elst, Angela Vincent, Souhel Najjar, Karl Bechter> ;The Lancet. Psychiatry. 2020 Feb 1
• 186 citations
  Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin.
  Thomas A Pollak, Belinda R Lennox, Sabine Müller, Michael E. Benros, Harald Prüss, Ludger Tebartz van Elst, Hans C. Klein, Johann Steiner, Thomas Frodl, Bernhard Boger...> ;The Lancet. Psychiatry. 2020 Jan 1
• 5 citations
  Editorial: Recent Advances in Psychiatry From Psycho-Neuro-Immunology Research: Autoimmune Encephalitis, Autoimmune Encephalopathy, and Mild Encephalitis.
  Karl Bechter, David Brown, Souhel Najjar> ;Frontiers in Psychiatry. 2019 Mar 29
• 13 citations
  Retinal vasculopathy with cerebral leukoencephalopathy (RVCL): A rare mimic of tumefactive MS.
  Jenelle Raynowska, Dhanashri P. Miskin, Bidyut Pramanik, Saeed Asiry, Todd Anderson, John A. Boockvar, Souhel Najjar, Asaff Harel> ;Neurology. 2018 Oct 9
• 29 citations
  Targeting DEC-205-DCIR2+ dendritic cells promotes immunological tolerance in proteolipid protein-induced experimental autoimmune encephalomyelitis.
  Inna Tabansky, Derin B. Keskin, Deepika Watts, Cathleen Petzold, Michael Funaro, Warren Sands, Paul Wright, Edmond J. Yunis, Souhel Najjar, Betty Diamond, Yonghao Cao,...> ;Molecular Medicine. 2018 May 3
• 18 citations
  Crosstalk between the immune system and neural pathways in interstitial cystitis/bladder pain syndrome.
  Kevin Duh, Michael Funaro, William DeGouveia, Sonia Bahlani, Dominic Pappas, Souhel Najjar, Inna Tabansky, Robert M. Moldwin, Joel N. H. Stern> ;Discovery Medicine. 2018 May 1
• 49 citations
  A clinical approach to new-onset psychosis associated with immune dysregulation: the concept of autoimmune psychosis
  Souhel Najjar, Johann Steiner, Amanda Najjar, Karl Bechter> ;Journal of Neuroinflammation. 2018 Feb 13
• 112 citations
  Neurovascular Unit Dysfunction and Blood–Brain Barrier Hyperpermeability Contribute to Schizophrenia Neurobiology: A Theoretical Integration of Clinical and Experiment...
  Souhel Najjar, Silky Pahlajani, Virginia A. De Sanctis, Joel N. H. Stern, Amanda Najjar, Derek J. Chong> ;Frontiers in Psychiatry. 2017 May 23
• 13 citations
  The role of B cells in multiple sclerosis: more than antibodies.
  Michael Funaro, Mark D. Messina, Maya Shabbir, Paul Wright, Souhel Najjar, Inna Tabansky, Joel N. H. Stern> ;Discovery Medicine. 2016 Nov 1
• 2 citations
  Erratum to: Advancing drug delivery systems for the treatment of multiple sclerosis.
  Inna Tabansky, Mark D. Messina, Catherine Bangeranye, Jeffrey Goldstein, Karen M. Blitz-Shabbir, Suly Machado, Venkatesh Jeganathan, Paul Wright, Souhel Najjar, Yongha...> ;Immunologic Research. 2016 Feb 19
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Journal Articles

• Meta-analysis of N-methyl-D-aspartate receptor antibodies in schizophrenia, schizoaffective disorder, bipolar disorder, and major depressive disorders  
  Pearlman D, Najjar S, Schizophr Res, 1/2/2014
• Neuroinflammation versus decreased Zif268 mRNA expression as causal mediators of decreased GAD67 mRNA expression within dorsolateral prefrontal cortex in schizophrenia...  
  Pearlman D, Najjar S, Am J Psychiatry, 1/1/2014
• Association between neuroinflammation and white matter pathology in schizophrenia: a systematic review Invited review for special issue on "white matter pathology in s...  
  Najjar S, Pearlman D, Schizophr Res, 1/1/2014
• Brain biopsy findings link major depressive disorder to neuroinflammation, oxidative stress, and neurovascular dysfunction: a case report  
  Najjar S, Pearlman D, Hirsch S, Friedman K, Strange J, Reidy J, Khoukaz M, Ferrell R, Devinsky O, Najjar A, Zagzag D, Biol Psychiatry, 1/1/2014
• Association between anti-basal ganglia antibodies and primary obsessive-compulsive disorder: a systematic review and meta-analysis  
  Pearlman D, Vora S, Marquis B, Najjar S, Dudley L, Br J Psychiatry, 1/1/2014
• Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contribute to major depressive disorder: a review of clinical and experimental evidence  
  Najjar S, Pearlman D, Devinsky O, Najjar A, Zagzag D, J Neuroinflammation, 1/1/2013
• Glutamic acid decarboxylase autoantibody syndrome presenting as schizophrenia  
  Najjar S, Pearlman D, Zagzag D, Golfinos J, Devinsky O, Neurologist, 1/1/2012
• Classifying seizures and epilepsies: limits of science and semantics  
  Devinsky O, Najjar S, Epilepsy Curr, 1/1/2011
• Refractory epilepsy associated with microglial activation  
  Najjar S, Pearlman D, Miller CD, Devinsky O, Neurologist, 1/1/2011
• Extra-limbic autoimmune encephalitis associated with glutamic acid decarboxylase antibodies: an under-diagnosed entity?  
  Najjar S, Pearlman D, Najjar A, Ghiasian, V, Zagzag D, Devinsky O, Epilepsy Curr, 1/1/2011
• Spontaneously resolving seronegative autoimmune limbic encephalitis  
  Najjar S, Pearlman D, Zagzag D, Devinsky O, Cogn Behav Neurol, 1/1/2011
• Paraneoplastic myelitis related to diffuse large B-cell lymphoma and Hodgkin's lymphoma: two case reports and literature review  
  Srour S, Goldberg E, Najjar S, Community Oncology, 1/1/2010
• Phenotypic heterogeneity and Type-1/2 PrPSc co-occurrence in Creutzfeldt-Jakob disease associated with a new mutation of PRNP  
  Puoti G, Nigro M, Chen S, Cali I, Cracco L, Blevins J, Najjar S, Hamilton RL, Gambetti P, J Neuropathol Exper Neurol, 1/1/2010
• Immunology and epilepsy  
  Najjar S, Bernbaum M, Lai G, Devinsky O, Rev Neurol Dis, 1/1/2008
• Pediatric language mapping: sensitivity of neurostimulation and Wada testing in epilepsy surgery  
  Schevon CA, Carlson C, Zaroff M, Weiner HJ, Doyle WK, Miles D, Lajoie J, Kuzniecky R, Pacia S, Vazquez B, Luciano D, Najjar S, Devinsky O, Epilepsia, 1/1/2007
• Race/ethnicity, sex, and socioeconomic Status as predictors of outcome after surgery for temporal lobe epilepsy  
  Burneo JG, Black L, Martin R, Devinsky O, Pacia S, Faught E, Vasquez B, Knowlton R, Luciano D, Doyle W, Najjar S, Kuzniecky R, Arch Neurol, 1/1/2006
• Adult-onset epilepsy in focal cortical dysplasia of taylor type  
  Siegel AM, Cascino GD, Elger CE, Devinsky O, Laff R, Najjar S, Sperling MR, LoRusso G, Cossu M, Urbach H, Aronica E, Meyer FB, Scheithauer BW, Dubeau F, Andermann F, Neurology, 1/1/2005
• Seizures in HIV patients: etiology and antiepileptic treatment  
  Mendez M, Vazquez B, Najjar S, Profiles in Seizure Management, 1/1/2004
• Epilepsy surgery in tuberous sclerosis: multistage procedures with bilateral or multilobar foci  
  Romanelli P, Najjar S, Weiner HL, Devinsky O, J Child Neurol, 1/1/2002
• Bilateral resective epilepsy surgery in a child with tuberous sclerosis  
  Romanelli P, Weiner HL, Najjar S, Devinsky O, Neurosurgery, 1/1/2001
• Phase II studies of the glycine antagonist GV150526 in acute stroke : the North American experience  
  The North American Glycine Antagonist in Neuroprotection (GAIN) Investigators, Stroke, 1/1/2000
• Evidence against the existence of a temporal lobe epilepsy personality syndrome  
  Devinsky O, Najjar S, Neurology, 1/1/1999
• The cerebellum: lower but not the lesser  
  Devinsky O, Najjar S, Neurology Network Commentary, 1/1/1998
• Atypical case of Becker muscular dystrophy, early identification and management  
  Cohen-Sobel E, Darmochwal V, Caselli M, Najjar S, Lambert C, J Am Pod Med Assoc, 1/1/1994
• Neuropathology of AIDS in surgical biopsy specimens  
  Miller DC, Najjar S, Budzilovich GN, Neurosurgery clinics of North America, 1/1/1994
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Books/Book Chapters

• The Blood-Brain Barrier in Brain Tumors 
  Chapter: The Blood-Brain Barrier in Health and Disease. 
  Shroff S, Jain R, Najjar S, Zagzag DScience Publishers2014
• Managing Epilepsy and Co-Existing Disorders 
  Chapter: Procedures in epilepsy patients. 
  Page 499 - 514Najjar S, Devinsky O, Rosenberg A, Nordli D, Ettinger AEditors: Ettinger AB and Devinsky O.Butterworth, Heinemann, Woburn, MA2002
• Rickets: causes and differential diagnosis 
  Najjar SDamascus Medical School1983

Abstracts/Posters

• Glial and white matter abnormalities in schizophrenia: systematic review.
  Pearlman D, Najjar S, 15th International Congress on Schizophrenia Research; Schizophr Res, Colorado Springs, CO, 1/1/2015
• Major depressive disorder and neurovascular unit dysfunction with blood - brain barrier hyperpermeability: A critical analysis of human and experimental data.
  Najjar S, Pearlman D, Devinsky O, Najjar A, Zagzag D, 12th Annual Psychoimmunology Expert Meeting; Neurol Psychiatry Brain Res, Germany, 1/1/2014
• Circulating N-methyl-D-aspartate receptor antibodies in neurological and psychiatric illnesses.
  Steiner J, Ehrenreich H, Najjar S, The 4th Biennial Conference, Schizophr Res, Florence, Italy, 1/1/2014
• Prevalence of anti-N-methyl-D-aspartate receptor autoantibodies in primary psychiatric disorders: a systematic-review.
  Pearlman D, Rao V, Kyazimzade S, Ptak D, Ferrell R, Brown JR, Najjar S, 9th Congress of the International Neuropsychiatric Association, Chicago, IL, 1/25/2013
• Association between anti-basal ganglia antibodies and primary obsessive-compulsive disorder: a systematic review and meta-analysis.
  Pearlman D, Vora S, Marquis B, Najjar S, Dudley L, 9th Congress of the International Neuropsychiatric Association, Chicago, IL, 1/25/2013
• Evidence of increased neuroinflammation in human tuberous sclerosis complex; potential implications for neurosurgical dysfunction.
  Dilsiz, P; Ruppe, V; Weiner, H; Shoshkes, Reiss C; Najjar S; French, J; Devinsky, O; Talos, D M, Epilepsy Curr, 1/1/2013
• Brain biopsy findings link major depressive disorder to neuroinflammation, oxidative stress, and neurovascular dysfunction: a case report.
  Najjar S, Pearlman D, Hirsch S, Friedman K, Strange J, Reidy J, Khoukaz M, Ferrell R, Devinsky O, Najjar A, Zagzag D, 9th Congress of the International Neuropsychiatric Association, Chicago, IL, 1/1/2013
• Epidemiology of mental illnesses in India: a secondary analysis of the Global Burden of Disease 2010 study.
  Lakkaraja M, Pearlman D, Kaul A, Ghebleh S, Karwar A, Brown JR, Bhandar R, Najjar S, Ferrell R, 9th Congress of the International Neuropsychiatric Association, Chicago, IL, 1/1/2013
• Voltage gated potassium channel encephalitis associated with focal diffusion restriction in basal ganglia and delayed development of unilateral chorea.
  Brys M, Gazzola D, Werely J, Najjar S, Rebecca G, Movement Disorders Society Congress, Sydney, Australia, 1/1/2013
• False positive localization of language sites during electrical mapping near epileptic foci.
  Laban O, Barr W, Doyle W, Najjar S, Raghavan M, Epilepsia, 1/1/2013
• Imaging Inflammation in a patient with intractable epilepsy associated with antibodies to glutamic acid decarboxylase.
  Butler T, Maoz A, Vallabhajosula S, Ichise M, Pervez F, Wang H, Thomas T, Silbersweig D, Emily S, Friedman D, Najjar S, French J, Devinsky O, Kuzniecky R, Annual Meeting of the American Neurological Association and American Epilepsy Society, 1/1/2011
• Detection of epileptogenic cortical malformations with surface-based MRI morphometry.
  Thesen T, Quinn B, Devinsky O, Carlson C, Halgren E, DuBois J, McDonald C, Leventer R, French F, Wang X, Hagler D, Felsovalyi O, Najjar S, Dale A, Kuzniecky R, 16th annual meeting of the Organization for Human Brain Mapping, HBM, Spain, 1/1/2010
• Two cases of hypocarnitinaemia suggestive of late onset mitochondrial dysfunction.
  Azab B, Najjar S, Wetz R, American College of Physicians; National scientific meeting, 1/1/2009
• Neurocysticercosis presenting with acute eosinophilic meningitis.
  Andrade P, Wettimuny S, Najjar S, Annual Meeting of the American College of Physicians, 1/1/2009
• A Case of ring-enhancing meningioma with rare histology.
  Abotaga S, Dhar M, Dabahian G, Najjar S, American College of Physicians; National scientific meeting, 1/1/2009
• Two case Reports and literature review of patients with paraneoplastic myelitis related to diffuse large B-cell lymphoma and Hodgkin's lymphoma.
  Goldberg E, Srour S, Najjar S, Society of Hospital Medicine Annual Meeting, 1/1/2009
• Clinical features of patients with unilateral mesial temporal sclerosis (MTS) with persistent seizures following antero-mesial temporal resection.
  Yousef, TA; Pacia, SV; Barr, W; Cohen, E; Doyle, W; Devinsky, O; Luciano, D; Vazquez, B; Miles, D; Najjar, S; Kuzniecky, R, Epilepsia, 1/1/2004
• Epilepsy surgery in tuberous Sclerosis. Congress of Neurosurgical Surgeons.
  Weiner H, Doyle W, Romanelli P, Najjar S, Miles D, Devinsky O, University of Neurosurgery, Pediatrics, 1/1/2002
• Efficacy of Zonisamide in Primary generalized epilepsy.
  Najjar S, 24th International Epilepsy Congress, 1/1/2001
• Excellent outcome of surgical treatment for refractory epilepsy associated with extratemporal MRI identified disorders of cortical development.
  Bernadette, E; Doyle, W; Devinsky, O; Pacia, S; Vazquez, B; Luciano, D; Najjar, S; Mesad, S; et al, Epilepsia, 1/1/1999
• Phase II studies of the glycine antagonist GV150526 in acute stroke. The North American Experience.
  The North American Glycine Antagonist in Neuroprotection (GAIN) Investigators, 23rd American Heart Association International Joint Conference on Stroke and Cerebral Circulation, Orlando, FL, 1/1/1998
• Transneuronal Degeneration in the Human Inferior Olivary Nucleus; an Immunohistochemical Study.
  Barron K, Najjar S, Koeppen A, American Academy of Neurology, 1/1/1992
• Methanol Intoxication.
  Najjar S, Canadian Association of Neuropathology, 1/1/1991
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Lectures

• Clinical and Pathological Features of Autoimmune Encephalitis. 
  Manhasset, NY - 1/1/2014
• Neuropsychiatric Manifestations of Autoimmunity & Malignancy. 
  Manhasset, NY - 1/1/2014
• Circulating N-methyl-D-aspartate receptor antibodies in neurological and psychiatric illnesses. 
  Florence, Italy - 1/1/2014
• Major depressive disorder and neurovascular unit dysfunction with blood-brain barrier hyperpermeability: A critical analysis of human and experimental data. 
  Gunzburg, Germany - 1/1/2014
• Prevalence of anti-N-methyl-D-aspartate receptor autoantibodies in primary psychiatric disorders: a systematic-review. (CME Credited) 
  Chicago, IL - 1/25/2013
• Circulating NMDAR Antibodies in Patients with Neurological and Psychiatric Illness. 
  Durham, NC - 1/1/2013
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