StephenMarkMassaMDPhD

PubMed

• 12 citations
  Small molecule modulation of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an advanced pathological...
  Selena Gonzalez, Tyne L.M. McHugh, Tao Yang, Wassim Syriani, Stephen M. Massa, Frank M. Longo, Danielle A. Simmons> ;Neurobiology of Disease. 2022 Jan 1
• 15 citations
  Small molecule modulation of the p75 neurotrophin receptor inhibits multiple amyloid beta-induced tau pathologies
  Tao Yang, Kevin C. Tran, Anne Y. Zeng, Stephen M. Massa, Frank M. Longo> ;Scientific Reports. 2020 Nov 23
• 9 citations
  Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice
  Tao Yang, Harry Liu, Kevin C. Tran, Albert Leng, Stephen M. Massa, Frank M. Longo> ;Acta Neuropathologica Communications. 2020 Sep 5
• 2 citations
  Next-generation alzheimer’s therapeutics: leveraging deep biology
  Frank M. Longo, Stephen M. Massa> ;The Journal of Prevention of Alzheimer's Disease. 2020 Jan 1
• 47 citations
  Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease
  Elliott J. Mufson, Scott E. Counts, Stephen D. Ginsberg, Laura Mahady, Sylvia E. Perez, Stephen M. Massa, Frank M. Longo, Milos D. Ikonomovic> ;Frontiers in Neuroscience. 2019 Jul 1
• 24 citations
  Modulation of the p75 neurotrophin receptor suppresses age-related basal forebrain cholinergic neuron degeneration.
  Youmei Xie, Rick B. Meeker, Stephen M. Massa, Frank M. Longo> ;Scientific Reports. 2019 Mar 27
• 84 citations
  Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP
  Yiguo Shen, David Kapfhamer, Angela M. Minnella, Ji-Eun Kim, Seok Joon Won, Yanting Chen, Yong Huang, Ley-Hian Low, Stephen M. Massa, Raymond A. Swanson> ;Nature Communications. 2017 Sep 22
• 9 citations
  Neurotrophin Receptor Signaling as a Therapeutic Target for Huntington's Disease.
  Danielle A. Simmons, Frank M. Longo, Stephen M. Massa> ;CNS & Neurological Disorders Drug Targets. 2017 Mar 31
• 13 citations
  A data-driven approach for evaluating multi-modal therapy in traumatic brain injury.
  Jenny Haefeli, Adam R. Ferguson, Deborah Bingham, Adrienne Orr, Seok Joon Won, Tina I. Lam, Jian Shi, Sarah Hawley, Jialing Liu, Raymond A. Swanson, Stephen M. Massa> ;Scientific Reports. 2017 Feb 16
• 16 citations
  A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.
  Danielle A Simmons, Nadia P Belichenko, Ellen C Ford, Sarah Semaan, Marie Monbureau, Sruti Aiyaswamy, Cameron M Holman, Christina Condon, Mehrdad Shamloo, Stephen M Ma...> ;Human Molecular Genetics. 2016 Nov 15
• 32 citations
  The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking
  Emmanuel Darcq, Nadege Morisot, Khanhky Phamluong, Vincent Warnault, Jérôme Jeanblanc, Frank M. Longo, Stephen M. Massa, Dorit Ron> ;The Journal of Neuroscience. 2016 Sep 28
• A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.
  Simmons DA, Belichenko NP, Ford EC, Semaan S, Monbureau M, Aiyaswamy S, Holman CM, Condon C, Shamloo M, Massa SM, Longo FM> ;Hum. Mol. Genet.. 2016-09-16
• 28 citations
  A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth
  Tao Yang, Stephen M. Massa, Kevin C. Tran, Danielle A. Simmons, Jayakumar Rajadas, Anne Y. Zeng, Taichang Jang, Sara Carsanaro, Frank M. Longo> ;Neuropharmacology. 2016 Nov 1
• 60 citations
  The BDNF valine 68 to methionine polymorphism increases compulsive alcohol drinking in mice that is reversed by tropomyosin receptor kinase B activation
  Vincent Warnault, Emmanuel Darcq, Nadege Morisot, Khanhky Phamluong, Linda Wilbrecht, Stephen M. Massa, Frank M. Longo, Dorit Ron> ;Biological Psychiatry. 2016 Mar 15
• 21 citations
  Amelioration of Cisplatin-Induced Experimental Peripheral Neuropathy by a Small Molecule Targeting p75NTR
  Amy Friesland, Zhiying Weng, Maria Duenas, Stephen M. Massa, Frank M. Longo, Qun Lu> ;Neurotoxicology. 2014 Dec 1
• 54 citations
  A Small Molecule p75NTR Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression
  Danielle A. Simmons, Juliet K. Knowles, Nadia P. Belichenko, Gargi Banerjee, Carly Finkle, Stephen M. Massa, Frank M. Longo> ;Plos One. 2014 Aug 25
• 60 citations
  Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP...
  Thuy-Vi V. Nguyen, Lin Shen, Lilith Vander Griend, Lisa N. Quach, Nadia P. Belichenko, Nay Saw, Tao Yang, Mehrdad Shamloo, Tony Wyss-Coray, Stephen M. Massa, Frank M. ...> ;Journal of Alzheimer's Disease. 2014 Jan 1
• 102 citations
  A Small Molecule TrkB Ligand Reduces Motor Impairment and Neuropathology in R6/2 and BACHD Mouse Models of Huntington's Disease
  Danielle A. Simmons, Nadia P. Belichenko, Tao Yang, Christina Condon, Marie Monbureau, Mehrdad Shamloo, Deqiang Jing, Stephen M. Massa, Frank M. Longo> ;The Journal of Neuroscience. 2013 Nov 27
• 43 citations
  A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury.
  Jian Shi, Frank M. Longo, Stephen M. Massa> ;Stem Cells. 2013 Nov 1
• 80 citations
  A small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model
  Juliet K. Knowles, Danielle A. Simmons, Thuy-Vi V. Nguyen, Lilith Vander Griend, Youmei Xie, Hong Zhang, Tao Yang, Julia Pollak, Timothy Chang, Ottavio Arancio, Marion...> ;Neurobiology of Aging. 2013 Aug 1
• 197 citations
  Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.
  Frank M. Longo, Stephen M. Massa> ;Nature Reviews. Drug Discovery. 2013 Jul 1
• 37 citations
  Beneficial effects of minocycline and botulinum toxin-induced constraint physical therapy following experimental traumatic brain injury.
  Tina I. Lam, Deborah Bingham, Ting Ju Chang, Chih Cheng Lee, Jian Shi, Dongmin Wang, Stephen M. Massa, Raymond A. Swanson, Jialing Liu> ;Neurorehabilitation and Neural Repair. 2013 Jun 18
• 69 citations
  Oral Administration of a Small Molecule Targeted to Block proNGF Binding to p75 Promotes Myelin Sparing and Functional Recovery after Spinal Cord Injury
  Chhavy Tep, Tae Hee Lim, Pyung On Ko, Sami Getahun, Jae Cheon Ryu, Virginia M. Goettl, Stephen M. Massa, Michele Basso, Frank M. Longo, Sung Ok Yoon> ;The Journal of Neuroscience. 2013 Jan 9
• 51 citations
  Delayed Administration of a Small Molecule Tropomyosin-Related Kinase B Ligand Promotes Recovery After Hypoxic–Ischemic Stroke
  Jullet Han, Julia Pollak, Tao Yang, Mohammad R. Siddiqui, Kristian P. Doyle, Kereshmeh Taravosh-Lahn, Egle Cekanaviciute, Alex Han, Jeremy Z. Goodman, Britta E. Jones,...> ;Stroke. 2012 Jul 1
• 116 citations
  Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor
  Joana C. D’Avila, Tina I. Lam, Deborah Bingham, Jian Shi, Seok Joon Won, Tiina M. Kauppinen, Stephen M. Massa, Jialing Liu, Raymond A. Swanson> ;Journal of Neuroinflammation. 2012 Feb 15
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