StephenMichaelSimsMD

PubMed

• 13 citations
  Subcellular elevation of cytosolic free calcium is required for osteoclast migration.
  Benjamin D. Wheal, Ryan J. Beach, Natsuko Tanabe, S. Jeffrey Dixon, Stephen M. Sims> ;Journal of Bone and Mineral Research. 2014 Mar 1
• 65 citations
  Loss of P2X7 nucleotide receptor function leads to abnormal fat distribution in mice.
  Kim L. Beaucage, Andrew Xiao, Steven I. Pollmann, Matthew W. Grol, Ryan J. Beach, David W. Holdsworth, Stephen M. Sims, Mark R. Darling, S. Jeffrey Dixon> ;Purinergic Signalling. 2014 Jan 1
• 34 citations
  Effects of Isoform-Selective Phosphatidylinositol 3-Kinase Inhibitors on Osteoclasts: ACTIONS ON CYTOSKELETAL ORGANIZATION, SURVIVAL AND RESORPTION
  Ryan P.P. Shugg, Ashley Thomson, Natsuko Tanabe, Adam Kashishian, Bart H. Steiner, Kamal D. Puri, Alexey Pereverzev, Brian J. Lannutti, Frank R. Jirik, S. Jeffrey Dixo...> ;The Journal of Biological Chemistry. 2013 Dec 6
• 23 citations
  P2 receptor networks regulate signaling duration over a wide dynamic range of ATP concentrations.
  Matthew W. Grol, Alexey Pereverzev, Stephen M. Sims, S. Jeffrey Dixon> ;Journal of Cell Science. 2013 Aug 15
• 1 citations
  Receptor-independent effects of 2′(3′)-O-(4-benzoylbenzoyl)ATP triethylammonium salt on cytosolic pH
  J. P. Reyes, Matthew W. Grol, Stephen M. Sims, S. Jeffrey Dixon> ;Purinergic Signalling. 2013 May 22
• 37 citations
  Monocytes from patients with osteoarthritis display increased osteoclastogenesis and bone resorption: the In Vitro Osteoclast Differentiation in Arthritis study.
  Marianne Durand, Svetlana V. Komarova, Ajay Bhargava, Diana P. Trebec-Reynolds, Keying Li, Cara Fiorino, Osama Maria, Noushin Nabavi, Morris F. Manolson, Rene E. Harri...> ;Arthritis and Rheumatism. 2013 Jan 1
• 38 citations
  Lysophosphatidic acid: a potential mediator of osteoblast-osteoclast signaling in bone.
  Stephen M. Sims, Nattapon Panupinthu, Danielle M. Lapierre, Alexey Pereverzev, S. Jeffrey Dixon> ;Biochimica Et Biophysica Acta. 2013 Jan 1
• 26 citations
  Inhibition of Na/K-ATPase promotes myocardial tumor necrosis factor-alpha protein expression and cardiac dysfunction via calcium/mTOR signaling in endotoxemia
  Ting Zhang, Xiangru Lu, Jenny Li, Peter Chidiac, Stephen M. Sims, Qingping Feng> ;Basic Research in Cardiology. 2012 Feb 21
• 41 citations
  Osteopontin Signals through Calcium and Nuclear Factor of Activated T Cells (NFAT) in Osteoclasts: A Novel RGD-dependent Pathway Promoting Cell Survival
  Natsuko Tanabe, Benjamin D. Wheal, Jiyun Kwon, Hong H. Chen, Ryan P.P. Shugg, Stephen M. Sims, Harvey A. Goldberg, S. Jeffrey Dixon> ;The Journal of Biological Chemistry. 2011 Nov 18
• 22 citations
  Essential role for calcium waves in migration of human vascular smooth muscle cells.
  Ricardo Espinosa-Tanguma, Caroline O′Neil, Tom Chrones, J. Geoffrey Pickering, Stephen M. Sims> ;American Journal of Physiology. Heart and Circulatory Physiology. 2011 Aug 1
• 23 citations
  P2 receptor expression, signaling and function in osteoclasts.
  Reyes Jp, Sims Sm, Dixon Sj> ;Frontiers in Bioscience. 2011 Jun 1
• 28 citations
  The increased in vitro osteoclastogenesis in patients with rheumatoid arthritis is due to increased percentage of precursors and decreased apoptosis - the In Vitro Ost...
  M. Durand, Gilles Boire, Svetlana V. Komarova, S. J. Dixon, Stephen M. Sims, Rene E. Harrison, Noushin Nabavi, Osama Muhammad Maria, Morris F. Manolson, Marcin J. Mizi...> ;Bone. 2011 Mar 1
• 39 citations
  Lysophosphatidic Acid Signals through Multiple Receptors in Osteoclasts to Elevate Cytosolic Calcium Concentration, Evoke Retraction, and Promote Cell Survival
  Danielle M. Lapierre, Natsuko Tanabe, Alexey Pereverzev, Martha Spencer, Ryan P.P. Shugg, S. Jeffrey Dixon, Stephen M. Sims> ;The Journal of Biological Chemistry. 2010 Aug 13
• 5 citations
  The 1.3 isoform of Na+–Ca2+ exchanger expressed in guinea pig tracheal smooth muscle is less sensitive to KB-R7943
  Paola Algara-Suárez, Rebeca Mejía-Elizondo, Stephen M. Sims, Victor M. Saavedra-Alanis, Ricardo Espinosa-Tanguma> ;Journal of Physiology and Biochemistry. 2010 Apr 29
• 36 citations
  Murine osteoclasts and spleen cell polykaryons are distinguished by mRNA phenotyping
  Hong-Sheng Tong, Dennis D. Sakai, Stephen M. Sims, Jeffrey Dixon, Moshe Yamin, Steven R. Goldring, Malcolm L. Snead, Cedric Minkin> ;Journal of Bone and Mineral Research. 2009 Dec 3
• 9 citations
  Platelet‐activating factor induces pseudopod formation in calcitonin‐treated rabbit osteoclasts
  Michel R. Gravel, Zhu Gang Zheng, Stephen M. Sims, S. Jeffrey Dixon> ;Journal of Bone and Mineral Research. 2009 Dec 3
• 83 citations
  Expression, signaling, and function of P2X7 receptors in bone
  Matthew W. Grol, Nattapon Panupinthu, Jasminka Korcok, Stephen M. Sims, S. Jeffrey Dixon> ;Purinergic Signalling. 2009 Feb 18
• 50 citations
  Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts
  Souzan Armstrong, Alexey Pereverzev, S. Jeffrey Dixon, Stephen M. Sims> ;Journal of Cell Science. 2009 Jan 1
• 21 citations
  Calcium Sensitization in Human Esophageal Muscle: Role for RhoA Kinase in Maintenance of Lower Esophageal Sphincter Tone
  Stephen M. Sims, Tom Chrones, Harold G. Preiksaitis> ;The Journal of Pharmacology and Experimental Therapeutics. 2008 Oct 1
• 46 citations
  Osteoclast activation in inflammatory periodontal diseases
  SH Wiebe, M Hafezi, HS Sandhu, Stephen M. Sims, S J Dixon> ;Oral Diseases. 2008 Jun 28
• 146 citations
  P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis
  Nattapon Panupinthu, Joseph T. Rogers, Lin Zhao, Luis Pastor Solano-Flores, Fred Possmayer, Stephen M. Sims, S. Jeffrey Dixon> ;The Journal of Cell Biology. 2008 Jun 2
• 72 citations
  Extracellular acidification enhances osteoclast survival through an NFAT-independent, protein kinase C-dependent pathway.
  Alexey Pereverzev, Svetlana V. Komarova, Jasminka Korcok, Souzan Armstrong, Gilles B. Tremblay, S. Jeffrey Dixon, Stephen M. Sims> ;Bone. 2008 Jan 1
• 10 citations
  Temporal and spatial dynamics underlying capacitative calcium entry in human colonic smooth muscle.
  Jason R. Kovac, Tom Chrones, Stephen M. Sims> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2008 Jan 1
• 21 citations
  Calcium sparks activate calcium-dependent Cl- current in rat corpus cavernosum smooth muscle cells.
  Beatrice A. Williams, Stephen M. Sims> ;American Journal of Physiology. Cell Physiology. 2007 Oct 1
• 36 citations
  Effects of Vitaxin, a novel therapeutic in trial for metastatic bone tumors, on osteoclast functions in vitro.
  Azza Gramoun, Seema Shorey, Jill D. Bashutski, S. Jeffrey Dixon, Stephen M. Sims, Johan N. M. Heersche, Morris F. Manolson> ;Journal of Cellular Biochemistry. 2007 Oct 1
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