StevenH.OlsonMD

PubMed

• 16 citations
  Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy.
  Amanda L. Woerman, Smita S. Patel, Sabeen A. Kazmi, Abby Oehler, Jisoo Lee, Daniel A. Mordes, Steven H. Olson, Stanley B. Prusiner> ;Plos Pathogens. 2020 Feb 4
• 5 citations
  Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity
  Jean-Marc M Grandjean, Alexander Y Jiu, John W West, Atsushi Aoyagi, Daniel G Droege, Manuel Elepano, Makoto Hirasawa, Masakazu Hirouchi, Ryo Murakami, Joanne Lee, Sas...> ;ACS Medicinal Chemistry Letters. 2020 Jan 30
• 54 citations
  Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines.
  Amanda L. Woerman, Abby Oehler, Sabeen A. Kazmi, Jisoo Lee, Glenda M. Halliday, Lefkos T. Middleton, Steve M. Gentleman, Daniel A. Mordes, Salvatore Spina, Lea T. Grin...> ;Acta Neuropathologica. 2019 Jan 28
• 27 citations
  Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome
  Aliesha Griffin, Priyadarshini Jaishankar, Jean-Marc M Grandjean, Steven H. Olson, Adam R. Renslo, Scott C. Baraban> ;Brain Communications. 2019 Jan 1
• 24 citations
  Photoredox Cyanomethylation of Indoles: Catalyst Modification and Mechanism
  Connor J O'Brien, Daniel G Droege, Alexander Y Jiu, Shivaani S Gandhi, Nick A. Paras, Steven H. Olson, Jay Conrad> ;The Journal of Organic Chemistry. 2018 Jun 25
• 30 citations
  Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.
  Amanda L. Woerman, Sabeen A. Kazmi, Smita S. Patel, Atsushi Aoyagi, Abby Oehler, Kartika Widjaja, Daniel A. Mordes, Steven H. Olson, Stanley B. Prusiner> ;Proceedings of the National Academy of Sciences of the United States of America. 2018 Jan 9
• 65 citations
  MSA prions exhibit remarkable stability and resistance to inactivation.
  Amanda L. Woerman, Sabeen A. Kazmi, Smita Patel, Yevgeniy Freyman, Abby Oehler, Atsushi Aoyagi, Daniel A. Mordes, Glenda M. Halliday, Lefkos T. Middleton, Steve M. Gen...> ;Acta Neuropathologica. 2018 Jan 1
• 25 citations
  Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines.
  Amanda L. Woerman, Smita S. Patel, Sabeen A. Kazmi, Abby Oehler, Yevgeniy Freyman, Lloyd Espiritu, Robert Cotter, Julian A. Castaneda, Steven H. Olson, Stanley B. Prus...> ;JAMA Neurology. 2017 Dec 1
• 14 citations
  Interactions between Microtubule-Associated Protein Tau (MAPT) and Small Molecules
  Jennifer N. Rauch, Steven H. Olson, Jason E. Gestwicki> ;Cold Spring Harbor Perspectives in Medicine. 2017 Jul 1
• 40 citations
  Developing Therapeutics for PrP Prion Diseases
  Kurt Giles, Steven H. Olson, Stanley B. Prusiner> ;Cold Spring Harbor Perspectives in Medicine. 2017 Apr 1
• 117 citations
  Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate in cultured cells
  Amanda L. Woerman, Atsushi Aoyagi, Smita S. Patel, Sabeen A. Kazmi, Iryna Lobach, Lea T. Grinberg, Ann C. McKee, William W. Seeley, Steven H. Olson, Stanley B. Prusiner> ;Proceedings of the National Academy of Sciences of the United States of America. 2016 Dec 13
• 24 citations
  Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice
  Kurt Giles, David B. Berry, Carlo Condello, Brittany N. Dugger, Zhe Li, Abby Oehler, Sumita Bhardwaj, Manuel Elepano, Shenheng Guan, B. Michael Silber, Steven H. Olson...> ;The Journal of Pharmacology and Experimental Therapeutics. 2016 Sep 1
• 9 citations
  Pharmacokinetics and metabolism of AMG 232, a novel orally bioavailable inhibitor of the MDM2-p53 interaction, in rats, dogs and monkeys: in vitro-in vivo correlation.
  Qiuping Ye, Min Jiang, Wotang T Huang, Yun Ling, Steven H. Olson, Daqing Sun, Guifen Xu, Xuelei Yan, Bradley K. Wong, Lixia Jin> ;Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 2015 Jul 15
• 34 citations
  A Selective Prostaglandin E2 Receptor Subtype 2 (EP2) Antagonist Increases the Macrophage-Mediated Clearance of Amyloid-Beta Plaques
  Brian M. Fox, Hilary Plake Beck, Philip Roveto, Frank Kayser, Qingwen Cheng, Hannah Dou, Toni Williamson, James J. S. Treanor, Hantao Liu, Lixia Jin, Guifen Xu, Ji Ma,...> ;Journal of Medicinal Chemistry. 2015 Jun 24
• 92 citations
  The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents
  Jude Canon, Tao Osgood, Steven H. Olson, Anne Y. Saiki, Rebecca Robertson, Dongyin Yu, John Eksterowicz, Qiuping Ye, Lixia Jin, Ada Chen, Jing Zhou, David Cordover, St...> ;Molecular Cancer Therapeutics. 2015 Mar 1
• 28 citations
  Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction.
  Yosup Rew, Daqing Sun, Xuelei Yan, Hilary Plake Beck, Jude Canon, Ada Chen, Jason Duquette, John Eksterowicz, Brian M. Fox, Jiasheng Fu, Ana Z. Gonzalez, Jonathan B. H...> ;Journal of Medicinal Chemistry. 2014 Dec 4
• 9 citations
  Optimization beyond AMG 232: discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction.
  Yingcai Wang, Jiang Zhu, Jiwen Jim Liu, Xiaoqi Chen, Jeffrey T. Mihalic, Jeffrey Deignan, Ming Yu, Daqing Sun, Frank Kayser, Lawrence R. McGee, Mei-Chu Lo, Ada Chen, J...> ;Bioorganic & Medicinal Chemistry Letters. 2014 Aug 15
• 15 citations
  Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction.
  Ming Yu, Yingcai Wang, Jiang Zhu, Michael D. Bartberger, Jude Canon, Ada Chen, David Chow, John Eksterowicz, Brian M. Fox, Jiasheng Fu, Michael W. Gribble, Xin Huang, ...> ;ACS Medicinal Chemistry Letters. 2014 Jul 9
• 27 citations
  Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres.
  Ana Z. Gonzalez, Zhihong Li, Hilary Plake Beck, Jude Canon, Ada Chen, David Chow, Jason Duquette, John Eksterowicz, Brian M. Fox, Jiasheng Fu, Xin Huang, Jonathan B. H...> ;Journal of Medicinal Chemistry. 2014 Mar 27
• 46 citations
  Selective and Potent Morpholinone Inhibitors of the MDM2-p53 Protein-Protein Interaction.
  Ana Z. Gonzalez, John Eksterowicz, Michael D. Bartberger, Hilary Plake Beck, Jude Canon, Ada Chen, David Chow, Jason Duquette, Brian M. Fox, Jiasheng Fu, Xin Huang, Jo...> ;Journal of Medicinal Chemistry. 2014 Mar 4
• 176 citations
  Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.
  Daqing Sun, Zhihong Li, Yosup Rew, Michael W. Gribble, Michael D. Bartberger, Hilary Plake Beck, Jude Canon, Ada Chen, Xiaoqi Chen, David Chow, Jeffrey Deignan, Jason ...> ;Journal of Medicinal Chemistry. 2014 Feb 5
• 55 citations
  Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors.
  Felix Gonzalez-Lopez de Turiso, Daqing Sun, Yosup Rew, Michael D. Bartberger, Hilary Plake Beck, Jude Canon, Ada Chen, David Chow, Tiffany L. Correll, Xin Huang, Lisa ...> ;Journal of Medicinal Chemistry. 2013 May 6
• 26 citations
  An expeditious synthesis of the MDM2-p53 inhibitor AM-8553.
  Brian Lucas, Benjamin Fisher, Lawrence R. McGee, Steven H. Olson, Julio C. Medina, Eugene Cheung> ;Journal of the American Chemical Society. 2012 Jul 16
• 115 citations
  Structure-based design of novel inhibitors of the MDM2-p53 interaction
  Yosup Rew, Daqing Sun, Felix Gonzalez-Lopez de Turiso, Michael D. Bartberger, Hilary Plake Beck, Jude Canon, Ada Chen, David Chow, Jeffrey Deignan, Brian M. Fox, Darin...> ;Journal of Medicinal Chemistry. 2012 May 9
• 20 citations
  Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors.
  Hilary Plake Beck, Michael DeGraffenreid, Brian M. Fox, John G. Allen, Yosup Rew, Stephen Schneider, Anne Y. Saiki, Dongyin Yu, Jonathan D. Oliner, Kevin Salyers, Qiup...> ;Bioorganic & Medicinal Chemistry Letters. 2011 May 1
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