StevenJonRussellMDPhD

Endocrinology • Boston, MA

Diabetes, Lipid Metabolism

Associate Professor, Medicine - Massachusetts General Hospital, Harvard Medical School

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Office
MGH Diabetes Research Center
50 Staniford Street, Suite 340
Boston, MA 02114
Phone+1 617-726-1848

Fax+1 617-643-0697
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Education & Training

Massachusetts General HospitalFellowship, Endocrinology, Diabetes, and Metabolism, 2003 - 2006
Massachusetts General HospitalResidency, Internal Medicine, 2001 - 2003
University of Texas Southwestern Medical SchoolClass of 2001
Trinity UniversityB.S., Biochemistry, 1990

Certifications & Licensure

MA State Medical License 2004 - 2025

Awards, Honors, & Recognition

Membership Alpha Omega Alpha, 2000
Membership Sigma Xi, 1997
President’s/Trustee Scholarship Trinity University, 1986

Clinical Trials

Continuous Glucose Monitoring With a Subcutaneous Sensor During Critical Illness and Surgery Start of enrollment: 2008 Jun 01
Completed
Not Applicable
Closed-loop Glucose Control for Automated Management of Type 1 Diabetes Start of enrollment: 2008 May 01
Completed
Not Applicable
Integration of Continuous Glucose Monitoring Into a BiHormonal Closed-Loop Artificial Pancreas Start of enrollment: 2010 Jul 01
Completed
Not Applicable
Pharmacokinetic Comparison of Intradermal Versus Sub-cutaneous Insulin and Glucagon Delivery in Type 1 Diabetes Start of enrollment: 2012 Aug 01
Unknown status
Phase 2
Outpatient Automated Blood Glucose Control With a Bi-hormonal Bionic Endocrine Pancreas Start of enrollment: 2013 Jan 01
Completed
Not Applicable
Inpatient Closed-loop Glucose Control Start of enrollment: 2013 Mar 01
Completed
Not Applicable
The Summer Camp Study: Blood Glucose Control With a Bi-Hormonal Bionic Endocrine Pancreas Start of enrollment: 2013 Apr 01
Completed
Not Applicable
Equivalence of A Stable Liquid Glucagon Formulation With Freshly Reconstituted Lyophilized Glucagon Start of enrollment: 2014 Apr 01
Completed
Phase 2, Phase 3
A Multicenter Study of Outpatient Automated Blood Glucose Control With a Bihormonal Bionic Pancreas Start of enrollment: 2014 Apr 01
Completed
Not Applicable
The Summer Camp Study 2: Blood Glucose Control With a Bi-Hormonal Endocrine Pancreas Start of enrollment: 2014 Jun 01
Completed
Not Applicable
Closed-Loop Glucagon Administration For Hypoglycemia Treatment Start of enrollment: 2014 Nov 01
Completed
Not Applicable
The iLet Introduction Study: A Feasibility Study of the iLet, a Fully Integrated Bihormonal Bionic Pancreas Start of enrollment: 2016 Mar 01
Terminated
Not Applicable
The Monitoring Study Start of enrollment: 2017 Apr 01
Completed
Not Applicable
Feasibility Trial Testing the Bionic Pancreas With ZP4207 Start of enrollment: 2016 Nov 01
Completed
Phase 2
Feasibility of Outpatient Closed Loop Control With the iLet Bionic Pancreas in Cystic Fibrosis Related Diabetes Start of enrollment: 2021 Aug 26
Completed
Not Applicable
Individualizing Automated Closed Loop Glucose Control Through Pharmacokinetic Profiling in an Insulin-Only Bionic Pancreas Start of enrollment: 2019 Mar 19
Terminated
Phase 2, Phase 3
The Set-Point Study for Type 2 Diabetes: Evaluating the Use of an Insulin Only Bionic Pancreas System in Type 2 Diabetes Start of enrollment: 2017 Jul 28
Completed
Not Applicable
The Bihormonal iLet Bionic Pancreas Feasibility Study Start of enrollment: 2019 May 15
Completed
Phase 2, Phase 3
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Publications & Presentations

PubMed

Testing the Real-World Accuracy of the Dexcom G6 Pro CGM During the Insulin-Only Bionic Pancreas Pivotal Trial.
Martin Chase Marak, Peter Calhoun, Edward R Damiano, Steven J Russell, Katrina J Ruedy, Roy W Beck> ;Diabetes Technology & Therapeutics. 2023 Nov 1
1 citations
Psychosocial Impact of the Insulin-Only iLet Bionic Pancreas for Adults, Youth, and Caregivers of Youth with Type 1 Diabetes.
Jill Weissberg-Benchell, Anthony T Vesco, Jenna Shapiro, Peter Calhoun, Edward R Damiano, Steven J Russell, Zoey Li, Firas H El-Khatib, Katrina J Ruedy, Courtney A Bal...> ;Diabetes Technology & Therapeutics. 2023 Oct 1
Utility and Safety of Backup Insulin Regimens Generated by the Bionic Pancreas: A Randomized Study.
Nelly Mauras, Edward R Damiano, Firas H El-Khatib, Martin Chase Marak, Peter Calhoun, Katrina J Ruedy, Courtney Balliro, Zoey Li, Roy W Beck, Steven J Russell> ;Diabetes Technology & Therapeutics. 2023 Jun 1
3 citations
The Bihormonal Bionic Pancreas Improves Glycemic Control in Individuals With Hyperinsulinism and Postpancreatectomy Diabetes: A Pilot Study.
Arpana Rayannavar, Lauren Mitteer, Courtney A. Balliro, El-Khatib Firas H, Katherine Lord, Colin P. Hawkes, Lance Ballester, Edward R. Damiano, Steven Russell, Diva D....> ;Diabetes Care. 2021 Sep 13
7 citations
The Evolution of Sox Gene Repertoires and Regulation of Segmentation in Arachnids.
Luis Baudouin-Gonzalez, Anna Schoenauer, Amber Harper, Grace Blakeley, Michael Seiter, Saad Arif, Lauren Sumner-Rooney, Steven Russell, Prashant P. Sharma, Alistair P....> ;Molecular Biology and Evolution. 2021 Jul 29
4 citations
Improvements in Glycemic Control Achieved by Altering the tmax Setting in the iLet® Bionic Pancreas When Using Fast-Acting Insulin Aspart: A Randomized Trial.
Steven Russell, Courtney A. Balliro, Magnus Ekelund, El-Khatib Firas H, Tina Graungaard, Evelyn Greaux, Mallory A. Hillard, Rabab Z. Jafri, Naveen Rathor, Raj Selagams...> ;Diabetes Therapy. 2021 Jun 19
27 citations
Performance of the Insulin-Only iLet Bionic Pancreas and the Bihormonal iLet Using Dasiglucagon in Adults With Type 1 Diabetes in a Home-Use Setting.
Luz E. Castellanos, Courtney A. Balliro, Jordan Sherwood, Rabab Z. Jafri, Mallory A. Hillard, Evelyn Greaux, Rajendranath Selagamsetty, Hui Zheng, El-Khatib Firas H, E...> ;Diabetes Care. 2021 Apr 27
27 citations
A Three-Way Accuracy Comparison of the Dexcom G5, Abbott Freestyle Libre Pro, and Senseonics Eversense Continuous Glucose Monitoring Devices in a Home-Use Study of Sub...
Rabab Z. Jafri, Courtney A. Balliro, El-Khatib Firas H, Michele Maheno, Mallory A. Hillard, Alexander J. O'donovan, Rajendranath Selagamsetty, Hui Zheng, Edward R. Dam...> ;Diabetes Technology & Therapeutics. 2020 Nov 9
17 citations
New and Emerging Technologies in Type 1 Diabetes
Jordan Sherwood, Steven Russell, Melissa S. Putman> ;Endocrinology and Metabolism Clinics of North America. 2020 Oct 14
2 citations
Characterisation of protein isoforms encoded by the Drosophila Glycogen Synthase Kinase 3 gene shaggy.
Dagmara Korona, Daniel J.H. Nightingale, Bertrand Fabre, Michael G. Nelson, Bettina Fischer, Glynnis Johnson, Jonathan G. Lees, Simon J. Hubbard, Kathryn S. Lilley, St...> ;Plos One. 2020 Aug 6
13 citations
Automated glycemic control with the bionic pancreas in cystic fibrosis-related diabetes: A pilot study.
Jordan Sherwood, Rabab Z. Jafri, Courtney A. Balliro, Hui Zheng, El-Khatib Firas H, Edward R. Damiano, Steven Russell, Melissa S. Putman> ;Journal of Cystic Fibrosis. 2020 Jan 1
14 citations
High-resolution transcriptional profiling of Anopheles gambiae spermatogenesis reveals mechanisms of sex chromosome regulation.
Chrysanthi Taxiarchi, Nace Kranjc, Antonios Kriezis, Kyros Kyrou, Federica Bernardini, Steven Russell, Tony Nolan, Andrea Crisanti, Roberto Galizi> ;Scientific Reports. 2019 Oct 16
7 citations
Task-related fMRI BOLD response to hyperinsulinemia in healthy older adults.
Victoria J. Williams, Bianca A. Trombetta, Rabab Z. Jafri, Aaron M. Koenig, Chase D Wennick, Becky C. Carlyle, Laya Ekhlaspour, Rexford S. Ahima, Steven Russell, David...> ;JCI Insight. 2019 Jul 25
4 citations
Comparison of Drosophila melanogaster Embryo and Adult Proteome by SWATH-MS Reveals Differential Regulation of Protein Synthesis, Degradation Machinery, and Metabolism...
Bertrand Fabre, Dagmara Korona, Jonathan G. Lees, Ikrame Lazar, Ido Livneh, Manon Brunet, Christine A. Orengo, Steven Russell, Kathryn S. Lilley> ;Journal of Proteome Research. 2019 Jun 7
32 citations
Chromatin accessibility plays a key role in selective targeting of Hox proteins.
Damiano Porcelli, Bettina Fischer, Steven Russell, Robert J. White> ;Genome Biology. 2019 Jun 3
15 citations
Men’s Refashioning of Masculine Identities in Uganda and Their Self-Management of HIV Treatment:
Steven Russell> ;Qualitative Health Research. 2019 Feb 14
11 citations
Duplication and expression of Sox genes in spiders
Christian L. B. Paese, Daniel J. Leite, Anna Schönauer, Alistair P. McGregor, Steven Russell> ;BMC Evolutionary Biology. 2018 Dec 27
18 citations
Triamcinolone acetonide extended-release in patients with osteoarthritis and type 2 diabetes: a randomized, phase 2 study.
Steven Russell, Robert Sala, Philip G. Conaghan, George Habib, Quang Vo, Rickey Manning, Alan Kivitz, Yvonne Davis, Joelle Lufkin, J.R. Johnson, Scott Kelley, Neil Bodick> ;Rheumatology. 2018 Dec 1
12 citations
Self-measurement of Blood Glucose and Continuous Glucose Monitoring - Is There Only One Future?
Lutz Heinemann, Andreas Stuhr, Adam Brown, Guido Freckmann, Marc D. Breton, Steven Russell> ;European Endocrinology. 2018 Sep 10
15 citations
A SoxB gene acts as an anterior gap gene and regulates posterior segment addition in a spider
Christian L. B. Paese, Anna Schoenauer, Daniel J. Leite, Steven Russell, Alistair P. McGregor> ;Elife. 2018 Aug 21
9 citations
The role of children in their HIV-positive parents' management of antiretroviral therapy in Uganda.
Ruth Nalugya, Steven Russell, Flavia Zalwango, Janet Seeley> ;African Journal of AIDS Research. 2018 Mar 4
6 citations
Dosage-Dependent Expression Variation Suppressed on the Drosophila Male X Chromosome.
Hangnoh Lee, Dong-Yeon Cho, Damian Wojtowicz, Susan T. Harbison, Steven Russell, Brian Oliver, Teresa M. Przytycka> ;G3. 2018 Feb 1
11 citations
Engineering the Drosophila Genome for Developmental Biology
Dagmara Korona, Stefan A. Koestler, Steven Russell> ;Journal of Developmental Biology. 2017 Dec 11
9 citations
Role of co-repressor genomic landscapes in shaping the Notch response.
Stephen Kk Chan, Gustavo Cerda-Moya, Robert Stojnic, Kat Millen, Bettina Fischer, Silvie Fexova, Lenka Skalska, Maria J. Gomez-Lamarca, Zoe Pillidge, Steven Russell, S...> ;Plos Genetics. 2017 Nov 20
11 citations
Impact of an Automated Bihormonal Delivery System on Psychosocial Outcomes in Adults with Type 1 Diabetes.
Jill Weissberg-Benchell, Danielle Hessler, Lawrence Fisher, Steven Russell, William H. Polonsky> ;Diabetes Technology & Therapeutics. 2017 Dec 1
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Journal Articles

The Future of Care for Type 1 Diabetes
Nathan DM, Russell SJ, Canadian Medical Association Journal, 1/1/2013
Impaired Thermogenesis and Adipose Development in Mice with Fat-Specific Disruption of Insulin and IGF-1 Signaling
Boucher J, Mori MA, Lee K, Liew CW, Macotela Y, Smyth G, Rourk M, Russell SJ, Bluher M, Kahn CR, Nature Communications, 1/1/2012
Role of microRNA Processing in Adipose Tissue in Stress Defense and Longevity
Mori MA, Raghavan P, Thomou T, Boucher J, Robida-Stubbs S, Macotela Y, Russell SJ, Kirkland JL, Blackwell TK, Kahn CR, Cell Metabolism, 1/1/2012
Obtaining surrogate consent for a minimal-risk research study in the ICU setting
Larkin ME, Beauharnais CC,Magyar K, Macey L, Grennan K, Boykin E, Russell SJ, Clinical Trials, 1/1/2012
A Bi-Hormonal Closed-Loop Blood Glucose Control Device for Type 1 Diabetes
El-Khatib FH*, Russell SJ*#, Nathan DM, Sutherlin RG, Damiano ER (*Co-first authors; #, Corresponding author), Science Translational Medicine, 1/1/2010
Efficacy Determinants of Subcutaneous Micro-Dose Glucagon during Closed-Loop Control
Russell SJ, El-Khatib FH, Nathan DM, Damiano ER, Journal of Diabetes Science and Technology, 1/1/2010
Continuous Glucose Monitoring Awaits Its "Killer App”
Russell SJ, Journal of Diabetes Science and Technology, 1/1/2008
Essential Role of Insulin and IGF-1 Receptor Signaling in Cardiac Development and Function
Laustsen PG, Russell SJ, Cui L, Entingh-Pearsall A, Holzenberger M, Liao R, Kahn CR, Molecular and Cellular Biology, 1/1/2007
Mitochondrial Gene Expression and Increased Oxidative Metabolism: Role in Increased Lifespan of Fat-Specific Insulin Receptor Knockout Mice
Katic M, Kennedy AR, Leykin I, Norris A, McGettrick A, Gesta S, Russell SJ, Bluher M, Maratos-Flier E, Kahn CR, Aging Cell, 1/1/2007
Endocrine Regulation of Aging
Russell SJ, Kahn CR, Nature Reviews Molecular Cell Biology, 1/1/2007
Evidence that Proteolysis of Gal4 Can Not Explain the Transcriptional Effects of Proteasome ATPase Mutations
Russell SJ, Johnston SA, Journal of Biological Chemistry, 1/1/2001
Selective Chemical Inactivation of AAA Proteins Reveals Distinct Functions of Proteasomal ATPases
Russell SJ, Gonzalez F, Joshua-Tor L, Johnston SA, Chemistry & Biology, 1/1/2001
The 19S Complex of the Proteasome Regulates Nucleotide Excision Repair in Yeast
Gillete TG, Huang W, Russell SJ, Reed SH, Johnston SA, Friedberg EC, Genes and Development, 1/1/2001
Sub-cellular Localization, Stoichiometry, and Protein Levels of 26S Proteasome Subunits in Yeast
Russell SJ, Steger KA, Johnston SA, Journal of Biological Chemistry, 1/1/1999
The 19S Regulatory Complex of the Proteasome Functions Independently of Proteolysis in Nucleotide Excision Repair
Russell SJ, Reed SH, Huang W, Friedberg EC, Johnston SA, Molecular Cell, 1/1/1999
Isolation and Characterization of SUG2: A Novel ATPase Family Component of the Yeast 26S Proteasome
Russell SJ, Sathyanarayana UG, Johnston SA, Journal of Biological Chemistry, 1/1/1996
The Synthesis and X-ray Crystallographic Analysis of a Stable Norbornadienone: 17-oxo-7,16-methano-7,16-diphenylcyclopenta[d,e] tribenzo[a,h,j]antharacene
Plummer BF, Currey JA, Russell SJ, Steffen LK, Watson WH, Bourne SA, Structural Chemistry, 1/1/1995
Sterically Congested Polycyclic Aromatic Hydrocarbons with Nonoptimal Geometries 4,5-Didehydroacenapthene as a Precursor for the Synthesis of 7,14 Diphenyl-8,9-(1’,8’...
Plummer BF, Russell SJ, Reese WG, Watson WH, Krawiec M, Journal of Organic Chemistry, 1/1/1991
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Lectures

Triamcinolone Acetonide Extended-Release in Patients with Osteoarthritis and Type 2 Diabetes: A Randomized, Phase 2 Study
Boston, MA - 6/15/2014

Press Mentions

Bionic Pancreas Bests Standard Care for Glycemic Control in T1DMSeptember 30th, 2022
Results of the Insulin-Only Bionic Pancreas Pivotal Trial, Which Were Presented at ADA's 82nd Scientific Sessions, Are Published This Week in the New England Journal of MedicineSeptember 30th, 2022
The iLet® Bionic Pancreas Significantly Reduced HbA1c and Improved Time in Range vs Standard of Care for a Diverse Range of People with Type 1 DiabetesApril 30th, 2022
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