StevenOSmithMD

PubMed

• The S505A thrombopoietin receptor mutation in childhood hereditary thrombocytosis and essential thrombocythemia is S505N: single letter amino acid code matters.
  Defour, J. P.,Levy, G.,Leroy, E.,Smith, S. O.,Constantinescu, S. N.> ;Leukemia. 2019 Jan 13
• A Novel Transgenic Rat Model of Robust Cerebral Microvascular Amyloid with Prominent Vasculopathy.
  Davis, J.,Xu, F.,Hatfield, J.,Lee, H.,Hoos, M. D.,Popescu, D.,Crooks, E.,Kim, R.,Smith, S. O.,Robinson, J. K.,Benveniste, H.,Van Nostrand, W. E.> ;Am. J. Pathol.. 2018 Nov 18
• β-Sheet Structure within the Extracellular Domain of C99 Regulates Amyloidogenic Processing.
  Hu, Y.,Kienlen-Campard, P.,Tang, T. C.,Perrin, F.,Opsomer, R.,Decock, M.,Pan, X.,Octave, J. N.,Constantinescu, S. N.,Smith, S. O.> ;Sci Rep. 2017 Dec 08
• His499 Regulates Dimerization and Prevents Oncogenic Activation by Asparagine Mutations of the Human Thrombopoietin Receptor.
  Leroy, E.,Defour, J. P.,Sato, T.,Dass, S.,Gryshkova, V.,Shwe, M. M.,Staerk, J.,Constantinescu, S. N.,Smith, S. O.> ;J. Biol. Chem.. 2015 Dec 03
• Uncovering the triggers for GPCR activation using solid-state NMR spectroscopy.
  Kimata, N.,Reeves, P. J.,Smith, S. O.> ;J. Magn. Reson.. 2015 Mar 24
• Capping of aβ42 oligomers by small molecule inhibitors.
  Fu, Z.,Aucoin, D.,Ahmed, M.,Ziliox, M.,Van Nostrand, W. E.,Smith, S. O.> ;Biochemistry. 2014 Nov 26
• Conformational Changes Induced by the A21G Flemish Mutation in the Amyloid Precursor Protein Lead to Increased Aβ Production.
  Tang, T. C.,Hu, Y.,Kienlen-Campard, P.,El Haylani, L.,Decock, M.,Van Hees, J.,Fu, Z.,Octave, J. N.,Constantinescu, S. N.,Smith, S. O.> ;Structure. 2014 Jan 28
• Amino acid conservation and interactions in rhodopsin: Probing receptor activation by NMR spectroscopy.
  Pope, A.,Eilers, M.,Reeves, P. J.,Smith, S. O.> ;Biochim. Biophys. Acta. 2013 Nov 05
• A Highly Redundant Gene Network Controls Assembly of the Outer Spore Wall in S. cerevisiae.
  Lin, C. P.,Kim, C.,Smith, S. O.,Neiman, A. M.> ;PLoS Genet.. 2013 Aug
• Fine Mapping of the Amyloid ?-Protein Binding Site on Myelin Basic Protein.
  Kotarba, A. E.,Aucoin, D.,Hoos, M. D.,Smith, S. O.,Van Nostrand, W. E.> ;Biochemistry. 2013 Apr 16
• Magic angle spinning nuclear magnetic resonance spectroscopy of g protein-coupled receptors.
  Goncalves, J.,Eilers, M.,South, K.,Opefi, C. A.,Laissue, P.,Reeves, P. J.,Smith, S. O.> ;Meth Enzymol. 2013
• Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation.
  Defour, J. P.,Itaya, M.,Gryshkova, V.,Brett, I. C.,Pecquet, C.,Sato, T.,Smith, S. O.,Constantinescu, S. N.> ;Proc Natl Acad Sci USA. 2013 Feb 12
• Insights into the activation mechanism of the visual receptor rhodopsin.
  Smith, S. O.> ;Biochem. Soc. Trans.. 2012 Mar 23
• Synthesis, purification, and characterization of single helix membrane peptides and proteins for NMR spectroscopy.
  Itaya, M., Brett, I.C., Smith, S.O.> ;Methods Mol Biol. 2012
• Orientation-specific signalling by thrombopoietin receptor dimers.
  Staerk, J., Defour, J., Pecquet, C., Leroy, E., Antoine-Poirel, H., Brett, I., Itaya, M., Smith, S.O., Vainchenker, W., Constantinescu, S.N.> ;EMBO J. 2011 Nov 2
• Highly conserved tyrosine stabilizes the active state of rhodopsin.
  Goncalves, J.A., South, K., Ahuja, S., Zaitseva, E., Opefi, C.A., Eilers, M., Vogel, R., Reeves, P.J., Smith, S.O.> ;Proc Natl Acad Sci U S A. 2010 Nov 16
• N-terminal domain of myelin basic protein inhibits amyloid beta-protein fibril assembly.
  Liao, M., Hoos, M.D., Aucoin, D., Ahmed, M., Davis, J., Smith, S.O., Van Nostrand, W.E.> ;J Biol Chem. 2010 Nov 12
• Structure and activation of the visual pigment rhodopsin.
  Smith, S.O.> ;Annu Rev Biophys. 2010
• Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils.
  Ahmed, M., Davis, J., Aucoin, D., Sato, T., Ahuja, S., Aimoto, S., Elliott, J.I., Van Nostrand, W.E., Smith, S.O.> ;Nat Struct Mol Biol. 2010 May
• What is the role of amyloid precursor protein dimerization?
  Khalifa, N.B., Van Hees, J., Tasiaux, B., Huysseune, S., Smith, S.O., Constantinescu, S.N., Octave, J., Kienlen-Campard, P.> ;Cell Adh Migr. 2010-04-01
• 6-s-cis Conformation and polar binding pocket of the retinal chromophore in the photoactivated state of rhodopsin.
  Ahuja, S., Eilers, M., Hirshfeld, A., Yan, E.Y., Ziliox, M., Sakmar, T.P., Sheves, M., Smith, S.O.> ;J Am Chem Soc. 2009-10-28
• Degradation of amyloid beta protein by purified myelin basic protein.
  Liao, M., Ahmed, M., Smith, S.O., Van Nostrand, W.E.> ;J Biol Chem. 2009-10-16
• An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia.
  Plo, I., Zhang, Y., Le Couédic, J. P., Nakatake, M., Boulet, J. M., Itaya, M., Smith, S. O., Debili, N., Constantinescu, S. N., Vainchenker, W., Louache, F., de Botton...> ;J Exp Med. 2009-08-03
• EGFR juxtamembrane domain, membranes, and calmodulin: kinetics of their interaction.
  Sengupta, P., Bosis, E., Nachliel, E., Gutman, M., Smith, S.O., Mihályné, G., Zaitseva, I., McLaughlin, S.> ;Biophys J. 2009-06-17
• Myelin basic protein binds to and inhibits the fibrillar assembly of Abeta42 in vitro.
  Hoos, M.D., Ahmed, M., Smith, S.O., Van Nostrand, W.E.> ;Biochemistry. 2009-06-09
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