StuartALiptonMDPhD

Professor and Founding Director, Neurodegeneration New Medicines Center, Step Family Foundation Endowed Chair, Scripps Research; Professor of Neurology/Neurosciences (adj), UC San Diego School of Medicine & Yale School of Medicine. Previously: Asst., Assoc, Prof., Department of Neurology, Harvard Medical School; Director, CNS Research Institute, Brigham and Women's Hospital, Boston, Massachusetts

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Office
4510 Executive Dr
Ste 325
San Diego, CA 92121
Phone+1 858-657-8540
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Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Harvard Medical SchoolResidency, Neurology, 1978 - 1981
Beth Israel Deaconess Medical CenterInternship, Internal Medicine, 1977 - 1978
Perelman School of Medicine at the University of PennsylvaniaClass of 1977

Certifications & Licensure

MA State Medical License 1981 - 2025
CA State Medical License 1999 - 2025
ME State Medical License Active through 1988
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

Member AAAS, Neuroscience section, 2011
Awardee Ernst Jung Prize in Medicine, 2004
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2013

Publications & Presentations

PubMed

Enzymatic and non-enzymatic transnitrosylation: "SCAN"ning the SNO-proteome.
Tomohiro Nakamura, Stuart A Lipton> ;Molecular Cell. 2024 Jan 18
1 citations
Metabolic Bypass Rescues Aberrant S-nitrosylation-Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer's Disease Human Neurons.
Alexander Y Andreyev, Hongmei Yang, Paschalis-Thomas Doulias, Nima Dolatabadi, Xu Zhang, Melissa Luevanos, Mayra Blanco, Christine Baal, Ivan Putra, Tomohiro Nakamura,...> ;Advanced Science. 2024 Mar 1
Reply to: Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection.
Chang-Ki Oh, Juan Piña-Crespo, Maria Talantova, Lauren N Carnevale, Charlotte Stoneham, Mary Lewinski, John Guatelli, Stuart A Lipton> ;Nature Chemical Biology. 2023 Nov 1
1 citations
Restorative effect of NitroSynapsin on synaptic plasticity in an animal model of depression.
Wing Sze Tse, Bartłomiej Pochwat, Bernadeta Szewczyk, Paulina Misztak, Bartosz Bobula, Krzysztof Tokarski, Remigiusz Worch, Marta Czarnota-Bojarska, Stuart A Lipton, M...> ;Neuropharmacology. 2023 Dec 15
2 citations
S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons.
Paschalis-Thomas Doulias, Hongmei Yang, Alexander Y Andreyev, Nima Dolatabadi, Henry Scott, Charlene K Raspur, Parth R Patel, Tomohiro Nakamura, Steven R Tannenbaum, H...> ;Cell Chemical Biology. 2023 Aug 17
53 citations
Apoptotic cell death in disease-Current understanding of the NCCD 2023.
Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A Aaronson, John M Abrams, Dieter Adam, Massimiliano Agostini, Patrizia Agostinis, Emad S Alnemri, Lucia Altucc...> ;Cell Death and Differentiation. 2023 May 1
5 citations
Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis.
Kosaku Okuda, Kengo Nakahara, Akihiro Ito, Yuta Iijima, Ryosuke Nomura, Ashutosh Kumar, Kana Fujikawa, Kazuya Adachi, Yuki Shimada, Satoshi Fujio, Reina Yamamoto, Nobu...> ;Nature Communications. 2023 Feb 4
4 citations
Aberrant protein S-nitrosylation contributes to hyperexcitability-induced synaptic damage in Alzheimer's disease: Mechanistic insights and potential therapies.
Swagata Ghatak, Tomohiro Nakamura, Stuart A Lipton> ;Frontiers in Neural Circuits. 2023 Jan 1
19 citations
Mechanistic insight into female predominance in Alzheimer's disease based on aberrant protein S-nitrosylation of C3.
Hongmei Yang, Chang-Ki Oh, Haitham Amal, John S Wishnok, Sarah Lewis, Emily Schahrer, Dorit Trudler, Tomohiro Nakamura, Steven R Tannenbaum, Stuart A Lipton> ;Science Advances. 2022 Dec 14
6 citations
Hidden networks of aberrant protein transnitrosylation contribute to synapse loss in Alzheimer's disease.
Stuart A Lipton> ;Free Radical Biology & Medicine. 2022 Nov 20
11 citations
Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging.
Felipe Cabral-Miranda, Giovanni Tamburini, Gabriela Martinez, Alvaro O Ardiles, Danilo B Medinas, Yannis Gerakis, Mei-Li Diaz Hung, René Vidal, Matias Fuentealba, Tim ...> ;The EMBO Journal. 2022 Nov 17
2 citations
Towards development of disease-modifying therapy for Alzheimer's disease using redox chemical biology pathways.
Stuart A Lipton> ;Current Opinion in Pharmacology. 2022 Oct 1
14 citations
Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection.
Chang-Ki Oh, Tomohiro Nakamura, Nathan Beutler, Xu Zhang, Juan Piña-Crespo, Maria Talantova, Swagata Ghatak, Dorit Trudler, Lauren N Carnevale, Scott R McKercher, Mali...> ;Nature Chemical Biology. 2023 Mar 1
8 citations
S-Nitrosylation of cathepsin B affects autophagic flux and accumulation of protein aggregates in neurodegenerative disorders.
Ki-Ryeong Kim, Eun-Jung Cho, Jae-Won Eom, Sang-Seok Oh, Tomohiro Nakamura, Chang-Ki Oh, Stuart A Lipton, Yang-Hee Kim> ;Cell Death and Differentiation. 2022 Nov 1
15 citations
S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia.
Chang-Ki Oh, Nima Dolatabadi, Piotr Cieplak, Maria T Diaz-Meco, Jorge Moscat, John P Nolan, Tomohiro Nakamura, Stuart A Lipton> ;The Journal of Neuroscience. 2022 Apr 6
48 citations
Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer's Disease, Parkinson's Disease, and Long-COVID through NRF2 Activation to Counteract th...
Takumi Satoh, Dorit Trudler, Chang-Ki Oh, Stuart A Lipton> ;Antioxidants. 2022 Jan 6
2 citations
Inhibition of autophagic flux by S-nitrosylation of SQSTM1/p62 promotes neuronal secretion and cell-to-cell transmission of SNCA/α-synuclein in Parkinson disease and L...
Oh, C., Nakamura, T., Lipton, S.> ;Autophagy Reports. 2022 Jan 1
8 citations
Emerging hiPSC Models for Drug Discovery in Neurodegenerative Diseases
Dorit Trudler, Swagata Ghatak, Stuart A. Lipton> ;International Journal of Molecular Sciences. 2021 Jul 30
35 citations
Protein S-nitrosylation and oxidation contribute to protein misfolding in neurodegeneration.
Tomohiro Nakamura, Chang-ki Oh, Xu Zhang, Stuart A. Lipton> ;Free Radical Biology & Medicine. 2021 Jul 2
17 citations
Protein Transnitrosylation Signaling Networks Contribute to Inflammaging and Neurodegenerative Disorders
Tomohiro Nakamura, Chang-ki Oh, Xu Zhang, Steven R. Tannenbaum, Stuart A. Lipton> ;Antioxidants & Redox Signaling. 2021 Aug 10
Correction to: TCA cycle metabolic compromise due to an aberrant S‑nitrosoproteome in HIV‑associated neurocognitive disorder with methamphetamine use.
Paschalis-Thomas Doulias, Tomohiro Nakamura, Henry Scott, Scott R McKercher, Abdullah Sultan, Amanda Deal, Matthew Albertolle, Harry Ischiropoulos, Stuart A Lipton> ;Journal of Neurovirology. 2021 Jun 1
5 citations
TCA cycle metabolic compromise due to an aberrant S-nitrosoproteome in HIV-associated neurocognitive disorder with methamphetamine use.
Paschalis-Thomas Doulias, Tomohiro Nakamura, Henry Scott, Scott R McKercher, Abdullah Sultan, Amanda Deal, Matthew Albertolle, Harry Ischiropoulos, Stuart A Lipton> ;Journal of Neurovirology. 2021 Jun 1
59 citations
Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.
Dorit Trudler, Kristopher L. Nazor, Yvonne S. Eisele, Titas Grabauskas, Nima Dolatabadi, James C. Parker, Abdullah Sultan, Zhenyu Zhong, Marshall S. Goodwin, Yona Levi...> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Apr 13
18 citations
S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD.
Elaine Pirie, Chang-ki Oh, Xu Zhang, Xuemei Han, Piotr Cieplak, Henry R. Scott, Amanda K. Deal, Swagata Ghatak, Fernando J. Martinez, Gene W. Yeo, John R. Yates, Tomoh...> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Mar 16
52 citations
α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss.
Dorit Trudler, Sara Sanz-Blasco, Yvonne S. Eisele, Swagata Ghatak, Karthik Bodhinathan, Mohd Waseem Akhtar, William P. Lynch, Juan C. Piña-Crespo, Maria Talantova, Jef...> ;The Journal of Neuroscience. 2021 Mar 10
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Press Mentions

SNO-Y Protein Levels Help Explain Why More Women Develop Alzheimer’sJanuary 6th, 2023
Beer, Dolphins and More Discoveries That Could Shed Light on Alzheimer’s DiseaseDecember 22nd, 2022
Brain Protein Offers Clues About Higher Risk in WomenDecember 17th, 2022
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Grant Support

Project II - Clinically-Safe Nmdar Antagonists Prevent NeurotoxicityEunice Kennedy Shriver National Institute Of Child Health &Human Development2012
Core A - Administrative And Statistical ComponentsEunice Kennedy Shriver National Institute Of Child Health &Human Development2012
Cellular/Molecular Pathophysiology Of Intellectual And Developmental DisabilitiesEunice Kennedy Shriver National Institute Of Child Health &Human Development2012
LA Jolla Interdisciplinary Neuroscience Center CoresNational Institute Of Neurological Disorders And Stroke2011
Administrative Core (SBMRI)National Institute Of Neurological Disorders And Stroke2011
Clinically-Safe Nmdar Antagonists Prevent NeurotoxicityEunice Kennedy Shriver National Institute Of Child Health &Human Development2011
Administrative/Neuroscience CoresEunice Kennedy Shriver National Institute Of Child Health &Human Development2011
Project 3: S-Nitrosylation Affects Protein Misfolding And Contributes To ParkinsoNational Institute Of Environmental Health Sciences2010–2011
LA Jolla-Parkinson'S Disease Center GrantNational Institute Of Environmental Health Sciences2010–2011
Core F: Research Development CoreNational Institute Of Environmental Health Sciences2010–2011
Administrative /Biostatistical CoreNational Institute Of Environmental Health Sciences2010–2011
Cellular/Molecular Pathophysiology Of Mental RetardationEunice Kennedy Shriver National Institute Of Child Health &Human Development2010–2011
LA Jolla Interdisciplinary Neuroscience Center Cores - Vital VNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center Cores - Structural BIO Core SalkNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center Cores - Structural BIO Core BUNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center Cores - Stem Cell Core BUNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center Cores - SalkNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center Cores - PRO Core Tsri SAT SiteNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center Cores - PRO Core SalkNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center Cores - PRO Core BUNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center Cores - Nueropathology Core UCSDNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center Cores - Molecular Imaging Hist CORNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center Cores - Htca CoreNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center Cores - Gene Core SalkNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center Cores - Gene Analysis Core BUNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center Cores - Electro Core SalkNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center Cores - Electro Core BUNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center Cores - Chemical CoreNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center Cores - Burnham AdminNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center Cores - Bioinfo Core SalkNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center Cores - BIO Info Core BUNational Institute Of Neurological Disorders And Stroke2010
LA Jolla Interdisciplinary Neuroscience Center CoresNational Institute Of Neurological Disorders And Stroke2010
Retinal Ganglion Cells: Ion Channels &TransmittersNational Eye Institute2010
LA Jolla Interdisciplinary Neuroscience Center Cores - Vital VNational Institute Of Neurological Disorders And Stroke2009
LA Jolla Interdisciplinary Neuroscience Center Cores - Structural BIO Core SalkNational Institute Of Neurological Disorders And Stroke2009
LA Jolla Interdisciplinary Neuroscience Center Cores - Structural BIO Core BUNational Institute Of Neurological Disorders And Stroke2009
LA Jolla Interdisciplinary Neuroscience Center Cores - Stem Cell Core BUNational Institute Of Neurological Disorders And Stroke2009
LA Jolla Interdisciplinary Neuroscience Center Cores - SalkNational Institute Of Neurological Disorders And Stroke2009
LA Jolla Interdisciplinary Neuroscience Center Cores - PRO Core Tsri SAT SiteNational Institute Of Neurological Disorders And Stroke2009
LA Jolla Interdisciplinary Neuroscience Center Cores - PRO Core SalkNational Institute Of Neurological Disorders And Stroke2009
LA Jolla Interdisciplinary Neuroscience Center Cores - PRO Core BUNational Institute Of Neurological Disorders And Stroke2009
LA Jolla Interdisciplinary Neuroscience Center Cores - Nueropathology Core UCSDNational Institute Of Neurological Disorders And Stroke2009
LA Jolla Interdisciplinary Neuroscience Center Cores - Molecular Imaging Hist CORNational Institute Of Neurological Disorders And Stroke2009
LA Jolla Interdisciplinary Neuroscience Center Cores - Htca CoreNational Institute Of Neurological Disorders And Stroke2009
LA Jolla Interdisciplinary Neuroscience Center Cores - Gene Core SalkNational Institute Of Neurological Disorders And Stroke2009
LA Jolla Interdisciplinary Neuroscience Center Cores - Gene Analysis Core BUNational Institute Of Neurological Disorders And Stroke2009
LA Jolla Interdisciplinary Neuroscience Center Cores - Electro Core SalkNational Institute Of Neurological Disorders And Stroke2009
LA Jolla Interdisciplinary Neuroscience Center Cores - Electro Core BUNational Institute Of Neurological Disorders And Stroke2009
LA Jolla Interdisciplinary Neuroscience Center Cores - Chemical CoreNational Institute Of Neurological Disorders And Stroke2009
LA Jolla Interdisciplinary Neuroscience Center Cores - Burnham AdminNational Institute Of Neurological Disorders And Stroke2009
LA Jolla Interdisciplinary Neuroscience Center Cores - Bioinfo Core SalkNational Institute Of Neurological Disorders And Stroke2009
LA Jolla Interdisciplinary Neuroscience Center Cores - BIO Info Core BUNational Institute Of Neurological Disorders And Stroke2009
Project 3: S-Nitrosylation Affects Protein Misfolding And Contributes To ParkinsoNational Institute Of Environmental Health Sciences2008–2009
LA Jolla-Parkinson'S Disease Center GrantNational Institute Of Environmental Health Sciences2008–2009
Core F: Research Development CoreNational Institute Of Environmental Health Sciences2008–2009
Administrative /Biostatistical CoreNational Institute Of Environmental Health Sciences2008–2009
Erythropoietin PLUS Igf-In Neuroprotection From AIDSNational Institute Of Neurological Disorders And Stroke2007–2009
LA Jolla Interdisciplinary Neuroscience Center CoresNational Institute Of Neurological Disorders And Stroke2006–2009
Retinal Ganglion Cells: Ion Channels &TransmittersNational Eye Institute2006–2009
Aids-Related Neurotoxicity And Novel Nmdar AntagonistsNational Eye Institute2005–2009
Clinically-Safe Nmdar Antagonists Prevent NeurotoxicityEunice Kennedy Shriver National Institute Of Child Health &Human Development2005–2009
Cellular/Molecular Pathophysiology Of Mental RetardationEunice Kennedy Shriver National Institute Of Child Health &Human Development1999–2009
Neurodegenerative Effects Of Botulinum ToxinsNational Institute Of Allergy And Infectious Diseases2004–2008
Neuroscience Research CoreEunice Kennedy Shriver National Institute Of Child Health &Human Development2007
S-Nitrosylation Of Matrix Metalloproteinases In AIDSNational Institute Of Neurological Disorders And Stroke2004–2007
Caspase Cleavage Of MEF2 Mediates Neuronal ApoptosisNational Institute Of Neurological Disorders And Stroke2003–2007
EPO PLUS IGF-I In Neuroprotection From AIDSNational Institute Of Neurological Disorders And Stroke2005–2006
Administrative/Neuroscience CoresEunice Kennedy Shriver National Institute Of Child Health &Human Development2005
Erythropoietin-Induced NeuroprotectionNational Institute Of Neurological Disorders And Stroke2002–2005
EPO PLUS Igf-In Neuroprotection From AIDSNational Institute Of Neurological Disorders And Stroke2004
Retinal Ganglion Cells--Ion Channels &TransmittersNational Eye Institute2000–2004
Neurobiology Of Disease -- Teaching WorkshopNational Institute Of Neurological Disorders And Stroke2001–2003
Chemokines And Macrophages In HIV Neuronal ApoptosisNational Institute Of Neurological Disorders And Stroke2001–2003
Aids-Related Neurotoxcity: GP120 And ChemokinesNational Eye Institute2000–2003
Developmental CoreNational Institute Of Mental Health2001–2002
HIV Associated Neurotoxicity And NMDA AntagonistsEunice Kennedy Shriver National Institute Of Child Health &Human Development1999–2002
Core--Neuroscience ResearchEunice Kennedy Shriver National Institute Of Child Health &Human Development1999–2002
Clinically SAFE NMDA Antagonists Prevent NeurotoxicityEunice Kennedy Shriver National Institute Of Child Health &Human Development1996–2002
Neurobiology Of Disease Teaching WorkshopsNational Institute Of Neurological Disorders And Stroke2000
Retinal Ganglion Cells--Ion Channels And TransmittersNational Eye Institute1999
AIDS Related Neurotoxicity GP120 And NMDA AntagonistsNational Eye Institute1999
AIDS Related Neurotoxicity GP120 And ChemokinesNational Eye Institute1999
Retinal Ganglion Cells--Ion Channels And TransmittersNational Eye Institute1997–1998
AIDS Related Neurotoxicity GP120 And NMDA AntagonistsNational Eye Institute1997–1998
Cellular/Molecular Pathophysiology Of Mental RetardationEunice Kennedy Shriver National Institute Of Child Health &Human Development1997
Core--Neuroscience CoreEunice Kennedy Shriver National Institute Of Child Health &Human Development1996–1997
Clinically SAFE NMDA Antagonists Prevent NeurotoxicityEunice Kennedy Shriver National Institute Of Child Health &Human Development1996–1997
AIDS Related Neurotoxicity GP120 And NMDA AntagonistsNational Eye Institute1995–1997
Retinal Ganglion Cells--Ion Channels And TransmittersNational Eye Institute1994–1997
Cellular/Molecular Pathophysiology Of Mental RetardationEunice Kennedy Shriver National Institute Of Child Health &Human Development1992–1997
Ca++ Channel Antagonists And Aids-Related NeurotoxicityNational Eye Institute1994
Thy-1 And Neurite Regeneration By Retinal Ganglion CellsNational Eye Institute1986–1994
Retinal Ganglion Cells: Ion Channels &TransmittersNational Eye Institute1991–1993
CA2+ Channel Antagonists And Aids-Related NeurotoxicityNational Eye Institute1991–1993
Developmental NeurologyNational Institute Of Neurological Disorders And Stroke1988–1993
Retinal Ganglion Cells--Ion Channels &TransmittersNational Eye Institute1988–1990
Communication And Regeneration Of CNS NeuritesNational Institute Of Neurological Disorders And Stroke1985–1988
Retinal Ganglion Cells: Ion Channel &TransmittersNational Eye Institute1987
RAT Retinal Ganglion Cells: Ion Channels &TransmittersNational Eye Institute1985–1986

Other Languages

Spanish

Hospital Affiliations

UC San Diego Medical Center - HillcrestSan Diego, California

Industry Relationships

Scientific Advisory Board Member, Eli LillyMember of Neuroscience SABDisclosure: Consultancy payment2015 - Present
Scientific Founder, ADAMAS Pharmaceuticals, Inc.Scientific Co-FounderDisclosure: Equity2000 - Present