SylviaMinaLeeMD

Oncology • Seattle, WA

Assistant Professor, Medicine, University of Washington School of Medicine

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Office
825 Eastlake Ave E
Seattle, WA 98109
Phone+1 855-557-0555

Fax+1 206-606-1025
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Education & Training

University of WashingtonFellowship, Hematology and Medical Oncology, 2006 - 2009
University of WashingtonResidency, Internal Medicine, 2003 - 2006
University of North Carolina at Chapel Hill School of MedicineClass of 2003

Certifications & Licensure

WA State Medical License 2006 - 2024

Clinical Trials

Vaccine Therapy Following Therapeutic Autologous Lymphocytes and Cyclophosphamide in Treating Patients With Metastatic Melanoma Start of enrollment: 2012 Mar 01
Completed
Phase 1
Tumor-Infiltrating Lymphocytes After Combination Chemotherapy in Treating Patients With Metastatic Melanoma Start of enrollment: 2013 Aug 20
Completed
Phase 2

Publications & Presentations

PubMed

79 citations
Non-viral precision T cell receptor replacement for personalized cell therapy.
Susan P Foy, Kyle Jacoby, Daniela A Bota, Theresa Hunter, Zheng Pan, Eric Stawiski, Yan Ma, William Lu, Songming Peng, Clifford L Wang, Benjamin Yuen, Olivier Dalmas, ...> ;Nature. 2023 Mar 1
2 citations
Associating sleep problems with advanced cancer diagnosis, and immune checkpoint treatment outcomes: a pilot study.
Arthur Sillah, Ulrike Peters, Nathaniel F Watson, Scott S Tykodi, Evan T Hall, Allison Silverman, Rachel C Malen, John A Thompson, Sylvia M Lee, Shailender Bhatia, Jos...> ;Supportive Care in Cancer. 2022 May 1
52 citations
Neoantigen-specific CD4T cells in human melanoma have diverse differentiation states and correlate with CD8T cell, macrophage, and B cell function.
Joshua R Veatch, Sylvia M Lee, Carolyn Shasha, Naina Singhi, Julia L Szeto, Ata S Moshiri, Teresa S Kim, Kimberly Smythe, Paul Kong, Matthew Fitzgibbon, Brenda Jeserni...> ;Cancer Cell. 2022 Apr 11
12 citations
Impact of HPV status on immune responses in head and neck squamous cell carcinoma.
Hannan A Qureshi, Xiaodong Zhu, Grace H Yang, Melissa Steadele, Robert H Pierce, Neal D Futran, Sylvia M Lee, Eduardo Méndez, A McGarry Houghton> ;Oral Oncology. 2022 Apr 1
7 citations
Performance status (PS) as a predictor of poor response to immune checkpoint inhibitors (ICI) in recurrent/metastatic head and neck cancer (RMHNSCC) patients.
Cameron Chalker, Jenna M Voutsinas, Qian Vicky Wu, Rafael Santana-Davila, Victoria Hwang, Christina S Baik, Sylvia Lee, Brittany Barber, Neal D Futran, Jeffrey J Hoult...> ;Cancer Medicine. 2022 Nov 1
High End-of-Life Health Care Utilization in a Contemporary Cohort of Head and Neck Cancer Patients Treated with Immune Checkpoint Inhibitors.
Cameron Chalker, Rafael Santana-Davila, Jenna M. Voutsinas, Qian Vicky Wu, Victoria Hwang, Christina S. Baik, Sylvia Lee, Brittany Barber, Neal D. Futran, Jeffrey J. H...> ;Journal of Palliative Medicine. 2021 Nov 30
2 citations
Prognostic Value of Early Fluorodeoxyglucose-Positron Emission Tomography Response Imaging and Peripheral Immunologic Biomarkers: Substudy of a Phase II Trial of Risk-...
Stephen R Bowen, Daniel S Hippe, Hannah M Thomas, Balukrishna Sasidharan, Paul D Lampe, Christina S Baik, Keith D Eaton, Sylvia Lee, Renato G Martins, Rafael Santana-D...> ;Advances in Radiation Oncology. 2021 Nov 21
139 citations
Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade.
Shivani Srivastava, Scott N. Furlan, Carla A. Jaeger-Ruckstuhl, Megha Sarvothama, Carolina Berger, Kimberly S. Smythe, Sarah M. Garrison, Jennifer M. Specht, Sylvia Le...> ;Cancer Cell. 2021 Feb 8
1 citations
Predictive lifestyle markers for efficacy of cancer immune checkpoint inhibitors: a commentary.
Arthur Sillah, Scott S. Tykodi, Evan T. Hall, John A. Thompson, Nathaniel F. Watson, Sylvia Lee, Shailender Bhatia, Joshua R. Veatch, Jeannie Warner, Ulrike Peters, Ra...> ;Future Oncology. 2021 Jan 5
A Phase II study of nab-Paclitaxel (nab-P) in patients with advanced non-small cell lung cancer with EGFR mutations after frontline tyrosine kinase inhibitor therapy.
Christina S. Baik, Sylvia Lee, Kitty Cook, Sarah G. Wallace, Rebecca Wood, Rafael Santana-Davila, Laura Q.M. Chow, Cristina P. Rodriguez, Keith D. Eaton, Renato G. Mar...> ;Cancer Treatment and Research Communications. 2021 Jan 1
13 citations
A Pilot Study of Atezolizumab Plus Hypofractionated Image Guided Radiation Therapy for the Treatment of Advanced Non-Small Cell Lung Cancer.
Angel Qin, Ramesh Rengan, Sylvia Lee, Rafael Santana-Davila, Bernardo H. L. Goulart, Renato G. Martins, Christina S. Baik, Gregory P. Kalemkerian, Khaled A. Hassan, Br...> ;International Journal of Radiation Oncology, Biology, Physics. 2020 Sep 1
101 citations
A Phase II Trial of Pembrolizumab and Vorinostat in Recurrent Metastatic Head and Neck Squamous Cell Carcinomas and Salivary Gland Cancer.
Cristina P. Rodriguez, Qian Vicky Wu, Jenna M. Voutsinas, Jonathan R. Fromm, Xiuyun Jiang, Venu G. Pillarisetty, Sylvia Lee, Rafael Santana-Davila, Bernardo H. L. Goul...> ;Clinical Cancer Research. 2020 Feb 15
58 citations
Endogenous CD4+ T Cells Recognize Neoantigens in Lung Cancer Patients, Including Recurrent Oncogenic KRAS and ERBB2 (Her2) Driver Mutations.
Joshua R. Veatch, Brenda Jesernig, Julia Kargl, Matthew Fitzgibbon, Sylvia Lee, Christina S. Baik, Renato G. Martins, A. McGarry Houghton, Stanley R. Riddell> ;Cancer Immunology Research. 2019 Jan 1
7 citations
Immunotherapy Approaches Beyond PD-1 Inhibition: the Future of Cellular Therapy for Head and Neck Squamous Cell Carcinoma.
Hannan A. Qureshi, Sylvia Lee> ;Current Treatment Options in Oncology. 2019 Mar 14
122 citations
Phase I Trial of ALT-803, A Novel Recombinant IL15 Complex, in Patients with Advanced Solid Tumors.
Kim Margolin, Chihiro Morishima, Vamsidhar Velcheti, Jeffrey S. Miller, Sylvia Lee, Ann W. Silk, Shernan G. Holtan, Andreanne M. Lacroix, Steven P. Fling, Judith C Kai...> ;Clinical Cancer Research. 2018 Nov 15
7 citations
Racial disparity in oncologic and quality-of-life outcomes in patients with locally advanced head and neck squamous cell carcinomas enrolled in a randomized phase 2 tr...
Margaret K. Guerriero, Mary W. Redman, Kelsey Baker, Renato G. Martins, Keith D. Eaton, Laura Qm Chow, Rafael Santana-Davila, Christina S. Baik, Bernardo H. L. Goulart...> ;Cancer. 2018 Jul 1
11 citations
Phase II trial of eribulin mesylate in recurrent or metastatic salivary gland malignancies.
Cristina P. Rodriguez, Renato G. Martins, Christina S. Baik, Laura Qm Chow, Rafael Santana-Davila, Bernardo H. L. Goulart, Sylvia Lee, Keith D. Eaton> ;Head & Neck. 2018 Mar 1
80 citations
Tumor-infiltrating BRAFV600E-specific CD4+ T cells correlated with complete clinical response in melanoma
Joshua R. Veatch, Sylvia Lee, Matthew Fitzgibbon, I-Ting Chow, Brenda Jesernig, Thomas M. Schmitt, Ying Ying Kong, Julia Kargl, A. McGarry Houghton, John A. Thompson, ...> ;The Journal of Clinical Investigation. 2018 Jan 23
6 citations
Predictors of outcome with cetuximab and paclitaxel for head and neck squamous cell carcinoma.
Bruna Pellini Ferreira, Mary W. Redman, Kelsey Baker, Renato G. Martins, Keith D. Eaton, Laura Q.M. Chow, Christina S. Baik, Bernardo H. L. Goulart, Sylvia Lee, Rafael...> ;The Laryngoscope. 2017 Jul 1
263 citations
Neutrophils dominate the immune cell composition in non-small cell lung cancer
Julia Kargl, Stephanie E. Busch, Grace H. Y. Yang, Kyoung-Hee Kim, Mark L. Hanke, Heather E. Metz, Jesse J. Hubbard, Sylvia Lee, David K. Madtes, Martin W. McIntosh, A...> ;Nature Communications. 2017 Feb 1
84 citations
T-Cell Therapy Using Interleukin-21–Primed Cytotoxic T-Cell Lymphocytes Combined With Cytotoxic T-Cell Lymphocyte Antigen-4 Blockade Results in Long-Term Cell Persiste...
Aude G. Chapuis, Ilana M. Roberts, John A. Thompson, Kim Margolin, Shailender Bhatia, Sylvia Lee, Heather L. Sloan, Ivy Lai, Erik A. Farrar, Felecia Wagener, Kendall C...> ;Journal of Clinical Oncology. 2016 Oct 23
67 citations
Combined IL-21–primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient
Aude G. Chapuis, Sylvia Lee, John A. Thompson, Ilana M. Roberts, Kim Margolin, Shailender Bhatia, Heather L. Sloan, Ivy Lai, Felecia Wagener, Kendall C. Shibuya, Jianh...> ;The Journal of Experimental Medicine. 2016 Jun 27
7 citations
Concurrent cetuximab and postoperative radiation in resected high-risk squamous cell carcinomas of the head and neck: A single-institution experience.
Daisuke Araki, Mary W. Redman, Renato G. Martins, Keith D. Eaton, Christina S. Baik, Laura Q.M. Chow, Bernardo H. L. Goulart, Sylvia Lee, Rafael Santana-Davila, Jay J....> ;Head & Neck. 2016 Apr 7
27 citations
Systemic Therapy of Metastatic Melanoma: On the Road to Cure
Shailender Bhatia, Scott S. Tykodi, Sylvia Lee, John A. Thompson> ;Oncology. 2015 Feb 15
71 citations
Phase 2 study of RO4929097, a gamma-secretase inhibitor, in metastatic melanoma: SWOG 0933
Sylvia Lee, James C. Moon, Bruce G. Redman, Tarek Chidiac, Lawrence E. Flaherty, Yuanyuan Zha, Megan Othus, Antoni Ribas, Vernon K. Sondak, Thomas F. Gajewski, Kim Mar...> ;Cancer. 2015 Feb 1
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Journal Articles

Phase I Trial of ALT-803, a Novel Recombinant Interleukin-15 Complex, in Patients with Advanced Solid Tumors
Jeffrey S Miller, Shernan G Holtan, Sylvia M Lee, Chihiro Morishima, Ann W Silk, Clinical Cancer Research